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Advanced Neuroscience - AD

Which one/ones of these are key concepts in AD research?
The tau cascade hypothesis
The amyloid cascade hypothesis
The dementia cascade hypothesis
The inflammation cascade hypothesis
Which one/ones of these are recognised forms of AD?
Early onset AD
Sporadic AD
Familial AD
Global AD
Which is most correct for the development of tau (T) and amyloid (A) aggregates?
T&A start in the same brain regions, and spread together
T&A start in different brain regions, but soon converge
T&A start in the same brain regions, but soon diverge
T&A start in different brain regions, and have different patterns of spread
Which is/are true?
Sporadic AD is mainly driven by increased beta-amyloid production?
Familial AD is mainly driven by increased beta-amyloid production?
Sporadic AD is mainly driven by reduced beta-amyloid clearance?
Familial AD is mainly driven by reduced beta-amyloid clearance?
Which is/are major functions for genes linked to AD?
Lipid metabolism
Inflammation
Endosomal/vesicular transportation
Tau metabolism
Variations in which gene(s) do not increase the risk for AD
APP
PSEN2
TREM2
MAPT
What does PSEN1 do?
Cleaves the C-terminal part of beta-amyloid
Cleaves the N-terminal part of beta-amyloid
Cleaves the C-terminal part of tau
Cleaves the N-terminal part of tau
Findings in which gene(s) implicate a role for microglia in AD?
TREM2
APOE
APP
PSEN1
What does the concept of PART imply?
Accumulation of tau is partly independent of AD
Accumulation of amyloid is partly independent of AD
With age, amyloid transforms tau from a normal to a pathological state
With age, tau transforms amyloid from a normal to a pathological state
Which one/ones of these is a rate limiting enzyme for beta-amyloid production?
BACE1
Alpha-cathepsin
TREM2
APOE
Which one/ones of these structures are implicated in AD?
Entorhinal cortex
Precuneus
Hippocampus
Anterior cingulate
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