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Which Macromolecule Makes Hormones? Take the Quiz!

Think you know which macromolecule makes hormones and which are not polymers? Take the challenge!

Difficulty: Moderate
2-5mins
Learning OutcomesCheat Sheet
Paper art molecules and hormone icons on yellow background for quiz on macromolecules polymers and hormone production

This macromolecules quiz helps you figure out which macromolecule makes hormones and how proteins, lipids, carbs, and nucleic acids fit in. Work through quick questions on polymers and monomers, and see where you need review before class. For a wider view, try the cell biology quiz next.

Which macromolecule class do most hormones belong to?
Proteins
Nucleic Acids
Carbohydrates
Lipids
Most hormones are peptide or protein hormones composed of amino acid chains, which belong to the protein macromolecule class. Protein hormones include insulin, growth hormone, and glucagon. They interact with specific receptors to regulate physiological functions. .
Insulin, a hormone regulating blood sugar, is an example of what macromolecule?
Nucleic Acid
Carbohydrate
Protein
Steroid
Insulin is a peptide hormone synthesized as a polypeptide chain and folded into its active form, classifying it as a protein. It is produced by pancreatic ?-cells to lower blood glucose. Insulin's structure consists of two peptide chains linked by disulfide bonds. .
Steroid hormones derive from which lipid precursor?
Cholesterol
Phospholipids
Waxes
Triglycerides
Steroid hormones such as cortisol, estrogen, and testosterone are synthesized from cholesterol, a lipid molecule with a four-ring structure. Enzymatic modifications of cholesterol yield diverse steroid hormones. This process occurs primarily in the adrenal glands and gonads. .
Which macromolecule is NOT a source of steroid hormones?
Lipids
Carbohydrates
Nucleic Acids
Proteins
Steroid hormones are lipid-derived molecules synthesized from cholesterol and related lipids, not from carbohydrates. Carbohydrates function primarily in energy storage and structural roles. Proteins and nucleic acids also do not serve as steroid precursors. .
Peptide hormones are composed of which monomer units?
Fatty Acids
Nucleotides
Simple Sugars
Amino Acids
Peptide hormones are short chains of amino acids linked by peptide bonds, making amino acids their monomeric building blocks. These chains fold into specific three-dimensional structures essential for receptor binding. Examples include insulin and oxytocin. .
Which of the following is a peptide hormone?
Estrogen
Growth Hormone
Thyroxine
Testosterone
Growth hormone is a protein-based hormone produced by the anterior pituitary, consisting of 191 amino acids. It stimulates growth, cell reproduction, and regeneration. Estrogen and testosterone are steroid hormones, while thyroxine is an amino acid derivative. .
Adrenaline (epinephrine) is classified as which type of macromolecule derivative?
Polysaccharide
Amino Acid Derivative
Steroid
Peptide
Adrenaline is derived from the amino acid tyrosine and belongs to the class of monoamine (amino acid derivative) hormones. It acts rapidly to prepare the body for 'fight or flight.' It is not a peptide or steroid. .
Thyroxine (T4) is synthesized from which amino acid?
Lysine
Phenylalanine
Tryptophan
Tyrosine
Thyroxine is produced by iodination and coupling of two iodinated tyrosine residues in thyroglobulin. Tyrosine is the precursor for both T4 and T3 thyroid hormones. .
Which macromolecule primarily stores energy long-term but does NOT produce hormones?
Carbohydrates
Proteins
Nucleic Acids
Lipids
Carbohydrates such as glycogen store energy for short-term use rather than serving as hormone precursors. Lipids and proteins, on the other hand, are sources for steroid and peptide hormones, respectively. Nucleic acids do not directly give rise to hormones. .
Steroid hormones are soluble in which type of environment?
Lipid
Carbohydrate
Protein
Water
Steroid hormones are lipophilic (fat-soluble) due to their nonpolar ring structures, allowing them to diffuse across cell membranes and bind intracellular receptors. Water solubility is low for these hormones. .
The macromolecule bond that links amino acids in peptide hormones is called a __________ bond.
Ester
Peptide
Phosphodiester
Glycosidic
A peptide bond, formed by a dehydration reaction between the amino group of one amino acid and the carboxyl group of another, links amino acids in peptide hormones. Glycosidic bonds link sugars, phosphodiester bonds link nucleotides, and ester bonds link fatty acids to glycerol. .
