INTERNAL MED.( DIAGNOSTIC) 1-100
Comprehensive Internal Medicine Diagnostic Quiz
Test your knowledge and improve your skills with our Comprehensive Internal Medicine Diagnostic Quiz. This quiz consists of 100 carefully crafted questions that cover a wide array of internal medicine topics.
Features:
- 100 challenging multiple-choice questions
- Focuses on clinical presentations and diagnoses
- Ideal for medical students, practitioners, and educators
A 55-year-old man has just arrived in accident and emergency complaining of 20 minutes of central crushing chest pain. Which feature is most indicative of myocardial infarction at this moment in time?
Inverted T waves
ST depression
ST elevation
Q waves
Raised troponin
A 66-year-old woman presents to accident and emergency with a 2-day history of shortness of breath. The patient notes becoming progressively short of breath as well as a sharp pain in the right side of the chest which is most painful when taking a deep breath. The patient also complains of mild pain in the right leg, though there is nothing significant on full cardiovascular and respiratory examination. Heart rate is 96 and respiratory rate is 12. The patient denies any weight loss or long haul flights but mentions undergoing a nasal polypectomy 3 weeks ago. The most likely diagnosis is:
Muscular strain
Heart failure
Pneumothorax
Angina
Pulmonary embolism
A 59-year-old man presents for a well person check. A cardiovascular, respiratory, gastrointestinal and neurological examination is performed. No significant findings are found, except during auscultation a mid systolic click followed by a late systolic murmur is heard at the apex. The patient denies any symptoms. The most likely diagnosis is:
Barlow syndrome
Austin Flint murmur
Patent ductus arteriosus
Graham Steell murmur
Carey Coombs murmur
A 60-year-old man presents to accident and emergency with a 3-day history of increasingly severe chest pain. The patient describes the pain as a sharp, tearing pain starting in the centre of his chest and radiating straight through to his back between his shoulder blades. The patient looks in pain but there is no pallor, heart rate is 95, respiratory rate is 20, temperature 37°C and blood pressure is 155/95 mmHg. The most likely diagnosis is
Myocardial infarction
Myocardial ischaemia
Aortic dissection
Pulmonary embolism
Pneumonia
You see a 57-year-old woman who presents with worsening shortness of breath coupled with decreased exercise tolerance. She had rheumatic fever in her adolescence and suffers from essential hypertension. On examination she has signs which point to a diagnosis of mitral stenosis. Which of the foilowing is not a clinical sign associated with mitral stenosis?
Malar flush
Atrial fibrillation
Pan-systolic murmur which radiates to axilla
Tapping, undisplaced apex beat
Right ventricular heave
A 76-year-old male is brought to accident and emergency after collapsing at home. He has recovered within minutes and is fully alert and orientated. He says this is the first such episode that he has experienced, but describes some increasing shortness of breath in the previous six months and brief periods of central chest pain, often at the same time. On examination, blood pressure is 115/88 mmHg and there are a few rales at both bases. On ECG there are borderline criteria for left ventricular hypertrophy. Which of the following might you expect to find on auscultation?
Mid-diastolic murmur best heard at the apex
Crescendo systolic murmur best heard at the right steral edge
Diastolic murmur best heard at the left sternal edge
Pan-systolic murmur best heard at the apex
Pan-systolic murmur best heard at the left sternal edge
A 63-year-old male was admitted to accident and emergency 2 days after discharge following an apparently uncomplicated MI. He complained of rapidly worsening shortness of breath over the previous 48 hours but no further chest pain. He was tachypnoeic and had a regular pulse of 110/minute, which proved to be sinus tachycardia. The jugular venous pressure was raised and a pan-systolic murmur was noted, maximal at the left sternal edge. Which of the following is the most likely diagnosis?
Mitral incompetence
Ventricular septal defect
Aortic stenosis
Dressler's syndrome
Further myocardial infarction
A 16-year-old male is referred for assessment of hypertension. On average, his blood pressure is 165/85 mmHg, with radiofemoral delay. There is a mid-systolic murmur maximal at the aortic area, and radiating to the back. Clinical fmdings and the ECG are compatible with left ventricular hypertrophy. What is the most likely underlying pathology?
Hypertrophic obstructive cardiomyopathy
Congenital aortic stenosis
Coarctation of the aorta
Patent ductus ateriosus
Atrial septal defect
A 46-year-old man develops sudden severe central chest pain after lifting heavy cases while moving house. The pain radiates to the back and both shoulders but not to either arm. His BP is 155/90 mmHg, pulse rate is 92 beats per minute and the ECG is normal. He is distressed and sweaty, but not nauseated. What would you consider the most likely diagnosis?
Pneumothorax
MI
Pulmonary embolism
Aortic dissection
Musculoskeletal pain
A 49-year-old woman presents with increasing shortness of breath on exertion developing over the past three months. She has no chest pain or cough, and has noticed no ankle swelling. On examination, blood pressure is 158/61 mmHg, pulse is regular at 88 beats per minute and there are crackles at both lung bases. There is a decrescendo diastolic murmur at the left sternal edge. What is the most likely diagnosis?
Aortic regurgitation
Aortic stenosis
Mitral regurgitation
Mitral stenosis
Tricuspid regurgitation
A 44-year-old woman attends her local accident and emergency department with a history of at least six months of frequent central chest pain in the early morning or during the night. She had no chest pain on exertion. This had been a particularly severe attack, lasting over 2 hours. Her pulse rate is 84/minute in sinus rhythm, and blood pressure is 134/86 mmHg. The ECG shows anterior ST segment elevation, but troponin levels do not rise. Subsequent coronary angiography is normal. What is the most likely diagnosis?
MI
Stable angina
Unstable angina
Anxiety
Variant angina
You see a 68-year-old man in clinic, with a 40 (cigarette) pack year history, who has been experiencing breathlessness on exertion and a productive cough of white sputum over the last four months. You assess his spirometry results which reveal an FEVl/FVC of 51 per cent with minimal reversibility after a 2-week trial of oral steroids. Cardiological investigations are normal. Which of the following is the most likely diagnosis?
