Immunology Final
Immunology Insights Quiz
Test your knowledge of immunology with our comprehensive quiz designed for students and professionals alike. Dive deep into various topics to assess your understanding of immunological principles!
- Multiple choice questions
- Focus on key immunological concepts
- Perfect for revision and self-assessment
Which of the following is mismatched
ABO antigens are carbohydrate antigens
H antigen consists of fucose 2 galactose and N-acetyl glucosamine
Group AB don't have A&B antibodies
Group A have one additional galactose while group B have N-acetyl galactosamine
Which of the following sentences is correct
Carbohydrate antigens are recognized by IgG
Protein antigens are recognized by IgA, IgE & IgM
The secondary humoral immune response is faster, with increased affinity increased amount of antibodies
In isotype switching the change of the antibody happens in constant domain of light chain (CL)
Which of the following is mismatched
IL-4 stimulate B-cell to produce IgE, IgG4
In secondary exposure to an antigen the kd value increase
Hyper IgM syndrome happens due to mutation in CD40/CD40L/NEMO
BCR signal isn't enough to activate B cell
B-1 cell is found in and produce
Mucosal tissue/IgM
Spleen/ IgG IgE IgA
Lymph node /IgG IgE IgA
Spleen/IgM
All Effector functions of Antibodies happen through FC region except:
Neutralization
Opsonization
Complement activation
Antibody dependent cellular cytotoxicity
Which of the Fc gamma receptors make feedback inhibition of various cellular response?
FcγRIIA (CD32)
FcγI (CD64)
FcγRIIIA (CD16)
FcγRIIIB (CD16)
FcγRIIB(CD32)
Which of the following is the dominant type of immunoglobulin (Ig) in the human serum?
IgE
IgG
IgA
IgD
IgM
11-years-old boy, comes to emergency department with bout facial swelling. In lab test, doctors found that his c4 levels is low. And when the doctor took the history of family, he know that his uncle suffers from the same problem .Doctors diagnose his case early component inhibitors deficiency ,what is disease that the boy suffer from ,what is the treatment respectively?
COPLEMENT DEFICIENCY, C4 inhibitors
SLE, C2 inhibitors
Hereditary Angioedema, C1 inhibitors
COPLEMENT DEFICIENCY, C4
Mucins are mostly
Lipids only
Proteins only
Glycosylated lipids
Glycosylated proteins
Oligosaccharides
Which of the following Ig needs neonatal FC receptor for transport:
IgA and IgM
IgG only
IgA only
IgM only
None of the above
An example of privileged immunological site:
Skin
Lung
Testis
Bone marrow (BM)
Nose
Defensins are an important part of the innate defense against bacterial invasion in the gut, and abnormalities in defensin production have been &associated with various diseases. Which of the following statement about defensins is true?
Mast cell granules are rich in alpha defensins
Defensins are not produced in the colon
Defensins are produced by Paneth cells located at the base of crypts
Human defensins are secreted in a fully active form by cells in the gut after IL-1 stimulation
Which of the following is mismatched?
Central tolerance - inactivation of self-reactive mature lymphocytes
PD1- endocytosis of B7
Peripheral tolerance - secondary lymphoid organs
A+B
All of the following are effects of the cytokines that are secreted by Treg cells except
Increase the expression of MHC class II
Inhibit the formation of IL-12 and IFN gamma
Promotes IgA formation
Reduce the amount of B7 molecules on the surface of APCs
The following are features of protein antigens that favor tolerance except:
Antigens without adjuvant
Low levels of costimulatory and cytokines
Prolonged persistence
Absence from generative organs
Which of the following molecules that some variants of them causing lupus-like autoimmune disease
CD25
Fc¥RIIB
Complement proteins
B+C
The type of compatibility test that is used in bone marrow transplantation is
HLA(MHC)typing
ABO and RH matching
Mixed lymphocyte reaction
Cross matching test
All of the above
The type of graft transplantation that is between different species
Xenogeneic
Allogeneic
Syngeneic
Autogeneic
Mechanical
The wrong statement is
If we cross mate between members of two strains, transplantation form son to parents is accepted
Transplantation between members of the same strain is always accepted
Transplantation between different strains is always rejected
If we cross mate between two different strians, transplantation from parents to son is accepted
Which of the following mismatch
Corticosteroid > Inhibition of IL-2
A gene in ABO system > N-acetyl-galactosamine
O blood group > universal acceptor
AB blood group > co-dominant inheritance
Which vaccine type does the rabies belong to
Conjugate vaccine
Inactivated vaccine
Toxoid vaccine.
Experimental vaccine.
Which microbe uses ‘hit& run’ evasion mechanism to evade the IS:
Rotavirus
Rabies
HSV
HIV
Which of the following regarding the eosinophils is not true:
IL 4 stimulates the eosinophils production.
They attack the parasite’s nervous system.
They are supported by TH 2.
They are the main effector cells which attack helminths.
Which of the following microbes can change its antigenic makeup and inhibit appearance of immunological memory:
Rhinoviruses
HIV
Neisseria gonorrhea.
All of the above
None of the above
Which HIV-Virus membrane protein binds to chemokine receptor of T-helper cell
Gp120
HLA
CD4 co-receptor
Gp41
All of the following are false except:
The DNA of the virus must be converted to RNA in order to fuse with the genetic material of T-helper cell.
