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Lymphatic System Quiz: Check Your Immune System Basics

20 quick questions, instant feedback in this lymphatic and immune system quiz.

Editorial: Review CompletedCreated By: Lincoln MacumberUpdated Aug 25, 2025
Difficulty: Moderate
Grade: Grade 10
Study OutcomesCheat Sheet
Paper art depicting the lymphatic system for a high school biology trivia quiz

This quiz helps you review the lymphatic system and how it supports immune defense. Answer 20 quick questions on nodes, vessels, spleen, and thymus, with instant feedback to spot study gaps. To build broader A&P skills, try our homeostasis quiz, practice structure basics with a connective tissue quiz, or reinforce anatomy terms in a body regions quiz.

What primarily propels lymph through lymphatic vessels in the limbs?
High arterial blood pressure
Rhythmic contractions of a lymphatic heart
Cilia lining the vessels
Skeletal muscle contractions and one-way valves
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Which leukocyte is typically the first to arrive in large numbers at sites of acute bacterial infection?
Eosinophils
Megakaryocytes
Neutrophils
Basophils
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Which is a classic cardinal sign of acute inflammation?
Redness (rubor)
Bradycardia
Hyperglycemia
Cyanosis
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What best defines an antigen?
A substance that can be specifically recognized by adaptive immune receptors
A hormone released by the pancreas
Any molecule with a carbohydrate group
A nonspecific inflammatory mediator
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Which is an example of natural passive immunity?
Transfer of maternal IgG across the placenta
Injection of an attenuated toxoid
Recovery from a viral infection
Vaccination with an inactivated pathogen
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Which lymph nodes primarily drain the upper limb and much of the breast?
Cervical lymph nodes
Popliteal lymph nodes
Axillary lymph nodes
Inguinal lymph nodes
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What is the primary role of the lymphatic system in fluid balance?
Returning excess interstitial fluid to the bloodstream
Pumping lymph with a central lymphatic heart
Producing all blood plasma proteins
Filtering glucose from the blood
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Which intestinal structure absorbs dietary fats into the lymphatic system as chylomicrons?
Lacteals
Brunner glands
Goblet cells
Peyer patches
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Which spleen function is essential for filtering the blood?
Regulation of blood glucose levels
Production of all leukocytes in adults
Removal of old and damaged erythrocytes
Secretion of digestive enzymes into the duodenum
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Which is an example of mucosa-associated lymphoid tissue (MALT)?
Adrenal cortex
Peyer patches in the ileum
Alveoli
Red bone marrow
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Which lymphocyte can directly kill virus-infected or tumor cells without prior sensitization?
Helper T cells
Natural killer (NK) cells
Plasma cells
Monocytes
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Which major lymphatic vessel drains lymph from most of the body, including the left head, left thorax, left upper limb, and both lower limbs?
Right lymphatic duct
Thoracic duct
Cisterna chyli only
Carotid duct
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What is the main function of the thymus in immunity?
Maturation and selection of T lymphocytes
Production of antibodies
Destruction of old red blood cells
Filtration of lymph for pathogens
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Formation of a membrane attack complex that creates pores in target cells is a function of which system?
Coagulation cascade
Renin-angiotensin system
Complement system
Kinin system only
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Which region of an antibody determines antigen specificity by binding the epitope?
Light-chain constant region only
Constant (Fc) region
Variable (Fab) region
Hinge region only
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Helper T cells primarily assist immunity by which action?
Filtering lymph mechanically
Destroying erythrocytes in the spleen
Producing antibodies directly
Secreting cytokines that activate B cells, cytotoxic T cells, and macrophages
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Which cell is the main effector of cell-mediated cytotoxicity by releasing perforin and granzymes into infected cells?
Basophil
Cytotoxic T lymphocyte (CD8+ T cell)
Neutrophil
B cell
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Which molecules present endogenous peptides to CD8+ T cells on nearly all nucleated cells?
MHC class I
CD28
MHC class II
CD4
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Which hypersensitivity reaction type underlies anaphylaxis mediated by mast cell degranulation?
Type IV (delayed-type, T cell-mediated)
Type III (immune complex)
Type II (antibody-mediated cytotoxic)
Type I (IgE-mediated)
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Which antigen-presenting cells capture antigens in tissues and migrate to lymph nodes to activate naive T cells?
Basophils
Neutrophils
Erythrocytes
Dendritic cells
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Study Outcomes

  1. Analyze the structure and function of the lymphatic system.
  2. Explain the role of lymph nodes and vessels in immune response.
  3. Evaluate how lymphatic and immune systems interact to maintain health.
  4. Identify the key components involved in lymph fluid circulation.
  5. Assess the impact of lymphatic system dysfunction on overall immunity.

Lymphatic & Immune Systems Cheat Sheet

  1. Understand the primary functions of the lymphatic system - Think of this system as your body's plumbing, pantry, and security team all rolled into one. It keeps fluid levels in check, helps you digest and transport fats, and fights off unwelcome invaders.
  2. Recognize the key components - The lymphatic system is made up of lymph fluid, a network of vessels, and lymphoid organs like lymph nodes, the spleen, and the thymus. Each part works together to filter, transport, and defend, giving you a well-oiled defense mechanism.
  3. Learn how lymphatic vessels prevent edema - These tiny tubes scoop up excess fluid that leaks out of your blood vessels and shuttle it back into circulation. Without them, you could end up looking like a puffy marshmallow!
  4. Explore the role of lymph nodes - Lymph nodes are like checkpoints for your body's defense squad, filtering out harmful particles and hosting lymphocytes that identify and neutralize threats. They're small but mighty hubs of immune action.
  5. Understand the spleen's function - The spleen filters your blood, recycles aged red cells, and supports immune responses by housing white blood cells. It's your body's multitasking powerhouse in the upper left abdomen.
  6. Learn about the thymus - This small gland is where T lymphocytes mature and specialize, a crucial step for your adaptive immune system to recognize and remember specific pathogens. Think of it as the boot camp for elite immune warriors.
  7. Recognize mucosa-associated lymphoid tissue (MALT) - MALT protects vulnerable areas like your gut and respiratory passages from pathogens by lining mucosal surfaces with friendly immune cells. It's the frontline barrier against invaders you breathe in or swallow.
  8. Understand fat absorption via lacteals - Specialized lymphatic capillaries in your small intestine, called lacteals, pick up dietary fats and fat-soluble vitamins, then carry them through lymph vessels before they enter the bloodstream. Without lacteals, you'd be a lot hungrier!
  9. Learn how lymph moves through the body - Unlike blood, lymph doesn't have a heart to pump it. Muscle contractions and one-way valves push the fluid along, making every stretch and step part of your internal lymph workout.
  10. Explore the lymphatic - immune connection - Lymph carries antigens to lymph nodes, where lymphocytes learn to recognize and respond to foreign substances. It's the ultimate collaboration between fluid transport and immune defense.
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