5DD/Dental Pharmacology/Prof. Tuy Thel 1-50

1. A patient presents complaining of a stomach upset 48 hours after starting a course of antibiotic for oral infection, this is an example of?

2. A patient who has been taking quantities of aspirin might show increased post operative bleeding because aspirin inhibits**?

σ� Synthesis of thromboxane A2 and prevents platelet aggregation

σ� Synthesis of prostacyclin and prevents platelet aggregation

σ� Synthesis of prostaglandin and prevents production of blood platelets

σ� Thrombin and prevents formation of the fibrin network

σ� Increase the absorption of vitamin K and prevents synthesis of blood clotting factors

5. The most potent virucidal properties: “another format of the same answer: Indicate which of the following has virucidal properties”?

6. Endogenous morphine like substance which can control pain is known as**?

7. Platelets play an important role in haemostasis; which of the following describes this role?

σ� They agglutinate and plug small, ruptured vessels

σ� They convert fibrinogen to fibrin

σ� They initiate fibrinolysis in thrombosis

σ� They supply fibrin stabilizing factors

8. Trichloroacetic acid, a strong acid, has been used by dentists for chemical cautery of hypertrophic tissue and aphthous ulcers; its mechanism of action is?

σ� Protein precipitation PPT

σ� Osmotic pressure

σ� Activation of tissue enzymes

σ� Neutralization

σ� Thermodynamic action

9. Which of the following adverse reaction of oral contraceptives is the most common and the most serious?

σ� Hepatotoxicity

σ� Hypotension

σ� Uterine neoplasia

σ� Thromboembolism disorder

σ� Decreased resistance to infection

10. A patient who has been taking quantities of aspirin might show increased post operative bleeding because aspirin inhibits:**?

σ� Synthesis of thromboxane A2 and prevents platelet aggregation

σ� Synthesis of prostacyclin and prevents platelet aggregation

σ� Synthesis of prostaglandin and prevents production of blood platelets

σ� Thrombin and prevents formation of the fibrin network

σ� Increase the absorption of vitamin K and prevents synthesis of blood clotting factors

11. Signs and symptoms that commonly suggest cardiac failure in a patient being assessed for oral surgery are,?

σ� Ankle oedema and dyspnea

σ� Erythema and pain

σ� Pallor and tremor

σ� Palpitations and malaise

σ� Elevated temperature and nausea

12. A 65 years-old woman arrived for dental therapy. The answered questionnaire shows that she is suffering from severe cirrhosis. The problem that can be anticipated in the routine dental therapy is:?

σ� Tendency towards prolonged haemorrhage

σ� Extreme susceptibility to pain

σ� Increased tendency to syncope

σ� Difficulty in achieving adequate local anaesthesia

σ� Recurring oral infection

13. The treatment of Localised Juvenile Periodontitis is frequently supplemented with tetracycline because flora involved is predominant?

σ� Strictly anaerobic

σ� Aerobic

σ� Facultative or microaerophilic

σ� Resistant to other antibiotic

14. Tetracycline hydrochloride conditioning of root surface in periodontal surgery is to?

σ� May enhance binding of fibronectin and fibroblast

σ� Sterilise the root surface

σ� Aids in re-mineralising the root surface

σ� Assist the biding of lamina dura

σ� Prevents post operative infections

15. Of all the factors that increase the resistance of teeth to dental caries THE MOST EFFECTIVE is?

σ� The intake of fluoride during the period of enamel mineralization and maturation

σ� The general nutrition of a child during the period of tooth formation

σ� Periodic topical fluoride application by dental health care following tooth eruption

σ� Sufficient intake of calcium and Vitamin D during the period of enamel mineralization and maturation

16. When the enamel of the tooth is exposed to preparation containing high concentrations of fluoride; the major reaction is?

σ� Fluorapatite

σ� S tannous fluoride

σ� Calcium fluoride

σ� Sodium fluoride

17. Several approaches have been suggested to increase the fixation of professionally applied topical fluoride, which of the following statements IS INCORRECT regarding increasing the fixation?

σ� Raise the PH of the fluoride solution

σ� Increase concentration of fluoride in solutions

σ� Increase the exposure time to topical fluoride

σ� Pre-treat the enamel with 0.5% phosphoric acid

σ� Use NH4F rather than NaF at a lower PH

18. Toxicity as a result of anaesthetic solution can be seen more when?

σ� Injection into vascular area

σ� Injection in supine position

σ� Injection without vasoconstrictors

σ� Intravenous injection

19. Which antibiotic administered in childhood may result in tooth discolouration?

20. An adult patient with a history of bacterial endocarditis requires prophylactic administration of antibiotic prior to removal of teeth. Indicate the pre-operative regimen**?