Asthma
Chronic obstructive pulmonary disease (COPD)
Left ventricular failure
Chronic bronchitis
Lung fibrosis
A 67-year-old woman is admitted to accident and emergency with pyrexia (38.1°e) and a cough productive of green sputum. The observations show a pulse rate of 101, BP 80/60 and respiratory rate of 32. She is alert and orientated in space and time. Blood results reveal a wee of 21, urea of 8.5 and chest x-ray shows a patch of consolidation in the lower zone of the right lung. She is treated for severe community-acquired pneumonia. Which of the following is the correct calculated eURB-65 score?
6
8
4
O
L
You are asked to interpret an arterial blood gas of a 76-year-old patient who was admitted to accident and emergency with an acute onset of breathlessness and low oxygen saturations. The test was taken on room air and read as follows: pH 7.37, P02 7.8, Pe02 4.1, He03 24, S02 89 per cent. Choose the most likely clinical interpretation from these arterial blood gas results:
Compensated respiratory acidosis
Type 1 respiratory failure
Compensated respiratory alkalosis
Type 2 respiratory failure
None of the above
A 54-year-old woman is seen in clinic with a history of weight loss, loss of appetite and shortnesss of breath. Her respiratory rate is 19 and oxygen saturations (on room air) range between 93 and 95 per cent. On examination, there is reduced air entry and dullness to percussion on the lower to midzones of the right lung. There is also reduced chest expansion on the right. From the list below, select the most likely diagnosis:
Right middle lobe pneumonia
Pulmonary embolism
Right-sided pleural effusion
Right-sided bronchial carcinoma
Right lower lobe pneumonia
A 45-year-old woman with unexpected weight loss, loss of appetite and shortness of breath presents to you in clinic. On examination, there is reduced air entry and dullness to percussion in the right lung. A pleural tap is performed and the aspirate samples sent for analysis. You are told that the results reveal a protein content of>30 g/L. From the list below, select the most likely diagnosis:
Bronchogenic carcinoma
Congestive cardiac failure
Liver cirrhosis
Nephrotic syndrome
Meig's syndrome
A 55-year-old woman, who has never smoked, presents to you on the ward with a history of weight loss, decreased appetite and fmger clubbing. You are told that her chest x-ray revealed opacity in the hilar region of the right lung suggesting a bronchogenic carcinoma. She is currently awaiting a CT-chest with bronchoscopy to follow. From the list below, select the most likely diagnosis:
Squamous cell carcinoma of the lung
Adenocarcinoma of the lung
Small cell carcinoma of the lung
Large cell carcinoma of lung
Carcinoid tumour of the lung
You see a 28-year-old man, with no past medical history, in accident and emergency who developed an acute onset of pleuritic chest pain and shortness of breath while playing football. On examination, oxygen saturations are 93 per cent on room air, respiratory rate 20 and temperature is 37.1°C. There is decreased expansion of the chest on the left side, hyper-resonant to percussion and reduced air entry on the left. The most likely diagnosis is:
Left-sided pneumothorax
Left-sided pneumonia
Left-sided pleural effusion
Lung fibrosis
Traumatic chest injury
You see a 67-year-old man who has been referred to the chest clinic following a three-month history of weight loss and signs which may suggest a Pancoast's tumour. Which of the following symptoms from the list below is not associated with a Pancoast's tumour?
Hoarse voice
Miosis
Anhydrosis
Exopthalmos
Ptosis
A SO-year-old Afro-Caribbean man, with no past medical history, presents with a four-month history of dry cough and shortness of breath on exertion. The patient's GP referred him to the chest clinic after performing blood tests which revealed a raised erythrocyte sedimentation rate (ESR) and serum angiotensin-converting enzyme (ACE) level. You review the patient's chest xray which reveals bilateral hilar lyphadenopathy. From the list below, select the most likely diagnosis:
Rheumatoid arthritis
Systemic lupus erythematosus (SLE)
Sarcoidosis
Idiopathic pulmonary fibrosis
Bronchogenic carcinoma
You are told by your registrar that a 69-year-old man has been admitted to the chest ward with dyspnoea, cyanosis and fnger clubbing. His chest x-ray shows bilateral lower zone reticulonodular shadowing. From the list below, which is the most likely diagnosis?
Bronchiectasis
Pulmonary fibrosis
Bronchogenic carcinoma
Bronchitis
COPD
You see a 70-year-old man diagnosed with hypersensitivity pneumonitis following a four-month history of shortness of breath at rest and cyanosis. Which of the following does not fall under the category of hypersensitivity pneumonitis?
Coal worker's lung
Pigeon fancier's lung
Mt1shroom picker's lung
Farmer's lung
Malt worker's lung
During the consultant ward round, you see a 78-year-old woman who is being investigated for hyponatraemia, weight loss and haemoptysis. A mass lesion was detected on a CT-chest scan which has been biopsied and sent for histological analysis. Your consultant has a high suspicion that the patient may have bronchogenic carcinoma. From the list below, select the most likely type of bronchogenic carcinoma that would explain the above patient's symptoms:
Large cell carcinoma
Small cell carcinoma
Adenocarcinoma
Squamous cell carcinoma
Alveolar cell carcinoma
A 56-year-old man attends your clinic with a three-month history of a productive cough with blood-tinged sputum, following his return from India. Associated symptoms include lethargy, night sweats and decreased appetite. He is normally ft and healthy with no past medical history. On examination, the patient's chest has good air entry bilaterally with no added sounds and his temperature is 37.3°C. A sputum sample sent from the patient's GP reveals a growth of acid fast bacilli. From the list below, which is the most likely diagnosis?
