L-03-01-P58 - Molecular Basis of Cancer III
Molecular Basis of Cancer Quiz
Test your knowledge on the molecular mechanisms that underpin cancer development and tumor progression. This quiz covers key concepts related to tumor suppressor genes, oncogenes, and the genetic factors involved in cancer.
- Multiple choice and true/false questions
- Focus on tumor suppressor genes and mechanisms of cancer
- Designed for students and professionals in the medical and biological sciences
59. Which of the following is incorrect about tumour suppressor genes (TSG)?
A. They are present in all cells
B. TSG can prevent rapid cell division/growth by preventing rapid cell cycling
C. They are involved in the transcription of regulatory inhibitory genes such as p53
D. TSG help negatively control rapid cell division and growth
E. They do not control apoptosis related proteins
60. True or False: Damage to tumour suppressor genes will cause an individual to develop cancer.
True
False
61. True or False: the loss of one copy of a tumour suppressor gene has no effect on the cell cycle progression/development of cancer.
True
False
62. Which of the following is true about retinoblastoma gene?
A. It is a rare childhood tumour that affects the neural precursor cells of the retina
B. The disease can can only be inherited
C. Only one copy of the Rb tumour suppressor needs to be lost for the disease to occur
D. Only the retina cells would have a mutant Rb gene on chromosome 13
E. None of the above
63. True or False: The Rb gene is found in every cell in the human body.
True
False
64. Which of the following is not a fun
A. Prevention of transcriptional activation of a variety of genes
B. Regulation of cellular processes such as differentiation, DNA replication and apoptosis
C. Acts as a regulator for the cell cycle progression
D. None of the above
E. All of the above
65. There are six main ways of losing the remaining normal copy of a tumour suppressor gene. Identify all six from the list below:
A. Non-disjunction
B. Mitotic recombination
C. Point mutation
D. Transverse mutation
E. Robertsonian mutation
F. Reversal mutation
G. Nonsense mutation
H. Non-disjunction and duplication
I. Gene conversion
J. Methylated rearrangement
K. Deletion
66. Cancer cells are able to survive because in many cases, they have developed the molecular mechanisms to evade cell death (apoptosis). One of the common genetic errors is in the p53 mutation. In fact, 50% of all tumours show a loss of fun
A. p53 can induce specific cell responses such as cell cycle arrest and apoptosis
B. It can aid with DNA repair following DNA damage
C. p53 becomes inactivated when a cell suffers from severe DNA damage
D. Defective p53 genes can cause chromosomes to become fragmented
E. None of the above
67. Mismatch repair genes (MMR) repair DNA if errors occur during DNA replication. In cancerous cells:
A. There is an increased concentration of MMR proteins
B. MMR genes stop following the “two-hit” hypothesis
C. The effectiveness and accuracy of DNA polymerase is affected
D. Both copies of MMR are mutated
E. Only the microsatellites are repaired while the rest of the DNA is damaged
68. Which of the following does not contribute to cancer?
A. Activation of oncogenes
B. Sunlight
C. Diet
D. Loss of tumour suppressor genes
E. Loss of mismatch repair genes
F. Hereditary cancers
G. Partial chromosomal deletion
H. Overexpression of Abl Tyrosine Kinase
I. Gene conversion
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