Osteoporosis

Which statement is true about bone physiology and pathophysiology?

Estrogen is important in women and men to prevent bone resorption.

Bone loss due to aging is predominantly from increased osteoclast apoptosis.

Osteoprotegerin prevents RANKL from binding to the Wnt signaling pathway.

Sclerostin inhibits cathepsin K, thereby decreasing bone resorption.

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