Quiz on Polygenic risk scores

What distinguishes a Polygenic Risk Score (PRS) from traditional monogenic genetic testing in cardiovascular disease?
They have a greater impact on the individual risk
PRS calculates the cumulative risk from thousands of common genetic variants (SNPs), each with a small effect size
PRS are mostly applicable to rare diseases
They follow mendelian inheritance patterns
What is currently one of the most significant barriers to the global implementation of PRS in cardiology?
Sequencing time
Extrapolation from discovery cohorts to implementation cohorts
Economic burden
Sex-related differences
What is the impact of a healthy lifestyle on the cardiovascular risk of individuals in the highest quintile of polygenic risk?
Negligible, as the genetic burden is the primary driver of events
Significant only when implemented during childhood
It substantially reduces absolute and relative risk throughout adult life
Only smoking cessation, but not diet or exercise, has shown a benefit
According to a recent consensus statement of the ESC in which patients do PRS have the highest potential for clinical impact?
Patients in the intermediate-high risk categories
Newborns
Patients with a known monogenic familial hypercholesterolemia
Secondary prevention
What are the main advantages of Polygenic Risk Scores (PRS)? Select the false statement
Can be used in clinical setting for risk stratification and disease prediction
Require invasive procedures and repeated biological sampling
Are based on genetic data
Can be available from birth
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