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2. Krones et al. Study gives evidence for?

IAsp use in paediatric age group

IAsp use in elderly age group

IAsp use and pregnancy

IAsp use and foetal outcome

3. In Van Bon et al. Unexplained hyperglycemia was defined as:

Plasma glucose more than 200 mg/dl

Plasma glucose more than 300 mg/dl

Plasma glucose more than 350 mg/dl

Plasma glucose more than 400 mg/dl

4. Novorapid is produced by

Substitution of B29 amino acid proline with aspartic acid

Deletion of B30 amino acid threonine

Adding fatty di-acid side chain at B29 position

Substitution of B28 amino acid proline with aspartic acid

5. Pharmacokinetic profile of novorapid as compared to Actrapid

Lesser Tmax, higher Cmax

Lesser Tmax, lesser Cmax

Higher Tmax, higher Cmax

10. In Heller study as compared to HI with Novorapid there was 72% reduction in?

Minor hypoglycemia

Nocturnal hypoglycemia

Severe nocturnal hypoglycemia

11. BIAsp 30 provides all except:

Improved postprandial blood glucose

Superior HbA1c reduction to basal–bolus for insulin intensification

Significantly reduced HbA1c in patients switching from BHI 30

Reduced major and nocturnal hypoglycaemia vs. BHI 30

13. True statement about Hermansen K et al study results?

Post prandial glycaemic control with BIAsp 30was superior to that with BHI 30 and Biphasic LisproMix 25/75

Time to maximum glucose concentration with BIasp 30 was shorter as compared to Biphasic LisproMix 25/75

Reduced maximum glucose concentration occurred earlier with BIAsp 30 compared to BHI 30

All of the above

15. In the 1 2 3 study By Garber et al published in 2009, Once-daily dosing of BIAsp 30 enabled _____% of all patients and twice daily BIAsp 30 enabled ______% to achieve the ADA HbA1c target <7.0%.

22% and 44%

30% and 62%

41% and 70%

60% and 80%

16. Which of the statement regarding A1CHIEVE study is incorrect?

One of the largest observational study with more than 60,000 patients

Patients were switched from NovoMix to basal bolus therapy

NovoMix therapy reduced the risk of both nocturnal and major hypos

Patients were switched from other treatment regimens to NovoMix

17. Post meal hyperglycaemia has been shown to be independently associated with all the following except?

Macrovascular disease

Retinopathy

Increased carotid intima media thickness

Increased cognitive function in elderly with Type 2 diabetes

19. Following statement is false about Euromix study?

BIAsp 30 once a day was compared to once daily glargine in this RCT.

Type 2 diabetes patients who were uncontrolled on basal insulin were randomized in this study

This was an observational study

All of the above

20. False statement about A1chieve study?

This is an observational study that included >66,000 type 2 diabetes patients across the globe

Over a period of 24 weeks there was a significant reduction in rates of major and nocturnal hypoglycaemias

The definition of major hypoglycaemia corresponded to blood glucose value of <70mg/dl in this study

None of the above

21. Ryzodeg® is a combination of

70% insulin aspart and 30% insulin degludec

50% insulin aspart and 50% insulin degludec

25% insulin aspart and 70% insulin degludec

30% insulin aspart and 70% insulin degludec

22. Ryzodeg® is not a premix insulin because

The long-acting basal component is protaminated

It requires resuspension

It is a combination of two distinct insulin analogues

None of the above

23. All of the following is true about Ryzodeg®, except:

It has two insulin analogues in same pen

It is based on NPH insulin technology

Two components do not interact in subcutaneous tissue

Two components are both in neutral PH

24. Insulin Detemir cannot be co formulated with Insulin aspart

Because it forms dihexamers

It exists in solution at acidic PH

It is not long acting

It forms hybrid hexamers

25. NovoMix & IDegAsp are pharmacologically different because

NovoMix has protamination technology

Basal insulin in Novomix is not a long acting

Lack of flat profile

All the above

27. All of the following are true about insulin degludec, except:

Soluble at PH 7.4

Can be co-formulated with short acting insulin analogues

Forms stable multi-hexamers

Forms hybrid-hexamers when combined with short acting insulin analogues

28. Which of the following about Ryzodeg® is false?

The rapid-acting pharmacokinetics of IAsp are preserved in IDegAsp at steady state

The flat, ultra-long pharmacokinetics of IDeg are preserved in IDegAsp at steady state

In a model of the subcutaneous environment, IDeg forms distinct multi-hexamers that are slowly absorbed, while IAsp immediately forms monomers that are rapidly absorbed

IDeg and IAsp exist as hybrid multi-hexamers

29. True about IDegAsp is all except

Ryzodeg™ can be used in elderly patients≥ 65 years old

Ryzodeg™ can be used in renal and hepatic impaired patients

Ryzodeg™ can be used in insulin infusion pumps

Ryzodeg™ must not be administered intramuscularly as it may change the absorption.