Pulmonary embolism
Tuberculosis
Bronchitis
Pneumonia
Bronchogenic carcinoma
A 37-year-old woman is admitted to accident and emergency with severe facial burns. Despite prompt management, she develops acute respiratory distress syndrome (ARDS). Which of the following is not associated with the diagnostic criteria for ARDS?
Bilateral infiltrates on chest x-ray
Acute onset
Pulmonary capillary wedge pressure > 19
Refractory hypoxaemia (Pa02:Fi02 <200)
Lack of clinical congestive heart failure
You see a 47-year-old man in clinic with a three-month history of epigastric dull abdominal pain. He states that the pain is worse in the mornings and is relieved after meals. On direct questioning, there is no history of weight loss and the patient's bowel habits are normal. On examination, his abdomen is soft and experiences moderate discomfort on palpation of the epigastric region. The most likely diagnosis is:
Gastric ulcer
Gastro-oesophageal reflux disease (GORD)
Duodenal ulcer
Gastric carcinoma
Gastritis
You see a 48-year-old lorry driver, who presents to you with a three-month history of heartburn after meals which has not been settling with antacids and PPis. You suspect that the patient has a hiatus hernia. The most appropriate investigation for diagnosing a hiatus hernia is:
Computer tomography (CT) scan
Chest x-ray
Upper GI endoscopy
Barium meal
Ultrasound
You see a 25-year-old woman who presents with a 24-hour history of watery diarrhoea. She states that she has opened her bowels 11 times since her onset of symptoms. Associated symptoms include nausea and vomiting with abdominal cramps and pain which started in the evening following a barbeque meal in the afternoon that day. The patient is alert and orientated and her observations include a pulse rate of 69, blood pressure of 124/75 and temperature of 37.1°C. On examination, her abdomen is soft, there is marked tenderness in the epigastric region and bowel sounds are hyperactive. The patient is normally fit and well with no past medical history. The most likely diagnosis is:
Irritable bowel syndrome
Gastroenteritis
Ulcerative colitis
Laxative abuse
Crohn's disease
You see a 54-year-old woman, referred to accident and emergency through her GP, with a week's history of jaundice and right upper quadrant abdominal pain. Associated symptoms include dark urine and pale stools. There is no history of weight loss and the patient does not consume alcohol. Her liver function tests reveal a bilirubin of 40 µmol/L, ALT of 40 iu/L, AST 50 iu/L and ALP of 350 iu/L. The most likely diagnosis is:
Gallstones
Viral hepatitis
Alcoholic hepatitis
Carcinoma of the head of the pancreas
Autoimmune hepatitis
You see a 75-year-old man with an acute episode of haematemesis, who was admitted the night before and is awaiting an upper GI endoscopy. You are asked on the ward round about the common causes of upper GI bleeding. From the list below, which of the following is the most common cause of upper GI bleeding?
Mallory-Weiss tear
Peptic ulcers
Oesophageal varices
Drug induced
Malignancy
A 67-year-old man presents feeling unwell and complaining of general malaise. He mentions a long history of alcohol abuse and his past medical history shows deranged liver function tests. Which of the following clinical signs does not form part of chronic liver disease?
Finger clubbing
Palmer erythema
Spider naevia
Koilonychia
Jaundice
You see a 52-year-old woman with rheumatoid arthritis in your clinic. She was referred by her GP after her ALP levels were found to be abnormally high at 300 iu/L. In addition, she was also found to be serum anti-mitochondrial antibody (AMA) positive. The most likely diagnosis is:
Primary biliary cirrhosis
Wilson's disease
Heriditary haemochromotosis
Primary sclerosing cholangitis
Alcoholic liver disease
You are told by your registrar that one of your inpatients has been diagnosed with primary sclerosing cholangitis (PSC). Your registrar suspects that the patient may have an associated condition. Primary sclerosing cholangitis is associated with which of the following diseases?
Thyroid disease
Systemic sclerosis
Rheumatoid arthritis
Ulcerative colitis
Irritable bowel syndrome
A 28-year-old man undergoes a sigmoidoscopy for longstanding diarrhoea and weight loss. On visualization of the rectum, the mucosa appears inflamed and friable. A rectal biopsy is taken and the histology shows mucosa) ulcers with inflammatory infiltrate, crypt abscesses with goblet cell depletion. From the list of answers below, which is the most likely diagnosis, describing the histology report?
Crohn's disease
Pseudomembranous colitis
Irritable bowel syndrome
Ulcerative colitis
No diagnosis - the report is inconclusive
You read a report which was handwritten in a patient's medical notes who you suspect has inflammatory bowel disease. The report reads, '... There is cobblestoning of the terminal ileum with the appearance of rose thorn ulcers. These findings are suggestive of Crohn's disease'. Select the most likely investigation that this report was derived from:
Colonoscopy
Sigmoidoscopy
Baiium follow through
Abdominal CT
Abdominal ultrasound
A 47-year-old woman has been experiencing a four-month history of diarrhoea and bloating. Associated symptoms include lethargy and weight loss. Full blood count reveals haemoglobin of 9.3 d/gL and MCV 70 fL. Which of the following investigations would be helpful in the patient's diagnosis?
