Im
Immunology Mastery Quiz
Test your knowledge of immunology with this comprehensive quiz! Designed for students, healthcare professionals, and anyone interested in the immune system, this quiz covers a wide range of topics related to antibodies, T-cells, and the complement system.
Challenge yourself with questions about:
- Antibody structure and fun
ction - Complement pathways
- MHC molecules
- Immunoglobulin classes
- T-cell interactions
1. All of the following are true with respect to IgM antibodies, EXCEPT
σ½ They fix complement
σ½ They occur on the surface of lymphocytes
σ½ They are glycoproteins
σ¾ They mediate allergic reaction
2. One principal function of complement is to:
Inactivate perforins
σ½ Mediate the release of histamine
σ¾ Bind antibodies attached to cell surfaces and to lyse these cells
σ½ Phagocytize antigens
3. One principal function of the Class I and Class II major histocompatibility
σ½ Transduce the signal to the T-cell interior
σ½ Mediate immunoglobulin class
σ¾ Present antigen for recognition by the T-cell receptor
σ½ Stimulate production of interleukins
4. The major role of the complement system is to work in conjunction with:
σ¾ Antibodies to lyse cells via the C8 and C9 components
σ½ MHC for cell recognition
σ½ Antibodies to opsonize cells
σ½ T-cell receptor for production of lymphokines
5. T-cell antigen receptors are distinguished from antibodies by which of the
σ½ T-Cell receptors are glycosylated
σ¾ T-cell receptors must interact with antigen
σ½ T-Cell receptors bind various cytokines
σ½ T-Cell receptors bind complement to lyse cells
6. T-cell receptors or antibodies react with antigens
Because both are made by lymphocytes
σ¾ Because they have specific receptors for antigen
σ½ Because both 'have light chain and heavy chain polypeptides
σ½ Cause histamine release
7. All of the following are true of antigen, EXCEPT:
They are the principal immunoglobulin class involved in allergic reactions.
σ½ They are involved in mediating anti-parasitic immune responses.
σ¾ They will cross the placenta and fix complement)
σ½ They can effect the release of histamine
9. Which of the following immunoglobulins is present normally in plasma at the highest concentration?:
σ¾ IgG
σ½ IgM
σ½ IgA
σ½ IgE
10. All of the following are true about antibodies, EXCEPT
σ½ They fix complement.
σ½ They occur on the surface of B-lymphocyte
σ½ They are glycoproteins.
σ¾ They are a single amino acid sequence
11. In the complement system, the classic pathway initiates by the complement :
σ¾ C1qrs
σ½ MBL
σ½ C4
σ½ C5
12. The immunoglobulin Joining chain (J-chain) is
σ½ Produced by T-Cells
σ½ Associated with IgM and IgG
σ¾ Associated with IgM and IgA
σ½ Produced by mast cells
13. All of the following are true, EXCEPT
σ½ An epitope is a portion of an antigen
σ½ The variable contain the antigen recognition site
σ¾ IgM antibody is pentavalent
σ½ IgG antibody is bivalent
14. Which immunoglobulin is the principal one found in secretions such as mucus? :
σ½ IgG
σ½ IgM
σ¾ IgA
σ½ IgD
15. Individuals unable to make the C4b would be expected to have frequent infections of the
σ½ Diabetis
σ½ Thalassemia
σ½ Liver disease
σ¾ Bacteria
16. The immunoglobulin class which is the least abundant in the normal adult is :
σ½ IgG
σ½ IgA
σ½ IgD
σ¾ IgE
17. Class of immunoglobulins occurs :
σ¾ Immunizations, going from IgM to IgG
σ½ Binds complement
σ½ Causes the histamine release
σ½ Mediates immunoglobulin class switching
18. In the alternative pathway of the complement system, the factors below are useful to prevent the generation of C3 convertase :
σ½ Factor P
σ¾ Factor F
σ½ C3-BP
σ½ C1-INH
19. To stabilise the C3 convertase of the alternative pathway, the factors below are useful
σ½ C3-BP
σ½ Factor F
σ¾ Factor P
σ½ C1-INH
20. The class of an immunoglobulin is determined by
σ½ The variable region
σ½ The J-chain
σ¾ The heavy chain
σ½ The carbohydrate
21. Light chains are:
σ½ Specific for each class of antibody
σ¾ Not specific for each class of antibody
σ½ Reactive with antigen
σ½ Have only a constant region
22. The T3 complex of the T-cell receptor :
σ¾ To transduce a signal to the cell's interior binding to antigen
σ½ Binds complement
σ½ Causes the histamine
σ½ Mediates Immunoglobulin class switching
23. Which of the following is NOT true of interleukins?:
σ½ They are cytokines which can be produced by various cells of the immune system.
