Part 1(1-49) Immunology

An educational illustration showing antibodies, T-cells, and the complement system in action, vibrant colors, and clear diagrams.

Immunology Challenge Quiz

Test your knowledge of immunology with this engaging quiz designed to deepen your understanding of antibodies, complement systems, and T-cell interactions. Whether you are a student, a teacher, or simply passionate about the immune system, this quiz provides an excellent opportunity to assess your comprehension.

49 multiple choice questions
Your score and correct answers provided at the end
Ideal for honing your immunology knowledge!

49 Questions12 MinutesCreated by TestingTree42

1. All of the following are true with respect to IgM antibodies, EXCEPT:

They fix complement

They occur on the surface of lymphocytes

They are glycoproteins

They mediate allergic reaction

2. One principal function of complement is to:

Inactivate perforins

σ� Mediate the release of histamine

σ� Bind antibodies attached to cell surfaces and to lyse these cells

σ� Phagocytize antigens

3. One principal function of the Class I and Class II major histocompatibility complex is to :

σ� Transduce the signal to the T-cell interior

σ� Mediate immunoglobulin class

σ� Present antigen for recognition by the T-cell receptor

σ� Stimulate production of interleukins

4. The major role of the complement system is to work in conjunction with:

σ� Antibodies to lyse cells via the C8 and C9 components

σ� MHC for cell recognition

σ� Antibodies to opsonize cells

σ� T-cell receptor for production of lymphokines

5. T-cell antigen receptors are distinguished from antibodies by which of the following :

σ� T-Cell receptors are glycosylated

σ� T-cell receptors must interact with antigen

σ� T-Cell receptors bind various cytokines

σ� T-Cell receptors bind complement to lyse cells

6. T-cell receptors or antibodies react with antigens:

σ� Because both are made by lymphocytes

Because they have specific receptors for antigen

Because both 'have light chain and heavy chain polypeptides

Cause histamine release

7. All of the following are true of antigen, EXCEPT:

σ� They contain epitopes.

σ� They will react with antibodies.

σ� They contain antigenic determinants.

σ� They contain paratopes

8. All of the following are true with respect to IgE molecules, EXCEPT :

σ� They are the principal immunoglobulin class involved in allergic reactions.

They are involved in mediating anti-parasitic immune responses.

They will cross the placenta and fix complement)

They can effect the release of histamine.

9. Which of the following immunoglobulins is present normally in plasma at the highest concentration?:

σ� IgG

σ� IgM

σ� IgA

σ� IgE

10. All of the following are true about antibodies, EXCEPT:

σ� They fix complement.

σ� They occur on the surface of B-lymphocyte

σ� They are glycoproteins.

σ� They are a single amino acid sequence

11. In the complement system, the classic pathway initiates by the complement :

σ� C1qrs

σ� MBL

σ� C4

σ� C5

12. The immunoglobulin Joining chain (J-chain) is:

σ� Produced by T-Cells

σ� Associated with IgM and IgG

σ� Associated with IgM and IgA

σ� Produced by mast cells

13. All of the following are true, EXCEPT:

σ� An epitope is a portion of an antigen

σ� The variable contain the antigen recognition site

σ� IgM antibody is pentavalent

σ� IgG antibody is bivalent

14. Which immunoglobulin is the principal one found in secretions such as mucus :

σ� IgG

σ� IgM

σ� IgA

σ� IgD

15. Individuals unable to make the C4b would be expected to have frequent infections of the :

σ� Diabetis

σ� Thalassemia

σ� Liver disease

σ� Bacteria

16. The immunoglobulin class which is the least abundant in the normal adult is :

σ� IgG

σ� IgA

σ� IgD

σ� IgE

17. Class of immunoglobulins occurs :

σ� Immunizations, going from IgM to IgG

σ� Binds complement

σ� Causes the histamine release

σ� Mediates immunoglobulin class switching

18. In the alternative pathway of the complement system, the factors below are useful to prevent the generation of C3 convertase :

σ� Factor P

σ� Factor F

σ� C3-BP

σ� C1-INH

19. To stabilise the C3 convertase of the alternative pathway, the factors below are useful :

σ� C3-BP

σ� Factor F

σ� Factor P

σ� C1-INH

20. Light chains are:

σ� Specific for each class of antibody

σ� Not specific for each class of antibody

σ� Reactive with antigen

σ� Have only a constant region

21. The T3 complex of the T-cell receptor :

σ� To transduce a signal to the cell's interior binding to antigen

σ� Binds complement

σ� Causes the histamine

σ� Mediates Immunoglobulin class switching

22. Which of the following is NOT true of interleukins:

σ� They are cytokines which can be produced by various cells of the immune system.

σ� They are hormones which allow one cell to communicate with another cell.

σ� They are in need of receptors on the target cell in order to mediate their effects.

