Pharmacie clinique Pf.vireak ( 79-115)

79) side effect is :

A noxious and unintended response to a medicine that occurs at normal therapeutic doses used in humans for prophylaxis, diagnosis, or therapy of disease, or for the modification of physiologic function

Any untoward medical occurrence that may be present during treatment with a medicine but does not necessarily have a causal relationship with this treatment. ADE include medication errors and overdoses.

Any unintended effect of a pharmaceutical product occurring at normal therapeutic dosesand is related to its pharmacological properties. Such effects may be well-known and even expected and require little or no change in patient management

All the above

82) Type A reaction is defined as:

Adverse effect that are known to occur from the pharmacology of the drug and are dose- related

Adverse effect that occur unpredictably and often have a high rate of morbidity and mortality.

Adverse effect that only occur during prolonged treatment and not with single doses

Adverse effect that occur when the drug is stopped, especially when it is stopped suddenly.

83) Type B reaction is defined as:

Adverse effect that are known to occur from the pharmacology of the drug and are dose- related.

Adverse effect that occur unpredictably and often have a high rate of morbidity and mortality

Adverse effect that only occur during prolonged treatment and not with single doses

Adverse effect that occur when the drug is stopped, especially when it is stopped suddenly.

84) Type C reaction is defined as:

Adverse effect that are known to occur from the pharmacology of the drug and are dose- related.

Adverse effect that occur unpredictably and often have a high rate of morbidity and mortality.

Adverse effect that only occur during prolonged treatment and not with single doses

Adverse effect that occur when the drug is stopped, especially when it is stopped suddenly.

85) Type D reaction is defined as:

Adverse effect that are known to occur from the pharmacology of the drug and are dose- related.

Adverse effect that occur unpredictably and often have a high rate of morbidity and mortality.

Adverse effect that occur remote from treatment, either in the children of treated patients, or in patients themselves year after treatment

Adverse effect that occur when the drug is stopped, especially when it is stopped suddenly.

86) Type E reaction is defined as:

Adverse effect that are known to occur from the pharmacology of the drug and are dose- related.

Adverse effect that occur unpredictably and often have a high rate of morbidity and mortality.

Adverse effect that only occur during prolonged treatment and not with single doses

Adverse effect that occur when the drug is stopped, especially when it is stopped suddenly

87) Concerning drug interaction, which is the appropriate answer:

Drug interaction is the modification of the action of one drug by another

There are three kinds of mechanism of drug interaction

Drug interaction can result from one or combination of their three kinds of mechanism

All the above

89) There is different type of drug interaction, which is/are the best answer:

Useful interaction

Drug-patient interaction

Drug-food interaction

All the above

90) Concerning drug interaction, using Angiotensin Converting Enzyme Inhibitor and thiazide diuretic in a patient with a hypertension is:

Increased effect

Minimizing side effect

Block acutely an unwanted effect

None of the above

91) Levodopa is used with dopa decarboxylase inhibitor in order to:

Minimizing side effect

Increasing effect

Block acutely an unwanted effect

All the above

92) A patient use gentamicin together with hydrocortisone, the mechanism of this drug interaction is:

Pharmaceutical interaction

Pharmacokinetic interaction

Pharmacodynamic interaction

Biological interaction

93) A patient use warfarin together with aspirin, the mechanism of this drug interaction is:

Pharmaceutical interaction

Pharmacokinetic interaction

Biological interaction

Pharmacodynamic interaction

94) A patient use lithium together with diuretic, the mechanism of this drug interaction is:

Pharmacodynamic interaction

Pharmacokinetic interaction

Biological interaction

Pharmaceutical interaction

97) Pharmacodynamic interaction:

Occur outside the body

Interaction between drug with a similar effect

Occur when one drug influences the way in which another is handle by the body

All the above

98) Medication errors are the most frequently source of preventable medical errors in a hospital. Which of the following is not preventable?

Selecting a drug that the patient is allergic to without knowing of the allergy

Selecting the wrong dose

Selecting the wrong duration

Overlooking drug-drug interactions

99) The medication use process steps are:

Diagnosing, prescribing, preparing, dispensing, administering and monitoring tasks performed in different departments by different people

Diagnosing, prescribing, preparing, dispensing, administering, billing and monitoring tasks performed in different departments by different people

Diagnosing, prescribing, dispensing, preparing, administering and monitoring tasks performed in different departments by different people

Documenting, prescribing, preparing, dispensing, administering and monitoring tasks performed in different departments by different people

100) The most common causes of medication errors are lack of knowledge about the drug and:

Lack of information about the patient

Lack of timely test results

Lack of time spent reviewing the case

Lack of communication between EHRs

102) Which statement about the process of drug discovery is true?

It only encompasses the non-clinical laboratory and animal testing.

It is the process which ascertains the effectiveness and safety of potential drug candidates

It is the process by which therapeutic compounds are formulated into medicines

It ensures there are no side-effects associated with the potential drug candidates

103) What are adverse drug reactions (ADRs)?

The synergistic effects that are seen when some drugs are administered concurrently

Responses to increased drug doses required to achieve the same physiological outcome

Unintended alternative physiological responses caused by the drug that cause harm to the patient

Harmful chemical interactions between two drugs that are used to treat the same clinical symptoms

104) In pharmacokinetics what does the acronym ADME stand for?

Absorption, Distribution, Metabolism, and Excretion

Excretion Administration, Differentiation, Metabolism, and Excretion

Absorption, Disintegration, Metabolism, and Efficacy

Administration, Distribution, Metabolism, and Efficacy

105) Which of the following is the correct definition of bioavailability?

Bioavailability describes the proportion of the drug administered that is metabolized very quickly and thus is not available to induce a physiological effect.

Bioavailability is used to describe the fraction of the dose of drug administered that is

Bioavailability is used to describe the fraction of the dose of drug administered that is present within the body and facilitates the desired physiological effects

Bioavailability is the length of time an administered drug is present in the body and thus is available to cause a physiological effect

106) The role of health professional:

Identifying and assessing ADRs in clinical practice

Preventing ADRs

Monitoring therapy

All of the above

109) Among the drugs with high risk of interaction, ciclosporin is: