Lecture 8
Which of these is FALSE in Therapeutic Cloning?
Nucleus extracted from somatic cell
Nucleus extracted from Egg Cell
Nucleus from somatic cell fused with denucleated egg cell
Nucleus from egg cell fused with denucleated somatic cell
When was the first success for embryo cloning?
Feb 12, 2004
Feb 12, 2006
Jan 12, 2004
Jan 12, 2006
How many cloned human embryos were developed to the blastocyst stage in the first success for human embryo cloning?
10
20
30
40
A cell that has the ability to continuously divide and differentiate into various kinds of cells and tissues.
Stem Cell
Nerve Cell
Muscle Cell
Somatic Cell
An undifferentiated cell that does not have any special function yet.
Stem Cell
Nerve Cell
Muscle Cell
Somatic Cell
Which of these is FALSE about stem cells?
Undergoes unlimited divisions
Undergoes limited divisons
Can renew itself
All of the Above
Gives rise to placenta and embryos.
Pluripotent
Totipotent
The outer layer of an embryo.
Ectoderm
Endoderm
Mesoderm
Produces surface layer of the skin and forms the nerves
Ectoderm
Endoderm
Mesoderm
The innermost layer of an embryo
Ectoderm
Endoderm
Mesoderm
Produces the digestive tube and the associated organs and lungs.
Ectoderm
Endoderm
Mesoderm
Between the outermost layer and innermost layer
Ectoderm
Endoderm
Mesoderm
Generates the blood, heart, kidney, gonads, bones and connective tissues.
Ectoderm
Endoderm
Mesoderm
First differentiation happens ...
At Blastocyst stage
In mesoderm
In ectoderm
In endoderm
What are the potential cell types that can be formed from Totipotent?
All cell types
Cells from mesoderm, endoderm and ectoderm
Cannot differentiate into many cell types within a particular cell line.
Differentiates into a number of different cell types
What are the potential cell types that can be formed from Pluripotent?
All cell types
Cells from mesoderm, endoderm and ectoderm
Cannot differentiate into many cell types within a particular cell line.
Differentiates into a number of different cell types
What are the potential cell types that can be formed from Multipotent?
All cell types
Cells from mesoderm, endoderm and ectoderm
Cannot differentiate into many cell types within a particular cell line.
Differentiates into a number of different cell types
What are the potential cell types that can be formed from Oligopotent?
All cell types
Cells from mesoderm, endoderm and ectoderm
Cannot differentiate into many cell types within a particular cell line.
Differentiates into a number of different cell types
Oligopotent is _________ specialised than multipotent cell types.
More
Less
What are the potential cell types that can be formed from Quadpotent?
Differentiates into 4 cell types
Differentiates into 3 cell types
Differentiates into 2 cell types
Highly specialized cell that can only differentiate into 1 cell type
What are the potential cell types that can be formed from Tripotent?
Differentiates into 4 cell types
Differentiates into 3 cell types
Differentiates into 2 cell types
Highly specialized cell that can only differentiate into 1 cell type
What are the potential cell types that can be formed from Bipotent?
Differentiates into 4 cell types
Differentiates into 3 cell types
Differentiates into 2 cell types
Highly specialized cell that can only differentiate into 1 cell type
What are the potential cell types that can be formed from Unipotent?
Differentiates into 4 cell types
Differentiates into 3 cell types
Differentiates into 2 cell types
Highly specialized cell that can only differentiate into 1 cell type
What are the potential cell types that can be formed from Nulipotent?
Differentiates into 4 cell types
Differentiates into 3 cell types
Terminally differentaited cells that no longer are able to undergo cell division
Highly specialized cell that can only differentiate into 1 cell type
What are the types of stem cells that can be formed from Totipotent?
Zygote - Blastomere
ESCs- IPSCs
Hematopoietic stem cells from the bone marrow
Myeloid precursors
What are the types of stem cells that can be formed from Pluripotent?
Zygote - Blastomere
ESCs- IPSCs
Hematopoietic stem cells from the bone marrow
Myeloid precursors
What are the types of stem cells that can be formed from Multipotent?
Zygote - Blastomere
ESCs- IPSCs
Hematopoietic stem cells from the bone marrow
Myeloid precursors
What are the types of stem cells that can be formed from Oligopotent?