HIV is an example of secondary immunodeficiencies that researchers don’t use in research.
HIV infection is from the appearing of primary symptoms to constitutional symptoms
The immunodeficiency which causes problems with pyogenic bacterial infections is known as ‘ Late complement component defect ‘.
All of the following happen in the Acute Phase of HIV infection except
At the beginning of this stage the immune system sharply increases.
The appearance of some symptoms like: fever and headache.
At the end of this stage the immune system increase.
At the beginning of this stage the immune system sharply decreases.
A 1 –year-old has a history of immune deficiency. He presents to hospital with bone weakness. After taking a blood sample, the lab report shows that the person’s blood lacks lymphocytes and calcium. The doctor diagnoses his case that is DiGeorge syndrome, what is the cause of this syndrome?
He has defection in the development of the bone marrow and thymus in the embryonic stages leads to lack of lymphocytes production.
He has defection in the development of the two third pharyngeal pouch, so he is born with an incomplete thymus gland and parathyroid gland.
He has defection in the development of the third pharyngeal pouch, so he is born without thymus gland and parathyroid gland. Therefore, severe immunocompromise.
He eats food that are not rich in calcium, he also has vitamin D deficiency.
Radioallergosorbent test measures the amount of:
IgE
IgA
IgM
IgG
A 4 - year - old boy has been brought into the emergency department with redness of the skin, itching and edma and he was diagnosed that he has urticaria. Which one of the following statements is not true?
He is tested by skin prick test
wheal and flare reaction by mast cell tryptase
Wheal and flare reaction by eosinophils tryptase
None of the above
Contact dermatitis takes longer time to develop after exposure to antigen:
True
False
Sulfonamide hemolytic anemia is a classical example of which type of a hypersensitivity reaction?
Type IV
Type III
Type IV
Does not induce any hypersensitivity reaction
Type II
Hemolytic disease of the newborn does not occur when:
An RH positive mother conceives and RH positive child.
An RH negative mother conceives and RH negative child.
An RH positive mother conceives and RH negative child.
All of the above
Celiac disease is associated with HLA- B27
True
False
The antigens that are more commonly associated with delayed hemolytic transfusion reactions is
Fyb
Fya
Jk (a+ b- )
Fy (a- b-)
The most common presentation of a hemolytic transfusion reaction is
Fever
Itchy
Wheezing
Hypotension
In allergic erythrocytes may be destroyed by inadvertent:
Overheating
Improper freezing technique
Mixing with nonisotonic solutions
None of the above
All the above
All the following are methods transfusion-Transmitted Infections except
Hepatitis B surface antigen (HBsAg)
Antibody to hepatitis C virus (anti-HCV)
Anti-HIV 1/2, HIV-1 antigen (p24)
Two answer are correct
None of the above
If plasma cells are affected by cancer it will become which type of cancer
Multiple myeloma
Acute lymphoblastic leukemia
Essential thrombocytosis
Chronic lymphocytic leukemia
Myeloproliferative disorder can develop into acute myeloid leukemia
True
False
Alp-fetoprotein is expressed when we have all of the following except
Colon cancer
Spleen cancer
GI cancer
Liver cancer
. All of the following are ways to get rid extracellular microbes expect :
Phagocytes
Complement activation
ADCC
Antibody production
The deficiency of the complement component factor D and properdin lead to the recurrent bacterial infection. Which of the following pathway is affected in this condition?
Alternative pathway
Classical pathway
Lectin binding pathway
None of the above
Maternal immunity to some antigens may be conveyed in-utero. This is an example of which type of immunity?
Natural active immunity
Artificial passive immunity
Artificial active immunity
Natural passive immunity
Immunity to viral infections
Agglutination test (direct) is used to confirm the diagnosis of
Lyme disease
HIB
BSE
Salmonella
HBV
Latex particles are often used in:
Agglutination tests.
Affinity chromatography.
Affinity measurements.
Adjuvants
Neutralization assays.
The RAST measures:
Antigen concentration.
IgE antibodies
IgM antibodies
IgG antibodies
Agglutination
12-years-old girl in emergency department with tachycardia and exophthalmos .when docter takes the history of patient, he found that in the last two month she lost his wight more than 10 Kg. And lab tests show that she has hyperthyroidism and high level of antibody in her serum.The doctor dignose his cases with Autoimmune HS II. What is the desease and what is the cause his case ?
Goodpasture syndrome, IgG autoantibodies bind to basment membrane of thyroid gland
Myasthenia gravis, IgG autoantibodies bind to acetylcholine
Gravis desease, IgG autoantibodies bind to TSH receptor and activete T cell to binds with orbit antigen
MS, autoantibodies aginst myelin basic protien
If you have 2 tubes. Tube A has IgG while tube B has IgA, In tube A there are antibody coated RBCs, so the test that use and RBCs will be respectively:
IF, lysis
CF, not lysis
IF, not lysis
CF, lysis
Newborn Baby borns with abnormal state because the expression of protien CEA. The dignosis of his case is :
Autoimmune desese
Colon cancer
Lymphoma
Cervical cancer
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