A 36-year-old woman who lives in the suburbs of a large city comes to your office for a tuberculin skin test. She will be volunteering in her daughter's school cafeteria and the school district requires tuberculin testing. You inject a small amount of Mycobacterium tuberculosis purified protein derivative (PPD) in the skin and 2 days later she returns for a reading. You measure 12 mm of induration. She reports no history of tuberculosis exposure and no underlying medical conditions. She has never before been tested for tuberculosis. She was born in the United States, is not a healthcare worker, and has never spent time in prison. What is the best next step in her management?
Chest X-ray
Observation@
Isoniazid for 6 months
Isoniazid with pyridoxine for 9 months
Isoniazid, rifampin and pyrazinamide for 8 weeks
A 22-year-old male student presents with an acute onset of fever, double vision, and painful swelling around his eyes. He also has significant muscle pain in his neck and jaw muscles. A week earlier, he experienced a period of abdominal pain, nausea, vomiting, and diarrhea, all of which resolved spontaneously. He has a history of intravenous drug abuse but has recently completed of a drug rehabilitation program. He is febrile. Physical examination shows "splinter" hemorrhages, periorbital edema, and chemosis. Chest is clear to auscultation. Cardiac exam reveals no murmur. Abdomen is soft and nontender with no organomegaly. His complete blood count is shown below: Hemoglobin 13.0 g/L MCV 85 fl Platelets 228,000/mm3 Leukocyte count 10,500/mm3 Neutrophils 56% Eosinophils 21% Lymphocytes 23% Based on these findings, what is the most likely diagnosis?
Trichinellosis
Botulism
Infective endocarditis
Guillain Barre syndrome
Angiooedema
A 55-year-old pig farmer is brought to the emergency department (ED) after having a seizure two hours ago. During his transit to the ED, he has another seizure. On arrival, he is unconscious, pulseless, and not breathing. Resuscitation is successful and the patient is stabilized; however, he does not do well over the next several days and is eventually declared dead. His wife says that he had been healthy most of his life, except for the past few weeks, when he was complaining of headaches. Autopsy shows multiple fluid-filled cysts in the brain parenchyma. Which of the following is the most likely diagnosis of this patient?
Neurocysticercose
Lymphoma
Metastase brain tumor
Glioblastoma multiforme
Tuberculoma of brain
A 12-year-old boy is brought to the emergency department because of severe pain near his left knee. He has sickle cell disease, and has been hospitalized previously for sickle cell crisis. Vital signs are notable for mild fever. Examination of the left lower extremity reveals a normal knee joint with marked tenderness and swelling over the proximal tibia. Labs show leukocytosis and elevated ESR. He is subsequently diagnosed with osteomyelitis. Which of the following organisms is the most likely cause of his condition?
Escherichia coli
Pseudomonas species
Salmonella species
Staphylococcus aureus
Group B streptococcus
A 55-year-old man has undergone renal transplantation due to end-stage renal failure. His postoperative course was uncomplicated. He is currently taking prednisone and cyclosporine. He is afebrile and his pulse is 80/min, respirations are 14/min, and blood pressure is 130/65 mm Hg. Physical examination is unremarkable. Which of the following should be added to his current medication regimen to prevent opportunistic infections?
Trimethoprim-sulfamethoxazole
Oseltamivir
Ltraconazole
Azithromycin
Penicillin
A 23-year-old male comes to ER with five-day history of diarrhea and abdominal pain. Initially, the diarrhea was watery occurring five-six times per day but yesterday he noticed blood in the stool which prompted his visit to ER. He describes his abdominal pain as colicky and severe. He also complains of nausea and decreased appetite but he has had no vomiting. His past medical history is insignificant and never had similar symptoms. He is not sexually active and he denies any illicit drug use. He has no history of recent travel. His father had colon cancer and his uncle died of liver cirrhosis. His temperature is 36.6C (98.0F), blood pressure is 123/82 mmHg and heart rate is 102/min. On examination, he has prominent periumbilical and right lower quadrant tenderness but no guarding or rebound. Rectal examination reveals brownish stool mixed with blood. Which of the following is the most likely diagnosis?
Clostridium difficile colitis
E coli infection
Lnflammatory bowel disease
Protozoal infection
Vibrio infection
A 24-year-old man is found to be HIV positive. He is asymptomatic. Physical examination is unremarkable. Laboratory tests show: CD4 count 400/micro-L HIV viral load 9,000 copies/mL VDRL negative Toxoplasma serology negative PPD test 6mm induration His chest x-ray is unremarkable. What is the most appropriate next step in the management of this patient?
Reassurance and repeat testing in 2 month
Isoniazid and pyridoxine for 9 months
Rifampin for 9 months
Rifampin, isoniazid, pyrazinamide, and ethambutol for 2 months, then isoniazid and rifampin for 4 months
Rifampin, isoniazid, and pyrazinamide for 6 months
A very worried 25-year-old woman comes to the office, presents a positive pregnancy test, and says, "I'm six weeks pregnant. Two months ago, I received the rubella vaccine and my doctor told me to avoid getting pregnant for the next three months. I'm very concerned about the health of my unborn baby. I'd like to know all the available options to prevent any harm to my baby." What is the most appropriate next step in the management of this patient?
Reassurance
Explain the risks and benefits of abortion
Advise abortion
Serological testing for rubella
Ultrasonography
A 65-year-old man presents to the emergency department with a two-day history of fever, headache, altered mental status, and vomiting. His past medical history is significant for renal transplantation secondary to polycystic kidney disease, hypertension, and diabetes. He takes aspirin, insulin, nifedipine, cyclosporine, and prednisone. He has no known drug allergies. His temperature is 39.2C (102.5F), pulse is 102/min, respirations are 18/min, and blood pressure is 120/75 mm Hg. He is alert but confused. Fundoscopy does not show any abnormalities. His neck is stiff. Lungs are clear to auscultation. He has a normal S1 and S2 with a II/IV systolic ejection murmur heard best in the right infraclavicular area. Complete blood count shows a WBC count of 17,000/cm3 with neutrophilic leukocytosis. His blood is drawn and sent for culture. Lumbar puncture is performed and the results are pending. Which of the following is the most appropriate empiric antibiotic therapy for this patient?