Anti-mitochondrial antibodies
Anti-smooth muscle antibodies
Anti-tissue transglutaminase antibodies
Anti-nuclear antibodies
Anti-neutrophil cytoplasmic antibodies
A 21-year-old man presents with painless haematuria which he has noticed in the last 3 days. He suffers from type 1 diabetes which is well controlled, but is otherwise fit and healthy. The patient has recently recovered from a mild throat infection. Urine dipstick analysis reveals blood and protein in the urine. The most likely diagnosis is:
Henoch-Schonlein purpura
Benign prostate hypertrophy
IgA nephropathy
Diabetic nephropathy
Urinary tract infection (UTI)
A 16-year-old boy presents with a low-grade fever which started 1 week ago. The patient also reports feeling fatigued and indicates pain in his joints. His parents mention that he has been visiting the toilet more often than usual. A urine dipstick shows trace proteins, while a blood test shows raised eosinophils. The most likely diagnosis is:
Acute tubulointerstitial nephritis
Renal failure
Diabetes mellitus
UTI
Reactive arthritis
A 42-year-old diabetic Asian male complains of dysuria, increased urinary frequency and general malaise for the past six months. In the last few days, he has noticed blood in the urine. Examination of the urine shows the presence of neutrophils with no organisms detected on urine culture. The most likely diagnosis is:
Tuberculosis
Renal cell cancer
Diabetic nephropathy
Bladder cancer
Nephritic syndrome
A 17-year-old patient is referred by his GP after presenting with periorbital oedema. The patient noticed the oedematous eyes 3 days ago, but reports feeling unwell since a throat infection 3 weeks ago with nausea and vomiting in the last week. A urine dipstick is positive for protein and blood while serum creatinine and urea are mildly deranged. The most likely diagnosis is:
Nephrotic syndrome
Nephritic syndrome
Renal failure
Glomerulonephritis
Von Grawitz tumour
A 32-year-old builder presents in accident and emergency in a distressed state. He reports suffering from chest pain for the last 2 weeks, the pain is sharp and only occurs when he moves heavy objects. He has a family history of cardiovascular disease and is worried about a heart attack. His blood gas findings are as follows: pH= 7.47; PC02= 3.3; P02= 15.3; bicarbonate= 17.53. The most likely diagnosis is:
Respiratory acidosis with metabolic compensation
Acute metabolic acidosis
Respiratory alkalosis with metabolic compensation
Metabolic acidosis with respiratory compensation
Acute respiratory alkalosis
A 52-year-old man complains of a 3-week history of malaise and shortness of breath. He has lost weight in the last few months but attributes this to a loss of appetite possibly due to stress at work. On examination, he has a palpable mass in the right lumbar region. He has no urinary symptoms. However, the urine dipstick detected blood. The most likely diagnosis is:
Renal abscess
Renal cyst
Renal carcinoma
Adrenal tumour
Pyelonephritis
A 37-year-old man presents with a 5-day history of haematuria. Abdominal examination is unremarkable. Urine analysis reveals hypercalciuria and excretion urography reveals small calculi within the papilla of the patient's right kidney. The patient has presented several times in the past with UTis and renal stones, but is otherwise healthy. The most likely diagnosis is:
Medullary sponge kidney
Renal cell carcinoma
Medullary cystic disease
Horse-shoe kidney
Tertiary hyperparathyroidism
A 64-year-old man is undergoing treatment for polycythaemia vera with chemotherapy, he has no other medical problems. Shortly after starting treatment, the patient becomes lethargic, feels unwell and suffers weight loss. He attributes this is to the chemotherapy. After 2 weeks, the patient becomes oliguric, complains of bilateral flank pain and becomes oedematous. The most likely diagnosis is:
Analgesic nephropathy
Renal infarction
Hyperuricaemic nephropathy
Acute tubulointerstitial nephritis
Chronic renal failure
A 67-year-old diabetic female is brought into accident and emergency following a collapse at her home. She was found by her daughter who said she saw the patient going to the toilet and then hearing her collapse. The patient did not lose consciousness and appears well. Her supine blood pressure is 100/70 and standing 115/79. Urine dipstick is positive for glucose, nitrates, leukocytes and haematuria. The most likely diagnosis is:
Diabetic ketoacidosis
UTI
Orthostatic hypotension
Diabetic nephropathy
Hypoglycaemia
An 18-year-old man presents with general malaise and lethargy for the last 2 weeks, he denies any weight loss and has maintained a good appetite. On examination, there are no abnormalities except for sacral oedema and a polyphonic wheeze. Urine dipstick is positive for protein only and blood pressure is 140/90. The most likely diagnosis is:
Nephroritic syndrome
Nephrotic syndrome
Goodpasture's disease
Thin-basement membrane nephropathy
Minimal change glomerulonephriti
A 6-year-old has a sore throat and has been given antibiotics. Three weeks later, he represents feeling feverish with nausea, vomiting and tea-coloured urine. Urine dipstick confirms haematuria and protein. Blood pressure is 100/60 mmHg. The most likely diagnosis is:
Nephritic syndrome
UTI
Acute tubulointerstitial nephritis
Minimal change glomerulonephritis
Post streptococcal glomerulonephritis
A 21-year-old man complains his urine has turned a faint red in the last week. He denies any significant changes in his diet or lifestyle and has no other medical problems except for sensorineural deafness diagnosed when he was young. On examination, you notice retinal flecks and urine dipstick confirms protein and blood. The most likely diagnosis is:
Alport's syndrome
Benign familial haematuria
Wolfram syndrome
LgA nephropathy
Down's syndrome
A 65-year-old overweight man presents with a 2-week history of haematuria. The patient denies any other symptoms and his blood pressure is 128/83 mmHg. He suffers from no other medical problems but admits to being a chronic smoker since the age of 16. He has tried to lose weight using herbal remedies for three years, but he has only noticed significant weight loss in the last week despite stopping the remedies months ago. The most likely diagnosis is:
Chinese herb nephropathy
Bladder cancer
Schistosomiasis
Acute tubulointerstitial nephritis
Renal cancer