σ½ They are hormones which allow one cell to communicate with another cell.
σ½ They are in need of receptors on the target cell in order to mediate their effects.
σ¾ They are able to bind antigen with a high level of specificity
24. The following statements are true for Immunoglobins, EXCEPT
σ½ Are antibodies
σ½ Five major classes : IgM, IgG, IgA, IgD, IgE
σ¾ All have receptors for complement
σ½ Possess both variable and constant regions
25. The following statements are true for Antibodies:
σ½ Are carbohydrates
σ½ Are made from alpha and beta chains
σ½ Contain no carbohydrate
σ¾ Contain heavy and light chains
26. Complement Deficiencies of C5, C6, C7, C8 and C9 can causes :
σ½ Susceptibility to pyogenic bacterial infections
σ½ Anaphylaxia
σ¾ Inability to attack the Gram-negative bacteria
σ½ Lack of opsonisation
27. Class II MHC are :
σ¾ Recognized by the CD4 protein
σ½ Used to kill by cytotoxic T-cells
σ½ Used to participate in cytotoxic function
σ½ Not able to carry an antigen fragment
28. The functional activity of the T-cell :
σ½ Is related with CD4 or CD8 associated polypeptides
σ½ Occurs after recognition of an epitope
σ½ Can be mediated through cytokines
σ¾ Is related with CD4 or CD8 associated polypeptides, Occurs after recognition of an epitope, Can be mediated through cytokines
29. The followings statement are TRUE for Target cell lysis and destruction except
σ½ Cytotoxic T-cells recognizing specific epitopes on the target cell surface
σ½ Perforin released from antigen-specific cytotoxic T-cells
σ½ Complement binding to IgG and IgM which have bound to epitopes on the target cell
σ¾ Complement binding to IgE antibodies which have bound to epitopes on the cell surface
30. The followings statement are TRUE, EXCEPT
σ½ MHC Class 1 bind antigen fragments and are recognized by the Tc-cell receptor
σ½ MHC Class I generally occur on all cells of the immune system
σ½ MHC Class II bind antigen and are recognized by the T-cell receptor and the CD4
σ¾ MHC Class II carrying antigen presented to cytotoxic T cells
31. What distinguishes helper T-cells from cytotoxic T-cells
σ½ Helper cells recognize antigen complexed with MHC class I molecules
σ½ Cytotoxic cells recognize antigen complexed with MHC class I molecules
σ½ Helper cells recognize antigen complexed with MHC class II molecules
σ¾ Cytotoxic cells recognize antigen complexed with MHC class I molecules and. Helper cells recognize antigen complexed with MHC class II molecules
32. Immunoglobulins are chemically
σ½ Glycogens
σ¾ Glycoproteins
σ½ Glycolipids
σ½ D. Lipo-proteins
33. Superantigens presented to T cells by :
σ¾ APC
σ½ B cell
σ½ Monocyte
σ½ Mast cell
34. Which of the following binds to an Fc receptor on mast cells and basophil
σ½ IgA
σ½ IgM
σ¾ IgE
σ½ IgG
35. Which of the following is NOT a structural chain in class I MHC?:
σ¾ β1
σ½ α1
σ½ α2
σ½ β2 –microglobin
36. Which of the following statements about leukocyte function is false?:
σ½ Leukocytes are involved in the immune response.
σ½ Neutrophils engulf damaged cells and pathogens by phagocytosis.
σ½ Eosinophils deliver toxic granules to kill parasites. They are also involved in allergic reactions.