Ceftriaxone
Ceftriaxone + vancomycine
Cefotaxime+ ampicilline
Ceftriaxone and vancomycine and ampiciline
Ceftazidime and vancomycine
A 30-year-old male has recently been diagnosed with HIV infection. He denies drug abuse. He is currently asymptomatic, and physical examination is unremarkable. He is in a stable heterosexual relationship. Laboratory studies show a CD4 count of 350/microL, HIV viral load of 15,000 copies/mL, negative VDRL, negative toxoplasma serology, tuberculin skin test of 7 mm induration, negative HBsAg, and positive anti-HBsAg antibodies. Hepatitis C antibodies are negative. Complete blood count, serum chemistries, and liver function tests are within normal limits. He has not received any vaccinations since being diagnosed with HIV. Which of the following vaccines is indicated in this patient?
BCG vaccine
Hepatitis A vaccine
Hepatitis B vaccine
Pneumococcal vaccine
Meningococcal vaccine
A 60-year-old Caucasian woman undergoes elective coronary artery bypass surgery and aortic valve replacement. Her postoperative course is complicated by acute renal failure, atrial fibrillation, and pulmonary edema. On the third postoperative day, extubation is attempted but not tolerated, thus warranting reintubation. On the fifth postoperative day, she develops a fever to 38.9 C (102 F). Her pulse is 110-120/min and irregular, respirations are 36/min, and blood pressure is 110/65 mmHg. Her chest x-ray shows right middle and lower lobe infiltrates. WBC count is elevated with bandemia. Gram stain of her sputum shows gram-negative rods. She is given intravenous ceftriaxone; however, she deteriorates over the next 24 hours. Which of the following is the most appropriate next step in the management of this patient?
Stop ceftriaxone and start piperacillin-tazobactam
Continue ceftriaxone and add vancomycin
Stop ceftriaxone and start clindamycin
Continue ceftriaxone and add ceftazidime
Continue ceftriaxone and add amphotericin
A 42-year-old man with advanced HIV infection has a two-week history of pain and difficulty with swallowing. He was given fluconazole for these symptoms one week ago, but his pain has worsened. His current medications include tenofovir, emtricitabine, efavirenz, and trimethoprim-sulfamethoxazole. His CD4 count is 90/microl and viral load is 300,000copies/ml. Endoscopy reveals large, irregular, linear ulcers in the esophagus. A biopsy of the abnormal mucosa reveals tissue destruction and the presence of intranuclear and intracytoplasmic inclusions. Which of the following is the most appropriate pharmacotherapy for this patient?
Prednisone
Acyclovir
Ganciclovir
Pentamidine
Ltraconazole
A 26-year-old man presents to the physician's office with a two-day history of multiple symptoms, including rash on his trunk, headache, fatigue, malaise, myalgias, and high-grade fever. The rash is not associated with pain, itching, or burning. It has expanded over the last two days. He went on a camping trip in Vermont two weeks ago, and recalls a tick bite at that time. There is a single lesion on his trunk, which is erythematous with central clearing. The rest of the examination is unremarkable. What is the most appropriate next step in the management of this patient?
Perform ELISA for confirmation of Lyme disease
Perform western blot for confirmation of Lyme disease
Give him oral doxycycline
Give him oral amoxicillin
Give him intravenous ceftriaxone
A 55-year-old Asian man with mitral stenosis secondary to rheumatic heart disease undergoes dental surgery for caries. Postoperatively, he does well and is discharged home. Two weeks later, he presents with fever, chills, fatigue, and feels "sick." Four out of four blood culture bottles are positive for gram-positive cocci. An echocardiogram is performed and shows mitral valve vegetations. Which of the following is the most likely causative organism of this patient's condition?
Groupe B streptococci
Streptococcus mutans
Streptococci bovis
Staphylococcus epidermis
Enterococci
A 16-year-old Asian boy presents with a two-day history of fever, malaise, and painful enlargement of his parotid glands. He has no significant past medical history. He was born in India, and has not received any childhood vaccinations. He recently returned from a one-week vacation in India. His vital signs are stable, except for a mild fever. Examination shows bilateral parotid enlargement. The rest of the examination is unremarkable. Which of the following organs is most likely to be affected by this patient's illness?
Testes
Pancreas
Liver
Kidney
Sleep
A 29-year-old man returns home to Colorado after a diving trip to Honduras in Central America. He was gone for 6 days. The day he returns, he starts to develop diarrhea, abdominal cramping, and nausea. There is no mucus and blood in the stool. He has no other medical problems and does not take medications. He does not use tobacco, alcohol or drugs. His temperature is 37.2 C (98.9 F), blood pressure is 120/74 mm Hg, pulse is 80/min, and respirations are 15/min. There is no lymphadenopathy. Chest is clear to auscultation. Abdomen is soft and non-tender. There is no organomegaly. Bowel sounds are increased. Stool is negative for leukocytes and fecal occult blood. Which of the following is the most likely pathogen responsible for his symptoms?
Giardia
Cyclospora
Escherichia coli
Vibrio cholerae
Salmonella
A 54-year-old patient walks into a blood donation camp at a community hospital. His blood report shows an ELISA positive for HIV and HBsAg. He is notified of this finding, and a subsequent western blot test is also positive for HIV. Considering this new diagnosis of HIV, which of the following is indicated in this patient?