Which of the following is a eicosanoid hormone involved in inflammation?
Cholesterol
Insulin
Prostaglandin
Cortisol
Prostaglandins are eicosanoids derived from arachidonic acid, acting locally to mediate inflammation, pain, and fever. They differ from steroid hormones and peptides in structure and action. .
Cortisol, a stress hormone, belongs to which macromolecule family?
Carbohydrates
Steroid Lipids
Proteins
Nucleic Acids
Cortisol is a glucocorticoid steroid synthesized from cholesterol in the adrenal cortex. It regulates metabolism and immune response. Its lipid nature allows cell membrane diffusion. .
Retinoic acid, used in gene regulation, is derived from which macromolecule class?
Carbohydrate
Nucleic Acid
Vitamin A (Lipid)
Protein
Retinoic acid is oxidized vitamin A, a fat-soluble vitamin derived from carotenoids (lipid class). It acts as a signaling molecule in gene transcription. .
Glucagon is classified as what type of macromolecule?
Carbohydrate
Lipid
Nucleic Acid
Protein
Glucagon is a peptide hormone produced by pancreatic ?-cells, consisting of 29 amino acids. It raises blood glucose by promoting glycogen breakdown. .
Which hormone is a glycoprotein characterized by carbohydrate attachments?
Thyroid-Stimulating Hormone (TSH)
Testosterone
Cortisol
Estrogen
TSH is a glycoprotein hormone with carbohydrate chains that influence its stability and receptor interaction. It stimulates the thyroid gland to produce T3 and T4. .
Which structural feature distinguishes steroid hormones from peptide hormones?
Four Fused Rings
Phosphate Backbone
Peptide Bonds
Carboxyl Groups
Steroid hormones possess a core structure of four fused carbon rings derived from cholesterol. This contrasts with peptide hormones, which are linear or folded amino acid chains linked by peptide bonds. .
What macromolecule is the main component of the peptide hormone insulin?
Protein
Polysaccharide
Lipid
DNA
Insulin is a protein hormone composed of two polypeptide chains (A and B) connected by disulfide bridges. It is synthesized as preproinsulin, then processed to proinsulin and mature insulin. .
Prolactin is a hormone composed of approximately how many amino acids?
~5000
~1000
~20
~200
Prolactin is a peptide hormone of about 198 - 199 amino acids secreted by the anterior pituitary. It stimulates milk production in mammals. .
Which molecule acts as a second messenger in many peptide hormone pathways?
Insulin
Triacylglycerol
cAMP
Glycogen
Cyclic AMP (cAMP) is a common second messenger generated by adenylate cyclase activation after peptide hormone binding to G-protein coupled receptors. It relays signals inside the cell. .
Oxytocin, a peptide hormone, contains how many amino acids?
9
100
50
20
Oxytocin is a nonapeptide (9 amino acids) hormone produced in the hypothalamus and released from the posterior pituitary. It regulates uterine contraction and milk ejection. .
Steroid hormones cross the cell membrane due to what property?
Negatively charged phosphate
Hydrophobic fatty acid chains
Sugar residues
Polar amino groups
Steroid hormones have hydrophobic ring structures and nonpolar side chains that allow them to freely diffuse through the phospholipid bilayer of cell membranes. This lipid solubility distinguishes them from peptide hormones. .
Which enzyme catalyzes the cleavage of preproinsulin to proinsulin in the endoplasmic reticulum?
Lipase
Endopeptidase
Amylase
Polymerase
Endopeptidases cleave signal peptides from preproinsulin in the ER to form proinsulin. Further processing in the Golgi and secretory vesicles yields active insulin. .
Which post-translational modification is critical for activating many glycoprotein hormones?
Phosphorylation
Acetylation
Glycosylation
Hydroxylation
Glycosylation adds carbohydrate moieties to specific Asn residues on glycoprotein hormones, influencing folding, stability, and receptor recognition. This modification occurs in the ER and Golgi. .
What is the role of the cholesterol side-chain cleavage enzyme in steroidogenesis?
Links cholesterol to glycerol
Degrades cholesterol to CO2
Converts testosterone to estrogen
Converts cholesterol to pregnenolone
The P450scc (side-chain cleavage) enzyme catalyzes the conversion of cholesterol to pregnenolone in mitochondria, which is the first step in all steroid hormone biosynthesis. .
Which type of interactions primarily allow peptide hormones to bind their receptors?
Ionic and hydrogen bonds
Covalent bonding
Van der Waals only
Hydrophobic interactions
