Immuno final 2021

An intricate illustration of the human immune system, showcasing various immune cells, antibodies, and pathogens interacting in a dynamic environment, vibrant colors, educational style.

Immunology Mastery Quiz

Test your knowledge with our comprehensive quiz on immunology, designed for students and professionals alike. This quiz consists of 35 questions covering various aspects of immunology, from antibodies and cytokines to autoimmune diseases and immunodeficiencies.

Challenging questions to enhance your understanding
Immediate feedback on your performance
Perfect for exam preparation or self-assessment

35 Questions9 MinutesCreated by LearningCell123

Specific phagocytosis is mediated by

Choose true about antibodies:

IgD are crucial for phagocytosis efficiency

IgM are secreted to mucoses

IgG4 do not activate complement

IgG represent 80% of serum antibodies

IgE contribute to antiparasitic response

Which of the following represent phagocytosis deficiency?

The kidney donor is having the following HLA: HLA: A-01,03, B-0.8,19 DR-0.5,12. In virtual PRA recipient express antiHLA4 antibodies (MFI 18956) and anti HLA 10 antibodies (MFI 2357)

These anti HLA antibodies can be recognized as DSA

These anti HLA antibodies are not DSA

Virtual cross match is negative

Virtual cross match is positive

The recipient is qualified for next stage of matching

Chose which is characterized by following features: represent membrane derived complement inhibitors, inhibit C3 and C5 convertase

Choose correct connection between tumor and relevant antigen

Choose correct about di George syndrome:

Choose true about type IV hypersensitivity:

Typically Th2 dependent

Macrophages represent the major effector cells

Complement components decrease is characteristic for most chronic inflammation present in course of hypersensitivity

It is a reaction to M. Tuberculosis infection

Represent sudden allergic reactions

Choose true about antiviral immunity:

Type I interferons do not contribute to antiviral responses

Tc appear within first 1-2 days

SIgM mainly contribute to mucosal defense

NK cells cytotoxicity appear earlier than Tc

IFN-y appear several hours post invasion

Choose true about anti-tumor immunity

Tumors induce different sorts of immunity

Local immunotolerance dominates in local tumor microenvironment

Tumors represent the source of different antigens

Tumors associated antigens are used in the clinical diagnostics and treatment monitoring

Immunotherapy is applied in tumors treatment

Which of the cell populations is characterized by the following features: - Represent 2,4% of WBC - These ingest acid marker, reveal red granules and double lobed glass like nucleus - Produce major basic protein (MBP) - Represent weak phagocytic activity - Elevate on the course of allergies and parasitic infections

Choose true about phagocytosis:

Chemotaxis is not involved

C3a and C5a represent chemotactic agent

Peptidoglycans belong to PRR recognized by PAMPs

Intracellular killing represents the final stage

Antibodies enhance phagocytosis

Humoral immunity induction, boost doses requirement and stability in storage refer to all type of vaccines except:

Neutrophiles activation and therefor elevated neutrophiles levels in the peripheral blood can result from

Choose true about interferons

Type II interferon is produced by the cells infected with the virus

Type I interferons inhibit viral replication inside the infected cells

Type II interferons activates macrophages

Type I interferons are produced by activated T cells

Type II interferons inhibits Th2 cells

Choose the most appropriate donor for the following recipient and prove your choice by compatibility calculation: The donor: HLA A-01,03 B-07,08 DR-01, 05 The recipients: 1. HLA A- 01,02 B-07,15 DR-01,16 2. HLA A- 02,07 B-04,06 DR-01,05 20 3. HLA A- 02,03 B-07,08 DR-02,03 4. HLA A- 01,03 B-07,44 DR-12,15 5. HLA A- 04,09 B-07,08 DR-01,05

Select true:

Acute accelerated rejection is the most common rejection after organ transplantation

HLA antigens do not correlate with autoimmune diseases

Positive cross-match enables kidney transplantation

Highly immunized individuals recognized with PRA level over 20%

Panel reactive antibodies (PRA) evaluates the level of recipients alloimmunization

Which of the following represent central tolerance induction mechanisms anatomic sequestration?

I; organ specific autoimmune disease result from hypersensitivity type II because, II; organ specific antibodies attack self antigens on the cells

Both are true without causative connection

Both are false

First is false, second is true

First is true second is false

Both are true with clear causative connection

Choose false about hypersensitivity

Desenzitations aims at decreasing level of IgE and increasing IgG

Radioimmunological RIST and RAST test are used in the diagnosis

Histamine represent one of the performed mediators responsible for clinical symptoms

Result from atopy which never reveals clinically

Anaphylactic reaction can appear as one of the clinical forms

Choose false about SLE

Immune complexes are deposited in the skin and kidneys

Women aged 30-40 are mainly predisposed

Granulomatous reaction mediated by macrophages is mostly involved

Anti ds-DNA antibodies play major role in diagnostics

This is a systemic disease which result from type III hypersensitivity

Choose true about vaccines:

Live attenuated vaccines are never used anymore

Live attenuated vaccines induce cellular immunity

Toxoid based vaccines induce cellular immunity

Polysaccharide vaccines are weakly immunogenic and require adjuvants

Recombined vaccines are classified as polysaccharide vaccines

Choose true about indirect immunofluorescence

This involves enzymatic markers

This is used to detect the antigens in the sample

This involves radiometric markers

This is used to detect the antibodies in the serum

This is used to assess the level of compliment components.

Choose true about immunodeficiencies

SCID represent the most common disorder among primary immunodeficiencies

Humoral immunity deficiencies are typically characterized by fungal infections

Anti HIV antibodies represent the most efficient immune mechanism against HIV infections

Thrombocytopenia represents a component of Wiskott Aldrich syndrome (WAS)

Bruton’s agammaglobulinemia is characterized by complete lack of mature B lymphocytes and consequently complete lack of antibodies

Positive lupus band test, anti-dsDNA antibodies and LE cells are characteristic for the following autoimmune disease:

Choose the wrong connection between ligand and receptor:

CD4-MHC I (MHC II)

TCR-MHC II

B7-CD28

CD4-MHC II

Choose correct about biological cross-match:

This is performed repeatedly

This is performed once before transplantation

The aim is to assess the alloimmunization level of the society

The aim is to assess the existence of anti-donors HLA antibodies

The lymphocytes are obtained from 30 unrelated individuals

Choose correct about autoimmune diseases

Organ specific antibodies are preset in course of myastaenia

Pernicious anemia is treated with lifelong B12 vitamin administration

Graves-basedow disease result from hypersensitivity type II

Autoantibodies are used in diagnosis of Hashimoto disease

Systemic autoimmune disease result from hypersensitivity type III

Choose true:

Type I interferons represent the major mechanism in antibacterial immunity

Type IV hypersensitivity is activated in the course of certain parasitic infections

Th1 is the major helper population involved in the secondary viral infection

The antibodies represent the major immune factor against bacterial toxins

T CD8+ cells cytotoxicity represent major effectory mechanism in primary viral infection

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