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(362.2) Dexamethasone For Allergic and Anaphylactic Reactions

1. Which of the following is NOT an effect of glucocorticoids?

A. a1-adrenergic receptor downregulation

B. Decreased endothelial adhesion molecule expression

C. Inhibition of pro-inflammatory mediator transcription

D. Promotion of anti-inflammatory mediator transcription

2. Which of the following is NOT true of the activity of dexamethasone?

A. High-potency glucocorticoid activity

B. Rapid onset of drug activity (pharmacokinetics)

C. Less than 2-hour delay for physiologic effects

D. Long-acting biologic effects

3. In anaphylaxis, glucocorticoids are historically justified for what reason?

A. To halt the reaction

B. To mitigate early-phase inflammatory responses

C. To prevent biphasic reactions

D. To hasten recovery

4. Based on current human and veterinary literature, the use of glucocorticoids in uncomplicated acute allergic reactions is…

A. Strongly recommended

B. Likely unnecessary

5. Based on current human and veterinary literature, the use of glucocorticoids in anaphylaxis is…

A. Recommended against

B. Currently standard, but neither recommended for nor against

C. Strongly recommended

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