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Quizzes > Health & Medicine

Sjogren's Syndrome Quiz: Do I Have It?

Quick, free Sjogren's symptoms quiz. Instant results.

Editorial: Review CompletedCreated By: Bank MaskanUpdated Aug 25, 2025
Difficulty: Moderate
2-5mins
Learning OutcomesCheat Sheet
Paper art quiz scene with test sheets and eye motifs for Sjogrens Syndrome dry eye lupus screening on coral background

This Sjogren's syndrome quiz helps you notice common signs like dry eyes, dry mouth, fatigue, and joint pain, and think about what to discuss with a healthcare professional. For a wider view of autoimmune issues, try our autoimmune symptom checker, and compare overlapping signs with the rheumatoid arthritis quiz.

What are the hallmark symptoms of Sjögren's syndrome?
Dry eyes and dry mouth
Joint pain and rash
Weight loss and fever
Muscle weakness
Sjögren's syndrome primarily affects the lacrimal and salivary glands, leading to dryness of eyes and mouth. Patients often report gritty or burning eye sensations and difficulty swallowing dry foods. Early management focuses on symptomatic relief for ocular and oral dryness. For more information see .
Which exocrine glands are most commonly affected in Sjögren's syndrome?
Thyroid and parathyroid glands
Pancreatic and adrenal glands
Lacrimal and salivary glands
Sebaceous and sweat glands
Sjögren's syndrome preferentially targets the lacrimal glands, causing dry eyes, and salivary glands, causing dry mouth. These glands have rich immune cell infiltration in affected patients. Destruction of these glands leads to classic sicca symptoms. Learn more at .
What term describes dry mouth in Sjögren's syndrome?
Xerostomia
Dysphagia
Xerophthalmia
Sialorrhea
Xerostomia refers specifically to dry mouth, a central feature of Sjögren's syndrome. Dry eyes are termed xerophthalmia. Sialorrhea is excessive salivation, the opposite of xerostomia. Comprehensive definitions are available at .
Which simple office test is used to measure tear production in suspected dry eye?
OCT
Schirmer test
Tonometry
Perimetry
The Schirmer test measures basal and reflex tear production by placing filter paper strips under the lower eyelid. Wetting less than 5 mm of the strip in 5 minutes is suggestive of aqueous tear deficiency. It is widely used as a screening tool for dry eye in Sjögren's. Details are at .
Which autoantibody is most characteristic of Sjögren's syndrome?
Anti-dsDNA
Anti-SSA (Ro)
Anti-centromere
Anti-Smith
Anti-SSA (Ro) antibodies are present in around 60 - 70% of patients with Sjögren's syndrome. They are highly associated with systemic manifestations and help confirm diagnosis. Anti-SSB (La) may co-occur but is less sensitive. For specifics see .
Which ratio best describes the female to male prevalence in Sjögren's syndrome?
2:1
1:1
9:1
3:1
Women are affected by Sjögren's syndrome approximately nine times more often than men. Hormonal and genetic factors may underlie this discrepancy. Understanding prevalence aids in raising clinical suspicion in female patients. Data reference at .
Which other autoimmune disease is commonly associated with secondary Sjögren's syndrome?
Myasthenia gravis
Type 1 diabetes
Rheumatoid arthritis
Multiple sclerosis
Secondary Sjögren's occurs in association with other autoimmune disorders, most frequently rheumatoid arthritis. It can also co-occur with lupus and scleroderma. Recognizing this overlap is important for comprehensive management. See .
What is the first-line symptomatic treatment for ocular dryness in Sjögren's?
Artificial tears
Topical corticosteroids
Systemic hydroxychloroquine
Oral pilocarpine
Artificial tears are the mainstay of symptomatic dry eye management. They lubricate the ocular surface and relieve discomfort. Preservative-free formulations are preferred for frequent use. More at .
Which simple procedure can help retain tears by blocking drainage?
Vitrectomy
Trabeculectomy
Punctal plugs
Canaliculoplasty
Punctal plugs are inserted into the tear drainage ducts to reduce tear outflow and improve ocular surface moisture. They are minimally invasive and reversible. Indicated for patients with moderate to severe aqueous deficiency. Details at .
Which oral medication can stimulate saliva production in Sjögren's patients?
Sulfasalazine
Cyclophosphamide
Methotrexate
Pilocarpine
Pilocarpine is a cholinergic agonist that stimulates muscarinic receptors, increasing salivary and lacrimal secretion. It is approved for treatment of dry mouth and dry eye in Sjögren's syndrome. Side effects include sweating and GI upset. See .
What does the term 'sicca' refer to in rheumatology?
Inflammation
Fatigue
Dryness
Swelling
'Sicca' is Latin for dryness, describing the characteristic dry eyes (xerophthalmia) and dry mouth (xerostomia) in Sjögren's syndrome. It highlights the exocrine gland involvement. Adequate hydration and lubricants are key management steps. More at .
Why is regular dental care important in Sjögren's syndrome?
Frequent gingival hyperplasia
Increased risk of dental caries
Greater enamel hardness
Higher wisdom tooth impaction
Dry mouth reduces protective saliva flow, increasing bacterial growth and dental caries risk. Patients require frequent fluoride treatments and dental checkups. Preventive measures lower rates of tooth decay and infections. See .
