New Part 5 (1020-1056) nana 1

97) A 62-year-old woman presents to her physician with complaints of heartburn, fatigue, and intermittent upper abdominal pain. The pain is often worse after meals and especially with spicy foods. She reports no recent nausea, vomiting, weight loss, dysphagia, or bright-red blood per rectum. However, her stools are darker than normal. Her last colonoscopy 2 years ago was unremarkable. Stool guaiac test result is positive. An initial complete blood cell count reveals: Hemoglobin: 10.1 g/dL, Hematocrit: 33.2%, Mean corpuscular volume: 74.6/mm³, Mean corpuscular hemoglobin concentration: 25.8%, WBC count: 9200/mm³ Platelet count: 176,000/mm³ Ferritin: 11 ng/mL. The patient undergoes upper endoscopy, which reveals erosive gastritis. She is started on omeprazole, 40 mg twice a day and oral iron sulfate supplementation, 325 mg three times a day with meals. Six months into treatment, abdominal pain and heartburn are resolved, but the patient still has fatigue and is pale. Repeat laboratory tests show: Hemoglobin: 9.9 g/dL, Hematocrit: 30.2%, Mean corpuscular volume: 74.2/mm³, Mean corpuscular hemoglobin concentration: 25.1% , WBC count: 9800/mm³ Platelet count: 198,000/mm³ Ferritin: 10 ng/mL. Repeat upper endoscopy is negative for bleeding and erosive gastritis. Stool guaiac test result is negative. Which of the following is the next best step in management?

98) A 58-year-old nurse with node-positive metastatic breast cancer comes to the office for her monthly follow-up visit. The tumor is estrogen receptor (ER) and progesterone receptor (PR) positive, and her whole body bone scan is positive for metastatic disease. She is being treated with systemic chemotherapy and hormonal therapy (Tamoxifen). She feels weak with vague muscle, joint, and bone pains. Physical examination reveals a hard, well-defined dominant mass in the left breast. Mucus membranes are moist. Laboratory studies show the following results. Sodium 145 mEq/dL, Potassium 3.9 mEq/dL, Chloride 103 mEq/dL, Bicarbonate 24 mEq/dL, Calcium 11.3 mg/dl, BUN 18 mg/dl, Creatinine 0.8 mg/dl, Glucose 146 mg/dl. Which of the following is the best next step in the management of her hypercalcemia?

99) You are called to the oncology floor to examine a 57-year-old female who is complaining of severe nausea and vomiting. Her other symptoms include some general malaise and a sore throat. She is receiving combination ABVD chemotherapy (Doxorubicin, Bleomycin, Prednisone, and Procarbazine). She was diagnosed with stage II Hodgkin's lymphoma 4 weeks ago. She tells you that she does not want to continue her therapy anymore since it is "making life even more miserable." She has lost 30 lbs (12.6kg) in a month. Her temperature is 38.5°C (101.3°F), pulse is 88/min, respirations are 18/min, and blood pressure is 109/68mm Hg. Her pulse oximetry reading in room air is 92%. Physical examination reveals a significantly cachectic patient with a dry mouth, enlarged cervical lymph nodes and hepatomegaly. How can this patient's vomiting be best managed?

100) An 80-year-old man with advanced prostate cancer and bony metastasis is complaining of severe back pain that has been progressively worsening for the past two weeks. His pain is so severe that it restricts him from playing golf. Eight months ago, he underwent orchiectomy, after which he was free from bone pain until now. Physical examination reveals tenderness at two sites in the lumbar region. Radionuclide bone scan shows an increased uptake in these areas. Which of the following is the most appropriate next step in the management of this patient?

101) A 65-year-old Hispanic male is brought to the emergency department after having one seizure episode. His past medical history is significant for non-small cell lung carcinoma, which was diagnosed two years ago and treated surgically. He had no residual disease at that time. CT scan of the brain with contrast now shows a solitary cortical mass in the right hemisphere of the brain at the grey-white matter junction. His chest x-ray is clear. He is admitted for further management and started on phenytoin. Which of the following is the most appropriate management for this patient?

102) A 35-year-old Caucasian female is hospitalized with swelling and tenderness of her right calf. Deep venous thrombosis is diagnosed through imaging studies, and the appropriate therapy is initiated. Three days later, she complains of right arm pain. Physical examination reveals a cold right upper extremity with no palpable peripheral pulse. Her laboratory values are listed below: Hematocrit 42%, WBC count 8,500/mm3, Platelets 76,000/mm3, PT 13 sec, aPTT 63 sec. Which of the following drugs was most likely used to treat this patient's deep venous thrombosis?

103) A 21-year-old previously healthy man presents to your office for a routine check-up. He has no current complaints. He does not smoke or consume alcohol. His family history is significant for cystic fibrosis in his older brother. He is sexually active with one partner and uses condoms regularly. He visits a dentist twice per year. His temperature is 36.6°C (97.9°F), pulse is 78/min, respirations are 14/min, and blood pressure is 120/76 mmHg. Physical examination reveals several non-tender, rubbery cervical lymph nodes, each measuring approximately 1 cm in diameter. There is no hepatosplenomegaly. Which of the following is the best next step in management of this patient?

104) A 32-year-old Caucasian female presents to your office for a routine check-up. Her past medical history is significant for generalized seizures controlled with chronic phenytoin therapy. The last seizure was six months ago. She does not smoke or consume alcohol. Physical examination is insignificant, except mild pallor. Laboratory values are: Hb 10.8 g/dL, MCV 105 fl, Platelet count 180,000/cmm, Leukocyte count 7,500/cmm, Segmented neutrophils 68%, Bands 1%, Eosinophils 1%, Lymphocytes 24%, Monocytes 6%. Which of the following supplementations could have prevented this patient's anemia?

1) A 46-year-old female is brought to the emergency department because of visual blurring and altered mental status. She was recently treated for gout. Physical examination shows moderate to severe splenomegaly and positive sternal tenderness. Laboratory studies reveal a WBC count of 120, 000/uL with left shifted myeloid series and basophilia. Bone marrow exam shows 3% blasts. Repeat CBC is ordered. The hematologist-on-call decides to start leukophereses emergently. What another drug should be given to this patient?

2) A 64-year-old male patient with deep vein thrombosis is being treated with unfractionated heparin. On the 4th day of treatment, his platelet count drops to 80,000/cmm. His previous platelet count on day 2 was within normal range. He denies any bleeding-related complications, and is completely asymptomatic. His complete examination does not reveal any signs of bleeding. His blood pressure is 128/80mm of Hg, pulse is 78/min, and respirations are 20/min. He is afebrile. What is the most appropriate next step in the management of this patient?

