Part 1(1-49) Immunology
Immunology Challenge Quiz
Test your knowledge of immunology with this engaging quiz designed to deepen your understanding of antibodies, complement systems, and T-cell interactions. Whether you are a student, a teacher, or simply passionate about the immune system, this quiz provides an excellent opportunity to assess your comprehension.
- 49 multiple choice questions
- Your score and correct answers provided at the end
- Ideal for honing your immunology knowledge!
1. All of the following are true with respect to IgM antibodies, EXCEPT:
They fix complement
They occur on the surface of lymphocytes
They are glycoproteins
They mediate allergic reaction
2. One principal function of complement is to:
Inactivate perforins
σ½ Mediate the release of histamine
σ¾ Bind antibodies attached to cell surfaces and to lyse these cells
σ½ Phagocytize antigens
3. One principal function of the Class I and Class II major histocompatibility complex is to :
σ½ Transduce the signal to the T-cell interior
σ½ Mediate immunoglobulin class
σ¾ Present antigen for recognition by the T-cell receptor
σ½ Stimulate production of interleukins
4. The major role of the complement system is to work in conjunction with:
σ¾ Antibodies to lyse cells via the C8 and C9 components
σ½ MHC for cell recognition
σ½ Antibodies to opsonize cells
σ½ T-cell receptor for production of lymphokines
5. T-cell antigen receptors are distinguished from antibodies by which of the following :
σ½ T-Cell receptors are glycosylated
σ¾ T-cell receptors must interact with antigen
σ½ T-Cell receptors bind various cytokines
σ½ T-Cell receptors bind complement to lyse cells
6. T-cell receptors or antibodies react with antigens:
σ½ Because both are made by lymphocytes
Because they have specific receptors for antigen
Because both 'have light chain and heavy chain polypeptides
Cause histamine release
7. All of the following are true of antigen, EXCEPT:
σ½ They contain epitopes.
σ½ They will react with antibodies.
σ½ They contain antigenic determinants.
σ¾ They contain paratopes
8. All of the following are true with respect to IgE molecules, EXCEPT :
σ½ They are the principal immunoglobulin class involved in allergic reactions.
They are involved in mediating anti-parasitic immune responses.
They will cross the placenta and fix complement)
They can effect the release of histamine.
9. Which of the following immunoglobulins is present normally in plasma at the highest concentration?:
σ¾ IgG
σ½ IgM
σ½ IgA
σ½ IgE
10. All of the following are true about antibodies, EXCEPT:
σ½ They fix complement.
σ½ They occur on the surface of B-lymphocyte
σ½ They are glycoproteins.
σ¾ They are a single amino acid sequence
11. In the complement system, the classic pathway initiates by the complement :
σ¾ C1qrs
σ½ MBL
σ½ C4
σ½ C5
12. The immunoglobulin Joining chain (J-chain) is:
σ½ Produced by T-Cells
σ½ Associated with IgM and IgG
σ¾ Associated with IgM and IgA
σ½ Produced by mast cells
13. All of the following are true, EXCEPT:
σ½ An epitope is a portion of an antigen
σ½ The variable contain the antigen recognition site
σ¾ IgM antibody is pentavalent
σ½ IgG antibody is bivalent
14. Which immunoglobulin is the principal one found in secretions such as mucus :
σ½ IgG
σ½ IgM
σ¾ IgA
σ½ IgD
15. Individuals unable to make the C4b would be expected to have frequent infections of the :
σ½ Diabetis
σ½ Thalassemia
σ½ Liver disease
σ¾ Bacteria
16. The immunoglobulin class which is the least abundant in the normal adult is :
σ½ IgG
σ½ IgA
σ½ IgD
σ¾ IgE
17. Class of immunoglobulins occurs :
σ¾ Immunizations, going from IgM to IgG
σ½ Binds complement
σ½ Causes the histamine release
σ½ Mediates immunoglobulin class switching
18. In the alternative pathway of the complement system, the factors below are useful to prevent the generation of C3 convertase :
σ½ Factor P
σ¾ Factor F
σ½ C3-BP
σ½ C1-INH
19. To stabilise the C3 convertase of the alternative pathway, the factors below are useful :
σ½ C3-BP
σ½ Factor F
σ¾ Factor P
σ½ C1-INH
20. Light chains are:
σ½ Specific for each class of antibody
σ¾ Not specific for each class of antibody
σ½ Reactive with antigen
σ½ Have only a constant region
21. The T3 complex of the T-cell receptor :
σ¾ To transduce a signal to the cell's interior binding to antigen
σ½ Binds complement
σ½ Causes the histamine
σ½ Mediates Immunoglobulin class switching
22. Which of the following is NOT true of interleukins:
σ½ They are cytokines which can be produced by various cells of the immune system.
σ½ They are hormones which allow one cell to communicate with another cell.
σ½ They are in need of receptors on the target cell in order to mediate their effects.
