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Quizzes > Health & Medicine

Mpox Quiz: Test Your Knowledge

Quick, free mpox knowledge test with 15 questions. Instant results.

Editorial: Review CompletedCreated By: Iker Vivas GarciaUpdated Aug 25, 2025
Difficulty: Moderate
Questions: 20
Learning OutcomesStudy Material
Colorful paper art depicting elements related to Mpox Knowledge Assessment Quiz.

This mpox quiz helps you check what you know about transmission, symptoms, prevention, and vaccine basics, and highlights topics you may want to review. After you finish, broaden your understanding with the clinical pharmacy quiz or explore gut health with the is my poop healthy quiz.

Which of the following is the most common route of human-to-human mpox transmission?
Mosquito bite
Airborne transmission over long distances
Direct contact with skin lesions
Ingestion of contaminated food
Mpox virus is most commonly spread by direct contact with lesions or bodily fluids of an infected person. Other routes such as contaminated food or distant airborne spread are not the primary modes of transmission.
Which animal group is considered the primary reservoir for mpox virus?
Domesticated livestock
Rodents such as squirrels and rats
Birds in wetland areas
Monkeys in tropical forests
Epidemiological studies have shown that various rodent species, including squirrels and rats, harbor mpox virus in endemic regions. While non-human primates can be infected, they are not the main reservoir.
What is the typical incubation period for mpox after exposure?
1 to 3 days
21 to 28 days
2 to 4 days
7 to 14 days
The incubation period for mpox usually ranges from 7 to 14 days before symptoms appear. Shorter or much longer intervals are less common.
Which of the following symptoms is characteristic of mpox infection?
Profuse watery diarrhea
Maculopapular rash progressing to pustules
Severe jaundice
Persistent productive cough
Mpox infection classically presents with a maculopapular rash that evolves into vesicles and pustules. Gastrointestinal, respiratory, or hepatic signs like jaundice are not typical primary features.
Which public health measure is most effective to prevent onward transmission of mpox in a community setting?
Isolating infected individuals until all scabs have fallen off
Widespread insecticide spraying
Universal use of surgical masks by healthy individuals
Routine antibiotic prophylaxis for all contacts
Isolation of confirmed cases until lesions have fully healed prevents direct and indirect spread of the virus. Antibiotics, insecticides, or mask use by uninfected individuals do not effectively block mpox spread.
Which vaccine is currently recommended for pre-exposure prophylaxis against mpox in laboratory personnel?
Influenza quadrivalent vaccine
JYNNEOS (modified vaccinia Ankara)
VARIVAX (varicella vaccine)
MMR (measles, mumps, rubella vaccine)
JYNNEOS is a non-replicating vaccinia-based vaccine approved for pre-exposure prophylaxis in at-risk laboratory workers. Other vaccines like VARIVAX or MMR do not protect against mpox.
What is the gold standard diagnostic test for confirming mpox infection?
Polymerase chain reaction (PCR) of lesion material
Complete blood count with differential
Viral culture from blood samples
Serologic testing for IgM antibodies
PCR testing of lesion swabs or crusts is the most sensitive and specific method to confirm mpox virus. Serology or routine blood tests lack the necessary specificity and timeliness.
A laboratory worker handles live mpox virus samples without respiratory protection. According to risk assessment guidelines, this exposure is classified as:
Negligible risk
Low risk
High risk
Intermediate risk
Direct handling of live virus without appropriate respiratory and barrier precautions is classified as high risk for laboratory exposures. Lesser contact scenarios would fall into lower categories.
During the prodromal phase of mpox, patients most commonly experience which symptom?
Petechiae
Conjunctival hemorrhage
Lymphadenopathy
Hematuria
Enlarged lymph nodes are a hallmark prodromal symptom that helps distinguish mpox from other rash illnesses. Bleeding or petechial signs are not typical early features.
The JYNNEOS vaccine against mpox utilizes which of the following platforms?
Live replicating vaccinia virus
mRNA-based vaccine
Non-replicating viral vector
Inactivated whole virus
JYNNEOS uses a modified, non-replicating vaccinia Ankara vector to safely elicit an immune response. It is not a live-replicating vaccine, nor is it mRNA or inactivated virus based.
Which of the following personal protective measures is most essential for healthcare workers to reduce mpox transmission?
Using surgical gowns without gloves
Proper hand hygiene with alcohol-based rub
Relying solely on social distancing
Wearing cloth masks only
Hand hygiene with alcohol-based rubs effectively removes the virus from skin surfaces. Single measures like cloth masks or gowns without gloves do not address all transmission routes.
Which scenario represents the highest risk of mpox transmission in a community setting?
Passing by an infected person in an open park
Attending a virtual meeting with an infected individual
Sharing bedding with someone who has active lesions
Sitting in the same room without direct contact
Prolonged indirect contact with contaminated bedding can transmit virus particles. Brief or distant interactions, including virtual meetings, carry negligible risk.
Which specimen collection method provides the most reliable sample for mpox PCR testing?
Nasopharyngeal swab
Urine specimen
Stool sample
Swab of lesion crust or fluid
Lesion crusts or fluid contain high viral loads and are preferred for PCR confirmation. Respiratory, stool, or urine specimens are less reliable for early diagnosis.
What is the correct order of skin lesion progression in mpox infection?
Papule â†' Macule â†' Pustule â†' Vesicle
Pustule â†' Vesicle â†' Papule â†' Macule
Macule â†' Papule â†' Vesicle â†' Pustule
Vesicle â†' Macule â†' Pustule â†' Papule
Mpox lesions classically evolve from flat macules to raised papules, then fluid-filled vesicles, and finally pustules. Incorrect sequences do not match the typical clinical progression.
Post-exposure vaccination against mpox is most effective when administered within how many days of exposure?
4 days
10 days
14 days
7 days
Vaccination within four days of exposure offers the highest potential to prevent or lessen disease. Delays beyond this window have reduced effectiveness.
Which clinical feature most reliably distinguishes mpox from smallpox in a symptomatic patient?
Higher rash density on palms
Predominant gastrointestinal symptoms
Rapid hemorrhagic progression
Prominent lymphadenopathy
Marked lymph node enlargement is characteristic of mpox and is generally absent in smallpox. Both diseases may present with rash but differ in lymphatic involvement.
An immunocompromised patient has been exposed to mpox. Which management step is most appropriate?
Delay vaccination until after illness onset
Provide only supportive care without vaccination
Administer JYNNEOS vaccine as post-exposure prophylaxis
Prescribe antibiotics for symptom relief
Immunocompromised individuals benefit from prompt post-exposure JYNNEOS vaccination to mitigate disease. Antibiotics and delaying vaccination are not recommended for viral exposure.
According to current guidelines, which group should receive pre-exposure mpox vaccination?
All international travelers
Children under 5 years of age
Pregnant healthcare workers
Laboratory personnel working with orthopoxviruses
Personnel handling orthopoxviruses are at high occupational risk and are recommended for pre-exposure vaccination. Broad groups like travelers or children are not routinely targeted.
A healthcare worker removes contaminated bedding used by an mpox patient without gloves. This exposure is classified as:
Low risk
High risk
Intermediate risk
No risk
Handling fomites contaminated with infectious material without appropriate barrier protection is considered intermediate risk. Direct unprotected lesion contact would be high risk.
Which public health intervention would be least effective in controlling a human mpox outbreak?
Widespread mosquito control measures
Contact tracing and monitoring
Isolation of confirmed cases
Vaccination of close contacts
Mpox is not transmitted by mosquitoes, so vector control is ineffective. Isolation, contact tracing, and ring vaccination directly interrupt human-to-human transmission.
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Learning Outcomes