3) A 19-year-old man comes to the office and says, "Doctor! I have been having a peculiar problem lately. My stool has a funny color. First, it was black and almost sticky. Yesterday, it became maroon. In fact, today I saw some bright red blood." He denies any associated pain or fever. He is adopted, and his family history is unknown. His vital signs are stable. Physical examination is normal, but his stool is positive for occult blood. Laboratory studies reveal a hematocrit of 29% and hemoglobin concentration of 9.6 g/dL. Colonoscopy reveals hundreds of colonic polyps, which are identified as adenomatous polyps with the biopsy. What is the appropriate recommendation for this patient at this point?

4) A 6-year-old, African-American boy presents with fever and pain in his extremities for the last several hours. The pain is unrelated to movement or posture. His pulse is 102/min, blood pressure is 110/70 mm Hg, temperature is 38°C (100.4°F), and respirations are 18/min. Physical examination reveals pallor, jaundice, and splenomegaly. Both lower legs are tender to palpation. Lab tests show the following: Hematocrit 20%, WBC count 13,000/micro-L, Platelet count 180,000/miro-L, Bilirubin 5.0 mg/dL, Direct bilirubin 1.2 mg/dL, Reticulocyte count 11%. Peripheral blood smear shows sickle shaped cells. Hemoglobin electrophoresis confirms the diagnosis of sickle cell anemia. After treating the child with analgesia, hydration, and oxygen therapy, the painful episode subsides. Which of the following measures should be employed to prevent aplastic crisis in this child?

5) A 22-year-old white male presented to the emergency room (ER) with the sudden onset of acute right upper quadrant pain. The ultrasound showed cholelithiasis. Initial evaluation revealed hemoglobin of 9 gm/dl with an MCV of 90 fl and a total reticulocyte count of 1000 cells per microliter. Peripheral smear revealed polychromatophilia and spherocytes. Liver function tests revealed an elevated indirect bilirubin and normal hepatic enzyme levels. Physical examination is consistent with pallor. The patient's parents were killed in an accident when he was 8-year-old, and the patient does not know anything about the family history. Which of the following is the most correct statement about this patient's condition?

6) A 70-year-old man presents to the urgent care clinic complaining of extensive bruising and bleeding gums. His medical history is significant for atrial fibrillation for which he takes metoprolol and warfarin. He has been stable on his current dose of warfarin for several months. He denies any recent use of NSAIDs or other over-the-counter medications. The patient reports that he has been taking his warfarin as prescribed and has been trying to "live a healthier life" lately. On further questioning, he reports trying to exercise more often, taking numerous vitamin supplements daily, and eating more vegetables. His new diet consists mainly of vegetables like spinach, Brussels sprouts, and broccoli, as well as copious amounts of green tea. Which of the following lifestyle changes is most likely responsible for this patient's bleeding?

7) A 26-year-old man comes with his girlfriend to the emergency department due to a very high fever. He just finished his second cycle of BEP (bleomycin, etoposide, cisplatin) chemotherapy for metastatic seminoma 4 days ago. Other than his fever, he has no complaints. He denies any chest pain, cough, diarrhea or any rash. He stopped smoking ever since he was diagnosed with his "deadly disease," but drinks alcohol occasionally. His temperature is 38.9°C (102°F), blood pressure is 118/70 mm Hg, pulse is 102/min, and respirations are 19/min. Physical examination reveals a pale man without any eyebrows or eyelashes. Chest auscultation is clear. Blood tests reveal: WBC 690/mm3 with 9% neutrophils, Hemoglobin 8.6 g/dl, Hematocrit 25%, Platelets 74,000/mm3. What is the best next step in the management of this patient?

8) A 34-year-old woman comes to the ER because of right lower leg swelling, redness, and pain. She has no significant past medical history and does not use any medications. Her mother has a history of pulmonary embolism. Her temperature is 36.7°C (98°F), pulse is 80/min, respirations are 16/min, and blood pressure is 120/76 mmHg. Examination shows tenderness to palpation in the right calf. Compressive ultrasonogram shows a deep vein thrombosis of the right leg. Further evaluation reveals an elevated plasma homocysteine level. She is started on heparin and warfarin therapy. What other additional therapy is indicated in this patient?

10) A 36-year-old male comes to your office complaining of progressive fatigability. His past medical history is significant for infiltrative pulmonary tuberculosis diagnosed two months ago. His current treatment includes isoniazid, rifampin, ethambutol, and pyrazinamide. Laboratory values are: Hemoglobin 8 g/dl, MCV 77 fl, MCHC 30%, ESR 17 mm/hr, Serum iron 170 micro-g/dl (N 50- 150 micro-g/dl ), Total iron binding capacity (TIBC) 280 micro-g/dl (N 300-360 micro-g/dl). Microscopy reveals two populations of red blood cells (RBC)-hypochromic and normochromic. What is the next best step in the management of this patient?

11) A 56-year-old male is admitted to the ICU for the management of hepatic encephalopathy. He is a known alcoholic. He is started on oral neomycin, lactulose, and a low-protein, high-carbohydrate diet. His blood pressure is 116/78 mm Hg, pulse is 78/min, temperature is 37.5°C (99.5°F), and respirations are 18/min. His labs reveal the following: Hb 10.2 g/dl, WBC 7,400/cmm, Hct 27%, Platelets 4 2,000/mm3, PT 18 sec, INR 2.02, PTT 31 sec. He has no evidence of active bleeding. Which of the following should be administered to this patient at this time?

13) A 47-year-old man comes to the office for the evaluation of a sore over his right ear. His sore bleeds and oozes, and has remained open for 3 weeks. He thinks that it has been growing slowly over the past year. He works for the postal service (USPS), and is usually out all day delivering mail. He admits to smoking approximately 2 packs of cigarettes daily for the last 13 years. Physical examination reveals a punched out 1.5 cm ulcer on his right auricle. There are no enlarged lymph nodes. Full thickness biopsy reveals proliferating malignant cells which arise from the epidermis and extend into the dermis in lobules or strands. What is the best next step in the management of this patient?

14) A 56-year-old man complains of fatigue and occasional palpitations. He has a 20-year history of diabetes mellitus and takes daily insulin therapy. He receives hemodialysis three times a week for end-stage renal disease. He was recently started on erythropoietin therapy for anemia (his pretreatment hemoglobin was 8.0 mg/dl). Physical examination at this visit reveals pale conjunctiva. Repeat laboratory studies show: Hemoglobin 9.2 mg/dl, MCV 77 fl, MCHC 30 g/dl, WBC count 7,000/mm3, Platelets 150,000/mm3, Hemoglobin A1c 7.5%, ESR 15 mm/hr. Which of the following is likely to be helpful in improving this patient's symptoms?

