MedChem: pH and pKa Qualitative Method

Generate an illustration depicting various chemical structures with fun<wbr>ctional groups, pH scales, and ionization concepts in a scientific environment, emphasizing the principles of medicinal chemistry.

MedChem Quiz: Understanding pH and pKa

Test your knowledge on the relationship between pH, pKa, and drug ionization with this engaging quiz focused on medicinal chemistry. Whether you are a student or a professional, this quiz will help reinforce your understanding of how pH affects drug properties.

Key Features:

10 questions covering essential concepts
Multiple choice and checkbox format for diverse learning
Score tracking to assess your knowledge

10 Questions2 MinutesCreated by AnalyzingChemistry134

Cefotaxime has acidic functional group (pKa = 3.4).Indicate whether it would be primarily ionized or primarily unionized at a stomach pH = 1.8

Primarily ionized

Primarily unionized

Determine what will happen to the functional group at a urinary pH = 6.1

Primarily ionized

Primarily unionized

Remain unchanged

Partially ionized

Which of the functional group on the drug will primarily unionized at a plasma pH = 7.4

What will happen if the pH = pKa?

Only acidic functional group that will ionized

The functional group will ionized 50% whether it is base or acid

The functional group will unionized 50% whether it is base or acid

Only basic functional group that will ionized

What will happen when pH > pKa?

The environment is more acidic than functional group

The acidic functional group are primarily ionized

The acidic functional group are primarily unionized

The basic functional group are primarily unionized

Why the functional group on Atenolol primarily ionized at stomach (pH = 1.8).

The environment (i.e., the pH) is more acidic than the functional group

PH < pKa

A basic functional group will be primarily ionized in an acidic environment.

A basic functional group will be primarily unionized in an acidic environment.

Choose which of the following are true?

When pH is less than pKa, the log [Base Form]/[Acid Form] will form a negative value

Acidic functional group are primarily unionized in an acidic environment

In acidic environment, proton are more available

When pH is less than pKa, the log [Base Form]/[Acid Form] will form a positive value

Drug having acidic functional group (pKa = 4.5) at gastric pH 2.1. Which of the following are true?

The log [Base Form]/[Acid Form] will form a negative value

The functional group will primarily ionized

The functional group will primarily unionized

PH > pKa

Based on the diagram above. Choose which are the following are true when the environmental pH = 8.4?

1.3 = log [Base Form]/[Acid Form]

The functional group will unionized

The environment is acidic

The functional group will ionized

Shown above is the structure of natamycin. It contains two functional group that could potentially ionized. The pKa value for natamycin are 4.6 and 8.4.Match the pKa values provided to the appropriate functional group by identify the functional group and state whether its acidic or basic.Then, determine whether it will ionized or not for each functional group at an intestinal pH = 6.2.Choose the correct answer.

Carboxylic Acid, pKa = 4.6, acidic, ionized. At an intestinal pH = 6.2, the environment (i.e., the pH) is more acidic than the functional group (i.e., the pH < pKa). A basic functional group will be primarily ionized in an acidic environment.

Primary amine, pka = 8.4, basic, unionized. At an intestinal pH = 6.2, the environment (i.e., the pH) is more acidic than the functional group (i.e., the pH < pKa). An acidic functional group will be primarily unionized in an acidic environment.

Carboxylic Acid, pKa = 4.6, acidic, unionized.At an intestinal pH = 6.2, the environment (i.e., the pH) is more acidic than the functional group (i.e., the pH < pKa). An acidic functional group will be primarily unionized in an acidic environment.

Primary amine, pka = 8.4, basic, ionized. At an intestinal pH = 6.2, the environment (i.e., the pH) is more acidic than the functional group (i.e., the pH < pKa). A basic functional group will be primarily ionized in an acidic environment.

MedChem: pH and pKa Qualitative Method

MedChem Quiz: Understanding pH and pKa

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