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Quizzes > Health & Medicine

Schizophrenia Test: Check Your Knowledge

Quick schizophrenia quiz to check your understanding. Instant results.

Editorial: Review CompletedCreated By: Marcin KrysiakUpdated Aug 25, 2025
Difficulty: Moderate
2-5mins
Learning OutcomesCheat Sheet
Paper art collage of brain layers charts symptoms causes myths quiz prompt on coral background

This schizophrenia test helps you check what you know about symptoms, causes, and myths in minutes. You will get clear feedback with each answer and spot areas to review. If you want related checks, try the do i have schizophrenia quiz, compare with a psychosis test, or explore a schizoaffective disorder test for context.

Schizophrenia is classified as which type of mental disorder?
Mood disorder
Anxiety disorder
Personality disorder
Psychotic disorder
Schizophrenia is characterized by psychosis, including hallucinations and delusions, which places it in the category of psychotic disorders. It differs from mood disorders, which primarily involve mood dysregulation, and anxiety or personality disorders. For more, see .
Which of the following is an example of a positive symptom of schizophrenia?
Alogia
Hallucinations
Flat affect
Avolition
Positive symptoms include experiences that add abnormal behavior, such as hallucinations and delusions. Negative symptoms like flat affect and alogia remove typical behaviors, while avolition reflects reduced motivation. Further details at .
Which of these is considered a negative symptom of schizophrenia?
Hallucinations
Delusions
Disorganized speech
Alogia (poverty of speech)
Negative symptoms involve the absence or reduction of normal behaviors, such as alogia which is poverty of speech. Hallucinations and delusions are positive symptoms, and disorganized speech is a disorganization symptom. See for more.
What is the typical age of onset for schizophrenia in most individuals?
Middle age (40 - 60)
Early adulthood (late teens to early 30s)
Childhood (under 12)
Early adolescence (13 - 17)
Schizophrenia most commonly emerges in late adolescence to early adulthood, typically between the late teens and early 30s. Childhood-onset and middle-age onset are much less common. For epidemiology details, see .
Approximately what percentage of the global population is affected by schizophrenia?
0.1%
5%
1%
10%
Schizophrenia affects about 1% of the global population, making it a relatively rare but serious psychiatric disorder. The prevalence is fairly consistent across countries and cultures. More statistics are available at .
Which of the following statements about schizophrenia is FALSE?
It is classified primarily as a mood disorder
It has a neurobiological component
It affects thinking, perception, and behavior
It involves hallucinations and delusions
Schizophrenia is not a mood disorder; it is primarily a psychotic disorder characterized by hallucinations, delusions, and cognitive disruptions. While mood symptoms can co-occur, they are not the defining feature. For diagnostic criteria, see .
Which neurotransmitter dysregulation is most closely linked to schizophrenia symptoms?
Serotonin
GABA
Acetylcholine
Dopamine
The dopamine hypothesis of schizophrenia suggests that overactivity in dopaminergic pathways contributes to positive symptoms like hallucinations. Other neurotransmitters play roles, but dopamine remains the most extensively studied. Read more at .
Which of these is a core diagnostic symptom required by DSM-5 for schizophrenia?
Auditory hallucinations
Grandiosity
Flight of ideas
Panic attacks
For a DSM-5 diagnosis, at least one core psychotic symptom - hallucinations, delusions, or disorganized speech - must be present. Auditory hallucinations are the most common type. Details are outlined in the .
Which of the following is the strongest single risk factor for developing schizophrenia?
Family history of schizophrenia
Dietary deficiencies
Viral infection in adulthood
Head injury in later life
A positive family history is the strongest known risk factor, reflecting the high heritability of schizophrenia. Environmental factors also contribute but are secondary. For genetic insights, see .
What is the approximate risk of schizophrenia in a child if one parent has the disorder?
1%
10%
50%
5%
A child with one affected parent has about a 10% lifetime risk of developing schizophrenia. Without family history, the risk is closer to 1%. More family risk data at .
Which brain region is most consistently found to have reduced volume in schizophrenia?
Motor cortex
Occipital lobe
Cerebellum
Hippocampus
Neuroimaging studies have repeatedly shown hippocampal volume reductions in schizophrenia, which may underlie memory impairments. Other regions are also affected but less consistently. For imaging reviews, see .
Which side effect is most commonly associated with first-generation (typical) antipsychotic use?
Sexual dysfunction
Agr anulocytosis
Tardive dyskinesia
Weight gain
Typical antipsychotics frequently cause extrapyramidal side effects, including tardive dyskinesia, due to dopamine D2 receptor blockade. Agranulocytosis is mainly associated with clozapine, while weight gain and sexual dysfunction are more common with atypicals. For side effect profiles, see .
Which symptom is characteristic of the prodromal phase of schizophrenia?
Catatonia
Full-blown hallucinations
Social withdrawal
Disorganized shouting