15) A 48-year-old Caucasian female is undergoing a routine work-up 9 months after radical mastectomy due to right-sided breast cancer. She has no present complaints, and says that she is 'full of energy'. Chest radiograph reveals an isolated pulmonary nodule, 2.0 cm in diameter, in the middle lobe of the right lung. CT confirms that the lesion is solitary with poorly defined margins, but completely within lung parenchyma. Bone scan is negative. CT abdomen and pelvis is normal. Transthoracic biopsy demonstrates adenocarcinoma with positive estrogen receptors (ER) and no HER-2/neu overexpression. Which of the following is the best management strategy for this patient?

16) A 56-year-old white male is being evaluated for having isolated IgG elevation. The level of serum IgG is 2400 (Normal is 700 to 1500), while the levels of the other paraproteins are within normal limits. The patient was previously admitted with a diagnosis of pneumonia, which resolved completely with levofloxacin. His other laboratory test results are as follows: Hemoglobin 13.0 g/dl, Serum Ca 8.0 mg/dl, BUN 18 mg/dl, Creatinine 1.1 mg/dl. Bone marrow biopsy reveals 2% of plasma lesions. What is the most appropriate next step in the management of this patient?

17) A 55-year-old Caucasian male is hospitalized after a massive hemorrhage from a duodenal ulcer. The hemorrhage was stopped with endoscopic manipulation. Two litters of Ringer lactate were infused and two units of packed red blood cells (RBC) ordered. Ten minutes after the transfusion of packed RBC had been started; the patient was complaining of tremor and feeling 'chilly.' His temperature is 39.4° C (103° F), blood pressure is 120/76 mmHg, pulse is 100/min, and respirations are 24/min. The transfusion was stopped, and acetaminophen was given. Direct antiglobulin test and plasma free hemoglobin level are negative. Urinalysis is normal. The reaction abated three hours after the transfusion had started. Which of the following actions could have prevented the reaction described?

18) A 44-year-old white male comes to the office and says, "I have had this persistent, upper abdominal pain for the past 2 months. My wife has peptic ulcer, and I think I also have an ulcer down there, so I take some of her medicines. At first, the medicines made the pain go away, but soon after the pain proved to be too tough for the medicines. I hardly want to eat anything now. Do you think all this is due to some reaction to those medicines?" Physical examination reveals mild tenderness in the epigastric region. Esophagogastroduodenoscopy reveals a mass in the pylorus, which the biopsy identifies as an infiltrating, low-grade, gastric mucosa-associated lymphoid tissue (MALT) lymphoma. Further work-up concludes that there are no regional lymph nodes involved. What is the best next step in the management of this patient?

19) A 42-year-old African-American woman presents to your office with bilateral knee pain that severely limits her mobility. She also complains of joint stiffness in the morning that takes several hours to improve. Her hand joints are symmetrically swollen. She has been taking over-the-counter ibuprofen and aspirin with little relief of symptoms. She has no other medical problems and does not use tobacco, alcohol, or illicit drugs. Her vital signs are within normal limits. Physical examination shows pain and swelling of both wrists and knees. Laboratory studies reveal: Hemoglobin 8.4 mg/dl, Serum iron 30 μg/dL (normal 50-150 μg/dL), Total iron binding capacity 230 μg/dL (normal 300-360 μg/dL), Ferritin 300 ng/dl. Which of the following is most likely to improve this patient's anemia?

20) A 25-year-old, G3P0 white female in her 8th week of gestation comes to the antenatal clinic. Her obstetric history is significant for two second trimester abortions. She is currently taking folic acid and iron supplementation. She does not smoke, but she drinks alcohol on social occasions. She is in a monogamous relationship with her husband. She has never been diagnosed with or treated for any STDs. Laboratory studies reveal the following: VDRL positive, FTA-ABS negative, Hct 33%, WBC 7,000/mico-L, Platelets 70,000/micro-L, PT 10 sec, APTT 40 sec. What is the most appropriate next step in the management of this patient?

21) A 64-year-old male, who rarely sees the doctor and doesn't believe in screening procedures, comes to office with the complaint of severe back pain. He has not felt comfortable for the past 4 months and is having severe pain in the back. He has found it difficult to sleep. He has hypertension, for which he takes hydrochlorothiazides regularly. He thinks that he has lost some weight. On examination, his BP is 165/90mm of Hg, while rest of vitals are stable. On rectal examination you find a rock hard 2 cm nodule in prostate. Biopsy shows poorly differentiated adenocarcinoma. Bone scans shows wide spread metastasis all over his skeleton. What is the most appropriate treatment for his metastatic disease?

22) A 65-year-old woman is very worried because she recently had a close family member and friend die, one after the other. First, her 85-year-old mother died of an ovarian cancer that was diagnosed 3 years ago. Last week, she lost her best friend to lung cancer that metastasized to the liver and brain. Today, her 58-year-old sister learned that she has breast cancer. She has regular pap smears and breast examinations. She has read in the paper that there are a few ways that have proved to be very successful in preventing breast cancer. Which of the following measures has the best evidence of preventing breast cancer in high-risk women?

23) A 16 year-old-girl with hereditary spherocytosis is scheduled for a splenectomy. She was previously managed with folate therapy and occasional blood transfusions, but her anemia became refractory to medical management alone. Before the operation, she is told that she will have an enhanced risk of developing pneumococcal sepsis. She then asks, "How long will these risks last?" What is the best response to her question?

24) A 42-year-old mildly overweight Caucasian male is being worked-up for his second episode of deep venous thrombosis in two years. Both episodes seem to have been unprovoked. He denies any recent prolonged immobility, long-distance travel or lower extremity trauma. He has no past medical history of diabetes, cancer or liver disease. A thrombophilia work-up is ordered for this patient. Use of which of the following drugs is most likely to give a false-positive result for protein S deficiency?

25) A 33-year-old computer programmer was diagnosed with ulcerative colitis last year. He had a colonoscopy and biopsy that showed pancolitis, after which no further work-up was done. This is his first visit to a physician in 6 months. He takes aminosalicylates and is in remission, without any symptoms. He is a member of the Ulcerative Colitis Support Group, which recently sent him a letter that said he should be screened for colon cancer. His vital signs are stable. Physical examination reveals mild tenderness on deep palpation of the lower abdomen. What is the best advice for him regarding his concerns?