Which objective measure assesses tear film stability in dry eye evaluation?
Fundus photography
Tear break-up time
Goldmann applanation tonometry
Fluorescein angiography
Tear film break-up time (TBUT) measures how long a fluorescein-stained tear film remains intact. Short TBUT (<10 seconds) indicates tear film instability commonly seen in Sjögren's. It complements Schirmer testing. Details at .
What histologic finding on minor salivary gland biopsy supports Sjögren's diagnosis?
Focal lymphocytic sialadenitis
Amyloid deposits
Granulomatous inflammation
Necrotizing vasculitis
Focal lymphocytic sialadenitis with a focus score ?1 (one focus per 4 mm²) is a key diagnostic criterion. It reflects autoimmune infiltration of salivary tissue. Other patterns suggest different pathologies. See .
How does the 2016 ACR/EULAR classification criteria weight the Schirmer test?
1 point if ?5 mm/5 min
2 points if ?10 mm/5 min
3 points if ?5 mm/5 min
No points for Schirmer
The ACR/EULAR criteria assign 1 point for Schirmer test result ?5 mm/5 min. Other items like anti-SSA and biopsy carry more weight. A total score ?4 classifies Sjögren's. Read more at .
Which laboratory finding is most frequently elevated in Sjögren's patients?
Serum amylase
Serum calcium
Serum creatinine
ESR
Elevated erythrocyte sedimentation rate (ESR) reflects systemic inflammation in many Sjögren's patients. It correlates with disease activity. Other routine labs are usually normal. More details at .
Which imaging modality can evaluate salivary gland structural changes in Sjögren's?
Abdominal ultrasound
Ultrasound of salivary glands
Chest CT
MRI of the brain
High-resolution ultrasound can detect inhomogeneity, hypoechoic areas, and increased vascularity in salivary glands. It is noninvasive and helpful in diagnosis and monitoring. Standard protocols exist for scoring changes. See .
Which salivary gland function test measures uptake and excretion of radiotracer?
Scintigraphy
MRI
CT scan
Sialography
Salivary gland scintigraphy uses technetium-99m pertechnetate to assess gland uptake and excretion functionally. Reduced uptake or delayed excretion suggests glandular dysfunction in Sjögren's. It complements biopsy and ultrasound. More at .
Which systemic complication has a markedly increased risk in Sjögren's syndrome?
Hepatocellular carcinoma
Melanoma
Osteosarcoma
Non-Hodgkin lymphoma
Sjögren's syndrome increases risk of B-cell non-Hodgkin lymphoma by up to 44-fold. Chronic lymphocytic infiltration and ectopic germinal center formation drive risk. Monitoring includes lab tests and imaging for lymphadenopathy. Reference at .
Which topical immunomodulator is approved for chronic dry eye in Sjögren's?
Cyclosporine ophthalmic emulsion
Topical adalimumab
Topical azathioprine
Topical methotrexate
Topical cyclosporine reduces ocular surface inflammation and increases tear production. It is FDA-approved for chronic dry eye, including Sjögren's-related keratoconjunctivitis sicca. Studies show improved tear metrics and symptoms. More at .
Which eye drop measurement indicates increased tear film osmolarity in dry eye disease?
150 mOsm/L
?260 mOsm/L
500 mOsm/L
?308 mOsm/L
In dry eye disease, tear osmolarity ?308 mOsm/L or an inter-eye difference >8 mOsm/L is diagnostic. Hyperosmolar tears damage ocular surface cells and promote inflammation. Osmolarity testing aids in clinical evaluation. Details at .
Which feature differentiates primary from secondary Sjögren's syndrome?
Presence of another autoimmune disease
Age at onset under 30
Male gender
Exclusive ocular involvement
Secondary Sjögren's occurs in conjunction with another established autoimmune disease like rheumatoid arthritis or lupus. Primary Sjögren's exists alone without associated systemic autoimmune conditions. Differentiation guides management. See .
What is the mechanism of action of pilocarpine in Sjögren's management?
Muscarinic receptor agonist
Calcium channel blocker
Beta-adrenergic blocker
TNF-alpha inhibitor
Pilocarpine is a nonselective muscarinic receptor agonist that stimulates exocrine gland secretion, increasing saliva and tear production. It binds M3 receptors on acinar cells. Its side effect profile relates to cholinergic stimulation. More at .
Which criterion in the 2016 ACR/EULAR classification carries the highest point value for Sjögren's?
Ocular staining score (1 point)
Anti-SSA/Ro positivity (3 points)
Schirmer test (1 point)
Unstimulated salivary flow (1 point)
Anti-SSA/Ro antibody positivity is weighted at 3 points, the highest single criterion, reflecting its diagnostic importance. Other objective tests each contribute 1 point. A total score ?4 classifies Sjögren's syndrome. See .
Which histologic feature in salivary gland biopsy indicates a high risk of lymphoma in Sjögren's?
Granulomatous inflammation
Necrosis
Fatty infiltration
Germinal center - like structures
Ectopic germinal center - like structures reflect organized lymphoid tissue and are associated with increased lymphoma risk. Their presence denotes advanced glandular autoimmune activity. Monitoring is intensified in these patients. Reference at .
Which biologic agent targets B cells and is used off-label in refractory Sjögren's syndrome?
Tocilizumab
Etanercept
Rituximab
