CHAPTER 4: Adaptive Immunity

Which MHC molecule is necessary for antigen recognition by CD4+ T cells?

Class I

Class II

Class III

No MHC molecule is necessary.

Which would be characteristic of a T-independent antigen?

The IgG antibody is produced exclusively.

A large number of memory cells are produced.

Antigens bind only one receptor on B cells.

It consists of a limited number of repeating determinants.

Humoral immunity refers to which of the following?

Production of antibody by plasma cells

Production of cytokines by T cells

Elimination of virally infected cells by cytotoxic cells

Downregulation of the immune response

Where does antigen-independent maturation of B lymphocytes take place?

Bone marrow

Thymus

Spleen

Lymph nodes

In the thymus, positive selection of immature T cells is based upon recognition of which of the following?

Self-antigens

Stress proteins

MHC antigens

μ chains

Which of these are found on a mature B cell?

IgG and IgD

IgM and IgD

Alpha and beta chains

CD3

How do cytotoxic T cells kill target cells?

They produce antibodies that bind to the cell.

They engulf the cell by phagocytosis.

They stop protein synthesis in the target cell.

They produce granzymes that stimulate apoptosis.

Which of the following can be attributed to antigen-stimulated T cells?

Humoral response

Plasma cells

Cytokines

Antibody

Which is a distinguishing feature of a pre-B cell?

μ chains in the cytoplasm

Complete IgM on the surface

Presence of CD21 antigen

Presence of CD25 antigen

When does genetic rearrangement for coding of antibody light chains take place during B-cell development?

Before the pre-B cell stage

As the cell becomes an immature B cell

Not until the cell becomes a mature B cell

When the B cell becomes a plasma cell

Which of the following antigens are found on the T-cell subset known as helper/inducers?

CD3

CD4

CD8

CD11

Where does the major portion of antibody production occur?

Peripheral blood

Bone marrow

Thymus

Lymph nodes

Which of the following would represent a double-negative thymocyte?

CD2–CD3+CD4–CD8+

CD2–CD3–CD4+CD8–

CD2+CD3+CD4–CD8–

CD2–CD3–CD4+CD8–

Which of the following best describes the T-cell receptor for antigen?

It consists of IgM and IgD molecules.

It is the same for all T cells.

It is present in the double-negative stage.

Alpha and beta chains are unique for each antigen.

A cell flow cytometry pattern belonging to a 3-year-old patient showed the following: normal CD4+ T-cell count, normal CD19+ B-cell count, low CD8+ T-cell count. Which type of immunity would be affected?

Production of antibody

Formation of plasma cells

Elimination of virally infected cells

Downregulation of the immune response

Which of the following is a unique characteristic of adaptive immunity?

Ability to fight infection

Ability to remember a prior exposure to a pathogen

A similar response to all pathogens encountered

Process of phagocytosis to destroy a pathogen

Clonal deletion of T cells as they mature is important in which of the following processes?

Elimination of autoimmune responses

Positive selection of CD3/TCR receptors

Allelic exclusion of chromosomes

Elimination of cells unable to bind to MHC antigens

Where do germinal centers occur?

In the thymus

In the bone marrow

In peripheral blood

In lymph nodes

CHAPTER 4: Adaptive Immunity

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