26) A 72-year-old Hispanic man comes to the clinic with complains of mild headache, and lethargy for the past several days. He complains of cough for the past 12 years, the cough has been bothering him more lately. The cough is mucoid, he has noticed blood in it once in a while. He has smoked 1 pack/day for 29 years. His vitals are, Temperature 37.0°C (98.6°F); BP 120/84 mm Hg; PR 78/min; RR 24/min. On examination of lungs, adventitious sounds are heard over all the lobes and scant crackles at the base. Laboratory studies show: WBC 7,600/mm3, Hemoglobin 13.6, Hematocrit 40%, Platelets 214,000mm3, Sodium 130 mEq/L, Potassium 3.6 mEq/L, Bicarbonate 18 mEq/L, Blood urea nitrogen 16 mg/dl, Creatinine 0.6 mg/dl, Glucose 95 mg/dl, Serum osmolality 260 mOsm/kg (normal 280), Urine osmolality 310 mOsm/kg. A chest x-ray shows a 2-centimeter left upper lobe mass and mediastinal adenopathy. What will be the next best step in management of this patient?

27) You are called by the hospice nurse to evaluate a 74-year-old man who refuses to eat. He has terminal colon cancer, which was diagnosed 8 months ago and has metastasized to his liver. He has already gone through chemotherapy with 5-Fiourouracil + oxaliplatin. During the past 4 months, his condition has gotten extremely worse. He has lost 501bs (27.6kg), and currently appears totally wasted. As you approach him, he says, "I don't feel like eating anything, and I don't want any more procedures, but I'll drink any pill that can make me feel better." His abdomen is distended with positive fluid thrills. His liver has several palpable nodules. What is the best pharmacological agent of choice for this patient's anorexia?

28) A 67 -year-old man presents to your office with a one month history of progressive fatigue and exertional dyspnea. He has no significant past medical history. Physical examination reveals enlarged, non-tender axillary lymph nodes bilaterally. His abdomen is soft and non-tender and the liver span is 10 cm. Serial fecal occult blood tests are negative. Laboratory values are as follows: Hemoglobin 7.8 mg/dl, MCV 90 fl, MCHC 33 g/dl, Reticulocytes 7%, WBC count 22,000/mm3, Platelets 200,000/mm3. Which of the following is most likely to improve this patient's symptoms?

29) A 22-year-old woman comes to the office for the evaluation of a breast mass which she discovered while taking a shower 2 months ago. She experiences severe pain in this mass during her menses. She looks very anxious because her 45-year-old friend was diagnosed with breast cancer last year, and who "now has all sorts of medicines that have made her lose her hair." She has no other problems. She has never been pregnant. She is an occasional smoker, and drinks 3-4 beers a week. There is no family history of breast cancer. Her vital signs are stable. Physical examination reveals a 4 x 5 x 6 cm firm, moveable, rubbery mass in her left breast. Ultrasound shows a cystic mass. Needle aspiration yields clear fluid, after which the mass disappears. What is the best approach in the management of this patient?

30) A 28-year-old male comes for complete physical examination for a new job he is starting next week. He is healthy and has no complaints. He smokes 1 pack/day cigarettes for the last 10 years. He drinks 4 oz of alcohol daily. His mother has hypertension and father has heart problems. Vitals signs are with in normal limits. Physical examination is within normal limits except for a painless, hard mass in left testicle. Ultrasound shows high likelihood of a testicular tumor. What is the next best step in management?

31) A 41-year-old woman comes to the office for the evaluation of a lump on her left breast. She feels, "generally well," and denies having any medical problems. She takes a multivitamin and Tums daily. She stopped smoking after getting married 21 years ago. She drinks wine only on weekends. Her only surgery was a bilateral tubal ligation last year, after giving birth to her fourth child. Physical examination of the left breast reveals a 4 cm lump at the 11 O'clock position and two axillary nodes on the left side. Mammography shows irregular micro-calcifications. The result of the FNA is suggestive for infiltrating ductal carcinoma. Which of the following is the single most important prognostic factor in this patient?

32) A 29-year-old woman comes to the office of a primary care physician complaining of pain in her right knee for the last 3 months. The pain is getting progressively worse and is not moving anywhere. She has tried ibuprofen but found little comfort. She is a housewife and unable to do household work because of this pain. She does not smoke nor drink and has hypertension well controlled by hydrocholorothiazide. Her vitals are stable and she is afebrile. On examination her right knee is a little swollen and tender with reduced range of motion. On x-ray, there is soap-bubble appearance in the epiphysis of distal femur. What is the next best step in the management of this patient?

33) A 55-year-old man has undergone renal transplantation due to end-stage renal failure. His postoperative course was uncomplicated. He is currently taking prednisone and cyclosporine. He is afebrile and his pulse is 80/min, respirations are 14/min, and blood pressure is 130/65 mm Hg. Physical examination is unremarkable. Which of the following should be added to his current medication regimen to prevent opportunistic infections?

34) A 24-year-old man is found to be HIV positive. He is asymptomatic. Physical examination is unremarkable. Laboratory tests show: CD4 count 400/micro-L, HIV viral load 9,000 copies/mL, VDRL negative, Toxoplasma serology negative, PPD test 6mm induration. His chest x-ray is unremarkable. What is the most appropriate next step in the management of this patient?

35) A very worried 25-year-old woman comes to the office, presents a positive pregnancy test, and says, "I'm six weeks pregnant. Two months ago, I received the rubella vaccine and my doctor told me to avoid getting pregnant for the next three months. I'm very concerned about the health of my unborn baby. I'd like to know all the available options to prevent any harm to my baby." What is the most appropriate next step in the management of this patient?

36) A 30-year-old male has recently been diagnosed with HIV infection. He denies drug abuse. He is currently asymptomatic, and physical examination is unremarkable. He is in a stable heterosexual relationship. Laboratory studies show a CD4 count of 350/microL, HIV viral load of 15,000 copies/mL, negative VDRL, negative toxoplasma serology, tuberculin skin test of 7 mm induration, negative HBsAg, and positive anti-HBsAg antibodies. Hepatitis C antibodies are negative. Complete blood count, serum chemistries, and liver function tests are within normal limits. He has not received any vaccinations since being diagnosed with HIV. Which of the following vaccines is indicated in this patient?

37) A 42-year-old man with advanced HIV infection has a two-week history of pain and difficulty with swallowing. He was given fluconazole for these symptoms one week ago, but his pain has worsened. His current medications include tenofovir, emtricitabine, efavirenz, and trimethoprim-sulfamethoxazole. His CD4 count is 90/microl and viral load is 300,000copies/ml. Endoscopy reveals large, irregular, linear ulcers in the esophagus. A biopsy of the abnormal mucosa reveals tissue destruction and the presence of intranuclear and intracytoplasmic inclusions. Which of the following is the most appropriate pharmacotherapy for this patient?