σ¾ Macrophages are phagocytic cells that are involved in the adaptive response
37. Immediate hypersensitivity reactions are below, EXCEPT:
σ½ If the antigen is an allergen
σ½ The consequence of antigen-antibody reactions
σ½ Result from histamine release
σ¾ Phagocytosis
38. Clinical abnormalities of the Immune system can result from the activities below, EXCEPT:
σ½ Can be facilitated by antibodies
σ½ Mediated the humoral and cellular immune system
σ½ Facilitated by T-cells
σ¾ All answers
Which of the followings are TRUE regarding an Immune response
σ¾ The function of the T3 complex is signal to the cell's interior after recognition the antigen
σ½ The T8 serves an auxiliary role with MHC class II in cytotoxic reactions
σ½ The T4 serves an auxiliary role with MHC class I in helper cell reactions
σ½ The T4 secrete antibody
41. The component of immune system that can cause inflammation is
σ¾ Complement
σ½ Immunoglobulin
σ½ T lymphocytes
σ½ Macrophage
42. In acute infection of Hepatitis B, the typical serologic course are:
σ¾ HBsAg
σ½ HBcAb
σ½ HBcAg
σ½ HBsAb
43. The disease below can cause allergic reaction:
σ½ Hepatitis
σ½ Thalassemia
σ½ Cancer
σ¾ Asthma
44. Which cells are proliferated from myeloid progenitor:
σ½ B cells
σ½ TH1
σ½ Lymphocytes
σ¾ Dendritic cells
45. The function of MHC class II is:
σ½ Recognized by CD4
σ½ Recognized by the CD8
σ¾ Participated in the presentation of Ag
σ½ Unable to carry antigen fragment
46. The function of Natural Killer cell is:
σ½ Response to bacteria infection
σ¾ Damaged the target cell membrane
σ½ Response to antibody
σ½ Kill pathogen
47. Which cell is directly secreted immunoglobulin
σ½ T lymphocyte
σ½ B lymphocyte
σ½ Macrophage
σ¾ Plasma cell
48. All of the following are true with respect to IgG antibodies, EXCEPT
σ½ They fix complement
σ½ They occur on the surface of B lymphocytes
σ½ They are glycoproteins
σ¾ They mediate allergic reaction
49. One principal function of complement is not true:
σ½ Activate perforins
σ½ Mediate the release of histamine
σ¾ Lyse target cells
σ½ Phagocytize antigens
50. One principal function of the Class I and Class II major histocompatibility
σ½ Transduce the signal to the T-cell interior
σ½ Mediate immunoglobulin class
σ¾ Help T cell for the recognition Antigen
σ½ Stimulate production of interleukins
51. The major role of the complement C3b is to work in conjunction with
σ½ Antibodies to lyse cells antgen
σ½ MHC for cell recognition
σ¾ Antibodies to opsonize cells
σ½ T-cell for production of lymphokines
52. T-cell antigen receptors (TCR) are distinguished from antibodies by which of the following:
σ½ TCR are glycosylated
σ¾ TCR interact only with antigen :
σ½ TCR bind various cytokines
σ½ TCR bind complement to lyse cells
53. T-cell receptors or antibodies react with antigens
σ½ Both are made by lymphocytes
σ¾ They have specific receptors for antigen
σ½ Both have light chain and heavy chain
σ½ Cause histamine release
54. All of the following are true for IgE molecules, EXCEPT:
σ½ They involved in allergic reactions.
σ½ They anti-parasitic immune responses.
σ¾ They can fix complement.
σ½ They can cause the release of histamine.
55. Which of the following immunoglobulin can across placenta with the highest concentration?
σ¾ IgG1
σ½ IgG2
σ½ IgG3
σ½ IgG4
56. All of the following are true about antibodies, EXCEPT
σ½ They fix complement.
σ½ They occur on the surface of B-lymphocyte
σ½ They are glycoproteins.
σ¾ They are polypeptide
57. In the complement system, the lytic pathway initiated by the complement
σ½ C1qrs
σ½ MBL
σ½ C4
σ¾ C5
58. All of the following are true, EXCEPT:
σ½ An epitope is a portion of an antigen
σ½ The variable contain the antigen recognition site
σ½ IgM antibody is pentamer
σ¾ IgG antibody is pentavalent
59. Which immunoglobulin is the principal one that is unkown function
σ½ IgG
σ½ IgM
σ½ IgA
σ¾ IgD
60. Individuals make up over C4a would be expected to have
σ½ Diabetis
σ¾ Anaphylaxia
σ½ Liver disease
σ½ Bacteria
61. The immunoglobulin class which is the second abundant in the normal adult is
σ½ IgG
σ¾ IgA :
σ½ IgD
σ½ IgE.
62. In the alternative pathway of the complement system, the factors below are useful to stabilise the generation of C3 convertase
σ¾ Factor P
σ½ Factor F
σ½ C3-BP
σ½ C1-INH
63. The factor that dissociated the initiation of C1qrs in the classical pathway is:
σ½ C3-BP
σ½ Factor F
σ½ Factor P
σ¾ C1-INH
64. The type of an immunoglobulin is determined by
σ½ The variable region
σ¾ The light chain
σ½ The heavy chain
σ½ The carbohydrate
65. Each of the following is a characteristic of antibodies, EXCEPT
σ½ They are proteins with variable and constant regions
σ½ They contain carbohydrates
σ¾ They are only secreted by T-cells
σ½ They combine specifically with antigen
66. The T3 complex of the T-cell receptor
σ¾ To transduce a signal to the cell's interior
σ½ Binds complement
σ½ Causes the histamine
σ½ Mediates Immunoglobulin class switching
67. Which of the following is NOT true of interleukins
σ½ Produced by cells of the immune system.
σ½ Relation between cells of immune system
σ½ They have receptors on the target cell.
σ¾ They bind antigen with a high specificity.