Hepatitis B vaccine
PPO skin test and anti-Toxoplasma antibody titer
Serum transaminases and lipid profile
Trimethoprim-sulfamethoxazole prophylaxis
Hepatitis C antigen
A 7-year-old Caucasian boy with a history of cystic fibrosis presents to the emergency department with a two-day history of high-grade fever and cough productive of purulent, green-colored sputum. He also complains of chest pain, which is worsened by breathing. His temperature is 39.6C (103.2F), pulse is 112/min, respirations are 26/min, and blood pressure is 90/60 mm Hg. Chest examination shows dullness on percussion and increased tactile fremitus in the right lung base. Chest x-ray shows a right lower lobe infiltrate. Which of the following is the most appropriate pharmacotherapy for this patient?
Ceftriaxone and gentamicin
Azithromycin
Piperacillin and ciprofloxacin
Dicloxacillin
Piperacillin and tobramycin
A 35-year-old HIV-positive male comes to the physician's office because of pain on swallowing and substernal burning for the last 3 days. Examination of the oral cavity is unremarkable. Lungs are clear to auscultation and percussion. His current medications include zidovudine, didanosine, indinavir, trimethoprim-sulfamethoxazole, and azithromycin. His last CD4 count is 40cells/microl. What is the most appropriate next step in the management of this patient?
Esophagoscopy with biopsy, cytology and culture
Oral Fluconazole
Oral Famotidine
Oral Acyclovir
Oral Ganciclovir
A 32-year-old homosexual male with HIV infection presented to his physician with skin lesions. He first noted these lesions last month, and has since observed a change in color from pink to violet. There is no associated pain, itching, or burning. He was diagnosed with HIV infection three years ago and has been noncompliant with his medications. His pulse is 80/min, blood pressure is 115/70 mm Hg, respirations are 14/min, and temperature is 37.1 C (98.8F). The appearance of his lesions is illustrated below: His CD4 count is 30/microl, and viral load is 300,000copies/ml. Which of the following is the most likely cause of his current condition?
Human herpesvirus 8 (HHV-8)
Human papillomavirus
Pneumocystis jiroveci
Poxvirus
Herpes simplex type 2 (HSV-2)
A 31-year-old, HIV-infected man from New York presents to the ER with anorexia, malaise, night sweats, fever, and weight loss of 6.8kg (151b) over the past one month. He also has a cough productive of yellow sputum. He was diagnosed with HIV two years ago. When last checked two months ago, his CD4 count was 220/microL. He is not taking any medications. His temperature is 39.2C (102.2F), pulse is 96/min, and blood pressure is 120/80 mm Hg. Physical examination reveals rales in his right upper chest. Laboratory studies show: Hematocrit 30% WBC count 3,400/microL Neutrophils 86% Bands 2% Lymphocytes 4% Monocytes 8% PPD test shows 3 mm induration. Chest x-ray reveals a right upper lobe cavitation. Sputum examination shows partially acid-fast, filamentous, branching rods. Based on these findings, which of the following organism is the most likely cause of this patient's pulmonary disease?
Pneumocystis jiroveci
Mycobacterium tuberculosis
Coccidioides species
Nocardia species
Streptococcus pneumonia
A 36-year-old man from Ohio presents with fever, malaise, fatigue, and skin lesions on his right forearm. His fever is low-grade, without any rigors or chills. His temperature is 38.4C (101 F), pulse is 87/min, and blood pressure is 124/74mm Hg. Examination shows 1-2cm warty, heaped-up skin lesions with a violaceous hue and sharply demarcated border. Some of these lesions are crusted. Wet preparation of purulent material from skin lesions shows yeast Based on these findings, what is the most likely diagnosis
Histoplasmosis
Blastomycosis
Coccidioidomycosis
Aspergillosis
Sporotrichosis
A 45-year-old man comes to the office and complains of intermittent, bloody diarrhea and abdominal pain for the past month. During this time period, he has lost six pounds. He was diagnosed with HIV infection in the past, but has refused antiretroviral therapy. Laboratory results show a CD4 count of 50cells/μL. The stool examination is negative. Colonoscopy with biopsy shows multiple colonic ulcerations and mucosal erosions. The biopsy shows large cells containing eosinophilic intranuclear and basophilic intracytoplasmic inclusions. What is the most likely cause of this patient's diarrhea?
Cryptosporidium
Cytomegalovirus
Entamoeba
Kaposi sarcoma
Mycobacterium avium complex
A 22-year-old man comes to the urgent care clinic with a one-week history of fever, sore throat, and malaise. He has tried several over-the-counter products with partial relief. His temperature is 38.8C (102F), pulse is 110/min, respirations are 18/min, and blood pressure is 130/70 mm Hg. Oropharyngeal examination reveals palatal petechiae with streaky hemorrhages and blotchy, red macules. The tonsils are enlarged and covered with whitish exudate. Mild jaundice is present. Enlarged lymph nodes are palpable posterior to the sternocleidomastoid muscle bilaterally. Axillary lymphadenopathy is also present. Abdominal examination reveals normal bowel sounds and mild hepatosplenomegaly. His complete blood count is shown below: Hemoglobin 14.0 g/L MCV 88fl Platelets 140,000/mm3 Leukocyte count 14,500/mm3 Neutrophils 33% Lymphocytes 66% Eosinophils 1% Which of the following is commonly associated with this patient's condition?
Bronchopneumonia
Splenic infarction
Hepatocellular carcinoma
Dilated cardiomyopathy
Autoimmune hemolytic anemia
A 25-year-old HIV-positive male comes to a physician with complaints of headache and left-sided weakness of recent onset. His temperature is 38C (100.8F), blood pressure is 115/70mm Hg, respirations are 14/min, and pulse is 73/min. Neurological examination reveals decreased power, hyperreflexia, and upgoing plantars in the left upper and lower limb. Neuroimaging by CT shows multiple ring-enhancing lesions. What is the most appropriate next step in management?