A 53-year-old man with HIV suffers a ruptured aortic aneurysm and is rushed into theatre, he undergoes a successful operation and is recovering on the wards in a stable condition. One day after the operation, he becomes oliguric with mildly elevated urea and creatinine. After 1 week, he becomes polyuric with a GFR of 30. The most likely diagnosis is:
Haemolytic-uraemic syndrome
Acute tubular necrosis
SIADH
HIV nephropathy
Acute renal failure
A 64-year-old woman with type 1 diabetes presents to clinic with several months of sinus problem and a 4-day history of oliguria. Her blood pressure is 137/80, serum results show mildly elevated urea and creatinine, absence of anti-GBM antibodies, while a C-ANCA assay is positive. Red blood cell (RBC) casts are present in the urine and her renal biopsy reveals glomerular crescents. The most likely diagnosis is:
Post-streptococcal glomerulonephritis
Goodpasture's syndrome
Minimal change glomerulonephritis
Rapidly progressive glor.erulonephritis
Wegener's granulomatosis
A 66-year-old woman with poorly controlled type 2 diabetes presents to accident and emergency with a 2-day history of severe pain in the right flank, nausea and fevers that come and go. On examination, the patient appears unwell, sweaty and has visible rigors with a temperature of 38°C. The patient denies any recent travel. Urine dipstick is positive for protein, blood, leukocytes and nitrates. A CT scan of the abdomen reveals gas in the renal parenchyma area. The most likely diagnosis is:
Renal stones
Renal infarction
Diabetic nephropathy
Renal TB
Pyelonephritis
A 33-year-old obese woman complains of tiredness. She has recently given birth to a healthy baby boy and is enjoying being a mother. However, she is becoming more reliant on her partner for support as she always feels exhausted and often becomes depressed. The patient has a poor appetite and often does not finish her meals, despite this she has gained 5 kg in the last 2 weeks. The most likely diagnosis is:
Postpartum depression
Eating disorder
Hyperthyroidism
Hypothyroidism
Occult malignancy
A 49-year-old man presents with a history of diffculty sleeping. He reports feeling increasingly tired and general weakness which he attributes to his poor sleep pattern. Additionally, the patient has noticed he has gained weight and sweats very easily. On examination, the patient has coarse facial features. The most likely diagnosis is:
Hyperthyroidism
Cushing's disease
Acromegaly
Hypothyroidism
Diabetes
A 42-year-old woman presents with visual disturbances. She reports having double vision which was intermittent initially but has now become much more frequent. In addition, she becomes breathless very easily and experiences palpitations. On examination, raised, painless lesions are observed on the front of her shins and fnger clubbing. The most likely diagnosis is:
De Quervain's thyroiditis
Thyroid storm
Phaeochromocytoma
Graves' disease
Plummer's disease
A 16-year-old girl presents to her GP complaining of a swelling in her neck which she has noticed in the last 2 weeks. She has felt more irritable although this is often transient. On examination, a diffuse swelling is palpated with no bruit on auscultation. The most likely diagnosis is:
Hyperthyroidism
Simple goiter
Riedel's thyroiditis
Thyroid carcinoma
Thyroid cyst
A 69-year-old man presents with confusion. His carers state that over the last month he has become increasingly lethargic, irritable and confused. Despite maintaining a good appetite, he has lost 10 kg in the last month. Blood results are as follows: Sodium 125 mmol/, Potassium 4 mmol/, Urea 3, Glucose (fasting) 6 mmol/, Urine osmolality 343 mmol/. The most likely diagnosis is:
Hypothyroidism
Dilutional hyponatraemia
Addison's disease
Acute tubulointerstitial neplu·itis
Syndrome of inappropriate anti-diuretic hormone (SIADH)
A 54-year-old woman presents to her GP complaining of a change in her breathing sound. She first noticed numbness, particularly in her fingers and toes, three months ago but attributed this to the cold weather. Her partner now reports hearing a high pitched, harsh sound while she is sleeping. Her BMI is 27. While measuring blood pressure, you notice the patient's wrist flexing. The most likely diagnosis is:
Obstructive sleep apnoea
Hypocalcaemia
DiGeorge syndrome
Guillain-Barré syndrome
Raynaud' s syndrome
A 47-year-old woman complains of weight loss. She has a family history of type 1 and type 2 diabetes but has never been diagnosed herself despite the finding of islet cell antibodies. In the last few months, however, she has noticed progressively increasing polyuria and poydipsia and 5 kg of weight loss. Her fasting plasma glucose is 8 mmol/ and urine dipstick shows the presence of ketones. The most likely diagnosis is:
Type 1 diabetes
Non-ketotic hyperosmolar state
Type 2 diabetes
Occult malignancy
Latent autoimmnune diabetes of adults (LADA)
A 55-year-old diabetic woman presents with altered sensations in her hands and feet. She rmds it difficult to turn pages of books and discriminating between different coins. When walking, the floor feels different and she likens the sensation to walking on cotton wool. The most likely diagnosis is:
Autonomic neuropathy
Diabetic amyotrophy
Acute painful neuropathy
Symmetrical sensory neuropathy
Diabetic mononeuropathy
A 29-year-old woman is referred to a diabetic clinic for poor diabetes management. She was diagnosed with type 1 diabetes at the age of 12 and prescribed actrapid insulin injections. Recently, the patient has been suffering fluctuations in her plasma glucose levels and her previously well-controlled glycated haemoglobin has risen to 8.1 per cent. The patient admits she has recently been avoiding using her injections. On examination, the patient has a raised, smooth lump that is firm on palpation at the lower abdomen. The most likely diagnosis is:
Worsening of diabetes
Lipohypertrophy
Injection scaning
Lipoma
Injection abscess
A 7-year-old girl presents with red striae which her mother noticed around her abdomen. The girl also has plethoric cheeks and, on her back, several faint, irregular brown macules are observed. The mother is particularly concerned about the early breast development that seems apparent on her daughter. Serum phosphate is decreased. The most likely diagnosis is:
Paget's disease of the bone
McCune-Albright syndrome
Cushing's disease
Hypopituitarism
Neurofibromatosis
