Grafalon Training Manual I (SOT)
Grafalon Training Manual I Quiz
This quiz is designed to test your knowledge on key concepts related to solid organ transplantation (SOT) and immunosuppression, focusing primarily on Grafalon. Engage with a variety of questions that cover definitions, clinical stages, and recent studies relevant to kidney transplantation.
- Assess your understanding of immunology in transplantation.
- Explore risk factors associated with graft fun
ction. - Learn about the implications of existing research in the field.
Which definition(s) are on the below is/are correct?
Post-transplant lymphoproliferative disease (PTLD): B cell proliferation due to therapeutic immunosuppression after organ transplantation.
Crossover renal transplantation (paired kidney exchange transplant): an exchange between two or more couples who are prevented result from donating their kidneys to their preferred recipients by ABO incompatibility or a positive cross-match.
Human leukocyte antigen (HLA) system: a gene complex encoding the major histocompatibility complex proteins in humans
Renal insufficiency: poor function of the kidneys that may be due to a reduction in blood-flow to the kidneys, caused by renal artery disease. Normally, the kidneys regulate body fluid and blood pressure, as well as regulating blood chemistry and remove organic waste
Immunoglobulin: any of a class of proteins present in the serum and cells of the immune system, which function as antibodies
Which organ procurement variables are risk factors for delayed graft function?
Age and health status of the donor
Marriage status of the donor
Cold ischemia time
Cold storage preservation
Inotropic support of donor
Which of the following is wrong about immunosupression in SOT?
Greater degree of immunosuppression may reduce the risk of rejection, but may also increase the risk of infection and cancer.
Induction therapy is treatment with a biological agent (i.e., polyclonal or monoclonal antibodies).
Induction therapy should begun immediately after transplantation
Maintenance immunosuppressive medication is a long-term treatment to prevent acute rejection and deterioration of graft function. [
The purpose of induction therapy is to deplete or modulate T-cell responses at the time of antigen presentation
Which are the below are the clinical stages of rejection?
Hyperacute rejection: Within minutes hours post transplant
Humoral rejection: Immediately or during first week
Acute rejection: Within first 6 months
Hyperdelayed rejection: Within first 6 months
Chronic rejection 6 months - years
Which definition(s) on the below is/are right?
CMV is probably the most important viral pathogen to consider in SOT recipients
Incidence of orthopedic diseases and bone fractures increased among kidney transplanted population
PTLD has an overall incidence of 1-2% after kidney transplantation (30 to 50 times higher than in the general population) and there is a strong association with EBV infection, with 98% of cases associated with latent EBV infection
Cancer is a major source of morbidity and mortality following solid organ transplantation
The incidence of cardiovascular disease (CVD) is high after kidney transplantation
Which is/are the below are right?
Song study found that Grafalon appears to be more effective than THG in improving the shortterm kidney transplantation outcomes and
Kamar et al. (2020) showed that in highly sensitised kidney-transplant patients without pre-formed donor-specific antibodies, both Grafalon and basiliximab can be used efficiently and safely
Thymoglobulin was associated with higher risk of infection, cytomegalovirus infection, de novo diabetes and malignancy compared to Grafalon
Kaden (2013) showed superiority of TDT + HDI Grafalon vs TDT alone in improving longterm graft survival was achieved without increasing the risk for infections, malignancies or other adverse events
Du et al. (2016) showed that reperfusion use of single high dose (9 mg/kg) Grafalon can effectively reduce incidence of acute rejection without affecting occurrence of infections, the incidence of delayed graft function and graft and patient survival
The incidence of new-onset diabetes after transplantation (NODAT) patients requiring insulin therapy in the +CS group approached statistical significance vs the -CS group in Cantarovich study
Right
Wrong
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