Triplet Repeat Diagnostic Techniques: Part 1 - Southern Blot
Based on the results shown in the southern blot, which individual is most likely to have a reduced gene product?
A
B
C
D
E
F
None of the above
Which of the individuals is a non-carrier female?
A
B
C
D
E
F
3.Why is FMRP expression sensitive to methylation status of the FMR1 gene?
A. Methylation occurs in the 5’ UTR.
B. The methylation masks a cryptic splice acceptor site.
C. Methylation is responsible for the repeat expansion instability.
D. None of the above
Which of the four classes of FMR1 repeat regions have the smallest CGG repeat size:
Normal
Grey Zone
Premutation
Full Mutation
Full mutation - methylated
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