Trimethoprim-sulfamethoxazole
Sulfadiazine and pyrimethamine
Brain biopsy
Brain irradiation
Anti-tuberculous therapy
A 43-year-old male presents to a physician with an ulcer on the shaft of his penis. The ulcer is non-tender, with a raised border and a smooth base. There is bilateral inguinal adenopathy. The rest of the examination is unremarkable. Dark field microscopy of a specimen from the ulcer base reveals spirochetes. Which of the following additional screening studies should be performed on this patient
VDRL
FTA-ABS
HIV antibodies by ELISA
Proctosigmoidoscopy
Serum prostate specific antigen
A 25-year-old female presents to her physician with a painful ulcerative lesion on her labia for the past 2 days. She also complains of dysuria. She admits to having sexual intercourse with multiple partners for the last 6 years. Tzanck preparations of one of her lesions reveal multi-nucleated giant cells. She is encouraged to undergo testing for HIV and other STDs. Which of the following is the most appropriate screening test for HIV infection?
HIV serology by ELISA
HIV serology by western blot
HIVviralload
Absolute CD4 count
P 24 antigen assay
A 73-year-old diabetic man presents with low-grade fever, facial pain over his right maxilla, and bloody nasal discharge for the last three days. For the last day, he has had diplopia. He was diagnosed with diabetes mellitus 10 years ago. For the last year, he has been on insulin. His most recent hemoglobinA1C was 12.0. His temperature is 39.0C (102.2F), pulse is 88/min, and blood pressure is 130/76mm Hg. Examination shows right-sided nasal congestion and necrosis of the right nasal turbinate with tenderness over the right maxillary sinus. There is chemosis and proptosis of his right eye. CT scan shows opacification of the right maxillary sinus. Which of the following is the most likely causative organism?
Rhizopus species
Staphylococcus aureus
Pseudomonas aeruginosa
Haemophilus influenzae
Moraxel/a cat arrha/is
An 18-year-old young man comes to your clinic with complaints of fatigue, malaise, fever, and sore throat for the past few days. His temperature is 38.8C (101 F), pulse is 90/min, respirations are 18/min, and blood pressure is 135/70 mm Hg. Physical examination reveals cervical lymphadenopathy, pharyngeal hyperemia, and splenomegaly. Complete blood count shows leukocytosis with predominant atypical lymphocytes. The heterophile antibody test is positive. When you ask if he has any questions, he replies with, "Well, I'm a rugby player in school, so I need to know when I can start playing again." What is the most appropriate advice for this patient?
He can start playing when he becomes afebrile
He can start playing when he is no longer fatigued
He can start playing when his labs normalize
He can start playing when his physical examination is normal
He can start playing whenever he wants
A 25-year-old man presents to the physician's office because of a clenched fist injury ("fight bite") incurred during a gang fight. The injury occurred two days ago and he has now started to develop pain, swelling, and redness around the wound. His immunizations are up to date. His wounds are cleaned in the clinic. Plain films of hand do not show evidence of foreign body or osteomyelitis. Which of the following is the most appropriate antibiotic for his current condition?
Amoxicillin-clavulanate
Clindamycin
Ampicilline
Erythromycine
Ciprofloxacine
A 30-year-old white, HIV-infected male from Ohio presents with low-grade fever, anorexia and weight loss of 3.6kg (Bib) for the past 3 weeks. His baseline PPD test was negative. His pulse is 87/min, blood pressure is 126/76 mm Hg, temperature is 38.3C (101F), and respirations are 18/min. Examination shows oropharyngeal ulcers and hepatosplenomegaly. Lab testing shows: Hematocrit 36% Platelet count 50,000/microL WBC count 3, 1 00/microL Blood culture establishes the diagnosis of histoplasmosis. What is the most appropriate next step in the management of this patient?
IV amphotericin B followed by lifelong treatment with itraconazole
IV amphotericin B till the cultures become negative
Ltraconazole till the cultures become negative
IV amphotericin B plus itraconazole till the cultures become negative
Lifelong treatment with itraconazole
A 67-year-old man presents to his primary care provider in January with fever and a productive cough. The patient had been seen ten days earlier with complaints of fever to 102F (39.0C), myalgias, rhinorrhea, and dry cough. At that time, his lung exam revealed occasional crackles. He was given a medication and told to follow up if his symptoms worsened. The symptoms did remit over the first five days, but he began to feel worse again two days ago. He smokes a half-pack of cigarettes per day and drinks alcohol several times a week. On exam today, his temperature is 102.3F (39.3C), and lung exam reveals increased tactile fremitus in the left lower lobe. What is the most likely pathogen responsible for his current condition?
Pneumocystis jiroveci
Klebsiella pneumoniae
Pseudomonas aeruginosa
Mycoplasma pneumoniae
Staphylococcus aureus
A 54-year-old diabetic woman comes to the emergency department because of increasing neck and facial pain, fever, and chills. A few weeks ago, she developed an infection on the side of her neck. She thought it would go away with over-the-counter medication, but the infection has now started to drain. For the past twenty years, she has had diabetes, which is well-controlled with an oral hypoglycemic. She denies trauma, travel, and smoking. Physical examination reveals an area of erythema and induration at the base of the neck. Serosanguineous fluid is draining from a small defect in the skin near the center of the lesion. There is no crepitus. Histological analysis of the discharge reveals the presence of gram-positive, branching bacteria. The treatment for this patient is·
Surgical debridement
Start triple combination TB therapy
Start amphotericin
Hyperbaric oxygenation
Intravenous penicillin
A 28-year-old man presents to ER with fever, chills, and generalized weakness for the past one week. He has no history of pre-existing heart disease, but he was admitted to the hospital six months ago for cellulitis of the right arm. His temperature is 40.0C (104 F), pulse is 110/min, respirations are 22/min, and blood pressure is 110/65 mmHg. Oropharynx is clear. Lungs are clear to auscultation. A holosystolic murmur is heard at the lower sternum which increases in intensity with inspiration. His blood is drawn and sent for culture. What is the most appropriate initial antibiotic therapy for this patient?