σ� They are able to bind antigen with a high level of specificity

23. The following statements are true for Immunoglobins, EXCEPT:

σ� Are antibodies

σ� Five major classes IgM, IgG, IgA, IgD, IgE

σ� All have receptors for complement

σ� Possess both variable and constant regions

24. The following statements are true for Antibodies:

σ� Are carbohydrates

σ� Are made from alpha and beta chains

σ� Contain no carbohydrate

σ� Contain heavy and light chains

25. Complement Deficiencies of C5, C6, C7, C8 and C9 can causes :

σ� Susceptibility to pyogenic bacterial infections

σ� Anaphylaxia

σ� Inability to attack the Gram-negative bacteria

σ� Lack of opsonisation

26. Class II MHC are :

σ� Recognized by the CD4 protein

σ� Used to kill by cytotoxic T-cells

σ� Used to participate in cytotoxic function

σ� Not able to carry an antigen fragment

27. The functional activity of the T-cell :

σ� Is related with CD4 or CD8 associated polypeptides

σ� Occurs after recognition of an epitope

σ� Can be mediated through cytokines

σ� Is related with CD4 or CD8 associated polypeptides, Occurs after recognition of an epitope, Can be mediated through cytokines

28. The followings statement are TRUE for Target cell lysis and destruction,EXCEPT :

σ� Cytotoxic T-cells recognizing specific epitopes on the target cell surface

σ� Perforin released from antigen-specific cytotoxic T-cells

σ� Complement binding to IgG and IgM which have bound to epitopes on the target cell

σ� Complement binding to IgE antibodies which have bound to epitopes on the cell surface

29. The followings statement are TRUE, EXCEPT :

σ� MHC Class 1 bind antigen fragments and are recognized by the Tc-cell receptor

σ� MHC Class I generally occur on all cells of the immune system

σ� MHC Class II bind antigen and are recognized by the T-cell receptor and the CD4

σ� MHC Class II carrying antigen presented to cytotoxic T cells

30. What distinguishes helper T-cells from cytotoxic T-cells :

σ� Helper cells recognize antigen complexed with MHC class I molecules

σ� Cytotoxic cells recognize antigen complexed with MHC class I molecules

σ� Helper cells recognize antigen complexed with MHC class II molecules

σ� Cytotoxic cells recognize antigen complexed with MHC class I molecules and. Helper cells recognize antigen complexed with MHC class II molecules

31. Immunoglobulins are chemically:

σ� Glycogens

σ� Glycoproteins

σ� Glycolipids

σ� D. Lipo-proteins

33. Which of the following binds to an Fc receptor on mast cells and basophils?:

σ� IgA

σ� IgM

σ� IgE

σ� IgG

34. Which of the following is NOT a structural chain in class I MHC?:

σ� β1

σ� α1

σ� α2

σ� β2 –microglobin

35. Which of the following statements about leukocyte function is false?:

σ� Leukocytes are involved in the immune response.

σ� Neutrophils engulf damaged cells and pathogens by phagocytosis.

Eosinophils deliver toxic granules to kill parasites. They are also involved in allergic reactions.

σ� Macrophages are phagocytic cells that are involved in the adaptive response.

36. Immediate hypersensitivity reactions are below, EXCEPT:

σ� If the antigen is an allergen

σ� The consequence of antigen-antibody reactions

σ� Result from histamine release

σ� Phagocytosis

37. Clinical abnormalities of the Immune system can result from the activities below, EXCEPT:

σ� Bacterial infection

σ� Abnormal lymphocyte proliferation

σ� HIV Infection

σ� T cell secrete cytokine

38. The function of immune system is to response:

σ� Can be facilitated by antibodies

σ� Mediated the humoral and cellular immune system

σ� Facilitated by T-cells

σ� All answers

39. Which of the followings are TRUE regarding an Immune response :

σ� The function of the T3 complex is signal to the cell's interior after recognition the antigen

σ� The T8 serves an auxiliary role with MHC class II in cytotoxic reactions

σ� The T4 serves an auxiliary role with MHC class I in helper cell reactions

σ� The T4 secrete antibody

40. The component of immune system that can cause inflammation is :

σ� Complement

σ� Immunoglobulin

σ� T lymphocytes

σ� Macrophage

41. In acute infection of Hepatitis B, the typical serologic course are:

σ� HBsAg

σ� HBcAb

σ� HBcAg

σ� HBsAb

43. Which cells are proliferated from myeloid progenitor:

σ� B cells

σ� TH1

σ� Lymphocytes

σ� Dendritic cells

44. The function of MHC class II is:

σ� Recognized by CD4

σ� Recognized by the CD8

σ� Participated in the presentation of Ag

σ� Unable to carry antigen fragment

45. The function of Natural Killer cell is:

σ� Response to bacteria infection

σ� Damaged the target cell membrane

σ� Response to antibody

σ� Kill pathogen

46. Which cell is directly secreted immunoglobulin:

σ� T lymphocyte

σ� B lymphocyte

σ� Macrophage

σ� Plasma cell

47. All of the following are true with respect to IgG antibodies, EXCEPT:

σ� They fix complement

σ� They occur on the surface of B lymphocytes

σ� They are glycoproteins

σ� They mediate allergic reaction

48. One principal function of complement is not true:

σ� Activate perforins

σ� Mediate the release of histamine

σ� Lyse target cells

σ� Phagocytize antigens

49. One principal function of the Class I and Class II major histocompatibility complex is to:

σ� Transduce the signal to the T-cell interior

σ� Mediate immunoglobulin class

σ� Help T cell for the recognition Antigen

σ� Stimulate production of interleukins

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Part 1(1-49) Immunology

Immunology Challenge Quiz

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