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Which one/ones of these are key concepts in AD research?

The tau cascade hypothesis

The amyloid cascade hypothesis

The dementia cascade hypothesis

The inflammation cascade hypothesis

Which one/ones of these are recognised forms of AD?

Early onset AD

Sporadic AD

Familial AD

Global AD

Which is most correct for the development of tau (T) and amyloid (A) aggregates?

T&A start in the same brain regions, and spread together

T&A start in different brain regions, but soon converge

T&A start in the same brain regions, but soon diverge

T&A start in different brain regions, and have different patterns of spread

Which is/are true?

Sporadic AD is mainly driven by increased beta-amyloid production?

Familial AD is mainly driven by increased beta-amyloid production?

Sporadic AD is mainly driven by reduced beta-amyloid clearance?

Familial AD is mainly driven by reduced beta-amyloid clearance?

Which is/are major functions for genes linked to AD?

Lipid metabolism

Inflammation

Endosomal/vesicular transportation

Tau metabolism

Variations in which gene(s) do not increase the risk for AD

APP

PSEN2

TREM2

MAPT

What does PSEN1 do?

Cleaves the C-terminal part of beta-amyloid

Cleaves the N-terminal part of beta-amyloid

Cleaves the C-terminal part of tau

Cleaves the N-terminal part of tau

Findings in which gene(s) implicate a role for microglia in AD?

TREM2

APOE

APP

PSEN1

What does the concept of PART imply?

Accumulation of tau is partly independent of AD

Accumulation of amyloid is partly independent of AD

With age, amyloid transforms tau from a normal to a pathological state

With age, tau transforms amyloid from a normal to a pathological state

Which one/ones of these is a rate limiting enzyme for beta-amyloid production?

BACE1

Alpha-cathepsin

TREM2

APOE

Which one/ones of these structures are implicated in AD?

Entorhinal cortex

Precuneus

Hippocampus

Anterior cingulate

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