Ampicillin-sulbactam
Clindamycin
Oxacillin
Penicillin G and gentamycin
Vancomycin
A 43-year-old HIV-positive male presents to your office with several exophytic purple skin masses on his lower abdomen. Physical examination reveals tender hepatomegaly and an abdominal CT scan shows nodular, contrast-enhanced intrahepatic lesions of variable size. Liver biopsy is attempted but severe hemorrhage results. Which of the following is the most likely cause of this patient's condition?
Mycobacteria
Spirochetes
Bartonella
Clostridia
Brucella
A 23-year-old, HIV-infected female presents with a five-day history of fever and productive cough. She is on antiretroviral therapy, and her CD4 count is 300/mm3. Her temperature is 39.0C (102.5F), pulse is 95/min, respirations are 22/min, and blood pressure is 115/76 mm Hg. Physical exam reveals dullness to percussion and bronchial breath sounds in the right lung base. Chest x-ray is shown below. What is the most likely cause of this patient's symptoms?
Streptococcus pneumonia
Mycobacterium tuberculosis
Disseminated coccidioidomycosis
Pneumocystis jiroveci (P. jiroveclj
Pseudomonas aeruginosa
A 7-year-old boy is brought to the office by his mother due to anal pruritus for the past month. His symptoms are most severe at night. Physical examination is normal, except for mild perianal erythema. Stool examination is normal. "Scotch tape test" is positive. Which of the following is the most appropriate treatment for this child's condition?
Pyrantel pamoate
Albendazole
Metronidazole
Thiabendazole
Lvermectin
A 45-year-old female presents to emergency room complaining of urinary frequency, burning during urination, and weakness. Her last menstrual period was one year ago, and she is not sexually active. She is not taking any medications. Her temperature is 37.8 C (100 F), blood pressure is 120/76 mmHg, pulse is 80/min, and respirations are 14/min. Very mild costovertebral angle tenderness is present. IV ceftriaxone is started. Two days later, the patient feels much better. Antibiotic susceptibility testing returned with an uropathogen (E. coli) highly sensitive to ceftriaxone, gentamicin, ciprofloxacin and trimethoprim/sulfamethoxazole (TMP/SMX). Which of the following is the most reasonable next step in the management of this patient?
Add ciprofloxacin to the regimen
Switch to TMP/SMX
Switch to gentamicin
Continue ceftriaxone
Discontinue antibiotic therapy
A 19-year-old man presents to your office with a one-week history of fever, fatigue, and sore throat. He denies diarrhea or rash. He has no significant past medical history. His brother died of cystic fibrosis at 14 years of age. He admits to occasional cigarette use and alcohol consumption. He has smoked marijuana several times but has never used injectable drugs. He is sexually active with one partner and uses condoms occasionally. Physical examination reveals enlarged tonsils with a whitish exudate and enlarged, slightly tender lymph nodes deep to the sternocleidomastoid muscle bilaterally. The exam is otherwise unremarkable. Which of the following is the best initial test in this patient?
Rapid plasma reagin (RPR)
HIV antibody determination
Lymph node biopsy
Purified protein derivative
Heterophile antibody test
A 24-year-old man from Long Island, New York, presents with fever, drenching sweats, and malaise for the past week. For the last few days, he has noted jaundice and dark-colored urine. He recalls being bitten by a tick two weeks ago. His surgical history includes splenectomy after a car accident 10 years ago. He does not use tobacco, alcohol, or illicit drugs. His temperature is 39.5C (103F), pulse is 106/min, and blood pressure is 110/70 mm Hg. Systemic examination is unremarkable, except for jaundice. Based on these findings, what is the most likely diagnosis?
Malaria
Babesiosis
Ehrlichiosis
Q fever
Lyme disease
A 37-year-old man comes to his primary care physician for the evaluation of slightly pruritic skin lesions around his anus. He denies fever, malaise, and anorexia. He is sexually active with multiple male partners and occasionally uses condoms. He has never been tested for HIV or other sexually transmitted diseases. He has no drug allergies. Examination shows skin-colored, verrucous, papilliform lesions around his anus. Which of the following is the most appropriate treatment for this patient?
Podophyllin
Erythromycin
Doxycicline
Tetracycine
Penicilline
28-year-old, HIV-infected female from Michigan is admitted with Pneumocystis jirovecii pneumonia (PCP) secondary to noncompliance with prophylaxis. She was diagnosed with HIV infection three years ago. Her C04 count on admission is 30/microl, and viral load is 300,000copies/ml. Her pneumonia is adequately treated with IV antibiotics, and she subsequently receives zidovudine, lamivudine, nelfinavir, and trimethoprim-sulfamethoxazole. What is the most appropriate drug to be added to her current regimen?