30. Which of the following is false?

IAsp: the pharmacokinetics of IAsp have been unaffected by renal impairment and hepatic impairment

IDeg: various degrees of renal impairment do not affect the pharmacokinetic profile or clearance of IDeg

IAsp: is contraindicated in mild to moderate renal impairment patients

None of the above

31. All employees should report any customer complaint (Product defect/AE/SAE) or safety information to

Safety Team (INAGREE@novonordisk.com)

GM (General Manager)

HQ (Head Quarters)

None of the above

34. In case if you observe errors in label, promotional material contact

Line Manager & QA

No need to report to any one

Distribute to HCP with error

Do not know

35. Corrections to printed or handwritten data must be made so that the original text is:

Strikethrough so nothing is readable

Strikethrough but readable

Completely covered using a whitener

Enter duplicate data

36. In NN, we follow any applicable laws, regulations and industry codes. We also follow our own business ethics standards and procedures (Novo Nordisk Code of Conduct). According to the Business Ethics Code of Conduct, which of the following statements is correct?

Local law and industry code may be disregarded, if my local legal department approves it

Novo Nordisk standards and procedures may be overruled if more stringent rules apply locally

Either of the above

37. An employee invites an HCP as a speaker for a meeting to be held on 20th August 2017. You send the request for contract preparation to the legal department by filling up the contract initiation template. Amount to be paid for the services is INR 50,000. When you will calculate FMV?

At the time of payment

At the time of preparation of the contract

Either of the above

None of the above

38. In a Sponsorship, the following is acceptable:

Payment routed to HCP’s directly need not include any follow up documentation.

While Sponsoring an event, commercial benefit for Novo Nordisk and disclosure of the fact that the event has been sponsored by Novo Nordisk is not required if sponsorship amount is below INR 5,00,000.00.

"Follow up on fund utilisation is not required if sponsorship amount is below INR 5,00,000.00.

The commercial benefit to Novo Nordisk, disclosure of the fact that the event has been sponsored by Novo Nordisk, agreement and proper follow-up documentation from the institution.

39. Ryzodeg meeting took place on 1st July 2017. Timings as per agenda was 8:00 to 10:00 PM, with dinner scheduled from 9:30 to 10:00 PM. Due to unavoidable circumstances, meeting started at 8:30 PM. Meeting ended at 10:45 pm. But hotel invoice was generated at 12:00 pm. How will you abide by 75/25 rule for the scientific meeting?

I will inform Manager and pay the hotel as per his instructions

I will pay the hotel and thereafter raise exception for deviation from 25/75 rule and document the reason for delay in the start of the meeting

There is no deviation as such in the situation as it occurred due to unavoidable circumstances

None of the above

40. An employee invites a doctor (HCP) as a speaker for a meeting. The HCP accepts the invitation. He is accompanied to the meeting by his friend, who is also a doctor and practices in the field of endocrinology.

It can be accommodated as the friend is also a doctor.

Though the friend is a doctor, he has not been invited to the event by Novo Nordisk. Therefore, you should politely let the HCP know that it is not accepted as per internal policies.

Though the friend is a doctor, he has not been invited to the event by Novo Nordisk. Therefore, you should politely let the HCP know that it is not accepted as per internal policies. If the friend still attends the event, you should document it

41. What is the Incentive amount you are eligible at 100% sales achievement p.a (Both Sales & Activity)?

200000

250000

700000

None of the Above

46. Which of the following factors are considered for career progression from a Product Specialist to a Sr product specialist?

3P Rating

Minimum years of experience

Recommendation form Line manager

All of the above

47. Which of the following options regarding Goal Setting is completely TRUE for 2018 process:

Your Goal plan will remain open until Goal plan sign- off and it is recommended to have maximum 5 goals with minimum 10% weight;

Your Goal plan will remain open until Goal plan sign- off and it is recommended to have maximum 10 goals with minimum 5% weight;

Your Goal plan will remain open until mid-year sign- off and it is recommended to have maximum 10 goals with minimum 5% weight;

Your Goal plan will remain open until mid-year sign- off and it is recommended to have maximum 12 goals with minimum 5% weight;

48. Which of the following statements is FALSE for 2018 performance management process:

Your performance rating will impact your annual salary increase

Your performance rating will not impact your selection to development programmes

Your 3P rating will serve as an input for career progression

Your performance rating will be solely decided by your manager’s discretion.

50. Which of the following statements is true for 2018 Talent Development Program Nomination?

Your performance rating will be considered for your nomination

Your performance rating along with manager’ inputs will be considered for your nomination

Your cumulative health score card will be considered for your nomination

Your sales performance will be considered for your nomination

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