  1. Identify common Mpox transmission routes
  2. Analyze key symptoms and incubation periods
  3. Evaluate effective prevention and control measures
  4. Demonstrate understanding of vaccination guidelines
  5. Apply risk assessment strategies in varied settings
  6. Interpret diagnostic criteria for Mpox infection

Cheat Sheet

  1. Understand Mpox Transmission Routes - Think of Mpox as a stealthy party crasher: it leaps from skin-to-skin contact, sneaks aboard contaminated towels or sheets, and even travels in respiratory droplets when someone coughs or sneezes. Surfaces and materials you touch can also harbor the virus if not properly cleaned. WHO Mpox Fact Sheet
  2. Recognize Key Symptoms and Incubation Periods - After an incubation window of 1 - 21 days, Mpox often kicks off with fever, headache, and muscle aches that feel like a stubborn flu. The signature sign is a rash that evolves from flat spots to raised bumps, then to fluid-filled blisters and scabs in distinct stages. Early recognition helps you seek care fast! WHO Mpox Fact Sheet
  3. Implement Effective Prevention Measures - Your best defense? Vaccination plus smart habits: avoid close contact with anyone showing symptoms, wash hands frequently, and disinfect shared surfaces. Proper hygiene acts like a shield, blocking Mpox from hitching a ride into your life. CDC Mpox Prevention Guidelines
  4. Follow Vaccination Guidelines - The JYNNEOS vaccine delivers two doses spaced four weeks apart to power up your immune system. If you miss your second dose window, don't panic - reschedule as soon as you can to complete your protection. Vaccines are your superhero armor! CDC Mpox Vaccination Guidelines
  5. Apply Risk Assessment Strategies - Be a Mpox detective: consider recent travel to endemic regions, close contact with infected individuals, or participation in crowded events. High-risk scenarios call for extra caution and possibly preemptive vaccination. A proactive mindset keeps you a step ahead! WHO Mpox Fact Sheet
  6. Interpret Diagnostic Criteria - Clinicians spot Mpox by matching symptoms - like the distinctive rash and fever - and confirm with lab tests, typically PCR assays that detect viral DNA. Accurate diagnostics distinguish Mpox from similar conditions and guide the right care. Fast testing means faster relief! WHO Mpox Fact Sheet
  7. Understand Infection Control in Healthcare Settings - In clinics and hospitals, PPE like gloves, gowns, masks, and eye protection form your frontline barrier against Mpox. Follow strict cleaning and waste-disposal protocols to keep treatment areas safe. Teamwork and vigilance stop the virus in its tracks! CDC Healthcare Infection Control
  8. Recognize High-Risk Groups - Children, pregnant people, and anyone with a weakened immune system face a tougher fight if Mpox strikes. Tailored monitoring and early intervention are crucial for these vulnerable groups. Compassionate care saves lives! WHO Mpox Fact Sheet
  9. Stay Informed About Mpox Variants - Mpox has two main clades - I and II - with slight differences in how easily they spread and how severe they can be. Keeping up with variant news helps you fine-tune your prevention strategies. Knowledge is your superpower! WHO Mpox Fact Sheet
  10. Practice Safe Handling of Animals - Wild rodents and primates in endemic areas can be secret Mpox carriers, so give them space and avoid direct contact. If handling is unavoidable, gear up with gloves and follow proper hygiene afterward. Zoonotic caution keeps both you and wildlife safe! CDC Mpox Prevention Guidelines
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