The Nucleus

Which of these modifications does not occur to mRNA post-transcription

5' CAP added

3' polyadenation

Addition of a lipid

Splicing

The cytoskeleton within the nucleus is known as the

Nucleofilament

Nuclear lamina

Nucleoporin

Cytosolic fibrils

Importins will bind to a cargo protein when what is present

NPC

NLS

NES

GEF

RanGTP is converted to RanGDP by what

RanGEF

RanGAP

RanGPA

NES

RanGDP is converted to RanGTP by what

RanGEF

RanGAP

RanGPA

NES

The exportin and cargo protein (which has an NES) bind to what to be exported from the nucleus

RanGEF

RanGAP

RanGTP

RanGDP

After releasing the cargo protein and its associated NLS, the importin and ____ are still bound and leave the nucleus by an NPC

RanGTP

RanGDP

NES

RanGEF

Importins and exportins travel through the NPC by sequential binding to what

Scaffold nucleoporins

FG repeats

Cytosolic fibrils

Nuclear basket

Importins and exportins are required for proteins over around what size

40KDa

50KDa

60KDa

70KDa

MRNA becomes mRNP by binding to adaptor proteins, these bind to

The spliced areas

The polyadenated areas

The 5' end (CAP complex)

The 3' end

Adaptor proteins allow export from the nucleus because

They reduce the size of the mRNP

Exportins need to bind to the adaptor proteins

They change the shape so it fits through the NPC

It allows for binding to RanGDP

Which rRNA is not synthesised by RNA polymerase I in the nucleolus

5.8S

18S

28S

The nucleolus-synthesised ribosomal material combine to create

80s ribosomes

45s pre-rRNA

90s pre-ribosome

Tandem repeats

The addition of ribosomal proteins to 45S pre-rRNA generates

80S ribosomes

Tandem repeats

90S pre-ribosome

Non transcribed spacers

Ribosomes are made up of two subunits: the large and small. The small subunit contains

5S rRNA

5.5S rRNA

18S rRNA

28S rRNA

SnoRNPs are complimentary to areas of rRNA and modify it at the 90S pre-ribosome in what ways?

Polyadenation of 3'

Methylation of hydroxyl groups on ribose

Addition of a CAP to 5'

Conversion of uridine to pseudouridine

Cleavage of 45S pre-rRNA (splicing ETS and ITS)

Addition of helix

The cleavage of the ETS requires exoribonucleases, the ITS utilises

Intraribonucleases

Infraribonucleases

Endoribonucleases

Entraribonucleases

The 60S subunit (large) of the ribosome is transported to the cytoplasm to later bind to the 40S subunit (small) and is comprised of which rRNA

5.8S

18S

28S

What organelle is the nuclear membrane often continuous with

Golgi apparatus

Mitochondria

Rough endoplasmic reticulum

Centrioles

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The Nucleus

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