38) A 26-year-old man presents to the physician's office with a two-day history of multiple symptoms, including rash on his trunk, headache, fatigue, malaise, myalgias, and high-grade fever. The rash is not associated with pain, itching, or burning. It has expanded over the last two days. He went on a camping trip in Vermont two weeks ago, and recalls a tick bite at that time. There is a single lesion on his trunk, which is erythematous with central clearing. The rest of the examination is unremarkable. What is the most appropriate next step in the management of this patient?

39) A 35-year-old HIV-positive male comes to the physician's office because of pain on swallowing and substernal burning for the last 3 days. Examination of the oral cavity is unremarkable. Lungs are clear to auscultation and percussion. His current medications include zidovudine, didanosine, indinavir, trimethoprim-sulfamethoxazole, and azithromycin. His last CD4 count is 40cells/microl. What is the most appropriate next step in the management of this patient?

40) A 25-year-old HIV-positive male comes to a physician with complaints of headache and left-sided weakness of recent onset. His temperature is 38°C (100.8°F), blood pressure is 115/70mm Hg, respirations are 14/min, and pulse is 73/min. Neurological examination reveals decreased power, hyperreflexia, and upgoing plantars in the left upper and lower limb. Neuroimaging by CT shows multiple ring-enhancing lesions. What is the most appropriate next step in management?

41) An 18-year-old young man comes to your clinic with complaints of fatigue, malaise, fever, and sore throat for the past few days. His temperature is 38.8°C (101°F), pulse is 90/min, respirations are 18/min, and blood pressure is 135/70 mm Hg. Physical examination reveals cervical lymphadenopathy, pharyngeal hyperemia, and splenomegaly. Complete blood count shows leukocytosis with predominant atypical lymphocytes. The heterophile antibody test is positive. When you ask if he has any questions, he replies with, "Well, I'm a rugby player in school, so I need to know when I can start playing again." What is the most appropriate advice for this patient?

42) A 25-year-old man presents to the physician's office because of a clenched fist injury ("fight bite") incurred during a gang fight. The injury occurred two days ago and he has now started to develop pain, swelling, and redness around the wound. His immunizations are up to date. His wounds are cleaned in the clinic. Plain films of hand do not show evidence of foreign body or osteomyelitis. Which of the following is the most appropriate antibiotic for his current condition?

43) A 30-year-old white, HIV-infected male from Ohio presents with low-grade fever, anorexia and weight loss of 3.6kg (Bib) for the past 3 weeks. His baseline PPD test was negative. His pulse is 87/min, blood pressure is 126/76 mm Hg, temperature is 38.3°C (101°F), and respirations are 18/min. Examination shows oropharyngeal ulcers and hepatosplenomegaly. Lab testing shows: Hematocrit 36%, Platelet count 50,000/microL, WBC count 3,100/microL. Blood culture establishes the diagnosis of histoplasmosis. What is the most appropriate next step in the management of this patient?

44) A 7-year-old boy is brought to the office by his mother due to anal pruritus for the past month. His symptoms are most severe at night. Physical examination is normal, except for mild perianal erythema. Stool examination is normal. "Scotch tape test" is positive. Which of the following is the most appropriate treatment for this child's condition?

45) A 37-year-old man comes to his primary care physician for the evaluation of slightly pruritic skin lesions around his anus. He denies fever, malaise, and anorexia. He is sexually active with multiple male partners and occasionally uses condoms. He has never been tested for HIV or other sexually transmitted diseases. He has no drug allergies. Examination shows skin-colored, verrucous, papilliform lesions around his anus. Which of the following is the most appropriate treatment for this patient?

46) A 28-year-old, HIV-infected female from Michigan is admitted with Pneumocystis jirovecii pneumonia (PCP) secondary to noncompliance with prophylaxis. She was diagnosed with HIV infection three years ago. Her C04 count on admission is 30/microl, and viral load is 300,000copies/ml. Her pneumonia is adequately treated with IV antibiotics, and she subsequently receives zidovudine, lamivudine, nelfinavir, and trimethoprim-sulfamethoxazole. What is the most appropriate drug to be added to her current regimen?

47) A 65-year-old Connecticut resident calls your office after finding a 3 mm red-brown tick attached to his right leg. He just returned from a hiking trip and was about to a take a shower when he discovered the tick. Which of the following is the best advice to give this patient?

49) A 65-year-old African-American man is hospitalized after a car accident. He has a vertebral fracture at the level of the fifth thoracic vertebra and is unable to move his lower extremities. Since his injury, he has needed a catheter for micturition. Which of the following is the most effective measure for decreasing the risk of a urinary tract infection in patients requiring bladder catheterization?

50) A 32-year-old man from Arkansas presents to physician with a two-day history of fever, headache, malaise, and myalgias. His family says that he seems slightly confused. He recalls having a tick bite two weeks ago after walking through the woods. His temperature is 39°C (102°F), pulse is 90/min, and blood pressure is 125/80 mm Hg. Neck is supple and there is no lymphadenopathy noted. Oropharynx is clear. Chest auscultation is unremarkable. Abdomen is soft and non-tender. There is no rash evident. Neurologic examination is nonfocal. Laboratory testing shows: Complete blood count:Hemoglobin 14.0 g/L, MCV 88 fL, Platelets 78,000/mm3, Leukocyte count 2,500/mm3, Neutrophils 56%, Eosinophils 1%, Lymphocytes 33%, Monocytes 10%. Liver studies:Total protein, serum 6.5 g/dL, Total bilirubin 1.0 mg/dL, Direct bilirubin 0.8 mg/dL, Alkaline phosphatase 110 U/L, Aspartate aminotransferase (SGOT) 98 U/L, Alanine aminotransferase (SGPT) 105 U/L. What is the most appropriate next step in the management of this patient?

51) A 22-year-old woman presents to the emergency department after she is bitten on her right arm by her neighbor's dog. She provoked the dog while it was eating. The dog is not immunized against rabies, but does not show any signs of rabies. Her right forearm shows a deep bite wound. Her last tetanus booster was 3 years ago. Her wound is cleaned with soap, water, and povidone-iodine solution. What is the most appropriate next step in the management of this patient?

52) A 25-year-old male comes to the clinic because of a painless ulcer on his penis. He denies fever or urethral discharge, but admits to recent sexual activity with a prostitute. He describes severe rash and face swelling with penicillin. Physical examination reveals a shallow, non-tender ulcer. There is no lymphadenopathy. Darkfield microscopy reveals spirochetes. Which of the following is the most appropriate treatment for this patient?

