HPCT Prelim Part 2
Recommended fixative for acid mucopolysaccharides.
Lead fixative
Chromate fixative
Acetone
Formaldehyde
Gas produced by the oxidation of methyl alcohol.
Formaldehyde
Acetone
Trichloroacetic acid
Osmium tetroxide
Which fixative composition is removed to improve cytoplasmic details?
Acetic acid
Neutral buffered formalin
Acrolein
Picric acid
For fixing brain tissues.
Heat fixation
Lead fixation
Glacial acetic acid
Acetone
Best general tissue fixative.
Acetic acid
Neutral buffered formalin
Acrolein
Picric acid
Pale yellow powder which dissolves in water to form a strong oxidizing solution.
Osmium tetroxide
Trichloroacetic acid
Glacial acetic acid
Picric acid
Excessive yellow staining of tissues.
Osmium tetroxide
Trichloroacetic acid
Glacial acetic acid
Picric acid
White crystalline precipitates due to prolonged standing.
Paraformaldehyde
Acid formaldehyde hematin
Osmium tetroxide
Mercuric chloride pigment
Brown/black granular deposits that may obscure microscopic details.
Paraformaldehyde
Acid formaldehyde hematin
Osmium tetroxide
Mercuric chloride pigment
For bacteriologic smears.
Heat fixation
Lead fixation
Glacial acetic acid
Acetone
For routine post mortem tissues.
Formol corrosive
Formol calcium
Both
Either
For BM biopsies.
B5 fixative
Heidenhain Susa
Helly's solution
Acetone
To study early degenerative processes and tissue necrosis.
Orth's fluid
Zenker
Helly's solution
Chromic acid
Preserved proteins.
Orth's fluid
Zenker
Helly's solution
Chromic acid
Best fixative for tissue containing iron granules.
NBF
Formol saline
Ethanol
Heat fixation
Traditional
-18 to -20C
-40 to -60C
5 to -10C
40C
RT
Rapid examination
-18 to -20C
-40 to -60C
5 to -10C
60C
RT
Optimum working temperature for cryostat
-18 to -20C
-40 to -60C
100C
40C
RT
For tissue with TB
-18 to -20C
100C
5 to -10C
40C
RT
Optimum condition for sectioning tissues.
-18 to -20C
100C
5 to -10C
40C
RT
CARDINAL SIGNS
RUBOR
Due to increased capillary permeability causing extravasation of blood.
DOLOR
Due to transfer of internal heat to the surface or site of injury.
FUNCTIO LAESA
Due to arteriolar and capillary dilatation with increased rate of blood flow towards the site of injury.
TUMOR
Due to pressure upon the sensory nerve by the exudate or tumor.
CALOR
Destruction of the functioning units of the tissue.
Large accumulation of pus
Pus
Effusion
Abscess
Pustule
Creamy fluid composed of large number of PMNs and necrotic tissue debris.
Pus
Effusion
Abscess
Pustule
Small accumulation of pus.
Pus
Effusion
Abscess
Pustule
Accumulation of serous fluid.
Pus
Effusion
Abscess
Pustule
Hypertension of the mucosa.
Seroud inflammation
Catarrhal inflammation
Suppurative inflammation
Fibrinous inflammation
Hemorrhagic inflammation
Purulent exudate
Serous inflammation
Catarrhal inflammation
Suppurative inflammation
Fibrinous inflammation
Hemorrhagic inflammation
Serum secretion from serosal mesothelial cells.
Serous inflammation
Catarrhal inflammation
Suppurative inflammation
Fibrinous inflammation
Hemorrhagic inflammation
Admixture of ood and other elements of exudate/bacterial infection and others.
Serous inflammation
Catarrhal inflammation
Suppurative inflammation
Fibrinous inflammation
Hemorrhagic inflammation
Exudation of large amount of fibrinogen.
Serous inflammation
Catarrhal inflammation
Suppurative inflammation
Fibrinous inflammation
Hemorrhagic inflammation
Excessive lack of nutritional supply which leads to wasting of tissues.
Vascular atrophy
Pressure atrophy
Starvation atrophy
Atrophy of disuse
Exhaustion atrophy
Blood supply to an organ/tissue becomes reduced below critical level.
