Tuberculosis and antibiotic resistance

Where do most cases of tuberculosis occur? (Multiple answers can be correct)

On which method does a drug susceptibility test (DST) rely on when determining if a strain of MTb is antibiotic resistant?

PCR

Microscopy

Culture

Radiology

The result of the Mantoux tuberculin skin test is unreliable when: (Multiple answers can be correct)

The patient has had a BCG vaccination

The patient has a latent TB infection or active TB disease

The patient has never had a TB infection

The patient is immunocompromised

Which TB manifestation is contagious?

TB meningitis

Latent TB (LTBI)

Pulmonary TB

All of the above

What causes the symptoms of TB disease?

The DTH response

The toxins produced by the bacterium

The Th1 response

The death of macrophages

Which persons have the highest risk of developing active TB disease from a TB infection?

Persons who smoke

Persons who have diabetes/undernutrition

Persons who have an HIV infection

Persons who have an alcohol use disorder

Preventive therapy: what drug is used in an IPT regime?

Rifampicin

Pyrazinamide

Isoniazid

Ethambutol

How long does the all-oral bedaquiline treatment take?

3-6 months

6-9 months

9-12 months

What was the effect of flunarizine in the conducted RCT by Mo et al.?

It alleviated hepatotoxicity of isoniazid treatment

It inhibited growth of the mycobacteria

It induced autophagy

It enhanced the antimycobacteriocidal ability of macrophages

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