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Guess the Diagnosis Game: Match Symptoms to the Most Likely Condition

Quick, free medical diagnosis quiz with short cases. Instant feedback.

Editorial: Review CompletedCreated By: Megan SartzUpdated Aug 24, 2025
Difficulty: Moderate
2-5mins
Learning OutcomesCheat Sheet
Paper art illustration showing medical symbols stethoscope pulse heart lung brain and quiz text on golden yellow background

This Guess the Diagnosis game helps you practice matching symptoms to likely conditions with quick, case-based questions. Build pattern skills, see where you need review, and try a differential diagnosis practice, test yourself with a medical knowledge quiz, or brush up terms in a medical abbreviation quiz.

A 23-year-old with fever, severe sore throat, anterior cervical lymphadenopathy, tonsillar exudates, and no cough most likely has which diagnosis?
Infectious mononucleosis
Epiglottitis
Viral pharyngitis
Group A streptococcal pharyngitis
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A 27-year-old with episodic wheezing, chest tightness at night, and reversible airflow limitation on spirometry most likely has which diagnosis?
Asthma
Heart failure with preserved ejection fraction
Chronic obstructive pulmonary disease
Bronchiectasis
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A 8-year-old with barking cough, inspiratory stridor, and steeple sign on neck X-ray most likely has which diagnosis?
Epiglottitis
Foreign body aspiration
Pertussis
Croup (laryngotracheobronchitis)
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A 45-year-old with right upper quadrant pain after fatty meals, positive Murphy sign, and fever most likely has which diagnosis?
Peptic ulcer disease
Acute pancreatitis
Acute cholecystitis
Acute cholangitis
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A 60-year-old smoker with chronic cough, sputum production, and blue bloater appearance most likely has which diagnosis?
Chronic bronchitis
Bronchiectasis
Emphysema-predominant COPD
Asthma
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A 55-year-old with crushing substernal chest pain radiating to the left arm, diaphoresis, and ST elevations in contiguous leads most likely has which diagnosis?
Panic attack
Unstable angina
Gastroesophageal reflux disease
ST-elevation myocardial infarction
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A 72-year-old with jaw claudication, scalp tenderness, new-onset headache, and elevated ESR most likely has which diagnosis?
Migraine with aura
Trigeminal neuralgia
Cluster headache
Temporal (giant cell) arteritis
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A 34-year-old with polyuria, polydipsia, weight loss, Kussmaul respirations, and ketones in urine most likely has which diagnosis?
Acute kidney injury
Diabetes insipidus
Diabetic ketoacidosis
Hyperosmolar hyperglycemic state
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A 29-year-old postpartum woman with unilateral leg swelling, warmth, and tenderness in the calf most likely has which diagnosis?
Deep vein thrombosis
Achilles tendinopathy
Baker cyst rupture
Cellulitis
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A 22-year-old with high fever, severe headache, neck stiffness, and photophobia most likely has which diagnosis?
Migraine
Sinusitis
Acute bacterial meningitis
Subarachnoid hemorrhage
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A 70-year-old with progressive memory loss, impaired daily activities, and normal level of consciousness most likely has which diagnosis?
Major depressive disorder
Wernicke encephalopathy
Alzheimer disease
Delirium
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A 5-year-old with sandpaper-like rash, strawberry tongue, and recent sore throat most likely has which diagnosis?
Scarlet fever
Kawasaki disease
Measles
Rubella
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A 65-year-old with sudden tearing chest pain radiating to the back, pulse asymmetry, and widened mediastinum on chest X-ray most likely has which diagnosis?
Pulmonary embolism
ST-elevation myocardial infarction
Aortic dissection
Acute pericarditis
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A 19-year-old with fever, diffuse maculopapular rash starting on face and spreading, cough, coryza, conjunctivitis, and Koplik spots most likely has which diagnosis?
Rubella
Scarlet fever
Measles (rubeola)
Fifth disease (parvovirus B19)
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A 40-year-old with perioral numbness, carpopedal spasms, Chvostek sign, and prolonged QT interval most likely has which diagnosis?
Hypocalcemia
Hypermagnesemia
Hyponatremia
Hyperkalemia
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A 47-year-old with fever, jaundice, right upper quadrant pain, and hypotension with confusion most likely has which diagnosis?
Acute cholangitis with Reynolds pentad
Pancreatitis
Acute cholecystitis
Acute hepatitis A
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A 75-year-old with acute onset of painless monocular vision loss and cherry-red spot on macula most likely has which diagnosis?
Central retinal artery occlusion
Central retinal vein occlusion
Acute angle-closure glaucoma
Retinal detachment
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A 50-year-old with painless jaundice, weight loss, and Courvoisier sign most likely has which diagnosis?
Gallstones
Acute hepatitis B
Primary sclerosing cholangitis
Pancreatic head carcinoma
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Severe hypertension, headache, palpitations, and episodic sweating point toward pheochromocytoma.
False
True
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Acute painless loss of central vision with drusen on fundus exam is typical of wet age-related macular degeneration.
False
True
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0

