Diabetes meds

Which of the followings is NOT true about biguanides?

They decrease hepatic gllucose production

They decrease insulin-mediated peripheral glucose uptake

Side effects may include diarrhea and abdominal discomfort

They are contraindicated in patients with renal insufficiency

Examples include metformin, glucophage, and glumetra

Sulfonylureas like glimiperide and glipizide

Are not known to cause hypoglycemia

Are not known to cause weight gain

Are contraindicated in patients who have a sulfa allergy

Are contra indicated in patients with renal insufficiency

TZDs are contraindicated in (select all that apply)

Patients with CHF

Patients with abnormal LFTs

Patients with sulfa allergy

Patients with renal insufficiency

Alpha-glucosidase inhibitors like Acarbose and Miglitol

Work by inhibiting carb digestion and reducing carb absorption

Work by increasing insulin secretion from beta cells

Work by decreasing hepatic glucose production

Blocks DPP-4, and increases incretin levels

Which medication class works with insulin to promote post prandial glucose absorption

DPP-4 inhibitors

Alpha-glucosidase inhibitors

Biguanides

Amylin-mimetics

Which medication can cause nasopharyngitis and headache as a side effect?

Symilin

Januvia

Actos

Metformin

Which of the following is NOT true about Byetta?

It is used as adjunct therapy to metformin, sulfonureas, and TZDs

Side effects are nausea, wt loss, increased satiety

Correct dosing is 5-10 mcg PO BID 60 minutes prior to meals

Which of the oral diabetes meds should be used as first line for type II diabetes (given there are no contraindications)?

Metformin

Januvia

Actos

Glipizide

Which of the following are considered "euglycemics"

Biguanides

Alpha glucosidase inhibitors

TZDs

Sulfonylureas

Which PO medication must be discontinued if a patient starts taking insulin?

Glimepiride

Metformin

Actos

Acarbose

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