C2 proteins
C2 Proteins Knowledge Quiz
Test your knowledge on the complexities of C2 proteins and related immunology topics with this comprehensive quiz! Designed for medical students, healthcare professionals, and anyone interested in the subject matter, this quiz features 18 thought-provoking questions.
Highlights of the quiz:
- Covers key concepts in immunoglobulins and plasma proteins
- Multiple choice format for engaging learning
- Ideal for enhancing your understanding in clinical biochemistry and laboratory medicine
The diagnosis of myeloma requires that two of the following are present
Organ damage, high level of uric acid, paraprotein in urine
Paraprotein in urine, anemia, low platelet count
Paraprotein in serum/urine, bone marrow infiltration with plasma cells, organ damage
Hypercalcemia, paraprotein in serum, pancytopenia
Paraprotein in serum, paraprotein in urine, organ damage
Indicate the wrong statement regarding the immunoglobulins
Polyclonak hyperimmunoglobulinemia (hypergammaglobulinemia) results in a diffuse increase in protein mass around the gamma globulin region on electrophoresis
Polyclonal hyperimmunoglobulinemia (hypergammaglobulinemia) results from an increased synthesis from a number of cell (lymphocyte) lines
All myelomas produce heavy chains
Paraproteins may be found in patients without any associated pathology
Paraproteins may arise from any if the immunoglobulin class
Indicate the wrong statement regarding the plasma proteins
Hypoalbuminemia can be induced by hypervolemia (or over hydration)
Increase in total protein in a serum sample is usually due to an increase in the globulin fraction
Decrease in total protein in a serum sample is usually due to hypoalbuminemia
Hypoalbuminemia occurs in advanced liver disease
Hypoealbuminemia in the inflammatory response is due to decreased albumin synthesis
Which serum level of CRP (mg/L) is most likely indicative of infection (if exceeded)
15
100
0.3
30
3 (10)
Which of the following are known to decrease in response to injury
Properdin, haptoglobin, C3 complement, a1-antitrypsin, selenium
T3, selenium, albumin, iron, HDL
Haptoglobin, C5 complement, HDL, LDL, ceruloplasmin, TSH
Haptoglobin, C4 and C5 complement, a1-antitrypsin, ceruloplasmin, fibrinogen
Haptoglobin, C3 complement, HDL, a2-macroglobulin, serum amyloid-A
Indicate the wrong statement regarding the immunoglobulins
Paraproteins are found in heavy chain disease
In 50% of cases of multiple myeloma only light chains are found
Light chains in urine are referred to as Bence-Jones proteinuria
Paraproteins may be found on electrophoresis
Paraproteins are found in multiple myeloma
All of the following acute phase proteins are known to increase in response to injury except
Properdin
Ceruloplasmin
A1-antitrypsin
C-reactive protein
Haptoglobin
Hypoealbuminemia due to increased loss occurs in
Nephrotic syndrome
Malnutrition
Liver disease
Acute phase response
Overhydration
Indicate the wrong statement regarding the metabolic response to injury
Ebb phase may progress to the recovery
ESR is useful in monitoring day-to-day changes in the inflammatory response
Albumin is useful in monitoring day-to-day changes in the inflammatory response
Ebb phase may progress to the SIRS
Flow phase may last for weeks
Indicate the wrong statement regarding the immunoglobulins/paraproteins
Paraprotein is an intact immunoglobulin (or its fragment)
Benign paraproteinemia refers to the presence of plasma fibrinogen in the gamma region on electrophoresis
Paraproteins are found in Waldenstrøms macroglobulinemia
Paraprotein (monoclonal hypergammaglobulinemia) and polyclonal hypergammaglobulinemia can be distinguished by gel electrophoresis
Urine electrophoresis can show the presence of Bence-Jones protein
Common biochemical derangements in SIRS include
Hypernatremia, hypoalbuminemia, high T3
SIAD, hypoalbuminemia, high T3
SIAD, hypoalbuminemia, low T3
Hypernatremia, hypoalbuminemia, high TSH
SIAD, low iron, high TSH
Hypoalbuminemia due to increased loss occurs in
Burns
Malabsorption
Liver disease
Acute inflammation
Malnutrition
Criteria for the diagnosis of SIRS include
Temp > 38, pCO2 <32mmHg, WBC > 12000 per mm3, heart rate >100/min, respiratory rate >20/min
Temp >37, pCO2 >32mmHg, WBC > 4000 per mm3, heart rate >100/min, respiratory rate >12/min
Temp > 38, pCO2 >32mmHg, WBC > 4000 per mm3, heart rate >90/min, respiratory rate >20/min
Temp > 38, pCO2 <32mmHg, WBC > 12000 per mm3, heart rate >90/min, respiratory rate >20/min
Temp > 38, pCO2 >32mmHg, WBC > 12000 per mm3, heart rate >100/min, respiratory rate >12/min
Normal serum CRP concentration (mg/L) is up to
30
3 (10)
15
0.3
100
Which of the following are known to increase in response to injury
Haptoglobin, C5 complement, HDL, LDL, ceruloplasmin, TSH
Properdin, haptoglobin, C3 complement, a1-antitrypsin, selenium
Haptoglobin, C3 complement, HDL, a2-macroglobulin, serum-amyloid-A
T2, selenium, C4 complement, fibrinogen, C-reactive protein, a2-macroglobulin
Haptoglobin, C4 and C5 complement, a1-antitrypsin, ceruloplasmin fibrinogen
Indicate the wrong statement regarding the CRP and ESR
The rate of change of ESR is less than that of CRP
CRP reflects an intensity of the acute phase response
In the evaluation of paraproteinemias CRP is more useful than ESR
ESR reflects an intensity of the acute phase response
ESR can be affected by anemia
Which protein binds iron in tissues
Ferritin
Transthyretin
Iron binding globulin
Transferrin
Haptoglobin
Below is a serum protein electrophoresis SPEP, arrow indicates
Y-globulin
A1-globulin
Albumin
A2-globulin
B-globulin
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