σ¾ They are able to bind antigen with a high level of specificity
23. The following statements are true for Immunoglobins, EXCEPT:
σ½ Are antibodies
σ½ Five major classes IgM, IgG, IgA, IgD, IgE
σ¾ All have receptors for complement
σ½ Possess both variable and constant regions
24. The following statements are true for Antibodies:
σ½ Are carbohydrates
σ½ Are made from alpha and beta chains
σ½ Contain no carbohydrate
σ¾ Contain heavy and light chains
25. Complement Deficiencies of C5, C6, C7, C8 and C9 can causes :
σ½ Susceptibility to pyogenic bacterial infections
σ½ Anaphylaxia
σ¾ Inability to attack the Gram-negative bacteria
σ½ Lack of opsonisation
26. Class II MHC are :
σ¾ Recognized by the CD4 protein
σ½ Used to kill by cytotoxic T-cells
σ½ Used to participate in cytotoxic function
σ½ Not able to carry an antigen fragment
27. The functional activity of the T-cell :
σ½ Is related with CD4 or CD8 associated polypeptides
σ½ Occurs after recognition of an epitope
σ½ Can be mediated through cytokines
σ¾ Is related with CD4 or CD8 associated polypeptides, Occurs after recognition of an epitope, Can be mediated through cytokines
28. The followings statement are TRUE for Target cell lysis and destruction,EXCEPT :
σ½ Cytotoxic T-cells recognizing specific epitopes on the target cell surface
σ½ Perforin released from antigen-specific cytotoxic T-cells
σ½ Complement binding to IgG and IgM which have bound to epitopes on the target cell
σ¾ Complement binding to IgE antibodies which have bound to epitopes on the cell surface
29. The followings statement are TRUE, EXCEPT :
σ½ MHC Class 1 bind antigen fragments and are recognized by the Tc-cell receptor
σ½ MHC Class I generally occur on all cells of the immune system
σ½ MHC Class II bind antigen and are recognized by the T-cell receptor and the CD4
σ¾ MHC Class II carrying antigen presented to cytotoxic T cells
30. What distinguishes helper T-cells from cytotoxic T-cells :
σ½ Helper cells recognize antigen complexed with MHC class I molecules
σ½ Cytotoxic cells recognize antigen complexed with MHC class I molecules
σ½ Helper cells recognize antigen complexed with MHC class II molecules
σ¾ Cytotoxic cells recognize antigen complexed with MHC class I molecules and. Helper cells recognize antigen complexed with MHC class II molecules
31. Immunoglobulins are chemically:
σ½ Glycogens
σ¾ Glycoproteins
σ½ Glycolipids
σ½ D. Lipo-proteins
32. Superantigens presented to T cells by :
σ¾ APC
σ½ B cell
σ½ Monocyte
σ½ Mast cell
33. Which of the following binds to an Fc receptor on mast cells and basophils?:
σ½ IgA
σ½ IgM
σ¾ IgE
σ½ IgG
34. Which of the following is NOT a structural chain in class I MHC?:
σ¾ β1
σ½ α1
σ½ α2
σ½ β2 –microglobin
35. Which of the following statements about leukocyte function is false?:
σ½ Leukocytes are involved in the immune response.
σ½ Neutrophils engulf damaged cells and pathogens by phagocytosis.
Eosinophils deliver toxic granules to kill parasites. They are also involved in allergic reactions.
σ¾ Macrophages are phagocytic cells that are involved in the adaptive response.
36. Immediate hypersensitivity reactions are below, EXCEPT:
σ½ If the antigen is an allergen
σ½ The consequence of antigen-antibody reactions
σ½ Result from histamine release
σ¾ Phagocytosis
37. Clinical abnormalities of the Immune system can result from the activities below, EXCEPT:
σ½ Bacterial infection
σ½ Abnormal lymphocyte proliferation
σ½ HIV Infection
σ¾ T cell secrete cytokine
38. The function of immune system is to response:
σ½ Can be facilitated by antibodies
σ½ Mediated the humoral and cellular immune system
σ½ Facilitated by T-cells
σ¾ All answers
39. Which of the followings are TRUE regarding an Immune response :
σ¾ The function of the T3 complex is signal to the cell's interior after recognition the antigen
σ½ The T8 serves an auxiliary role with MHC class II in cytotoxic reactions
σ½ The T4 serves an auxiliary role with MHC class I in helper cell reactions
σ½ The T4 secrete antibody
40. The component of immune system that can cause inflammation is :
σ¾ Complement
σ½ Immunoglobulin
σ½ T lymphocytes
σ½ Macrophage
41. In acute infection of Hepatitis B, the typical serologic course are:
σ¾ HBsAg
σ½ HBcAb
σ½ HBcAg
σ½ HBsAb
42. The disease below can cause allergic reaction:
σ½ Hepatitis
σ½ Thalassemia
σ½ Cancer
σ¾ Asthma
43. Which cells are proliferated from myeloid progenitor:
σ½ B cells
σ½ TH1
σ½ Lymphocytes
σ¾ Dendritic cells
44. The function of MHC class II is:
σ½ Recognized by CD4
σ½ Recognized by the CD8
σ¾ Participated in the presentation of Ag
σ½ Unable to carry antigen fragment
45. The function of Natural Killer cell is:
σ½ Response to bacteria infection
σ¾ Damaged the target cell membrane
σ½ Response to antibody
σ½ Kill pathogen
46. Which cell is directly secreted immunoglobulin:
σ½ T lymphocyte
σ½ B lymphocyte
σ½ Macrophage
σ¾ Plasma cell
47. All of the following are true with respect to IgG antibodies, EXCEPT:
σ½ They fix complement
σ½ They occur on the surface of B lymphocytes
σ½ They are glycoproteins
σ¾ They mediate allergic reaction
48. One principal function of complement is not true:
σ½ Activate perforins
σ½ Mediate the release of histamine
σ¾ Lyse target cells
σ½ Phagocytize antigens
49. One principal function of the Class I and Class II major histocompatibility complex is to:
σ½ Transduce the signal to the T-cell interior
σ½ Mediate immunoglobulin class
σ¾ Help T cell for the recognition Antigen
σ½ Stimulate production of interleukins
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