Azithromycin
Genciclovir
Fluconazole
Itraconazole
Rifabutin
A 27-year-old, HIV-positive man comes to his physician with a two-day history of fever, profuse watery diarrhea, and abdominal cramps. He has been taking zidovudine, didanosine, and indinavir for the past eight months. His temperature is 37.9C (100.2F), pulse is 102/min, respirations are 14/min, and blood pressure is 105/70 mm Hg. He is started on fluid and electrolyte support. What is the most appropriate next step in the management of this patient
Stop antiretroviral therapy and send stool for Clostridium difficile toxin assay
Colonoscopy with biopsy of the colonic mucosa
Stool examination for ova and parasites
Stool examination for ova and parasites@ D. Start empiric treatment for cytomegalovirus
Loperamide and lactose-free diet until diarrhea subsides
A 65-year-old Connecticut resident calls your office after finding a 3 mm red-brown tick attached to his right leg. He just returned from a hiking trip and was about to a take a shower when he discovered the tick. Which of the following is the best advice to give this patient?
Crush the tick with your fingers
Remove the tick with tweezers
Apply petroleum jelly over the tick
Come to the office tomorrow for tick removal
Let the tick detach spontaneously
A 75-year-old female nursing home resident complains of cough and fever. Her past medical history is significant for hypertension, myocardial infarction (experienced two years ago), and a traumatic right foot amputation. Her current medications are atenolol, hydrochlorothiazide, and aspirin. Her temperature is 39.4 C (103 F), pulse is 110/min, respirations are 22/min, and blood pressure is 110/76 mmHg. Crackles are present at right lung base. Chest x-ray reveals a right lower lobe infiltrate. Which of the following pathogens is the most likely cause of this patient's condition?
Staphylococcus aureus
Streptococcus pneumoniae
Haemophilus influenzae
Anaerobic bacteria
Gram-negative rods
1. Quel est le diagnostic d’un patient avec état dyspnéique fébrile après 48h d’hospitalisation? (QRU) (SBA)
Pneumonie communitaite
Pneumonie nosocomiale
Pneumonie inhalation
Brohnochite aigue
Pneumocytose
2. Devant un tableau de Pneumonie au cours d’hospitalisation, quel examen clinique faites-vous? (QRU) (SBA)
Auscultation cardiaque
D. Regardez sur son état veineux
Regardez son sonde urinaire
Examen neurologie
C. Intérogatoire pour savoir s’il y a des troubles de déglutition
Examen clinique montrait une toux avec des crachats verdâtres avec des crépitants basale droite, quel examen paraclinique demandez-vous pour confirmer le diagnostic ? (QRU) (SBA)
CRP + NSF + VS
Tubage gastrique
Radiographie
Bronchoscopie
Echo abodomino pelvienne
4. La Radio pulmonaire montrait une opacité floue basale droite. Le diagnostic est confirmé pour une Pneumonie nosocomiale, quel est le germe le plus souvent peut responsable dans cette pathologie?
Streptococcus susi
Streptococcus pneumoniae à SDP
Staphylococcus Blanc
Staphylococcus Méti-Résistant
Pseudomonase spp
5. Quel est le traitement proposez-vous pour une Pneumonie nosocomiale (germe indéterminé)? (QRU) (SBA)
Ceftazidime
Ceftriaxone + Moxifloxacine
Ceftazidime+_vancomycine
Amoxicilline + Acide clavulanique
Carbapenem
6. Quel sont les examens para-cliniques nécessares pour diagnostiquer d`une infection à cryptocoque chez patients VIH+: (QRU) (SBA)
Tx.CD4
PCR et VS
LCR culture
LCR test à l`encre de Chine
Coloration de Ziel
7. Quand peut on débuter le traitement par des ARV chez d`une méningite tuberculeuse (QRU) (SBA)
1 mois après induction des anti TB
A la fin du traitement d`attaque par des anti-TB
Deux semaines après induction des anti TB
Quand le patient à tolérer avec des anti TB
Une semaine après induction des anti-TB
8. Le but d`utilisation des corticoïdes dans le traitement de méningite à TB
Lutte contre oedème cérébrale
Effet sinergique avec les anti-TB
Amélioration des effets indésirables des Anti-TB
Aider les effets des Antibiotique
Lutte contre la réaction paradoxale
9. Etude des LCR: Quel sont les arguments possible pour diagnostiquer le méningite à TB (QRU) (SBA
A. Hypo-albuminorrachie
PMN predominent
Normoproteinurachie
Hyperproteinorachie
Predominent lymphocyte
10. Quand peut on débuter des AVR chez le patient VIH ?
CD4<350
CD4>500/mm3
CD4<250/mm3
Stade de clinique 4 (OMS classification)
Stade de clinique de SIDA ou stade C (CDC classification)
11. Définition d’une infection nosocomiale
Avant d’être hospitalisé
Au cours d’une hospitalisation
Après 48h d’hospitalisatio
Après une semaine d’hospitalisation
Après avoir réalisé des gestes invasifs (intubé ventilé, FOGD, Sonde urinaire…)
12. Quelle antibiotiques anti-staphylococcique à choisir devant une infection due au Staph Méti-R
Vancomycine
Ceftriazone
Amoxicilline
Cefaxidime
Oxaciline
13. Quelle antibiotique peut-on donner pour une infection dû au group de Pseudomonas :
Bactrime
Ofoxacine
Ceftiaxone
Acide flucinique
Ceftaxidime
14. Quelles sont les infections nosocomiales le plus rencontrée au Cambodge
Infection digestive
Infection urinaire
Infection respiratoire
Infection post operatoire
Infection sur catherter
15. Quel est le cause de l’hyper-éosinophilie le plus rencontré au Cambodge
Cause parasite
Cause allergie
Cause neoplasme
Maladie du sang
Utilisation de antiobiotique
16. Devant une hyperéosinophilique, quel examen demander vous en premier intention
CRP+ VS+NFS
Auto anticorp
BOM
Coproculture
Examen de la selle et parasite
17. Dans quel l’instant pouvez-vous faire en association les antibiotiques
Pneumopathies communotaires graves et hypoxémiantes
La pyélonéphrite aigue simpl
Infections Streptococciqu
Fièvre chez le sujet lymphopéni
Abcès amibienne du foie
18. Quels sont les points suivient de l’echec antibiothérapie
nouvelle infection
persistance des signes > 48h
pas d’ extension localisé
réapparition au cours de la convalescente
disparition de métastase septique
19. Le choix de l’antibiothérapie tenir compte selon
le diagnostic bactériologique sans signe Clinique
Site de infection
le patient a présenté une fièvre aigue seule
Les laboratiore
Le tarif
20. Chez un malade adulte en état de choc hypovolémique par déshydratation suite à des pertes digestives, quel est le principe de votre expansion volémique initiale ?
