Ofori Kahoot
Aspirin and NSAIDs Quiz
Test your knowledge on the pharmacology of Aspirin and Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) with this engaging quiz! Delve into the mechanisms of action, structural characteristics, and side effects of these common medications.
- 9 Thought-provoking questions
- Multiple choice and checkbox format
- Perfect for pharmacology students and professionals
Aspirin has anti-platelet (at low dose) effects compared to other NSAIDs because
It is the only NSAID that irreversibly acetylate the COX-1 active site
It is the only NSAID that reversibly blocks COX-1
It is the only NSAID that reversibly blocks COX-2
Aspirin acetylates the Ser-530 amino acid in the active site of the COX-1
True
False
Which of the following is true about the COX enzymes?
COX-1 has a wider hydrophobic “lip”
COX-2 has a wider hydrophobic “lip”
COX-1 is inducible
COX-2 inhibition causes GI side effects
Which of the following metabolites is the major culprit for the hepatotoxicity of acetaminophen (Tylenol)?
GSH
Sulfation product
N-acetyl-p-benzoquinone imine (NAPQI)
Which of the following drugs is a arylacetic acid derivative?
Naproxen
Flurbiprofen
Ibuprofen
None of the drugs
Nabumetone presents with low incidence of GI irritation because
Prodrug doesn’t have carboxylic acid thus less irritation of stomach
Prodrug has carboxylic acid thus less irritation of stomach
Diclofenac sodium has the tendency to cause hepatotoxicity because
It is a phenylacetic acid
It is a phenylpropionic acid
It forms an electophilic quinoimine metabolite that is hepatotoxic
It forms an ester that is hepatotoxic
Which of the following is/are true about the SAR of NSAIDs. Select all that apply.
Usually a 2 carbon separating the aromatic ring and the carboxylic acid
Usually a 1 carbon separating the aromatic ring and the carboxylic acid
Anti-inflammatory effects reside in the S-(+) enantiomer
Anti-inflammatory effects reside in the R-(-) enantiomer
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