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Celestial Protocol Knowledge Check

What cabozantinib targets are utilized as rational in the protocol for testing cabozantinib in HCC?

VEGFR, MET & AXL

MET & cKIT

VEGFR & MET

Why was a 2:1 randomization selected?

Enhance enrollment speed to complete trial quickly

Incentive for the patient to participate in PBO trial

Because cabozantinib is an active therapy

Per the protocol, why was PBO selected as the comparator arm?

No approved agents in 2L after sorafenib progression & recommended by EORTC.

Increase probability that cabozantinnib would meet primary endpoint of OS

Celestial is a blinded study and PBOs could be made to look like cabozantinib

What Child-Pugh score must all patients have for inclusion in Celestial?

Child-Pugh B

Child-Pugh A

Child-Pugh B & C

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