54) A 36-year-old woman who lives in the suburbs of a large city comes to your office for a tuberculin skin test. She will be volunteering in her daughter's school cafeteria and the school district requires tuberculin testing. You inject a small amount of Mycobacterium tuberculosis purified protein derivative (PPD) in the skin and 2 days later she returns for a reading. You measure 12 mm of induration. She reports no history of tuberculosis exposure and no underlying medical conditions. She has never before been tested for tuberculosis. She was born in the United States, is not a healthcare worker, and has never spent time in prison. What is the best next step in her management?

56) A 5-year-old Hispanic girl is brought to the emergency department (ED) due to a cat bite on her right upper extremity. She was bitten after rambunctiously playing for several minutes with the cat, which had just been given to her as a birthday gift. Her most recent booster tetanus vaccine was one year ago. Her temperature is 36.7°C (98°F), blood pressure is 108/70 mm Hg, pulse is 107/min, and respirations are 21/min. Physical examination reveals a deep puncture wound on the volar aspect of her right forearm. Before going to the ED, her mother cleaned the wound with hydrogen peroxide. There is no visible debris in the wound, and little bleeding is evident. Neurovascular function is intact. Her wound is cleaned in the ED with Betadine and lavaged with saline solution. What is the best next step in managing this girl's care?

57) A 57-year-old male comes to your office in the middle of January. He complains of a 4-day history of a nonproductive cough and coryza. He also has vague muscle aches and a mild headache. He denies any shortness of breath or chest pain. His past medical history is significant for hyperlipidemia and impaired glucose tolerance. He takes aspirin and simvastatin 40 mg at bedtime. He has no known drug allergies. His medical records show that he did not show up for his scheduled annual influenza vaccine this year. His temperature is 38.5°C (101.3°F), blood pressure is 135/80 mm Hg, and pulse is 88/min. Physical examination shows conjunctival redness and an erythematous oropharynx. The tympanic membranes are clear. The heart sounds are audible with no added murmurs, rubs or gallops. His breath sounds are vesicular in quality and equal bilaterally. Which of the following is the most appropriate next step in management?

58) A 60-year-old Caucasian woman undergoes elective coronary artery bypass surgery and aortic valve replacement. Her postoperative course is complicated by acute renal failure, atrial fibrillation, and pulmonary edema. On the third postoperative day, extubation is attempted but not tolerated, thus warranting reintubation. On the fifth postoperative day, she develops a fever to 38.9°C (102°F). Her pulse is 110-120/min and irregular, respirations are 36/min, and blood pressure is 110/65 mmHg. Her chest x-ray shows right middle and lower lobe infiltrates. WBC count is elevated with bandemia. Gram stain of her sputum shows gram-negative rods. She is given intravenous ceftriaxone; however, she deteriorates over the next 24 hours. Which of the following is the most appropriate next step in the management of this patient?

59) A 34-year-old man is traveling in Southeast Asia on business. He is staying in Western-style hotels and eating food in large restaurants. He has not eaten from street vendors. One week after arrival, he develops symptoms of anorexia, nausea, and abdominal cramps followed by the sudden onset of watery diarrhea. He has no fever or chills and there is no blood or pus in the stools. Which of the following is the most appropriate therapy for his condition?

60) A 45-year-old woman is undergoing chemotherapy for breast cancer. She presents 10 days after her last chemotherapy with fever (temperature > 38.5°C), but no other symptoms except a sore throat and mouth. On examination, she looks well, there is oral mucositis, ears are normal, lungs are clear, and the central line site is clean. The CXR, urinalysis, and biochemistry are normal. Her WBC is 800/mL and the absolute neutrophil count is low ( < 500). Which of the following is the most appropriate next step in management?

61) A 74-year-old man residing in a nursing home develops symptoms of high fever, diarrhea, chest pain, and nonproductive cough. His temperature is 40°C, blood pressure 120/80 mm Hg, respiration 24/min, and oxygen saturation 90%. He has bibasilar crackles, normal heart sounds, and a soft nontender abdomen. His CXR reveals bilateral lower lobe infiltrates. He is not able to provide any sputum, and the urine is positive for legionella antigen. Which of the following is the most appropriate antibiotic choice?

62) A 28-year-old female presents to her internist with a 2-day history of low-grade fever and lower abdominal pain. She denies nausea, vomiting, or diarrhea. On physical examination, there is temperature of 38.3°C (100.9°F) and bilateral lower quadrant tenderness, without point or rebound tenderness. Bowel sounds are normal. On pelvic examination, an exudate is present and there is tenderness on motion of the cervix. Her white blood cell count is 15,000/μL and urinalysis shows no red or white blood cells. Serum β-hCG is undetectable. Which of the following is the best next step in management?

63) Two students from a university dormitory building have contracted meningitis due to Neisseria meningitides. Which of the following students in the dormitory are most likely to benefit from chemoprophylaxis?

64) You are a physician in charge of patients who reside in a nursing home. Several of the patients have developed influenza-like symptoms, and the community is in the midst of influenza A outbreak. None of the nursing home residents have received the influenza vaccine. Which course of action is most appropriate?

65) A 22-year-old university student complains of fatigue and malaise for the past 2 weeks. She also reports feeling feverish, and recently had a sore throat. Physical examination reveals enlarged tonsils and palpable cervical lymph nodes. There is also tenderness in the right upper quadrant on deep palpation, and minimal splenomegaly. Laboratory data show hemoglobin 13 g/dL; hematocrit 40%; platelets 340,000/mL; WBC 9400/mL, with 35% segmented neutrophils, 1% eosinophils, and 64% lymphocytes, of which 36% were atypical. A heterophil antibody (sheep cell agglutination) test is positive. Which of the following is the most appropriate initial treatment for this condition?

66) A 44-year-old renal transplant patient develops severe cough and shortness of breath on exertion. On examination, he appears dyspneic, respirations 24/min, pulse 110/min, and oxygen saturation 88%. His lungs are clear on auscultation and heart sounds are normal. CXR shows bilateral diffuse perihilar infiltrates. Bronchoscopy and bronchial brushings show clusters of cysts that stain with methenamine silver. Which of the following is the most appropriate next step in management?

67) A businesswoman needs to make frequent trips to South America, but every time she is there, she develops traveler’s diarrhea, which requires her to change her business schedule. To prevent future episodes during business trips, she is inquiring about prophylaxis methods. Which of the following is the most helpful advice for her?