Vascular atrophy
Pressure atrophy
Starvation atrophy
Atrophy of disuse
Exhaustion atrophy
Inactivity or diminished function of a tissue/organ which leads to narrowing of the blood vessels.
Vascular atrophy
Pressure atrophy
Starvation atrophy
Atrophy of disuse
Exhaustion atrophy
Persistent pressure on the organ/tissue which may directly injure the cells.
Vascular atrophy
Pressure atrophy
Atrophy of disuse
Exhaustion atrophy
Starvation atrophy
Prolonged overwork.
Vascular atrophy
Pressure atrophy
Starvation atrophy
Atrophy of disuse
Exhaustion atrophy
Regressive alteration in adult cells manifested by variation in size, shape, and orientation.
Metaplasia
Dysplasia
Aplasia
Neoplasia
Anaplasia
Continuous abnormal proliferation of the cells without control.
Metaplasia
Dysplasia
Aplasia
Neoplasia
Anaplasia
Incomplete/defective development of tissue/organ.
Metaplasia
Dysplasia
Aplasia
Neoplasia
Anaplasia
Transformation in one type of adult cell to another.
Metaplasia
Dysplasia
Aplasia
Neoplasia
Anaplasia
Used as criterion toward malignancy.
Metaplasia
Dysplasia
Aplasia
Neoplasia
Anaplasia
Failure of an organ to reach its full, mature size.
Agenesia
Hypoplasia
Hyperplasia
Atresia
Hypertrophy
Failure of an organ to form an opening.
Agenesia
Hypoplasia
Hyperplasia
Atresia
Hypertrophy
An increase in size of an organ or tissue due to increase in the number of cells.
Agenesia
Hypoplasia
Hyperplasia
Atresia
Hypertrophy
Non-appearance of an organ.
Agenesia
Hypoplasia
Hyperplasia
Atresia
Hypertrophy
Increase in size of tissues or organs.
Agenesia
Hypoplasia
Hyperplasia
Atresia
Hypertrophy
TISSUE TUMORS (Benign)
Smooth muscle
Leiomyoma
Bone
Lipoma
Cartilage
Hemangioma
Adipose tissue
Chondoma
Striate muscle
Rhabdomyoma
Blood Vessels
Osteoma
TISSUE TUMORS (Malignant)
Bone liver cells
Adenocarcinoma
Renal epithelium
Renal cell carcinoma
Testicular epithelium
Seminoma
Glands and ducts
Hepatocarcinoma
TISSUE TUMORS (Malignant)
Striated muscle
Leiomyosarcoma
Hematopoietic cells
Chondrosarcoma
Cartilage
Leukemia
Smooth muscle
Rhabdomyosarcoma
Fibroud tissue
Fibrosarcoma
Lymphoid tissue
Lymphoma
Tumor perforates visceral peritoneum or directly invades other organs/structures.
TX
T0
T1
T4
Tis
Primary tumor cannot be assessed.
TX
T0
T1
T4
Tis
Tumor invades submucosa
TX
T0
T1
T4
Tis
No evidence of primary tumor
T2
T0
T1
T4
Tis
Tumore invades muscularis propria.
TX
T2
T3
T4
Tis
Metastased in four or more regional lymph nodes.
NX
N0
N1
N2
No regional lymph node metastases.
NX
N0
N1
N2
Regional lymph nodes could not be assessed.
NX
N0
N1
N2
Programmed cell death.
Necrosis
Apoptosis
Pathologic cell death
Necrosis
Apoptosis
Due to disease or injury.
Necrosis
Apoptosis
Helps eliminate unwanted cells.
Necrosis
Apoptosis
Necrosis of tissue rich in liquid.
Liquefaction necrosis
Caseous necrosis
Coagulation necrosis
Gangrenous necrosis
Fat necrosis
Tombstone formation
Liquefaction necrosis
Caseous necrosis
Coagulation necrosis
Gangrenous necrosis
Fat necrosis
Chalky white appearance
Liquefaction necrosis
Caseous necrosis
Coagulation necrosis
Gangrenous necrosis
Fat necrosis
Yellow, cheesy, crumbly material.
Liquefaction necrosis
Caseous necrosis
Coagulation necrosis
Gangrenous necrosis
Fat necrosis
Sulfide gas formation
Liquefaction necrosis
Caseous necrosis
Coagulation necrosis
Gangrenous necrosis
Fat necrosis
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