σ� Amoxicillin 2 gram an hour before operation orally

σ� Penicillin 250 mg orally six hours before operation

σ� Tetracycline 250-500 mg orally 2 hours before treatment

σ� NSAID 400mg orally 1 hours before treatment

21. Q24/ Which one of the following is at risk of local anaesthetic injections ?

σ� Inject rapidly

σ� Aspirate before injection

σ� Use the smallest effective volume

σ� Use the weakest efficient percentage strength

22. At what rate is closed chest cardiac compression should be in an adult**?

σ� 12 times a minute

σ� 24 times a minute

σ� 50 times a minute

σ� 80 times a minute

23. A young patient presented with rheumatic fever and suspected allergy to penicillin. The antibiotic of choice is?

24. Disorder of steroid will result in?

σ� All are corrects

σ� Osteoporosis

σ� Delayed healing

σ� Adrenal suppression

25. Patient with morphine coma; what is the medication of choice to reverse its act?

σ� Naloxone

σ� Epinephrine

σ� Amphetamine

σ� Bradykinin

26. The MOST common staphylococcal infections is?

σ� A localised purulent infection of the skin

σ� Diffuse purulent infection of the skin

σ� Staphylococcal osteomyelitis

σ� Impetigo

27. The antibiotic of choice for infections of pulpal origin is?

σ� penicillin V

σ� lincomycin

σ� erythromycin

σ� tetracycline

28. Increased bleeding is associated with a prolonged administration of? 1.Warfarin (Coumadin).

2.codeine.

3.acetylsalicylic cacid.

4.acetaminophen.

29. Adrenal corticosteroids? 1.cause diabetes. 2.cause retention of sodium and fluid. 3.heighten the immune response. 4.decrease the immune response.

30. The most common complication of a venipuncture is?

σ� hematoma.

σ� syncope.

σ� thrombophlebitis.

σ� embolus.

31. Which of the following statements are correct? 1.Narcotic and non-narcotic analgesics are equipotent. 2.Non-narcotic analgesics do not alter consciousness. 3.Non-narcotic analgesics are safer and less toxic. 4.Non-narcotic analgesics produce less side effects.

σ� (2) (3) (4)

σ� (1) (2) (3)

σ� (3) and (4)

σ� All of the above.

32. A major clinical problem of penicillintherapy is its?

σ� allergenicity.

σ� high toxicity.

σ� rapid development of tolerance.

σ� narrow spectrum of activity.

σ� induction of nephritis.

33. If a patient is allergic to penicillin, the alternative antibiotic would be ?

35. Which of the following does NOT influence the rate of induction during inhalation anesthesia?

σ� Hemoglobin content of the blood.

σ� Blood supply to the lungs.

σ� Pulmonary ventilation.

σ� Concentration of the anesthetic in the inspired mixture.

σ� Solubility of the anesthetic in blood.

36. Most anaphylactic reactions to penicillin occur? 1. When the drug is administered parenterally. 2. In patients who have already experienced an allergic reaction to the drug. 3. Within minutes after drug administration. 4. When the drug is administered orally. 5. In patients with a negative skin test to penicillin allergy.

σ� (1) (2) (3)

σ� (2) (3) (4)

σ� (3) and (4)

σ� All of the above.

37. Corticosteroids may be used for the management of?

38. When used ALONE, which of the following agents will not produce satisfactory anesthesia?

σ� Nitrous oxide.

σ� Cyclopropane.

σ� Chloroform.

σ� Fluothane.

39. Which of the following would you prescribe for an anxious dental patient with a peptic ulcer?

40. Tetracycline will cause crowndiscolouration when prescribed at the age of? 1. 6 months in utero. 2. 2 years. 3. 7 years. 4. 14 years.

σ� (1) (2) (3)

σ� (2) (3) (4)

σ� (3) and (4)

σ� All are corrects.

41. Which of the following complications might occur after administration of a local anesthetic agent? 1. Convulsions. 2. Nausea. 3. Respirator y depression. 4. Cardiovascular collapse

42. Unconsciousness in syncope results from?

σ� cerebral hypoxia.

σ� cerebral hyperemia.

σ� neurogenic shock.

σ� electrolyte imbalance.

43. The most effective drug for relief of angina pectoris is?

44. The appearance of a rash, itching, broncho-constriction and fever after the administration of a drug are the result of?

σ� allergy.

σ� tolerance.

σ� idiosyncrasy.

σ� teratogenicity.

45. Diazepam (valium)? 1. Is a benzodiazepine 2. Is contraindicated in a patient with glaucoma. 3. Is anxiolytic. 4. Produces muscle relaxation when given orally.

46. Which of the following statements is/are true regarding diazepam? 1. Its long duration of action is partly due to active metabolites. 2. It does not produce antianxiety effects after intramuscular administration. 3. Intravenous administration is more reliable than oral. 4. Its sedative effect can be reversed by naloxone.

47. For a patient with cardiovascular disease,local anesthesia?

σ� affects blood pressure less than general anesthesia.

σ� affects blood pressure more than general anesthesia.

σ� is responsible for bacteremia.

σ� None of the above.

48. The inorganic ion that is implicated in primary hypertension is?

σ� sodium.

σ� fluoride.

σ� potassium.

σ� magnesium.

49. Which of the following is the most important factor in the preoperative evaluation of a patient?

σ� Medical history.

σ� Laboratory data.

σ� Electrocardiogram.

σ� Pulse and blood p ressure.

50. In a standard dental cartridge (carpule) containing 1.8ml 2% lidocaine with epinephrine 1/100,000, the amount of vasoconstrictor is?

5DD/Dental Pharmacology/Prof. Tuy Thel 1-50

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