68) A 30-year-old male patient complains of fever and sore throat for several days. The patient presents to you today with additional complaints of hoarseness, difficulty breathing, and drooling. On examination, the patient is febrile and has inspiratory stridor. Which of the following is the best course of action?

69) A 35-year-old previously healthy male develops cough with purulent sputum over several days. On presentation to the emergency room, he is lethargic. Temperature is 39°C, pulse 110, and blood pressure 100/70. He has rales and dullness to percussion at the left base. There is no rash. Flexion of the patient’s neck when supine results in spontaneous flexion of hip and knee. Neurologic examination is otherwise normal. There is no papilledema. A lumbar puncture is performed in the emergency room. The cerebrospinal fluid (CSF) shows 8000 leukocytes/μL, 90% of which are polys. Glucose is 30 mg/dL with a peripheral glucose of 80 mg/dL. CSF protein is elevated to 200 mg/dL. A CSF Gram stain shows gram-positive diplococci. Which of the following is the correct treatment option?

70) A young man has recently been bitten by a stray dog. He has a penetrating wound to the right forearm. The dog is nowhere to be found. In the emergency room, the wound is cleaned with water and povidone-iodine solution. Which of the following is the most appropriate next step in management?

71) A 22-year-old male, recently incarcerated and now homeless, has received one week of clarithromycin for low-grade fever and left upper-lobe pneumonia. He has not improved on antibiotics, with persistent cough productive of purulent sputum and flecks of blood. Repeat chest x-ray suggests a small cavity in the left upper lobe. Which of the following statements is correct?

72) A 23-year-old woman visits your office because of headache, malaise, anorexia, pain in both sides of her jaw, and discomfort in both lower abdominal quadrants. Physical examination reveals enlarged parotid glands; bilateral lower quadrant abdominal tenderness; a temperature of 38.7°C; and a pulse rate of 92/min. Serologic testing (IgM) confirms the diagnosis of mumps. Which of the following is the most appropriate treatment for this condition?

73) A 25-year-old woman complains of dysuria, frequency, and suprapubic pain. She has not had previous symptoms of dysuria and is not on antibiotics. She is sexually active and on birth control pills. She has no fever, vaginal discharge or history of herpes infection. She denies back pain, nausea, or vomiting. On physical examination she appears well and has no costovertebral angle tenderness. A urinalysis shows 20 white blood cells per high power field. Which of the following statements is correct? .

74) A 40-year-old woman cut her finger while cooking in her kitchen. Two days later she became rapidly ill with fever and shaking chills. Her hand became painful and mildly erythematous. Later that evening her condition deteriorated as the erythema progressed and the hand became a dusky red. Bullae and decreased sensation to touch developed over the involved hand. What is the most important next step in the management of this patient?

75) A 60-year-old man comes to the physician because of a 2-week history of worsening fatigue. He has chronic renal insufficiency, hypertension, diabetes mellitus, hypercholesterolemia, hypothyroidism, polymyalgia rheumatica and depression. He was started on lisinopril for the prevention of proteinuria from diabetic nephropathy. Physical examination shows a few basal crackles. He is being considered for dialysis. Laboratory studies show hyperkalemia with serum K + of 6.0 mEq/L. EKG shows no abnormalities. Which of the following is the best treatment to remove K+ from his body?

76) A 45-year-old man with advanced chronic renal failure comes to the physician because of edema of his feet. His temperature is 37°C (99°F), blood pressure is 150/100mm Hg, pulse is 78/min, and respirations are 15/min. Examination shows bilateral ankle edema. Laboratory studies show BUN of 62 mg/dl, serum creatinine of4.2 mg/dl, serum potassium of 5.6 meq/l, serum sodium of 146 meq/l, and total plasma cholesterol of 260 mg/dl. Which of the following is most likely to improve the prognosis of his disease?

78) A 23-year-old male hospitalized for confusion and seizures is treated with intravenous high-dose acyclovir. On the third day of hospitalization, his serum creatinine level increases to 3.4 mg/dl from a baseline of 0.9 mg/dl at admission. The observed finding could have been potentially prevented by which of the following?

79) A 27-year-old man comes to the physician because of a 1-day history of fever and joint pains. He is being treated with cephalexin for a skin infection. His urine has turned darker. His temperature is 38.5°C (101.3°F), blood pressure is 125/70 mm Hg, pulse is 90/min, and respirations are 15/min. Examination shows a skin rash; examination otherwise shows no abnormalities. Urinalysis shows: 8 RBCs/HPF, 12 WBCs/HPF with white cell casts, eosinophiluria, and a mild degree of proteinuria. Laboratory studies show a BUN of 40 mg/dl and serum creatinine of 2.2 mg/dl. Which of the following is the most appropriate next step in management?

80) A 30-year-old man is admitted to the hospital with a diagnosis of acute renal failure secondary to poststreptococcal glomerulonephritis. On his fifth hospital day, he develops retrosternal, non-radiating chest pain which is relieved by leaning forward. He denies the use of tobacco or drugs. He drinks alcohol occasionally. He has no past history of any serious illness. His temperature is 37.6°C (99.8°F), blood pressure is 145/95 mm Hg, pulse is 80/min, and respirations are 20/min. A pericardial friction rub is heard on chest auscultation. The rest of the examination shows no abnormalities. EKG shows ST segment elevation in all leads, with elevation of the PR segment in lead aVR. The chest x-ray is normal. Urinalysis shows hematuria, red cell casts and mild proteinuria. Laboratory studies show a BUN level of 60 mg/dl and a serum creatinine level of 3 8 mg/dl. What is the most appropriate next step in management?

81) A 47-year-old diabetic woman comes to the physician due to the recent onset of tremors. She has undergone combined pancreatic and kidney transplantation secondary to end stage renal disease and diabetes. She takes multiple medications, including immunosuppressants. Her temperature is 36.1° C (97°F), blood pressure is 152/90 mm Hg, pulse is 78/min, and respirations are 16/min. Examination shows gum hypertrophy. Laboratory studies show: Hb 13.0 g/dl, WBC 8,000/cmm, Serum Na 135 mEq/L, Serum K 5.3 mEq/L, BUN 26 mg/dl, Serum Creatinine 1.7 mg/dl. Which of the following immunosuppressants is most likely responsible for her presentation?