An 18-year-old man presents to clinic worried about his scant pubic hair development. Examination reveals undescended testes and plasma testosterone, luteinizing hormone and follicle stimulating hormone were found to be low. A karytotype test was 46, XY. The patient was otherwise well, but during neurological examination struggled during the olfactory test. The most likely diagnosis is:
Hypogonadotropic hypogonadism
Klinefelter's disease
Androgen insensitivity syndrome
5-alpha reductase deficiency
Kallman's syndrome
A 15-year-old girl complains of headaches which started 6 weeks ago. The headaches initially occurred 1-2 times a week but now occur up to five times a week, they are not associated with any neurological problems, visual disturbances, nausea or vomiting. The girl also reports a white discharge from both of her nipples. She has not started menstruating. The most appropriate investigation is:
Lateral skull x-ray
CT scan
MRI scan
Thyroid function tests
Serum prolactin measurement
A 47-year-old woman is referred to the endocrine clinic complaining of a two- month history of tiredness. Despite wearing several items of clothing, the patient appears intolerant to the room temperature. She has noticed an increase in weight, particularly around her waist. The most appropriate investigation is:
Radioiodine scan
Thyroid stimulating hormone (TSH)
Total tetraiodothyronine level (T4)
Tri-iodothyronine level (T3)
Ultrasound scan of the neck
A 58-year-old woman presents with an acutely painful neck, the patient has a fever, blood pressure is 135/85 mmHg and heart rate 102 bpm. The patient explains the pain started 2 weeks ago and has gradually become worse. She also notes palpitations particularly and believes she has lost weight. The symptoms subside and the patient presents again complaining of intolerance to the cold temperatures. The most likely diagnosis is:
Thyroid papillary carcinoma
Plumrer's disease
De Quervain's thyroiditis
Hyperthyroidism
Thyroid follicular carcinoma
A 6-year-old girl presents to accident and emergency with severe abdominal pain, nausea and vomiting. On examination, the patient is tachypnoeic, capillary refill is 3 seconds and she has a dry tongue. While listening to the patient's lungs, you detect a sweet odour from her breath. The most likely diagnosis is:
Diabetic ketoacidosis
Non-ketotic hyperosmolar state
Gastroenteritis
Pancreatitis
Adrenal crisis
A 45-year-old Asian man is diagnosed with Cushing's disease in India. He undergoes a bilateral adrenalectomy and recovers well from the operation. On his return to the UK one year later, he complains of a constant dull headache, peripheral visual disturbances and increasing pigmentation of the skin creases of both hands. The most likely diagnosis is:
Ectopic ACTH secreting tumour
Prolactinoma
Nelson syndrome
Addison's disease
Side effects fom iatrogenic steroid intake
A 29-year-old woman is found unconscious by her partner and rushed to accident and emergency. She is a type 1 diabetic and has maintained excellent glucose control using insulin injections. Blood biochemistry results demonstrate a moderately raised level of insulin, no detectable C-peptide and very low blood glucose. Her partner mentions she is a lawyer and has been working particularly hard in the last week, eating quick meals and occasionally missing meals. The most likely diagnosis is:
Hyperosmolar coma
Diabetic ketoacidosis
Insulin overdose
Hypoglycaemic coma
Autonomic neuropathy
A 37-year-old man presents with symptoms of an acute headache, vomiting, malaise and visual disturbance. A neurological examination reveals a bitemporal superior quadrantanopia. A CT scan shows a hyperdense area within the pituitary gland. The most likely diagnosis is:
Kallman syndrome
Septo-optic dysplasia
Sheehan's syndrome
Empty sella syndrome
Pituitary apoplexy
A 38-year-old woman presents to clinic complaining of changes in her appearance and weight gain. She has recently been through a divorce and attributed her weight gain to this. However, despite going to the gym her clothes are still tight, especially around her waist, her face seems puffy and flushed. The most likely diagnosis is:
Hyperthyroidism
Cushing's disease
Acromegaly
Hypothyroidism
Diabetes
A 60-year-old diabetic man recovering from sepsis after collapsing at home was treated with appropriate antibiotics after blood culture and aggressive fluid management with 0.9 per cent saline for 2 days for hypotension. Although blood pressure returned to normal, the patient had the following abnormal biochemical blood results: pH 7.32, PC02 5.2, P02 11.1, Sodium 147 mmol/, Potassium 3.5 mmol/, Chloride 119 mmol/, Bicarbonate 19.5. The most likely diagnosis is:
Diabetic ketoacidosis
Lactic acidosis
Conn's syndrome
Renal tubular acidosis type 1
Hyperchloremic acidosis
A 57-year-old woman, who has recently returned from a holiday in America, presents with dull grey-brown patches in her mouth and the palms of her hand which she has noticed in the last week. She has also noticed she gets very dizzy when rising from a seated position and is continually afraid of fainting. The most likely diagnosis is:
Addison's disease
SIADH
Conn's syndrome
Waterhouse-Friderichsen syndrome
17-hydroxylase deficiency
A 36-year-old woman presents to the rheumatology outpatient clinic with a two-month history of stiff hands and wrists. She mentions that the pain is particularly bad for the first few hours after waking up and is affecting her work as a dentist. On examination, the wrists, metacarpophalangeal joints and proximal interphalangeal joints are swollen and warm. What is the most likely diagnosis?
Rheumatoid arthritis
Osteoarthtitis
Septic arthritis
Polymyalgia rheumatica
Reactive arthtitis
A 55-year-old man presents to his GP with a 2-week history of pain in his hands. The pain is particularly bad in his right hand. On examination, brown discoloration of the nails with onycholysis is noted and the distal interphalangeal joints are tender on palpation. What is the most likely diagnosis?
Rheumatoid arthritis
Dermatomyositis
Reactive arthritis
Osteoarthritis
Psoriatic aithritis
A 75-year-old woman presents to accident and emergency complaining of pain in her knees. She mentions that this has been troubling her for several months. Pain is generally worse in the evenings and after walking. On examination, there are palpable bony swellings on the distal interphalangeal joints of the fingers on both hands. In addition, there is reduced range of movement and crepitus in the knees. What is the most likely diagnosis?
