ADH
Understanding SIADH: Test Your Knowledge
Welcome to the SIADH quiz! This quiz is designed to assess your knowledge of the Syndrome of Inappropriate Antidiuretic Hormone secretion (SIADH) and its related conditions. You’ll encounter a range of questions that challenge your understanding of the physiological, morphological, and clinical aspects of SIADH.
- Test your knowledge with 4 multiple-choice questions.
- Receive immediate feedback on your answers.
- Perfect for students, teachers, and medical professionals!
All of the following are are true regarding SIADH EXCEPT...
Presents with associated hyponatremia
Can be cause by carbamazepine
Presents with severely dilute urine
Can be a result of a paraneoplastic syndrome
Often asymptomatic
What is the main morphological difference between hereditary SIADH and hereditary nephrogenic diabetes insipidus?
Nephrogenic diabetes insipidus involves ectopic production of ADH, SIADH is gain of function of AVPV2
SIADH is loss of function of AVPV2 receptors, nephrogenic diabetes insipidus is gain of function
SIADH effects primarily AVPV2, nephrogenic diabetes insipidus effects primarily AVPV1
Nephrogenic diabetes insipidus involves ectopic production of ADH, SIADH is loss of function of AVPV2
SIADH is gain of function of AVPV2 receptors, nephrogenic diabetes insipidus is loss of function
A classic SIADH patient will present with...
High plasma osmolarity, high serum sodium, euvolemia
Low plasma osmolarity, low serum sodium, euvolemia
Low plasma osmolarity, high serum sodium, hypovolemia
Low plasma osmolarity, low serum sodium, hypovolemia
High plasma osmolarity, low serum sodium, euvolemia
Which parameter would you expect to decrease in a patient with nephrogenic diabetes insipidus?
Plasma ADH concentration
Clearance of water
Urine volume
Aquaporin2 channels on principal cell membrane
Plasma osmolarity
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