Peptide hormones interact with their receptors via noncovalent forces, mainly ionic and hydrogen bonds, ensuring specificity and reversibility. Hydrophobic contacts and Van der Waals forces also contribute but are secondary. .
Which transcription factor regulates the Steroidogenic Acute Regulatory (StAR) protein gene in hormone-producing cells?
SF-1
CREB
p53
NF-?B
SF-1 (Steroidogenic Factor-1) is a nuclear receptor transcription factor that upregulates StAR gene expression, facilitating cholesterol transport into mitochondria for steroidogenesis. .
Cortisol synthesis occurs primarily in which cellular organelles?
Lysosome
Mitochondria and smooth ER
Nucleus
Golgi apparatus
Steroidogenesis enzymes for cortisol are located in the mitochondrial inner membrane and smooth endoplasmic reticulum of adrenal cortical cells. These organelles work together to convert cholesterol into cortisol. .
Which molecule serves as a second messenger in many hormone signaling pathways?
Insulin
Glycogen
cAMP
Triacylglycerol
cAMP is generated by adenylate cyclase upon hormone receptor activation and propagates the signal to intracellular targets such as PKA. It is a central second messenger in many G-protein coupled receptor pathways. .
Which hormone requires a G-protein coupled receptor and cAMP signaling, reflecting its nature as a peptide hormone?
Estrogen
Cortisol
Glucagon
Thyroxine
Glucagon is a peptide hormone that binds GPCRs on hepatocytes, activating adenylate cyclase to increase cAMP and trigger glycogenolysis. Thyroxine, cortisol, and estrogen use different receptors and pathways. .
Erythropoietin is a glycosylated protein hormone. How many N-linked carbohydrate chains are typically attached?
20
3
None
10
Human erythropoietin has three N-linked glycosylation sites and one O-linked site, which enhance its stability and bioactivity. Glycosylation is crucial for its circulation half-life. .
Vitamin D functions similarly to steroid hormones. From which macromolecule precursor is it synthesized?
Glucose
Cholesterol
Amino Acids
RNA
Vitamin D3 (cholecalciferol) is synthesized from 7-dehydrocholesterol in the skin upon UV exposure. It then undergoes activation in liver and kidney resembling steroid hormone synthesis. .
Which feature does NOT apply to steroid hormones?
Lipid solubility
Water solubility
Derived from cholesterol
Intracellular receptor binding
Steroid hormones are lipid-soluble, derived from cholesterol, and bind intracellular receptors. They are NOT water-soluble, which distinguishes them from peptide hormones. .
Which macromolecule serves as the immediate substrate for the synthesis of all steroid hormones?
Palmitic acid
Glycogen
Cholesterol
Acetyl-CoA
Cholesterol is the immediate precursor for steroid hormones. It undergoes side-chain cleavage and further enzymatic steps to yield progesterone, cortisol, estrogens, and androgens. .
Which hormone binds nuclear receptors and directly regulates gene transcription?
Estrogen
Insulin
Oxytocin
Glucagon
Estrogen is a steroid hormone that diffuses into cells, binds estrogen receptors in the nucleus, and modulates gene expression. Insulin and glucagon use membrane receptors; oxytocin is a peptide. .
The enzyme aromatase converts androgens to estrogens. What is its macromolecular classification?
Cytochrome P450 monooxygenase (enzyme/protein)
Lipoprotein
Glycoprotein
Carbohydrate polymer
Aromatase is a member of the cytochrome P450 superfamily, which are heme-containing enzymes (proteins) that catalyze the aromatization of androgens to estrogens in steroidogenic tissues. .
In steroid biosynthesis, which transport protein shuttles cholesterol into mitochondria for side-chain cleavage?
Steroidogenic acute regulatory protein (StAR)
Albumin
Transferrin
Hemoglobin
StAR protein facilitates the transfer of cholesterol from the outer to the inner mitochondrial membrane, a rate-limiting step in steroid hormone production. Without StAR, steroidogenesis is impaired. .
Which domain of receptor tyrosine kinases binds peptide hormones extracellularly?
Transmembrane domain
Extracellular ligand-binding domain
Kinase domain
SH2 domain
Receptor tyrosine kinases have an extracellular domain that specifically binds peptide hormones or growth factors, a transmembrane helix, and an intracellular tyrosine kinase domain for signal transduction. .
Which cofactor is required for thyroid peroxidase to iodinate tyrosine residues in thyroglobulin?
H2O2
NADH
CoA
ATP
Thyroid peroxidase uses hydrogen peroxide as an oxidizing agent to iodinate the tyrosine residues on thyroglobulin, which leads to T3 and T4 hormone formation. .
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Study Outcomes