Rheumatoid arthritis
Osteoarthritis
Reactive arthritis
Polymyalgia rheumatica
Gout
A 30-year-old man presents to his GP with a 1-week history of painful, swollen knees and a painful right heel. Further history reveals that he has been experiencing burning pains while urinating for the past 2 weeks and that his eyes have become red and itchy. What is the most likely diagnosis?
Septic arthritis
Gout
Ankylosing spondylitis
Enteropathic arthritis
Reactive arthritis
A 70-year-old woman presents to accident and emergency with sudden onset pain and swelling in the right knee. Her past medical history includes hypertension and hypercholesterolaemia. She is currently taking aspirin, ramipril and simvastatin. On examination, she is apyrexial and the right knee is swollen. There is reduced range of movement in the knee due to swelling and pain. X-ray of the right knee shows chondrocalcinosis. What is the most likely diagnosis?
Gout
Pseudo-gout
Septic arthritis
Reactive arthritis
Osteoarthritis
A 70-year-old woman presents to her GP complaining of severe unilateral headache over the left side of her head. On further questioning, she mentions that she has been having bilateral shoulder and neck pains over the past few weeks. She has also been feeling lethargic. On examination, the left side of her scalp is painful to touch. What is the most likely diagnosis?
Polyarteritis nodosa
Polymyositis
Hypothyroidism
Migraine
Giant cell arteritis
A 60-year-old woman presents to her GP with a two-month history of lethargy and weakness. She mentions that she is finding it increasingly difficult to climb the stairs and do the housework. On examination, there is wasting and weakness of the proximal muscles in the upper and lower limbs. What is the most likely diagnosis?
Dermatomyositis
Polymyositis
Polymyalgia rheumatica
Kawasaki's disease
Polyarteritis nodosa
A 30-year-old Afro-Carribean woman presents to accident and emergency with a 1-week history of progressive shortness of breath and fever. On further questioning, she mentions that her hands have been painful and stiff over the past few months and she has been having recurrent mouth ulcers. Chest x-ray confrms bilateral pleural effusions and blood tests reveal a raised ESR and a normal CRP. What is the most likely diagnosis?
Systemic lupus erythematosus
Systemic sclerosis
Sjogren's syndrome
Discoid lupus
Bechet's disease
A 34-year-old Afro-Carribean woman has been admitted for management and investigation of increasing shortness of breath. On further questioning, she mentions that her hands have been painful and stiff over the past few months and she has been having recurrent mouth ulcers. Chest x-ray confrms bilateral pleural effusions and blood tests reveal a raised ESR and a normal CRP. A diagnosis of systemic lupus erythematosus (SLE) is suspected and a full autoantibody screen is sent to the laboratory. Which of the following auto-antibodies is most specific to the suspected diagnosis?
Anti-nuclear antibody
Rheumatoid factor
Anti-double stranded DNA antibody
Anti-centromere antibody
Anti-mitochondrial antibody
A 27-year-old woman presents to accident and emergency complaining of sudden onset shortness of breath, right-sided pleuritic chest pain and haemoptysis. She has a past medical history of three miscarriages and a deep venous thrombosis in the right leg. CTPA confirms a large pulmonary embolism. What is the most likely underlying diagnosis?
SLE
Primary anti-phospholipid syndrome
Raynaud's disease
Systemic sclerosis
Bechet's disease
A 45-year-old woman presents to the rheumatology clinic with a three-month history of itchy, dry eyes and a persistently dry mouth. She also mentions that her fingers have been extremely cold, occasionally turning blue after going outside in the morning. Sbirmer's test is positive. What is the most likely diagnosis?
Systemic sclerosis
Raynaud's disease
SLE
Primary Sogren's syndrome
Secondary Sjogren's syndrome
A 30-year-old woman presents to accident and emergency with worsening stiffness in the hands, wrists and feet. She mentions that the pain has been particularly bad in the mornings. On examination, there is a palpable spleen. Initial blood tests reveal a low neutrophil count and a raised C-reactive protein. The most likely diagnosis is:
Felty's syndrome
Reactive arthritis
Still's disease
Infectious mononucleosis
Serum sickness
A 53-year-old man, who works as a chef, presents to accident and emergency with sudden onset severe pain, tenderness and swelling of the first metatarsophalangeal joint. The pain is making it difficult for him to mobilize. He has had two previous similar episodes. Blood tests reveal a raised serum orate level. The most likely diagnosis is:
Gout
Pseudo-gout
Septic arthritis
Reactive arthritis
Osteoarthritis
A 30-year-old Turkish man presents to accident and emergency with oral ulcers, genital ulcers and painful legs. On examination, there are apthous ulcers in the mouth, genital ulceration, erythema nodosum over the shins. He is admitted under the medical team on call and a skin pathergy test is positive. What is the most likely diagnosis?
Henoch-Schonlein purpura
Lyme disease
Berger's disease
Caplan's syndrome
Behcet's disease
A 23-year-old woman presents to accident and emergency with a purpuric rash over the buttocks and lower limbs and haematuria. She is finding it difficult to mobilize due to pain in her ankles and knees. What is the most likely diagnosis?
Henoch-Schonlein purpura
Perthes' disease
Behcet's disease
Still's disease
Ehlers-Danlos syndrome
A 67-year-old man presents to his GP with pain in his pelvis. During the consultation, he mentions that his friends have been commenting that his head appears larger than before. In addition, he has noticed deterioration in hearing in his left ear. On neurological examination, a left-sided sensorineural deafness in detected. Closer inspection of the legs reveals bowing of the tibia. What is the most likely diagnosis?