Zygote - Blastomere
ESCs- IPSCs
Hematopoietic stem cells from the bone marrow
Myeloid precursors
What is the differentiation potential of the blastocyte stage?
Totipotent
Pluripotent
Multipotent
Oligopotent
After how many days of the egg fertilization does the blastocyst stage start?
1 - 2 days
2 - 3 days
3 -4 days
4 - 5 days
What are the types of cursors that form from the Myeloid precursor?
Progenitor cells
Precursor cells
Both
None
What are the types of stem cells that can be formed from Quadripotent?
Mesenchymal and progenitor cell
Neuronal stem cells
Murine foetal liver stem cells
Mast cell precursors that differentiate into mast cells
What are the types of stem cells that can be formed from Tripotent?
Mesenchymal and progenitor cell
Neuronal stem cells
Murine foetal liver stem cells
Mast cell precursors that differentiate into mast cells
What are the types of stem cells that can be formed from Bipotent?
Mesenchymal and progenitor cell
Neuronal stem cells
Murine foetal liver stem cells
Mast cell precursors that differentiate into mast cells
What are the types of stem cells that can be formed from Unipotent?
Mesenchymal and progenitor cell
Neuronal stem cells
Murine foetal liver stem cells
Mast cell precursors that differentiate into mast cells
What are the types of stem cells that can be formed from Nulipotent?
Neurons
Red Blood Cells
Skin Cells
All of the above
What is used for the treatment of Immunodeficient and Leukemia?
Bone marrow transplants
Stem cells
Pluripotents
Multipotents
Who developed the first human embryonic stem cell lines?
James Thomson
Shin Moon
Woo Hwang
None of the above
What year were the the human embryonic stem cell lines first developed?
1970
2004
1998
1989
Prerequisite for transplantation of allogeneic stem cells
Histocompatibility
Fetal Tissue
Bone Marrow Tansplants
All of the above
Patient uses their own stem cells
Autologus
Allogenic
Xenogenic
None of the above
Patient uses a donor's stem cells
Autologus
Allogenic
Xenogenic
None of the above
The stem cells for autologus are extracted from __________ blood rather than __________.
Peripheral, bone marrow
Bone marrow, peripheral.
Relatives that donate stem cells to a patient.
Familial-Allogenic
Unrelated-Allogenic
Non related person donates stem cells to a patient.
Familial-Allogenic
Unrelated-Allogenic
Stem cells gained from different species.
Autologus
Allogenic
Xenogenic
None of the above
Striatal Porcine Fetal Ventral Mesencephalic Xenotransplant is used for...
Parkinson's Disease
Addison's disease
Bone Marrow
All of the above
Which of these is FALSE about Xenogenic?
No ethical concerns
Large amount of tissue available
Life-long immunosupression
No risk of rejection
Used to cure chronic-blood related disorders such as sickle cell disease, thalassemia, leaukemia.
Placenta as a source of stem cellls
Umbilical cord as a source of blood stem cells transplant
Bone Marrow Transplant
Cell Therapy
Which of these is the least prone to rejection?
Placenta as a source of stem cellls
Umbilical cord as a source of blood stem cells transplant
Bone Marrow Transplant
Cell Therapy
Stem cells have not yet developed features that can be recognized by the recipient's immune system.
Placenta as a source of stem cellls
Umbilical cord as a source of blood stem cells transplant
Bone Marrow Transplant
Cell Therapy
Stem cells in a donor's marrow are used to replace the blood cells of the victims of....
Leukemia
Sickle Cell Disease
Thalasemia
All of the above
Grafts new skin cells and grows new corneas
Placenta as a source of stem cellls
Umbilical cord as a source of blood stem cells transplant
Bone Marrow Transplant
Cell Therapy
Which of these has had major progress in therapy?
Alzheimer's
Parkinson's
Heart diseases
All of the above
Which of these may cure eye diseases?
Placenta as a source of stem cellls
Umbilical cord as a source of blood stem cells transplant
Bone Marrow Stem Cells
Cell Therapy
A natural protein involved in the growth of the cornea.
Keratocan
Integrin
Glycoprotein
Elastin
Has the ability to switch roles and produce keratocan.
Placenta as a source of stem cellls
Umbilical cord as a source of blood stem cells transplant
Bone Marrow Stem Cells
Cell Therapy
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