GWR
Pediatric Immunology Quiz
Test your knowledge on pediatric immunological disorders with this engaging quiz designed for healthcare professionals and students alike. Delve into clinical scenarios and diagnostic challenges to enhance your learning and retention of vital information.
Key Features:
- 10 carefully crafted questions
- Focus on real-world clinical presentations
- Immediate feedback on your answers
- 20months old boy with bloody diarrhoea, AIHA, eczema and pneumonia.
- Bloods:
- TLC 6.5 x 10^/L
- Hb 9.5g/dL
- Platelet 10000 (PBF small platelets)
- DLC normal
- IgG: 7.5g/L (3-9)
- IgA: 4.75 g/L (0.15-0.7)
- IgM : 0.25g/L (0.4-1.6)
Wiskott aldrich syndrome
Hyper IgE syndrome
8 month old boy, admitted with severe pneumonia, not responding to IV antimicrobials, responded To IV Cotrimoxazole
ix:
TLC: 8.3 x 10^9/L
DLC: P 10, L 73, M 8, E 8
ANC: 0.83 x 10^9/L
HIV: Negative
IgG: 0.85g/L (3-9)
IgA: 0.1g/L (0.15-0.7)
IgM: 2.8g/L (0.14-1.6)
Hyper IgM syndrome
Selective IgA deficiency
He was born term, with low birth weight 2.1kg. Dysmorphic, has truncus arteriosus, seizures secondary to hypocalcemia
Goldenhar Syndrome
DiGeorge syndrome
BW 3.5kg, 3months of dry cough and runny nose, 5months of recurrent otitis media, persistent pneumonia, oral thrush, 6months weight of <3rd centile
TLC: 4.8x10^9/L
DLC: P 85/ L 15/ M 3/ E 0
ALC: 0.76
HIV : Negative
IgG: 0.3g/L (3-9)
IgA: NIL (0.15-0.7)
IgM: 0.12 g/Ll (0.4-1.6)
Common variable immunodeficiency
Severe combined immunodeficiency
Early onset dermatitis, cold abscesses and lung infections (Staph aureus, aspergillus), multisystem disease with skeletal and connective tissues abnormalities, High IgE >2000 (10x normal value for age), may normalise to adult levels
Job's syndrome
Chronic granulomatous disease
Term newborn with omphalitis, delayed separation of umbilical cord at day 21
No pus in wound, high fever
Chediak Higashi syndrome
Leucocyte adhesion defect
Well until 10months old.
Had 1 episode of pneumonia with recurrent otitis media.
Always requiring antibiotics.
Maternal brother died at 14 years old
TLC: 5.1 x 10^9/L
DLC: P 45, L 43 , M 10, E 3
HIV: Negative
IgG: 1.5g/L (3-9)
IgA: 0.02g/L (0.15-0.7)
IgM: 0.1g/L (0.4-1.6)
X-linked Agammaglobulinemia
Common variable immunodeficiency disease
-Blood film of a 2 weeks old boy, with perianal redness and omphalitis
-Septic
-Erythema gangrenosum
-Blood C&S grew staph aureus
TLC: 11.5x 10^9/L
ANC: 0.17
IgG: 16.5g/L (3-9)
IgA: 1.75 g/L (0.15-0.7)
IgM : 2.5g/L (0.4-1.6)
Bone marrow: Normal neutrophilsbut severe block from promyelocyte to myelocyte stage
Shwachman-Diamond syndrome
Severe congenital neutropenia
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