82) A 45-year-old male patient comes to the physician's office for a routine check-up. He denies any symptoms and says he feels "perfectly healthy." He was diagnosed with hypertension and mixed hypercholesterolemia a year ago. He is currently taking hydrochlorothiazide, amiloride and simvastatin daily. He does not use tobacco, alcohol or drugs. His blood pressure today is 135/85 mm Hg. Physical examination shows no abnormalities. Routine blood results reveal the following: CBC: Hb 14.2g/dL, Ht 42%, MCV 86 fl, Platelet count 260,000/cmm, Leukocyte count 8,500/cmm, Neutrophils 70%, Eosinophils 1%, Lymphocytes 24%, Monocytes 5%. Serum: Serum Na 140 mEq/L, Serum K 5.7 mEq/L, Chloride 100 mEq/L, Bicarbonate 24 mEq/L, BUN 10 mg/dL, Serum Creatinine 1.1 mg/dL, Calcium 9.0 mg/dL, Blood Glucose 118 mg/dL, Total cholesterol 220 mg/dL, LDL cholesterol 130 mg/dL. The blood sample is checked and is not hemolysed. The EKG shows normal sinus rhythm. What is the most appropriate next step in the management of this patient?

83) A 50-year-old man comes to the emergency department due to a sudden onset of severe, colicky pain in the right flank. He was admitted twice in the past for similar complaints; he was managed conservatively and sent home on both occasions. He has no other medical problems. He does not use tobacco, alcohol or drugs. His vital signs are stable. He is given IV fluids and narcotics. Laboratory studies show: Hb 14.5 g/dL, WBC 13,000/cmm; no bands, Platelets 300,000/cmm, BUN 16 mg/dl, Serum Creatinine 0.8 mg/dl. CT scan of the abdomen without contrast shows renal calculi. Which of the following is the best advice for the prevention of future stones in this patient?

84) A 64-year-old male with a past medical history of hypertension, diabetes and chronic renal insufficiency presents with gross hematuria. His baseline serum creatinine is 1.6-1.7 mg/dl. The patient's medications include aspirin, hydrochlorothiazide, enalapril, and simvastatin. He has no known environmental, medication, or contrast allergies. On physical examination, the patient has a blood pressure of 130/80 mm Hg. The examination is otherwise unremarkable. Contrast CT scan of the abdomen is planned to evaluate his condition. Which of the following interventions would be most helpful in preventing contrast-induced kidney damage?

85) A 26-year-old man comes to the emergency department because of a sudden onset of severe rightsided flank pain. The pain is colicky and radiates from the flank to the scrotum. He also has nausea, vomiting and dark-colored urine. He has never had these symptoms before. His temperature is 37°C (98.6°F), blood pressure is 126/70 mm Hg, pulse is 90/min, and respirations are 18/min. Examination shows no abnormalities. He is given adequate analgesia. Non-contrast helical CT shows a 4 mm radiopaque stone in the right upper ureter. Laboratory studies show serum calcium of 9.8 mg/dl, serum creatinine of 0.9 mg/dl, and BUN of 15mg/dl. Urinalysis shows hematuria but no casts. Which of the following is the most appropriate next step in management?

87) A 72-year-old woman with poorly controlled type 2 diabetes mellitus presents to your clinic one week after being discharged from the hospital. She had been admitted with pyelonephritis secondary to a multi-drug resistant organism, and received several days of intravenous antibiotics. Her serum creatinine on admission had been 2.1 mg/dl. Today it is found to be 4.9 mg/dl. Urinalysis reveals rare epithelial casts and no white blood cells. FENa is greater than 2%. What antibiotic did she most likely receive during her hospitalization?

88) A 58-year-old man comes to the physician and complains of "problems with erection." He has recurrent and persistently painful erections. His other medical problems include ulcerative colitis, kidney stones, insomnia, depression, hypertension, drug-induced diabetes, obesity and hypercholesterolemia. He does not use tobacco, alcohol, or drugs. He takes prednisone, mesalamine, insulin, 6mercaptopurine, simvastatin, glyburide, enalapril, trazodone, and fluoxetine. He has no known drug allergies. His vital signs are stable. The general physical examination is unremarkable. Avoidance of which of the following medications could have prevented his condition?

89) A 30-year-old woman comes to the physician due to the recent onset of occipital headaches. She has taken acetaminophen several times, but the pain returns. She has no fever or visual problems. She has not had similar episodes in the past. She has no history of serious illness. Her temperature is 36.1°C (98°F), blood pressure is 160/90 mm Hg, pulse is 88/min, and respirations are 16/min. Physical examination shows a rightsided renal bruit Which of the following is the most appropriate treatment for this patient's condition?

90) A 45-year-old man with known cirrhosis due to hepatitis C is admitted to the hospital for abdominal discomfort and confusion. Physical examination reveals a distended abdomen, leg edema, and deep yellow discoloration of the skin and sclerae. Bibasilar crackles are heard on chest auscultation. His serum sodium level is 127 mEq/L, potassium level is 2.9 mEq/L, and creatinine level is 1.3 mg/dl. On day 3 of his hospitalization, the serum creatinine is 4.2mg/dl. A urinalysis reveals: Protein negative, Glucose negative, WBC 4-5/hpf, RBC 0-1/hpf. Renal ultrasound is normal and the post-void residual urinary volume is less than 50 ml. He is given 2 L of normal saline intravenously with no change in his serum creatinine concentration. This patient's kidney dysfunction can be best corrected by which of the following?

91) A 56-year-old man develops oliguria three days after having a kidney transplantation. His postoperative course was uncomplicated. His blood pressure is 160/100 mm Hg and heart rate is 90/min. Palpation of the transplant reveals mild tenderness. Laboratory studies show: Serum sodium 145 mEq/L, Serum potassium 5.5 mEq/L, Serum calcium 8.6 mg/dl, Serum creatinine 3.2 mg/dl, BUN 30 mg/dl. His serum cyclosporine level is normal. Renal ultrasonography does not detect dilatation of the calyces. Biopsy of the transplant shows heavy lymphocyte infiltration and vascular involvement with swelling of the intima. Which of the following is the most appropriate next step in management?

92) A 25-year-old woman comes to the physician because of a 3-day history of burning micturition and increased urinary frequency. She has suprapubic discomfort. She denies having unusual vaginal discharge. She has been sexually active and monogamous for the past 4 years with her husband. Her temperature is 37.1°C (98.9°F), blood pressure is 110/70 mm Hg, pulse is 68/min, and respirations are 15/min. Examination shows suprapubic tenderness without flank tenderness. The rest of the examination is normal. Urinalysis shows: Specific gravity 1.020, Blood Trace, Glucose Negative, Ketones Negative, Leukocyte esterase Positive, Nitrites Positive, WBC 40-50/hpf, RBC 6-10/hpf, Bacteria 50+. Which of the following is the most appropriate next step in management?