Pharmaco- Chak Thida

An agonist describes on the drug action to:
Change in biologic function through its chemical action.
Bind to a receptor, stimulus cellular activity
Regulatory molecule in the biologic system
Bind to a receptor, inhibit cellular activity.
Direct at parasites infecting the patient.
An antagonist describes on the drug action to:
Change in biologic function through its chemical action.
Bind to a receptor, stimulus cellular activity.
Regulatory molecule in the biologic system.
Bind to a receptor, inhibit cellular activity.
Direct at parasites infecting the patient.
Pharmacokinetics and pharmacodynamic is the effect of the:
Drug on a drug; Body on the drug
Body on the drug; Drug on a drug
Drug on the body; Body on the drug
Body on the drug; Drug on the body
Drug on a drug; Drug on a drug
Psychoactive drugs:
Interact between drugs and their receptor
Interact with particular target sides
Interact with all receptors
Change in physiological function
Change in psychological function
Psychopharmacology mention about the drugs effect mean:
Interact between drugs and their receptor
Interact with particular target sides
Interact with all receptors
Change in physical symptoms
Change in psychological function
What type of drugs can cross the blood-brain barrier (BBB)?
Large and lipid-soluble
Large and lipid-insoluble
Small and lipid-soluble
Small and lipid-insoluble
Which of the following is an example of a drug acting directly through receptors?
Protamine binds to heparin anticoagulants
Adrenergic beta blockers induced tachycardia
Epinephrine for increasing blood pressure
Cancer chemotherapeutic agents
Mannitol for subarachnoid hemorrhage
Pharmacokinetic principal absorption: What organ is responsible for metabolism in the "first pass effect"?
Brain
Heart
Kidney
Liver
Spleen
Which of the following enteral administration routes has the largest first-pass effect?
SL (sublingual)
Buccal
Rectal
Oral
Which of the following locations would most trap a lipid soluble drug?
Blood
Intestines
Brain
Stomach
A decrease in drug-protein binding will lead to which of the following?
Decrease in the unbound drug concentration
Increase in free drug
Increase in rate of drug elimination
Decrease in volume of distribution
Which of the following is the least important for passage through capillary walls but the most important for passage through the cell wall?
Molecular size
Lipid solubility
Diffusion constant
PH
PKa
Which of the following metabolically active tissues is the principle organ for drug metabolism?
Skin
Kidneys
Lungs
Liver
GI Tract
Anxiolytic drug are used to treat:
Symptoms of Depression
Symptoms of Anxiety
Symptoms of Psychosis
Symptoms of Bipolar
What is the major effect of Prozac?
Loss of hair
Loss of sexual desire
Weight loss
Weight gain
Drug Called benzodiazepine are used to treat:
Depression
Schizophrenia
Mood disorders
Anxiety disorders
What is meant by a binding site
The target area that is occupied by a drug when it binds
The proportion of te drug to which a drug target binds.
The group function used by a drug in binding to the target
The bounds involved in binding a drug to its target
Which of the following pairs of receptors illustrates convergent evolution?
The D2 ad D3 dopaminergic receptor subtypes
The D4 and D5-dopaminergic receptor subtypes
The β1 and β2-adrenoceptor subtypes
The M3 and M5-muscarinic receptor subtypes
Which of the following terms is used to describe a drug that has the same effect on a receptor as the endogenous chemical messenger?
Agonist
Antagonist
Partial agonist
Inverse agonist
Benzodiazepine have found wide use in:
An increasing muscle tension and anxiety
Maintenance muscle tension and anxiety
Decreasing muscle tension and anxiety
Balancing muscle tension and anxiety
Benzodiazepine use with small dose effect on:
Produce Sleep/Sedation
An increasing muscle tension
Release depressive mood
Decrease muscle tension
Benzodiazepine use with large dose effect on:
Produce Sleep/Sedation
Release anxious feeling
Release depressive mood
Muscle relaxant
Half-life of Xanax is:
6-12 hours
9-12 hours
12- 16 hours
12- 24 hours
Half-life of Clonazepam is:
1-2 hours
3-4 hours
5-6 hours
7-8 hours
Contra-indication of Benzodiazepine could be:
Obsessive thought
Respiratory depression
Compulsive thought
Panic attack
Adverse effect of Benzodiazepine is:
Increased concentration
Decreased concentration
Increase attention
Increase memory
Adverse effect of Anti-histamine is:
Extrapyramidal syndromes
Orthostatic Hypotension
Fever and rash
Urine retention
Structure of anti-depressant type:
Selective Serotonin Reuptake inhibitor
Typical anti-depressant
Tricyclic anti-depressant
Tetracyclic anti-depressant
All tricyclics block reuptake pumps for both 5HT and NE, inserted H1 receptor will produce adverse effect such as:
Weigh gain
Constipation
Blurred vision
Deceased blood pressure
All tricyclics block reuptake pumps for both 5HT and NE, inserted M1 cholinergic will produce adverse effect such as:
Weigh gain
Constipation
Dizziness
Deceased blood pressure
All tricyclics block reuptake pumps for both 5HT and NE, inserted alpha-1 adrenergic will produce adverse effect such as:
Weigh gain
Constipation
Drowsiness
Deceased blood pressure
Long-term treatment is usually required for patients with schizophrenia in order to:
Prevent relapse
Balance functioning
Balance brain function
Prevent side effect
Shot-term treatment is usually required for psychotic patients in order to:
Calm and sedate patient
Stop psychotic feature
Calm and better functioning
Prevent side effect
The typical antipsychotic drug is the most well-known as high potency drug such:
Chlorpromazine
Haloperidol
Thioridazine
Perphenazine
The antipsychotic drug “ Risperidone” is:
1st generation
2nd generation
Typical antipsychotic
1st and 2nd generation
The most likely due to increases prolactin secretion due to its dopamine receptor blocking action in the pituitary and hypothalamus
Chlorpromazine
Haloperidol
Thioridazine
Perphenazine
The main antipsychotic drug effects via interference with central dopaminergic pathways in the mesolimbic and medullary chemoreceptor of the brain is.
Chlorpromazine
Haloperidol
Thioridazine
Perphenazine
Which is antipsychotic drug may cause agranulocytosis and hypotension.
Chlorpromazine
Haloperidol
Thioridazine
Perphenazine
The equivalent dose of 2 types antipsychotic drug is
25mg Chlorpromazine = 1mg haloperidol
50mg Chlorpromazine = 1mg haloperidol
25mg Chlorpromazine = 2mg haloperidol
50mg Chlorpromazine = 2mg haloperidol
Psychopharmacology mention about the drugs action mean:
Interact between drugs and their receptor
Interact with particular target sides
Interact with all receptors
Change in physiological function
Change in psychological function
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