The prodromal phase often features subtle changes such as social withdrawal, decreased motivation, and mild cognitive disturbances before acute psychosis emerges. Hallucinations and catatonia typically appear later. Learn more at .
Cognitive Behavioral Therapy (CBT) for schizophrenia primarily targets which aspect?
Motor side effects
Mood swings
Positive symptoms such as delusions
Negative symptoms
CBT for psychosis focuses on helping patients reframe and cope with positive symptoms like delusions and hallucinations. While it can also support negative symptom management, its primary role is in reducing distress from psychotic experiences. More info at .
What type of hallucination is most commonly experienced by individuals with schizophrenia?
Auditory
Visual
Olfactory
Tactile
Auditory hallucinations, such as hearing voices, are the most prevalent type in schizophrenia. Visual and other sensory hallucinations occur but are less frequent. For prevalence data, see .
The dopamine hypothesis of schizophrenia attributes positive symptoms to overactivity in which brain pathway?
Mesocortical
Tuberoinfundibular
Mesolimbic
Nigrostriatal
Excess dopaminergic activity in the mesolimbic pathway is thought to produce positive symptoms like hallucinations and delusions. The mesocortical pathway relates more to negative symptoms, and other pathways govern movement and prolactin release. For details, see .
Which clinical scale is widely used to assess positive, negative, and general psychopathology symptoms in schizophrenia?
PANSS (Positive and Negative Syndrome Scale)
HAM-D (Hamilton Depression Rating Scale)
MMPI (Minnesota Multiphasic Personality Inventory)
BPRS (Brief Psychiatric Rating Scale)
The PANSS is specifically designed to measure positive and negative symptoms along with general psychopathology in schizophrenia research and clinical trials. BPRS also measures psychiatric symptoms but is less detailed for negative symptoms. More at .
Clozapine is uniquely indicated for which subtype of schizophrenia?
Brief psychotic disorder
First-episode schizophrenia
Treatment-resistant schizophrenia
Catatonic schizophrenia
Clozapine is reserved for treatment-resistant cases after failure of at least two other antipsychotics due to its superior efficacy in such patients. It is not first-line for initial episodes or catatonic subtypes. For prescribing guidelines, see .
Hypofrontality in schizophrenia is associated with impairment in which cognitive function?
Long-term memory
Working memory
Visual-spatial coordination
Auditory processing
Reduced prefrontal cortex activity, or hypofrontality, is linked to deficits in working memory and executive function in schizophrenia. Other memory types are less directly affected by frontal dysfunction. See for neuroimaging studies.
Which gene variant is most frequently studied for its association with schizophrenia risk?
MTHFR C677T mutation
APOE ?4 allele
BDNF Val66Met variant
COMT Val158Met polymorphism
The COMT Val158Met polymorphism affects dopamine metabolism in the prefrontal cortex and has been extensively researched for its link to schizophrenia. Other genes like BDNF have been studied but less consistently. For genetic reviews, see .
Which serious hematological side effect necessitates regular monitoring in patients on clozapine?
Neuroleptic malignant syndrome
Orthostatic hypotension
Tardive dyskinesia
Agranulocytosis
Clozapine carries a risk of agranulocytosis, a dangerous drop in white blood cells, which requires frequent blood count monitoring. Tardive dyskinesia and NMS are risks of antipsychotics but not unique to clozapine. See for clozapine monitoring guidelines.
Which non-pharmacological intervention specifically aims to enhance social interaction skills in schizophrenia?
Psychoanalysis
Group psychoeducation
Art therapy
Social skills training
Social skills training uses role-play and feedback to improve communication and social interaction for individuals with schizophrenia. Group psychoeducation provides illness information, but social skills training directly targets behavioral practice. More at .
Which NMDA receptor antagonist has been used in research to model schizophrenia-like symptoms?
Benzodiazepine
LSD
Amphetamine
Ketamine
Ketamine, an NMDA receptor antagonist, can induce transient psychosis-like symptoms in healthy individuals, supporting the glutamate hypothesis of schizophrenia. LSD primarily acts on serotonin receptors, and amphetamine affects dopamine. For more, see .
A 22q11.2 microdeletion greatly increases risk for schizophrenia; on which chromosome is this region located?
Chromosome 22
Chromosome 11
Chromosome 10
Chromosome 15
The 22q11.2 microdeletion syndrome, also known as DiGeorge syndrome, is found on chromosome 22 and is one of the strongest cytogenetic risk factors for schizophrenia. Individuals with this deletion have a significantly elevated lifetime risk. For cytogenetic details, see .
Typical antipsychotic drugs exert their therapeutic effects primarily by antagonizing which receptor subtype?
5-HT2A serotonin receptor
D2 dopamine receptor
NMDA glutamate receptor
D1 dopamine receptor
First-generation antipsychotics block D2 dopamine receptors in mesolimbic pathways to reduce positive symptoms. While they can affect other receptors, D2 antagonism is key to their mechanism. For pharmacology specifics, see .
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Study Outcomes

