3 ADME pt. 2
Understanding Toxicokinetics: ADME Quiz
Test your knowledge on the fascinating world of toxicokinetics with this engaging quiz! Dive into the complex concepts surrounding the Absorption, Distribution, Metabolism, and Excretion (ADME) of chemicals and their implications for human health.
- 11 challenging questions
- Multiple-choice format
- Evaluate your understanding of chemical disposition and physiological effects
The disposition of a chemical is described by its concentration in the plasma with respect to time.
Classical Toxicokinetics
Physiological Toxicokinetics
The disposition of a chemical is described in specific organ/tissue compartments. • compartments correspond to actual organs/tissues
Classical Toxicokinetics
Physiological Toxicokinetics
One compartment model is the simplest, experimental, intramuscular injection, concentration decreasing non linearly
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Half life is One parameter that is determined through toxicokinetic studies is the chemical half life (t 1/2 )
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BEIsmeasure an individuals chemical exposure by taking a blood/urine/air sample and analyze for chemical/metabolite/nontoxic change in body
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ACETONE & BENZENE
Start of shift
End of shift
Advantage of physiological toxicokinetics isThe models can provide the time course of distribution of xenobiotics to any organ • Allows for the estimation of the effects of changing physiologic parameters on tissue concentrations
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Volume of each compartment
Anatomical data
Physiologic data
Blood flow, ventilation, elimination • Thermodynamic data: relates
Anatomical data
Physiological data
Relates to the total concentration of a xenobiotic in tissue
Thermodynamic data
Transport data
Membrane transport (Passive, specialized)
Thermodynamic data
Transport data
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