Osteomalacia
Osteoporosis
Acromegaly
Ricketts
Paget's disease
A 16-year-old boy presents to his GP complaining of nosebleeds and bleeding after brushing his teeth. He is unsure of how long this has been occurring but decided to seek advice after having to continually excuse himself from lessons. On examination you notice he has some skin bruises. A blood test shows a prolonged bleeding time and activated partial thromboplastin time (APTT), while platelet count and prothrombin times are all normal. The most likely diagnosis is:
Von Willebrand disease
Liver disease
Disseminated intravascular coagulation
Congenital afibrinogenaemia
Glanzmann's thrombasthenia
A 22-year-old Caucasian woman presents with a 1-day history of a painful right leg which is erythematous on appearance and tender on palpation. She states that she has had this problem many times in the last few years and her family has also suffered from similar problems. Her grandmother died of a pulmonary embolism. The most likely diagnosis is:
Antithrombin deficiency
Factor V Leiden mutation
Protein S deficiency
Lupus anticoagulant
Protein C deficiency
A 44-year-old Asian female presents with a two-month history of shortness of breath and lethargy. She denies any intolerance to the cold or any changes in her weight and on examination appears slightly pale. She states that she has recently become a vegetarian. A blood film shows the presence of elliptocytes and blood results show the following: Haemoglobin 9.9 g/dL, Mean cell volume (MCV) 75 f, Ferritin Low. The most likely diagnosis is:
Iron deficiency anaemia
Sideroblastic anaemia
Anaemia of chronic disease
Thalassaemia trait
Hereditary elliptocytosis
A 47-year-old teacher complains of difficulty maintaining her concentration at work teaching secondary school children. She states that over the last four months she has become increasingly tired and easily fatigued. She has noticed it has become more diffcult for her to lift books, rise from her chair and she has also noticed a tingling sensation in her fmgers. Examination shows a positive babinski sign and absent reflexes. A blood test reveals the following: Haemoglobin 10 g/dL, MCV 103 f. The most likely diagnosis is:
Hypothyroidism
Vitamin B12 deficiency
Folic acid deficiency
Liver disease
Alcohol toxicity
A 55-year-old man complains of a 4-week history of general malaise and fatigue, he has also noticed his trousers have become more loose fitting. A blood test shows the following results: Haemoglobin 12 g/dL, MCV 90 f, Platelet count 250 x 109/L, WBC 10 x 109/L, Serum iron 10 µmoVL, Total iron-binding capacity 40 µmoVL, Serum ferritin 160 µg/L. The most likely diagnosis is:
Thalassaemia
Iron deficiency anaemia
Anaemia of chronic disease
Macrocytic anaemia
Aplastic anaemia
A 45-year-old man collapses at home and is brought to accident and emergency. He has a fever at 39.5°C and blood pressure is 90/60 mmHg, although he is in a lucid state. Bruises can be seen on his skin which he remembers being present before he fell. Blood tests show the patient to have a normocytic anaemia with a low platelet count and increased fibrin split products. The most likely diagnosis is:
Warm autoimmune haemolytic anaemia
Cold autoimmune haemolytic anaemia
Paroxysmal nocturnal haemoglobinuria
Disseminated intravascular coagulation
Thalassaemia minor
A 23-year-old Asian man presents to his GP complaining of shortness of breath following exercise. He has always been a little unfit and decided to start going to the gym but noticed that even after 4 weeks he is still quite short of breath. He denies any coughing or wheezing and on examination you notice mild pallor but the patient says he has always been slightly pale in colour. Investigation results are given below: Haemoglobin 12 g/dL, MCV 70 f, Serum iron 14 umoVL, Ferritin 60 ug/L, Transferrin saturation 35 per cent, Mean cell haemoglobin 22 pg, Haemoglobin electrophoresis HbA2 increased. The most likely diagnosis is:
A thalassaemia trait
Anaemia of chronic disease
B thalassaemia trait
Haemoglobin H disease
Iron deficiency anaemia
A 65-year-old woman suffers significant bleeding during a difficult bowel resection and is prescribed three units of blood after the operation is completed. It is the frst time she has required a blood transfusion and her details are checked carefully. Approximately 4 hours after the transfusion the patient feels acutely unwell and complains of fever, chills and a dry cough. Blood pressure is 110/80 mmHg, temperature 38°C and oxygen saturation is 94 per cent. The most likely diagnosis is:
Immediate haemolytic transfusion reaction
Febrile non-haemolytic transfusion reaction
Delayed haemolytic transfusion reaction
IgA deficiency
Transfusion-related lung injury
A 52-year-old woman presents complaining of a two-month history of increasing fatigue and numbness in both of her arms and legs. She lives at home with her husband and has found it diffcult coping with the daily activities of living. She suffers from hypothyroidism which is well controlled with thyroid replacement medication. A peripheral blood smear shows hypersegmented neutrophils. A blood test reveals the following: Haemoglobin 10 g/dL, Mean corpuscular volume 110 f, Platelets 150 x 109/L. Liver function tests: ALT 25 IU/L, AST 27 IU/L, GGT 22 IU/L, ALP 100 IU/L, Urea 5 mmol/L, Creatinine 100 µmol/L. The most likely diagnosis is:
Thrombotic thrombocytopenic purpura
Iron deficiency
Folic acid deficiency
Liver disease
Pernicious anaemia
During a busy ward round you are asked to visit a patient the consultant has not had an opportunity to see. The only details you are given are that the patient is female and was admitted the previous day with bleeding abnormalities, you are given the results of her blood investigations: Prothrombin time Unaffcted, Partial thromboplastin time Prolonged, Bleeding time Prolonged, Platelet count Unaffected. What is the most likely diagnosis?
Factor V deficiency
Warfarin therapy
Glanzmann's thrombasthenia
Bernard Soulier syndrome
Von Willbrand disease
A 14-year-old girl is brought to clinic by her parents who have been worried about a fever the patient has had for the last week. The patient looks pale and unwell. Blood tests reveal a neutropenia with normal red blood counts (RBCs) and platelets. A bone marrow exam reveals no abnormalities. The patient has been otherwise fit and well. There is no organomegaly or lymphadenopathy. The most likely diagnosis is:
Acute myeloid leukaemia
Aplastic anaemia
Acute lymphoblastic leukaemia
Bacterial infection
Thrombotic thrombocytopenic purpura
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