1 à à 1,5 ml/kg de cristalloïdes / 20 minutes
100 à 150 ml/kg de cristalloïdes / 20 minutes
10à à 15 ml/kg de cristalloïdes / 20 minutes
1 à à 1,5 ml/kg de colloïdes / 20 minutes
D. 100 à à 15o ml/kg de colloïdes / 20 minutes
21. Vous êtes appelé au lit d’un patient de 57 ans aux antécédents de BPCO qui présente une DRA avec des signes d’ACR imminent. Vous suspectez un pneumothorax (distension thoracique + silence + tympanisme unilatéral). Que faites (QRU)
Vous augmentez l’O2 à 6l/min
. Vous appelez un réanimateur pour exsuffler le PNO
Vous vérifiez la coagulation avant d’exsuffler
Vous transferer au Rea
Vous appelez les autres
22. Chez quel(s) patients la prescription d’O2 est-elle potentiellement iatrogène ?
A. Chez tous les BPCO
B. Chez tous les Insuffisants respiratoires chroniques obstructifs
C. Chez tous les insuffisants respiratoires chroniques restrictifs
D. Chez tous les patients hypoxiques chroniques
E. Chez tous les patients hypercapniques chroniques
23. Chez un patient fébrile hospitalisé, les arguments suivant pour ne pas commencer tout de suite une ATB-thérapie sont corrects, sauf un
A. Sa température n’est pas très élevée à 37.8°C
B. Il présente une déshydratation intra-cellulaire qui peut expliquer sa fièvre
C. Il n’y a pas de syndrome inflammatoire biologique
D. Il n’y a pas de signes de gravité clinique ni biologique
E. Il existe des arguments pour une infection virale
24. Vous prenez en charge un malade en ACC à l’hôpital. Il était en détresse respiratoire depuis plusieurs heures auparavant. Avant de poser un scope, quelle est votre hypothèse pour son tracé ECG ? (QR
B. Dissociation Electro-Mécanique
Asystiolie
Fibrilaltion ventriculaire
Tachycardie ventriculaire
Torsade de point
25. Vous réalisez une RCP de base chez un patient en ACC. Dans quel ordre réalisez-vous les gestes ? A = Airways (LVAS) ; B = Breathing = ventilation ; C = Circulation = MCE (QRU)
A-B-C
B-A-C
C-A-B
C-B-A
B-C-A
26. Patient VIH avec crise convulsive généralisée cédant spontanément, Quel est votre diagnostic neurologique? (QRU)
A. Criseépileptique partielle simple
C. Criseépileptique partielle secondairement généralisée
A. Criseépileptique partielle complique
Etat de mal epileptique
D. Criseépileptique partielle generalize tonico-clonique
27. Patient VIH avec crise convulsive fébrile, CD4 à a20/mm3, quel diagnostic évoquezvous en priorité?
Hypoglycemie
Toxoplasmose cerebral
Metastase cerebral
AVC hemorragique
LEMP
28. Quelsont les éléments typiques que vous recherchez sur le scanner pour conforter votre diagnostic?
C. Hyperdensité spontanée parenchymateuse, non systématisé
Abces cerebrle unique
Oedeme peri lesionnel
E. Dilatation quatriventriculaire
B. Image en cocarde multiple
29. Les Streptocoques sont:
A. Cocci gram negatives
B. Bacci gram positives
A. Cocci gram positive
C. Cocco-Bacci gram positives
D. Batéries à croissants lentes
30. Le dermohypodermite est souvent cause par une infection à
A. Staphylocoque méticilline sensible
A. Staphylocoque méticilline resistance
C. Staphylocoque d’auré
D. Streptocoque pneumoniea
Streptocoque
31. Comment traite-t-on la rage?
Vaccin anti rage
Serum anti rage
Pas de traitement spécifique, traitement symptomatique (Réanimation etc)
Anti viraux
Antiobiotique a large spectre
32. Quel est la principale source qui donne la rage aux humaines?
Chien
Chat
Singe
Poulet
Chauffes-souris
33. Comment peut-on faire avec la plaie mordue en suspicion de la rage?
Laver la plaie et puis suturer
Laver la plaie avec de Bétadine et suturer puis donner des antibiotiques
Laisser la plaie en air mais il ne faut pas donner des antibiotiques
F. Laisser la plaie à l’aire et ne rien faire
Laver la plaie avec de savon mais il ne faut pas suturer. Donner une Vaccination anti-rabique et anti-tétanique en même temps avec donner d’antibiothérapie si necessair
