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Celestial Protocol Knowledge Check

What cabozantinib targets are utilized as rational in the protocol for testing cabozantinib in HCC?
VEGFR, MET & AXL
MET & cKIT
VEGFR & MET
Why was a 2:1 randomization selected?
Enhance enrollment speed to complete trial quickly
Incentive for the patient to participate in PBO trial
Because cabozantinib is an active therapy
Per the protocol, why was PBO selected as the comparator arm?
No approved agents in 2L after sorafenib progression & recommended by EORTC.
Increase probability that cabozantinnib would meet primary endpoint of OS
Celestial is a blinded study and PBOs could be made to look like cabozantinib
What Child-Pugh score must all patients have for inclusion in Celestial?
Child-Pugh B
Child-Pugh A
Child-Pugh B & C
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