  1. Understand Hormone-Producing Macromolecules -

    Learn which macromolecule makes hormones in the body and how its structure enables hormone synthesis and regulation.

  2. Identify True Statements About Macromolecules -

    Evaluate key characteristics to determine which statement is true about macromolecules and reinforce your grasp of biomolecule principles.

  3. Differentiate Macromolecule Classes -

    Compare the functions of macromolecules to distinguish among proteins, lipids, carbohydrates, and nucleic acids.

  4. Analyze Polymer vs. Non-Polymer Structures -

    Recall which of the following macromolecules are polymers and recognize exceptions in macromolecular composition.

  5. Apply Knowledge in a Macromolecules Quiz -

    Test your bio IQ through targeted questions to solidify your understanding of macromolecules and their biological roles.

Cheat Sheet

  1. Protein Hormones -

    Proteins are the primary macromolecule that makes hormones in the body, as peptide hormones like insulin and glucagon are chains of amino acids linked by peptide bonds. Many hormone names end with "-in," which is a handy mnemonic for protein-based hormones (think insulin, oxytocin, prolactin). Understanding their primary to quaternary structures helps you grasp how they fold and bind to specific receptors, as covered in most university biochemistry curricula.

  2. Steroid Hormones (Lipids) -

    Steroid hormones like cortisol, estrogen, and testosterone are derived from the lipid macromolecule cholesterol and play critical roles in metabolism, stress response, and reproduction. Lipids are not polymers, which is a key exception when answering "all of the following macromolecules are polymers except…," making lipids the odd one out. A neat mnemonic is "ster checked out from cholesterol," linking steroid with sterol structure.

  3. Carbohydrate Polymers -

    Carbohydrates are polymers made of monosaccharide units, such as glucose in starch and glycogen, serving mainly for energy storage and structural support rather than hormone function. A classic true statement about macromolecules is that they're built via dehydration synthesis, joining monomers by glycosidic bonds and releasing water. When studying for a macromolecules quiz, remember the general formula (CH2O)n and visualize ring structures in sugars to anchor your understanding.

  4. Nucleic Acids and Information Flow -

    Nucleic acids - DNA and RNA - are macromolecules tasked with storing and transmitting genetic information, not producing hormones. Their monomers, nucleotides, join via phosphodiester bonds, forming long chains that guide protein synthesis, including hormone proteins. When learning functions of macromolecules, slot nucleic acids under "information molecules" to keep the four biomolecule roles straight.

  5. Four Macromolecule Types Mnemonic -

    Remember the four major macromolecule classes - Carbohydrates, Lipids, Proteins, and Nucleic acids - using the mnemonic "CHOP" to ace your functions of macromolecules review. Carbs provide energy, lipids store energy and form membranes, proteins catalyze reactions and include hormones, while nucleic acids handle genetic code. This quick recall trick is a lifesaver during a macromolecules quiz or when checking "which statement is true about macromolecules" under exam pressure.

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