Quiz on Genetics of atrial fibrillation - Council on Cardiovascular Genomics - Insight Volume 13

What of the following characteristics would not increase your awareness to perform a genetic test in a patient with anew onset atrial fibrillation?

Young age

Master athlete

Family history

LVEF dysfunction

What is approximately the diagnostic yield of genetic testing in patients with early-onset AF?

<1%

10%

30%

50%

What is the current recommendation to perform genetic testing in patients with early-onset AF (<45 years) according to the current ESC guidelines on AF published in 2020?

Class I

Class IIa

Class IIb

There are no recommendations

You have decided to perform a genetic test in a 37‑year‑old female with early‑onset AF and a normal echocardiography. The results report a pathogenic loss‑of‑function variant in SCN5A. All the following steps are recommended except one:

Start treatment with flecainide to prevent recurrences

Schedule periodic Holter monitoring

Perform a high-lead ECG

Offer cascade screening of relatives

All of the following genes should be covered by any gene panel addressing early-onset atrial fibrillation except one:

DES

MYH11

LMNA

KCNQ1

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