Infliximab
Rituximab is an anti-CD20 monoclonal antibody that depletes B cells, reducing autoantibody production. It has shown benefit in systemic and glandular manifestations in refractory cases. Controlled trials have mixed results but it remains an option. More at .
Which marker is most associated with the interferon signature in Sjögren's patients?
CXCL10
TGF-beta
IL-10
IL-4
CXCL10 is upregulated by type I interferons and is elevated in serum and salivary glands of Sjögren's patients. It correlates with disease activity and systemic manifestations. It reflects the interferon-driven pathology. See .
What is the role of non-invasive tear film breakup time (NIBUT) in clinical assessment?
Evaluates corneal thickness
Assesses intraocular pressure
Quantifies tear production
Measures tear film stability without dyes
NIBUT uses imaging to detect tear film breakup without fluorescein dye, avoiding reflex tearing. Lower NIBUT indicates tear instability. It is useful in early dry eye detection and monitoring therapy. Details at .
Which cytokine has been implicated in fibrotic changes of salivary glands in Sjögren's?
IL-2
TGF-beta
IL-17
IFN-gamma
TGF-beta promotes extracellular matrix deposition and fibrosis in chronic glandular inflammation. In Sjögren's, elevated TGF-beta correlates with gland destruction and fibrosis. Therapeutic targeting is under investigation. Read more at .
Which diagnostic test evaluates basal tear secretion without anesthetic?
Schirmer I test
Fluorescein clearance test
Jones test
Schirmer II test
Schirmer I measures basal and reflex tears without topical anesthesia. In contrast, Schirmer II uses nasal stimulation. Schirmer I is standard for Sjögren's screening. Read about methodology at .
Which ocular surface staining score is used to quantify corneal epithelial damage?
Goldmann scale
Snellen chart
Hertel scale
Oxford grading scale
The Oxford grading scale uses fluorescein and lissamine green staining patterns to grade corneal and conjunctival damage from 0 to V. It is widely used in dry eye studies. It correlates with symptom severity. More at .
Which complication of Sjögren's can lead to corneal ulceration?
Retinal detachment
Elevated intraocular pressure
Severe aqueous deficiency
Vitreous hemorrhage
Severe aqueous tear deficiency exposes corneal epithelium to air, leading to breakdown and ulceration. Prompt ocular lubrication and anti-inflammatory therapy prevent this. Severe cases may require therapeutic contact lenses. See .
Which neuropathic pain feature may present in Sjögren's dry eye?
Paresthesia in hands
Burning or shooting ocular pain
Throbbing joint aches
Muscle cramps
Neuropathic ocular pain presents as burning, shooting, or shock-like sensations despite normal exam findings. It involves corneal nerve dysfunction in chronic dry eye. Management may include neuromodulators. Learn more at .
Which systemic therapy is reserved for severe extraglandular manifestations in Sjögren's?
Pilocarpine
Topical fluorometholone
Artificial tears
Cyclophosphamide
Cyclophosphamide is used in severe systemic complications like vasculitis or interstitial lung disease in Sjögren's. Its potent immunosuppression necessitates careful monitoring. Milder cases are managed with hydroxychloroquine. See .
Which HLA allele is most strongly associated with primary Sjögren's syndrome?
HLA-B27
HLA-DR4
HLA-DQ2
HLA-DRB1*03
HLA-DRB1*03 (DR3) is linked to anti-SSA positivity and increased risk of primary Sjögren's syndrome. Genetic predisposition involves multiple loci but DR3 shows the strongest association. This knowledge aids in research and risk stratification. Reference at .
Which chemokine is elevated in salivary glands and correlates with lymphoid neogenesis in Sjögren's?
CCL2
IL-8
CCL5
CXCL13
CXCL13 is produced by follicular dendritic cells and attracts B cells, promoting ectopic germinal center formation in salivary glands. Its levels correlate with disease severity and lymphoma risk. It is a potential therapeutic target. More at .
Which novel therapeutic target aims to block type I interferon signaling in Sjögren's?
Infliximab
Tocilizumab
Etanercept
Anifrolumab
Anifrolumab, an anti - type I interferon receptor monoclonal antibody, is under investigation for Sjögren's due to the interferon signature seen in patients. Preliminary studies suggest reduction in systemic disease activity. It represents a precision-medicine approach. Details at .
Which cell therapy is being explored to restore salivary gland function in Sjögren's?
Dendritic cell vaccines
Mesenchymal stem cells
CAR-T cells
Natural killer cells
Mesenchymal stem cells have immunomodulatory and regenerative properties, and early trials show improved salivary flow and reduced inflammation. They may home to damaged glands and secrete trophic factors. Clinical studies are ongoing. See .
Which microRNA has been implicated in salivary gland apoptosis in Sjögren's research?
miR-142-3p
miR-21
miR-155
miR-146a
miR-142-3p is overexpressed in salivary gland epithelial cells in Sjögren's and promotes apoptosis by targeting survival pathways. This microRNA represents a potential biomarker and therapeutic target. Functional studies confirm its role in glandular dysfunction. More at .
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Study Outcomes

