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Quizzes > Health & Medicine

Dirty Genes Quiz: Check Your Genetic Wellness Basics

Quick, free genetic health quiz to test your knowledge. Instant results.

Editorial: Review CompletedCreated By: Olivia RayUpdated Aug 28, 2025
Difficulty: Moderate
2-5mins
Learning OutcomesCheat Sheet
Paper art illustration for Dirty Genes Quiz on a coral background, promoting genetic wellness knowledge.

This Dirty Genes Quiz helps you spot everyday factors that can influence mood, energy, and metabolism, and understand what "dirty genes" might mean for your wellness. As you go, explore our dna test quiz, a how toxic are you quiz on lifestyle exposures, or a short diagnostic quiz for broader check-ins.

Which best describes a "dirty gene" in the context of wellness?
Any gene that increases athletic performance
A gene with poor lab hygiene during sequencing
A gene whose expression is disrupted by lifestyle and environment (It is not broken, but functioning suboptimally due to inputs)
A gene that is permanently mutated and cannot be helped
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Epigenetics primarily refers to which concept?
Changes in DNA sequence over a lifetime
Only inherited traits from parents
Reversible changes in gene expression without altering DNA sequence (Tags like methylation and acetylation tune gene output)
Random mutations caused by stress
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Which food is naturally high in folate to support methylation?
Butter
Whole milk
Spinach (Leafy greens are rich in natural folate)
White rice
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Which habit can most reliably lower blue-light impact on the sleep gene network in the evening?
Eating more protein at lunch
Taking a multivitamin in the morning
Drinking more water
Wearing blue-light-blocking glasses or using warm light after sunset (Reduces circadian disruption)
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Glutathione is best described as:
The body's master antioxidant supporting detoxification (Neutralizes reactive species and aids liver pathways)
A mineral that builds bone
A neurotransmitter that causes sleep
A digestive enzyme for fats
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Which is the most direct lifestyle support for healthy circadian gene expression?
High-protein dinner at midnight
Morning bright light exposure (Anchors the central clock)
Drinking coffee at 9 pm
Napping all afternoon
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Which nutrient most directly supports the methylation cycle?
Methylfolate (Provides methyl groups to drive methylation)
Zinc oxide
Vitamin C
Iron
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Homocysteine is best described as what in wellness tracking?
A fat-soluble vitamin
A neurotransmitter
An amino acid intermediate reflecting methylation balance (High levels can signal methylation issues)
A gut microbe
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COMT enzyme activity most directly influences which personal experience?
Your eye color
How quickly you clear catecholamines like dopamine and epinephrine (Affects stress and focus)
How you digest lactose
Your risk of celiac disease
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DAO (diamine oxidase) primarily helps break down which compound from food?
Fructose
Gluten
Histamine (DAO degrades histamine from the gut)
Lactose
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CYP1A2 activity most closely relates to your response to:
Vitamin D absorption
Sodium retention
Caffeine metabolism (Determines fast or slow caffeine clearance)
Lactose digestion
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Which amino acid most directly boosts glutathione synthesis when dietary sulfur is adequate?
Glycine (A key building block of glutathione)
Leucine
Tryptophan
Tyrosine
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Which pattern best supports methylation if you notice flushing from high-dose niacin?
Increase niacin further
Reduce niacin and prioritize methyl donors like methylfolate and B12 (Niacin can soak up methyl groups)
Avoid leafy greens
Cut all protein
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PEMT function is supported by which nutrient for healthy cell membranes and bile flow?
Choline (PEMT uses choline to make phosphatidylcholine)
Iodine
Silica
Vitamin K1
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During DAO-related histamine flare-ups, which category of foods is typically limited?
All fats
All proteins
Aged and fermented foods
All carbohydrates
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Which mineral is a key cofactor for many antioxidant enzymes including SOD?
Fluoride
Zinc (Zinc is essential for SOD1 activity)
Selenium
Calcium
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Which nutrient best supports DAO activity when histamine from food is a concern?
Lead
Fluoride
Aluminum
Copper (DAO is a copper-dependent enzyme)
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Which cofactor pairing is key for transsulfuration of homocysteine toward glutathione?
Biotin and chromium
B6 with cysteine and serine availability (B6-dependent enzymes drive this path)
Folate and vitamin C
Vitamin K and copper
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Which lab strategy best distinguishes B12 status issues affecting methylation?
Body weight
Only total serum B12
MMA and homocysteine alongside B12 (Functional markers reflect cellular B12)
Random urine color
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Copper is irrelevant to DAO function.
False
True
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0

Study Outcomes

  1. Understand Core Concepts of Dirty Genes -

    Understand the definition and underlying mechanisms of "dirty genes" as introduced in the popular Dirty Genes book and reinforced by this free dirty genes quiz.

  2. Identify Key Gene Functions -

    Identify critical gene functions and learn how the dirty genes test highlights disruptions that can impact metabolic and cognitive health.

  3. Analyze Real-World Health Implications -

    Analyze scenarios from the dirty genes consequences quiz to see how gene dysfunction can manifest in everyday wellness challenges.

  4. Assess Your Genetic Wellness Knowledge -

    Evaluate your understanding of genetic wellness principles through targeted questions in this dirty genes knowledge quiz.

  5. Apply Strategies for Optimal Gene Function -

    Apply actionable insights from the quiz feedback to develop habits that support gene cleaning and overall genetic wellness.

Cheat Sheet

  1. Gene Expression and "Dirty" Genes -

    Gene expression controls how DNA is transcribed into proteins; when this process is disrupted, genes become "dirty," leading to imbalanced enzymes or hormones (NIH). For example, faulty regulation of the CREB transcription factor can skew cortisol levels, illustrating a real-life impact you might encounter on the dirty genes quiz. Remember the phrase "DNA to RNA to PRO" to recall the central dogma and spot expression errors.

  2. Single Nucleotide Polymorphisms (SNPs) -

    SNPs are the most common type of genetic variation, where a single base change can alter gene function (University of Cambridge). A handy mnemonic is "Single Nucleotide Pinpoint" to remember you're zeroing in on one-letter changes - like the MTHFR C677T variant that affects folate metabolism. Knowing how SNPs stack up helps you ace the dirty genes test by linking specific variants to wellness outcomes.

  3. Epigenetic Modifications -

    Epigenetics studies how environmental factors switch genes on or off without altering DNA sequence (Nature Reviews Genetics). Use "M-A-C" (Methylation, Acetylation, Chromatin) to recall the three major modification types; for instance, hypermethylation often silences detox genes under chronic stress. Grasping these concepts will boost your score on the dirty genes consequences quiz by showing you the dynamic gene - environment interplay.

  4. Detoxification Enzyme Phases I & II -

    Phase I (cytochrome P450) adds reactive groups; Phase II conjugates toxins for safe excretion (WHO). For example, CYP1A2 in Phase I transforms caffeine, then glutathione in Phase II neutralizes reactive intermediates - think "P450 then Glue" - to remember the sequence. This formulaic understanding is a key fact you'll review in our free dirty genes quiz.

  5. Interpreting Quiz Results for Lifestyle Tweaks -

    Once you complete the dirty genes knowledge quiz, map your top variants to tailored interventions - e.g., an MTHFR hit means swap folic acid for methylfolate (University of Michigan). Create a simple "Gene→Action" chart: list variant, impact, and targeted change (diet, supplement, habit). This strategy turns quiz insights into actionable steps, ensuring you get real-world benefits from your dirty genes test results.

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