Quiz on phamaceutics lecture 1

A medical professional examining an eye chart in a clinical setting, surrounded by various pharmaceutical products related to ophthalmology, bright and professional atmosphere

Ocular Pharmacology Quiz

Welcome to the Ocular Pharmacology Quiz! Test your knowledge and understanding of pharmaceutical principles related to ocular drug delivery systems. This quiz covers essential topics such as drug formulations, ocular pharmacokinetics, and specific ocular delivery methods.

Prepare yourself with questions that will challenge your grasp of ocular therapeutics, including:

The efficacy of various drug delivery methods
Ocular formulations and their components
Mechanisms of action for therapeutics

42 Questions10 MinutesCreated by StudyingEyes517

Drugs that ingested orally or by IV are inefficient because.................

Which of the following is an advantage of ocular delivery?

The therapeutic agent is available at higher conc than may be achieved following oral administration

The local administration of the drug ensures that the incidence of side effects is minimized

Ease of administration by the patient

All of above

Which of the following of requirements can be neglected during preparation of ophthalmic solution?

Isotonicity value

Proper packing

Drug toxicity

Preservative

If u found acetylcysteine in the formulation of ophthalmic product, what would be its role?

Decrease the rate of decomposition of active ingredient

Improves solution clarity

Increases the ocular contact time

Add lubricating effect to the eye

Which of the following is / are the process by which we can obtain purified water used for ophthalmic drops ?

- distillation

- reverse osmosis

- deionization

- all of the above

For which the the topical emulsion opthalmic drops is preferred over the topical solution ophthalmic drop products ?

- as the drug is oily so using the emulsion enhances its miscibility

- oils may be used as the vehicle of of the ophthalmic fluids owing to the instability of the drug in water

- to achieve a sustained release effect for the drug and then reduce frequency of administration in some cases

All of the above

Vegetable oils such as olive oil, castor oil, and sesame oil have been used but they are subject to rancidity and, therefore, must be used carefully.

True

Flase

A formulator intended to prepare ophthalmic drops for multiple use and he used benzalkonium chloride as preservative but the optimal amount is not enough to achieve suitable preservation. So how can you help this miserable formulator ?

- adding EDTA to decrease activity against certain pseudomonas Strain rendering bacteria more permeable to the benzalkonium chloride

- adding parabens to potentiate the preservation power and destablizing the outer membrane of the bacterial cell ,rendering the bacteria more permeable to the benzalkonium chloride

- adding EDTA because it chelates the divalent cations which stabilize the outer membrane of the bacterial cell, rendering the bacteria more permeable to the diffusion of the benzalkonium chloride

Which of the following is / are the advantages of Gel-forming solution ?

- provide increased contact time with the possibility of improved drug absorption

- increased duration of therapeutic effect

- decrease duration of therapeutic effect

- provide decreased contact time with the possibility of improved drug absorption

We can solve the muco-non-adhesiveness of poloxamer by adding mucoadhesive polymers such as .............

- Carbopol 940

-Hydroxypropylmethyl cellulose (HPMC)

- hydroxyethylcellulose ( HEC)

- All of the above

Which of the following is the advantage of converting a water-soluble form active ingredients to a insoluble form as in ophthalmic suspension?

-to extend the practical shelf life compared to the water-soluble form

- to improve the compatibility with other necessary compositional ingredients

- to provide depot effect (sustained release)

- to improve bioavailability and efficacy.

- all of the above

Drugs that have only limited stability in liquid form are prepared as sterile powders for reconstitution by the pharmacist prior to dispensing to the patient.

True

Flase

Which of the following is the cons of using semisolid dosage form " ointments" ?

-greasy nature

-The blurring of vision produced -imprecise dosing

-difficult self administration.

- all of the above

Which of the following is true about Ocusert Pilo ?

-Multilayered structure consisting of a drug containing core surrounded on each side by a layer of copolymer membranes through which the drug diffuses at a constant rate.

- releases pilocarpine continuously at a steady rate for 7 days for treatment of glaucoma.

- a drug reservoir alginic acid

- rate controller ethylene vinyl acetate (EVA) copolymer membrane

All mentioned

Which of the following is the advantage of the erodible ocular inserts ?

- not having to be removed

- providing a more precise dosage to the eye from

- dosage precision is lost in this system

Which of the following is natural polymer of erodible polymer for erodilbe solid dosage form ?

Collagen

- hyaluronic acid

- cellulose derivatives

- none of the above

Which of the following is true about lacriserts ?

-Sterile rod shaped device made up of hydroxyl propyl cellulose without any preservative.

- For the treatment of dry eye syndromes

- They act by imbibing water from the cornea and conjunctiva and form a hydrophilic film which lubricates the cornea.

All mentioned

Topical and systemic administration often fails to achieve therapeutic concentrations in the vitreous cavity. So this leds the scientists to the development of new dosage form such ...........

- irrigating solutions,

-intraocular injections

- vitreous inserts

- all of the above

Intraocular irrigating solution is balanced salt solution was developed specifically for ocular surgical use to maintain both the anatomic and physiologic integrity of intraocular tissues. So how can we achieve this balance?

- It contains the five essential ions: sodium, potassium, calcium, magnesium, and chloride. In addition to containing citrate, acetate ions, and a potential source of bicarbonate.

- It is formulated to be iso osmotic with aqueous humor and has a neutral to slightly alkaline physiological pH.

- They are required to be preservative-free to prevent toxicity They must be non-pyrogenic, therefore requiring sterile water for injection WFI) as the vehicle

All mentioned

Viscoelastics are injected into the anterior chamber of the eye during surgery in cataract surgery and for corneal transplantation and other intraocular surgeries as They provide essential protection of the corneal endothelium

True

False

Intravitreal implant is .................surgically implanted in the vitreous cavity releases drug over months period .

Tablet

-solution

Suspension

Emulsion

Which of the following is the advantage of the liposomes in ophthalmic dosage form?

- being biodegradable

- being biocompatible

- enhance the corneal permeation of drugs by binding to corneal surface

- improving residence time

- they can be used in treatment of superficial and deep ocular disease

- all of the above

Nanostructured lipid carriers are composed of solid lipid and oil formulated into nanoparticles by homogenization and They have the advantages of facilitating corneal permeation owing to their lipophilicity, their adherence to the corneal membranes.

True

False

Unlock and Upgrade

Remove all limits from your Quizzes

Quiz on phamaceutics lecture 1

Ocular Pharmacology Quiz

More Quizzes