  1. Recognize Dry Eye Symptoms -

    Identify common indicators of dry eye and link them to possible Sjögren's syndrome manifestations.

  2. Differentiate Dry Eye Types -

    Analyze characteristics that distinguish routine dry eye from autoimmune-related dry eye in the dry eye and sjögren's syndrome quiz context.

  3. Understand Lupus Screening Connections -

    Summarize how the sjögren's syndrome and lupus screening quiz highlights overlapping signs between these autoimmune disorders.

  4. Self-Assess Risk Factors -

    Apply the do i have sjögren's syndrome quiz framework to evaluate your symptoms and gauge your personal risk.

  5. Know When to Seek Professional Help -

    Determine next steps by interpreting quiz results and understanding when to pursue further medical evaluation.

Cheat Sheet

  1. Autoimmune glandular damage -

    Sjögren's syndrome results from lymphocytic infiltration of lacrimal and salivary glands, causing tear and saliva deficiency (Arthritis & Rheumatology, 2016). Anti-SSA/Ro and anti-SSB/La autoantibodies are detected in ~70% of patients, signalling B-cell hyperactivity. Use the mnemonic "S-S-L" (Sjögren's, Salivary/lacrimal, anti-SSA/SSB autoantibodies) to anchor this concept when taking a do i have sjögren's syndrome quiz.

  2. Sicca symptom triad and mnemonic -

    Classic presentation includes the Sicca triad: dry eyes, dry mouth, and parotid enlargement (Johns Hopkins Rheumatology). Recall "SICCA" (Sicca Inflammation, Circulating autoAbs, Complement low, Autoimmune) to remember key features. This trick helps on any dry eye and sjögren's syndrome quiz where you must list hallmark symptoms.

  3. Schirmer's test and ocular staining -

    Schirmer's test measures tear production: <5 mm wetting in 5 minutes is considered positive (American Academy of Ophthalmology). Fluorescein or lissamine green staining highlights corneal damage - higher score means worse dryness. In a sjögren's syndrome and lupus screening quiz, knowing these cutoff values is crucial for ocular screening items.

  4. Lupus overlap and serologic screening -

    Up to 30% of Sjögren's patients exhibit SLE features, so screening with ANA, anti-dsDNA, and complement (C3/C4) is recommended (Lupus Foundation of America). A positive ANA is common in both conditions, but anti-dsDNA and anti-Smith are more specific for lupus. Remember to differentiate drug-induced dryness or MGD when you encounter related questions in a sjogren's syndrome and lupus screening quiz.

  5. ACR/EULAR classification "3-3-1-1" rule -

    The 2016 ACR/EULAR criteria assign 3 points each for anti-SSA/Ro positivity or focal lymphocytic sialadenitis on gland biopsy, and 1 point each for positive ocular staining, Schirmer's test, or unstimulated salivary flow (≥4 points for diagnosis). This "3-3-1-1" scoring system streamlines your approach. Use it when tackling the do i have sjögren's syndrome quiz to confidently classify cases.

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