Exam 2016, del 2

A colorful illustration representing DNA, chromosomes, and molecular biology concepts, with a scientific lab background and diagrams of PCR and genetic analysis.

Molecular Genetics Quiz

Test your knowledge on molecular genetics and chromosomal abnormalities with our engaging quiz! This quiz covers a range of topics, including PCR techniques, karyotyping, and the role of DNA in cancer.

Prepare to challenge your understanding of:

Restriction Enzymes
Mosaicism and Nondisjunction
Forensic DNA Analysis
Protein Translation

18 Questions4 MinutesCreated by AnalyzingData749

What are restriction enzymes?

Vitamins such as vitamin A

Are used in Sequenom

Enzymes that are limited (i.e, restricted) in how big they can become

Enzymes that cut/cleave through a DNA helix wherever they encounter a specific sequence of nucleotides

Mark techniques used in detection of 10000 bpnucleotide deletion:

A male patient has an invertion in one of his chromosomes, mark the correct karyotype:

46 XY, ins(7p2)

46 XY, inv(2q1)

46 XX, ins(4q21)

46 XX, inv(9p13)

Place in order the following steps involved in PCR:(1) newly synthesized strands act as templates, (2) heat seperates strands of target DNA, (3) complementary base pairing between primers and template, (4) DNA nucleotide bases attached by DNA polymerase; new strand synthesized

Mosaicisms:

All cells have the same karyotype

Some cells of the same patient have another karyotype

Can be seen in Down Syndrome

It is difficult to observe individual chromosomes with a light microscope during interphase because

The DNA has not been replicated yet

They have uncoiled to form long, thin strands

They leave the nucleus and are dispersed to other parts of the cell

Enzymes digest the DNA

Smooth endoplasmic reticulum :

Contains RNA

Is responsible for lipid synthesis

Is responsible for protein synthesis

Contains own DNA

This karyogram belongs to:

Patient with Down syndrome

Healthy man

Patient with klinefelter Syndrome

Patient with Turner syndrome

The term Nondisjunction refers:

Failure of a chromatid pairs to separate during meiosis resulting in

Monosomy or trisomy condition

Chromatid pairs separate during meiosis resulting in point mutation

Failure of a chromatid pairs to separate during G1 resulting in monosomy or trisomy condition

Failure of a chromatid condensation during meiosis resulting in monosomy condition

Hydrogen bonds are formed between:

Guanine and Cytosine

Thymine and Cytosine

Adenine and Guanine

Thymine and Uracil

Translation of the mRNA into proteins can be blocked in a specific way by:

RNA interference

Antisense molecules like LNA and PNA

Helicase

RNA polymerase

5’ UTR:

Encodes information to make a protein

Is not translated into a protein

Can be found only in mature mRNA

Is the initiation place of translation

what would be the effect on the primary structure of the coded protein if a single base was deleted from a messenger RNA transcript?

No effect

A single amino acid residue is changed

A complete change in amino acid sequence from the point deletion, frameshift

In frame mutation

Which of the following statements about forensic analysis of DNA is true?

A DNA profile using short tandem repeats (microsatellites) is unique to an individual

Forensic analysis makes use of mutations in coding sequnces to distinguish between individuals

PCR is used for DNA profiling

PCR is used for DNA profiling (DNA fingerprinting) DNA fingerprinting cannot be used for paternity testing

Which of the following statements is not true about cancer?

A cancer is a genetic disease which can be inherited

Cancer is primarily a disease caused by DNA polymorphisms

A cancer is caused by mutations which gives the cell growth advantage

A tumor is not regarded as malignant until it spreads to other parts of the body forming secondary tumors

What is the theoretical progression of nucleic acid amplication by PCR?

1,2,3,4,5,6,…

1,10,100,1000,10000,…

2,4,8,16,32,…

2,4,24,96,384,1024,…

The karyotype of one patient consists of 69 (69 XXY) chromosomes. Such chromosomal alteration can be an example of:

Triploidy

Aneuploidy

Tetraploidy

Trisomy

Which of the following is true for tumor suppressor protein?

A protein which gives a cell a growth advantage

A protein which inhibits cell proliferation

A protein which helps mitosis

Both alleles have to be inactivated to start carcinogenesis

Exam 2016, del 2

Molecular Genetics Quiz

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