  1. Understand Key Schizophrenia Symptoms -

    Analyze the hallmark positive and negative symptoms of schizophrenia to recognize how they manifest in daily behavior.

  2. Differentiate Symptom Categories -

    Distinguish between positive, negative, and cognitive symptoms to deepen your comprehension of schizophrenia's complexity.

  3. Debunk Common Myths -

    Identify and correct widespread misconceptions about schizophrenia to foster a more accurate understanding and reduce stigma.

  4. Analyze Risk Factors and Causes -

    Examine biological, environmental, and genetic influences to grasp the multifaceted origins of schizophrenia.

  5. Apply Knowledge to Promote Awareness -

    Utilize your quiz insights to support compassionate conversations and advocacy for individuals living with schizophrenia.

  6. Evaluate Your Understanding -

    Reflect on your quiz performance to pinpoint areas for further learning and reinforce your mental health knowledge.

Cheat Sheet

  1. Core Positive and Negative Symptoms -

    Schizophrenia is characterized by positive symptoms like hallucinations and delusions, and negative symptoms such as social withdrawal and flat affect (NIMH, 2023). Recognizing both helps differentiate it from mood disorders. For instance, hearing voices when no one is there signals a positive symptom, while reduced speech indicates a negative one.

  2. Neurobiological Basis: Dopamine Hypothesis -

    The dopamine hypothesis suggests that overactivity at D2 receptors in the mesolimbic pathway underlies positive symptoms (Howes & Kapur, 2009). Antipsychotic medications often target these receptors to restore balance. Think "Too Much Dâ‚‚ = Dueling Delusions" to recall the link between D2 and delusional thinking.

  3. DSM-5 Diagnostic Criteria Mnemonic -

    DSM-5 requires at least two core symptoms (delusions, hallucinations, disorganized speech, disorganized behavior, or negative symptoms) over one month and functional decline (APA, 2013). Use the mnemonic "DISH + N" (Delusions, Illusions [hallucinations], Speech disorg., Hectic behavior, plus Negative) to recall all five. Remember: at least one must be delusions, hallucinations, or disorganized speech.

  4. Risk Factors and Prevalence Statistics -

    Genetic predisposition is strong: monozygotic twins show ~50% concordance, while dizygotic twins are ~15% (Gottesman, 1991). Environmental factors like prenatal infection or urban upbringing also raise risk. Globally, schizophrenia affects about 1% of the population, making it a critical public health focus.

  5. Debunking Common Myths -

    Schizophrenia does not mean "split personality"; it involves fragmented thinking, not multiple identities (WHO, 2021). It's also not caused by poor parenting or personal weakness. Educating with facts - like "1 in 100 people, not 1 in 2" - boosts awareness and reduces stigma.

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