34. Quel est le germe qui donne le plus une infection sur une cathétère perfusée?
Streptocoque
Staphylocoque
Pseudomonase
Leptospirose
E coli
35. Les staphylocoques méticilline resistant
A. Peut être traité par de Cloxacilline
B. Toujours sensible aux Penicilline M
C. Vancomycine est le meilleur traitement
D. Ceftriaxone est aussi efficace
E. Les quinolones peuvent être utilisée en monothérapie
36. Comment pour lutter contre une infection nosocomiale?
Hygien de la main
B. Utiliser des antibiotiques de larges spectres
C. Utiliser des antibiotiques en association
A. Séparer des patients
E. Laver les vêtements des patients
37. Les hémocultures
A. Peuvent être fait après les antibiotiques
D. Ne jamais fait sur le membre perfusé de patient
B. Peuvent être fait sur les cathétère perfusées
C. Une foie seullement
E. Fait même s’il n’ y a pas de temperature
38. L’ECBC
C. Les batériologies des crachats pour bien identifier les cause de pneumonie
D. Test rapide pour Leptospirose
E. Peut être fait seulement une fois par jour
B. Examen des crachats pour rechercher des Melioidose
A. Examen des crachats pour rechercher des BK
39. Melioidose est causé par
A. Burkhodelia cepacia
C. Burkhodelia pseudomallei
B. Burkhodelia thailandensis
D. Pseudomonase aeroginosa
E. Acinetobacter baumanei
40. Infection de la dengue
D. Le PCR de la dengue est le test le plus fiable pour confirmer le diagnostique
C. Peut être traité par des antibiotique
B. Seulement pour les enfants
E. Peut donner une fièvre avec foyer pulmonaire
A. Il y a 3 sérotype de la dengue
41. Choléra
A. Jamais entendu au Cambodge
Seulement en Afrique
D. Peut eviter par des moyens hygièniques
Non treatable
Pas besoin antibiotique
42. Tuberculose pulmonaire
B. Gen X-pert est le test pour détecter les BK
Non treatable
C. Culture de BK est fait par le milieu de culture Ashdown
D. La durée totale pour la culture de BK est de 2 semaines
E. La recherche de PCR BK est le test le plus pratique au Cambodge
43. Tuberculose pulmonaire
A. Si resistant au Rifampicine, on peut utiliser seullement INH + PZA + ETH pendant 6 mois
B. Les quinolones ne peuvent pas être utilisé dans la deuxième ligne
D. La radiographie pulmonaire est inutile dans le cas d’une méningite tuberculose
E. Il ne faut pas donner des corticoids
C. Streptomycine doit être ajouté dans une méningite tuberculose
44. Une infection urinaire
A. Leuccyturie > 105
B. Leucocyturie < 105 avec Bactiruie positive
C. Leuccyturie > 105 avec Bactiurie negative mais nitrite positive
D. Leuccyturie > 104 avec Batiurie > 105
E. Leucocyturie negative mais presence des germes
45. Quel le germe le plus rencontré dans une infection urinaire?
A. Staphylocoque
Streptocoque
E coli
Samonella
Kleisella
46. Quel le germe le plus rencontré dans une infection respiratoire bas?
Steptocoque
Kleisela
Pneumonia
D. Burkhodellia pseudomallei
H influenza
47. Le germ le plus rencontré pour une méningite au Cambodge
H influenza
Streptocoque pneumonia
B. Streptocoque suis
Crytocoque
Ecoli
48. Leptospirose
Infection viral
Pas de moyen diagnostque
A. Fièvre ictéro-hémorragique
Pas de treatement specifiqeu
E. Maladie contagieuse
49. Rickettiose
B. Doxicycline est le traitement le plus efficace
Maladie contagiouse
Pas de moyen diagnostique
A. Causé par une piqure d’insecte
C. Ceftriaxone est le meilleur medicament
Endocardite infectiese
C. Diagnostique se fait par une ETT +/- ETO avec une hémoculture positive
Pas besoin de hemoculture
B. Diagnostique se fait par une ETT + ETO avec une hémoculture positive
E. Si les hémocultures sont negatives, on peut éliminer le diagnostique d’endocardit
Souvent origine viral
{"name":"A 36-year-old woman who lives in the suburbs of a large city comes to your office for a tuberculin skin test. She will be volunteering in her daughter's school cafeteria and the school district requires tuberculin testing. You inject a small amount of Myc", "url":"https://www.quiz-maker.com/QPREVIEW","txt":"A 36-year-old woman who lives in the suburbs of a large city comes to your office for a tuberculin skin test. She will be volunteering in her daughter's school cafeteria and the school district requires tuberculin testing. You inject a small amount of Mycobacterium tuberculosis purified protein derivative (PPD) in the skin and 2 days later she returns for a reading. You measure 12 mm of induration. She reports no history of tuberculosis exposure and no underlying medical conditions. She has never before been tested for tuberculosis. She was born in the United States, is not a healthcare worker, and has never spent time in prison. What is the best next step in her management?, A 22-year-old male student presents with an acute onset of fever, double vision, and painful swelling around his eyes. He also has significant muscle pain in his neck and jaw muscles. A week earlier, he experienced a period of abdominal pain, nausea, vomiting, and diarrhea, all of which resolved spontaneously. He has a history of intravenous drug abuse but has recently completed of a drug rehabilitation program. He is febrile. Physical examination shows \"splinter\" hemorrhages, periorbital edema, and chemosis. Chest is clear to auscultation. Cardiac exam reveals no murmur. Abdomen is soft and nontender with no organomegaly. His complete blood count is shown below: Hemoglobin 13.0 g\/L MCV 85 fl Platelets 228,000\/mm3 Leukocyte count 10,500\/mm3 Neutrophils 56% Eosinophils 21% Lymphocytes 23% Based on these findings, what is the most likely diagnosis?, A 55-year-old pig farmer is brought to the emergency department (ED) after having a seizure two hours ago. During his transit to the ED, he has another seizure. On arrival, he is unconscious, pulseless, and not breathing. Resuscitation is successful and the patient is stabilized; however, he does not do well over the next several days and is eventually declared dead. His wife says that he had been healthy most of his life, except for the past few weeks, when he was complaining of headaches. Autopsy shows multiple fluid-filled cysts in the brain parenchyma. Which of the following is the most likely diagnosis of this patient?","img":"https://www.quiz-maker.com/3012/images/ogquiz.png"}