Study Outcomes

  1. Identify Key Clinical Patterns -

    Recognize hallmark symptoms of common and rare diseases presented in each quiz scenario.

  2. Analyze Symptom Clusters -

    Examine combinations of signs and symptoms to narrow down potential diagnoses effectively.

  3. Differentiate Similar Conditions -

    Evaluate subtle distinctions between diseases with overlapping symptoms to improve diagnostic accuracy.

  4. Apply Diagnostic Reasoning -

    Use logical approaches and medical intuition to hypothesize the most likely diagnoses in a time-sensitive format.

  5. Recall Disease Trivia -

    Reinforce your memory of important disease facts and epidemiological information encountered throughout the quiz.

  6. Assess Diagnostic Confidence -

    Reflect on your quiz performance to identify strengths and areas for further learning in medical diagnosis.

Cheat Sheet

  1. Pattern Recognition and Disease Archetypes -

    Develop mental "templates" for classic presentations to boost your success in the guess the diagnosis game by matching symptom clusters to prototype illnesses. Studies from leading medical schools show experts narrow down differentials in seconds using pattern recognition, improving both speed and accuracy. Try creating flashcards of archetypes - like "strep throat" (fever, sore throat, tender cervical nodes) - to reinforce key features.

  2. Differential Diagnosis with VINDICATE Mnemonic -

    Use the VINDICATE mnemonic (Vascular, Infectious, Neoplastic, Degenerative, Iatrogenic, Congenital, Autoimmune, Traumatic, Endocrine) to systematically generate potential causes when you guess my illness in a medical diagnosis quiz. This framework, endorsed by many university curricula, ensures you consider a broad spectrum rather than anchoring on the first idea. Practice by listing possible categories for a symptom - like chest pain - before diving into tests.

  3. Bayesian Reasoning for Pre- and Post-Test Probability -

    Apply simple Bayesian logic to adjust disease probabilities when new information arrives, a strategy highlighted in journal articles from the BMJ and NEJM. In a disease trivia quiz or clinical setting, start with an epidemiological "prior" (how common is the disease?) then update with test sensitivity and specificity to get a "posterior" probability. For example, a +LR of 5 for a D-dimer in pulmonary embolism greatly increases your confidence when pre-test odds were moderate.

  4. Know Key Red Flags by Organ System -

    Memorize urgent red flags - like "worst headache of life" for subarachnoid hemorrhage or "saddle anesthesia" for cauda equina syndrome - to ace the guess the diagnosis challenge and keep patients safe. Official guidelines from neurology and emergency medicine societies highlight these critical warnings. Use mnemonics such as "SNOOP" (Systemic symptoms, Neurologic signs, Onset sudden, Older age, Previous headache history) to recall headache red flags.

  5. Structured History Taking with OLDCARTS -

    Master the OLDCARTS acronym (Onset, Location, Duration, Character, Aggravating/Alleviating factors, Radiation, Timing, Severity) to gather focused patient data in any medical diagnosis quiz or real-life scenario. Research from reputable teaching hospitals shows structured histories uncover 80% of diagnoses before tests. Practice asking each OLDCARTS element in role-play to refine your question flow and boost diagnostic accuracy.

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