68. The following statements are true for IgE, EXCEPT
σ½ They produce allergic reaction
σ½ The least immunoglobulin in the plasma
σ½ They bind to mast cells
σ¾ Can cross the placental barrier
69. IgE produce by :
σ½ Mast cells
σ½ B-cells
σ½ T-cells
σ¾ Plasma cells
70. The following statements are true, EXCEPT
σ½ IgM and IgG can fix complement
σ½ IgA is a secretory immunoglobulin
σ½ IgE mediates hypersensitivity
σ¾ IgD provides passive immunity
71. The following statements are true for Antibodies, EXCEPT
σ¾ Non immunogen
σ½ Composed of variable and constant regions
σ½ Made of heavy and light chains
σ½ They have hypervariable region
72. The following statements are not true for Immunoglobins
σ½ They have Fab
σ½ Five major classes of immunoglobulin
σ¾ All have receptors for complement
σ½ Possess both variable and constant regions
73. The following statements are true for Antibodies
σ½ Are carbohydrates
σ½ Are made from alpha and beta chains
σ½ Contain cytoplasmic region
σ¾ Have variable region
σ½74. The Biological Effects of C3b is :
σ½ Susceptibility to bacterial infections
σ½ Anaphylaxia
σ¾ Phagocyte activation
σ½ Lack of opsonisation
75. The following statement is for MHC Class I:
σ¾ Recognized by the CD8 protein
σ½ Used to kill by cytotoxic T-cells
σ½ Participated in helper function
σ½ D. Not able to carry an antigen fragment
76. The major histocompatibility complex proteins function to
σ½ Degrade T4 and T8 polypeptides
σ½ Bind antibody for lymphokine production
σ½ Bind complement for cell lysis
σ¾ Bind antigen for presentation to T-cells
77. Variable domains are:
σ½ Needed to bind complement
σ½ Located at the N-terminal of heavy chains
σ½ Transported IgG across the placenta
σ¾ Specific recognition of antigen
78. The light chains of antibodies are distinguished by:
σ½ Their constant specific region
σ½ Their variable region domains
σ¾ Kappa or lambda types
σ½ The J-chains that bind to them
79. Which of these cell types can play a primary role in attacking and killing cancer cells?:
σ½ Platelet
σ¾ Cytotoxic
σ½ T cell
σ½ Mast cell
80. The J-chain is
σ½ Made only by epithelial cells
σ½ For immunoglobulin multimer formation
σ¾ For immunoglobulin multimer formation and Facilitates secretion of pentameric lgM
σ½ Facilitates secretion of pentameric lgM
81. The functional activity of the T-cell:
σ½ Is related with CD4 or CD8 associated polypeptides
σ½ Occurs after recognition of an epitope
σ½ Can be mediated through cytokines
σ¾ All answers
82. The followings statement are FALSE for Target cell lysis and destruction
σ½ Tc recognizing specific epitopes
σ½ Perforin released from Tc
σ½ C3b fix to IgG and IgM which have epitopes
σ¾ C3b fix to IgE which have epitopes
83. The followings statement are TRUE, EXCEPT:
σ½ MHC I bind antigen and recognized by the Tc
σ½ MHC I presented on all cells of the immune
σ½ MHC II bind antigen and recognized by the Th
σ¾ MHC II carrying antigen presented to Tc
84. What distinguishes helper T-cells from cytotoxic T-cells:
σ½ Th recognize antigen with MHC I
σ½ Tc recognize antigen with MHC I
σ½ Th recognize antigen with MHC II
σ¾ Tc recognize antigen with MHC I and Th recognize antigen with MHC II
85. Clinical abnormalities of the Immune system can result from the following statement, EXCEPT
σ½ Deficiency diseases
σ½ Abnormal lymphocyte proliferation
σ½ HIV Infection
σ¾ T cells proliferation
86. Which of the following represent immune system dysfunctions:
σ¾ Severe immunodeficiency
σ½ Mast cells release histamine
σ½ Facilitated by antibodies
σ½ T cells proliferation
87. The following statement are for adaptive immune response, EXCEPT :
σ½ Is mediated by the humoral and cellular of the immune
σ½ Can be facilitated by antibodies
σ½ Can be facilitated through T-cells
σ¾ Can be facilitated through macrophage cells
88. Which of the followings are NOT TRUE regarding an immune response
σ½ The principal function of the T3 complex is signal transduction to the cell's interior
σ½ The T8 serves an auxiliary role with MHC class I proteins in cytotoxic reactions
σ½ The T4 serves an auxiliary role with MHC class II proteins in helper cell reactions
σ¾ Lymphokines are produced by T-cells in response to antigen presentation by antibody
89. Skin is a________ barrier:
σ¾ Anatomical
σ½ Physiological
σ½ Phagocytic
σ½ Inflammatory
90. Which among the following is anti-bacterial ?:
σ½ Interferon
σ¾ Lysozyme
σ½ Hormone
σ½ Protein
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