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Histology Practice Test: 20 Questions to Check Your Tissue Knowledge

Quick, free histology practice quiz with instant results and helpful feedback.

Editorial: Review CompletedCreated By: True Skills-Muhammad Ibrahim FanclubUpdated Aug 27, 2025
Difficulty: Moderate
Grade: Grade 10
Study OutcomesCheat Sheet
Colorful paper art promoting Histology Hustle, a trivia quiz for students to learn tissue structures and functions.

This histology practice test helps you check tissue types, cell features, and common stains in 20 quick questions. You'll get instant results and short tips to spot strengths and gaps before an exam. To go deeper, try the histology identification quiz, the epithelial tissue quiz, or the connective tissue quiz.

Which tissue type lines the inside of blood vessels and the heart (endothelium)?
Simple cuboidal epithelium
Stratified squamous epithelium
Simple squamous epithelium
Transitional epithelium
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What is the primary stain that colors cytoplasm pink in an H&E stain?
Eosin
Hematoxylin
Toluidine blue
Safranin
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Which organelle is most responsible for packaging and modifying proteins for secretion?
Mitochondrion
Lysosome
Golgi apparatus
Centrosome
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Which epithelial shape describes cells that are taller than they are wide?
Columnar
Squamous
Cuboidal
Transitional
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Which connective tissue cell type produces collagen fibers in tendons and ligaments?
Fibroblast
Mast cell
Chondrocyte
Osteoclast
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Which neuroglial cell forms myelin in the central nervous system?
Schwann cell
Oligodendrocyte
Microglia
Astrocyte
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Which epithelial type is specialized for stretching in the urinary bladder?
Stratified columnar
Pseudostratified ciliated columnar
Simple cuboidal
Transitional epithelium (urothelium)
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Which protein predominantly composes thick filaments in muscle fibers?
Actin
Myosin
Tropomyosin
Troponin
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Where are Purkinje fibers found as part of the conduction system?
Heart
Spinal cord
Liver lobules
Cerebral cortex
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Which connective tissue fiber type provides great tensile strength and is most abundant in tendons?
Elastic fibers
Type II collagen
Type I collagen
Reticular fibers (Type III collagen)
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Which structure in compact bone contains blood vessels and runs longitudinally through osteons?
Lacuna
Haversian (central) canal
Canaliculi
Volkmann canal
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Which glial cells are the resident macrophages of the central nervous system?
Microglia
Satellite cells
Ependymal cells
Astrocytes
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Which epithelial arrangement has nuclei at different heights giving a layered appearance, but all cells contact the basement membrane?
Stratified cuboidal epithelium
Simple columnar epithelium
Pseudostratified columnar epithelium
Transitional epithelium
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Which connective tissue is characterized by parallel bundles of collagen and resists unidirectional tension?
Reticular connective tissue
Dense irregular connective tissue
Areolar connective tissue
Dense regular connective tissue
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Which cell type secretes the organic bone matrix (osteoid) before mineralization?
Chondrocyte
Osteocyte
Osteoblast
Osteoclast
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Which cell is the primary antigen-presenting cell found in the epidermis?
Langerhans cell
Keratinocyte
Melanocyte
Merkel cell
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Which collagen type predominates in reticular fibers of lymphoid organs?
Type I collagen
Type III collagen
Type IV collagen
Type II collagen
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Which layer of the gastrointestinal tract contains Meissner (submucosal) plexus?
Mucosa
Submucosa
Serosa
Muscularis externa
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Which cells in the thyroid gland line the follicles and produce thyroglobulin?
Follicular cells
Parafollicular (C) cells
Oxyphil cells
Chief cells
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Which central nervous system lining cells possess cilia and help circulate cerebrospinal fluid?
Oligodendrocytes
Ependymal cells
Microglia
Astrocytes
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Study Outcomes

  1. Understand fundamental tissue structures and their clinical relevance.
  2. Analyze differences between various tissue types.
  3. Apply histological principles to practical exam scenarios.
  4. Evaluate the organization and function of different tissues.
  5. Synthesize key concepts to enhance exam preparedness.

Histo Quiz Practice Test Cheat Sheet

  1. Four primary tissue types - Get ready to meet the dream team of your body: epithelial, connective, muscle, and nervous tissues. Each one has its own special structure and superpower, from lining your organs to firing off electrical signals. Dive into the basics and see how they work together to keep you alive and kicking.
  2. Key traits of epithelial tissue - Epithelial tissue loves organization: its cells have a clear top and bottom (polarity), are held tight by special junctions, and don't have their own blood supply. This neat arrangement makes them perfect for shielding surfaces and absorbing nutrients. Learn why this "cellular sheet" is so crucial for protection and exchange.
  3. Types of epithelial layers and shapes - Simple vs. stratified tells you how many layers of cells you're dealing with, while squamous, cuboidal, and columnar describes their shape. Whether it's a single layer for speedy diffusion or multiple layers for fortress-like protection, each combo has a unique job. Picture them in action and never mix them up again!
  4. Connective tissue components - Cells, fibers (think collagen for strength, elastic for stretch, reticular for scaffolds), and ground substance form the supportive matrix that holds everything together. This trio makes connective tissue the ultimate bodybuilder of the tissue world. See how these parts join forces to give shape and structure to organs.
  5. Muscle tissue varieties - Ready to move? Skeletal muscle gives you power for those biceps curls, cardiac muscle keeps your heart beating like a champ, and smooth muscle handles involuntary jobs like digesting your lunch. Each type has a unique look and job - meet the movers and shakers of your body.
  6. Nervous tissue essentials - Neurons are the lightning bolts of your system, sending rapid signals thanks to their special structure of dendrites, axons, and synapses. Glial cells play the sidekick role, supporting and protecting neurons. Discover how this tag team keeps information zipping around your brain and nerves.
  7. Cell junctions and communication - Tight junctions seal cells together, desmosomes act like spot welds for strength, and gap junctions open channels for fast messaging. These tiny connections let cells stick, seal, and talk to each other - critical for tissue integrity and teamwork. Explore how junctions keep cells in sync.
  8. Extracellular matrix magic - More than just fluffy filling, the extracellular matrix provides support, guides cell behavior, and regulates growth and repair. Its mix of proteins and sugars is like a dynamic playground for cells. Dig into how this "outer territory" shapes tissue function.
  9. Tissue repair and regeneration - When tissues get injured, stem cells and the extracellular matrix team up to repair the damage. Inflammation kicks off cleanup, new cells rebuild, and scar tissue forms if things get too intense. Follow the fascinating steps of your body's own construction crew.
  10. Top histology resources - Virtual labs, digital atlases, and interactive tutorials turn histology from a chore into a thrill ride. Explore high-res slides, zoom into cell details, and quiz yourself on tissue identification. Fuel your studies with tools that make learning tissues downright fun.
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