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WBC Identification Quiz: Spot the Leukocyte in Each Image

Quick, free white blood cells quiz to test your ID skills. Instant results.

Editorial: Review CompletedCreated By: Parvathy VinodUpdated Aug 23, 2025
Difficulty: Moderate
2-5mins
Learning OutcomesCheat Sheet
Paper cut illustration of white blood cells on golden yellow background with bold quiz title and call to test leukocyte ID skills

This WBC identification quiz helps you practice recognizing leukocytes in images and sharpen your hematology basics. Review structure and function with a histology identification quiz, go deeper on cells in a diagnostic cytology quiz, or refresh immunity topics with a lymphatic system quiz. Get instant feedback as you go.

Which leukocyte typically shows a bilobed nucleus with large, uniform orange-red cytoplasmic granules on a Wright-Giemsa smear?
Neutrophil
Eosinophil
Basophil
Monocyte
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Which white blood cell has coarse, dark purple granules that often obscure a segmented nucleus?
Eosinophil
Basophil
Lymphocyte
Neutrophil
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Which cell is identified by a multilobed (3-5) nucleus and fine, pale lilac granules?
Basophil
Monocyte
Neutrophil (segmented)
Eosinophil
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Which leukocyte is classically the largest in peripheral blood and has kidney-shaped or indented nucleus with gray-blue, ground-glass cytoplasm?
Basophil
Eosinophil
Monocyte
Small lymphocyte
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Which cell is a small, round cell with dense clumped chromatin and scant, pale blue cytoplasm?
Small mature lymphocyte
Monocyte
Plasma cell
Neutrophil (band)
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A leukocyte with abundant basophilic cytoplasm that often skims around adjacent red cells (cell hugging) and has an eccentric nucleus best represents which cell?
Monocyte
Reactive (atypical) lymphocyte
Small lymphocyte
Neutrophil
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Which neutrophil precursor has an indented (kidney-bean) nucleus that is less than half the width of a full circle?
Promyelocyte
Myelocyte
Band neutrophil
Metamyelocyte
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A cell with eccentric nucleus, clumped clockface chromatin, deeply basophilic cytoplasm, and a perinuclear hof is most consistent with which leukocyte-lineage cell?
Plasma cell
Myeloblast
Monocyte
Reactive lymphocyte
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Large granular lymphocytes with azurophilic cytoplasmic granules typically represent which subset?
NK cells or cytotoxic T cells
Basophils
B blasts
Helper T cells
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Which cell type shows toxic granulation and Dohle bodies during severe bacterial infection?
Eosinophil
Monocyte
Neutrophil
Basophil
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Which marrow precursor has a high nuclear-to-cytoplasmic ratio, fine chromatin, prominent nucleoli, and may contain Auer rods?
Metamyelocyte
Myeloblast
Myelocyte
Promyelocyte
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Which granulocyte precursor is characterized by abundant primary (azurophilic) granules and a slightly eccentric nucleus without visible nucleoli?
Myelocyte
Myeloblast
Promyelocyte
Metamyelocyte
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Which stage shows the first appearance of specific (secondary) granules with an eccentric, round to oval nucleus and no nucleoli?
Metamyelocyte
Promyelocyte
Band neutrophil
Myelocyte
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Hyposegmented, bilobed neutrophils with coarse chromatin resembling pince-nez glasses are characteristic of which anomaly?
Pseudo-Pelger in sepsis
Pelger-Huet anomaly (true)
Alder-Reilly anomaly
Hypersegmentation in B12 deficiency
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Which pathologic lymphoid cell shows cytoplasmic projections giving a "hairy" outline on smear?
Reed-Sternberg cell
Hairy cell (B-cell)
Plasma cell
Sezary cell
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Which neutrophil abnormality is characterized by extremely coarse, dark granulation resembling toxic granulation but present in all granulocytes due to a storage disease?
Pelger-Huet anomaly
Alder-Reilly anomaly (mucopolysaccharidoses)
Chediak-Higashi syndrome
May-Hegglin anomaly
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Which inherited disorder features giant peroxidase-positive lysosomal granules in neutrophils and other leukocytes?
Wiskott-Aldrich syndrome
Alder-Reilly anomaly
Pelger-Huet anomaly
Chediak-Higashi syndrome
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Chediak-Higashi syndrome shows giant lysosomal granules in leukocytes on smear.
False
True
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Alder-Reilly anomaly is due to mucopolysaccharide storage and shows coarse granulation in granulocytes.
True
False
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Which cell is most likely when a large cell with abundant basophilic cytoplasm, prominent nucleoli, and irregular folded nucleus is seen in peripheral blood during monocytic leukemia?
Prolymphocyte
Myeloblast
Monoblast
Plasma cell
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0

Study Outcomes

  1. Understand Leukocyte Morphology -

    Gain clarity on the key morphological features of neutrophils, lymphocytes, monocytes, eosinophils, and basophils to build a solid foundation for WBC identification.

  2. Differentiate Granulocytes and Agranulocytes -

    Learn to distinguish between granulocytic and agranulocytic white blood cells using hallmark granule patterns and nucleus shapes in the quiz.

  3. Analyze Microscopic Images -

    Develop the skills to scrutinize authentic cell images and pinpoint characteristic details that define each leukocyte type in our white blood cell identification quiz.

  4. Apply Morphological Criteria -

    Use established staining and morphological rules to accurately classify leukocytes, reinforcing your practical ability to identify white blood cells under the microscope.

  5. Evaluate Diagnostic Features -

    Assess crucial diagnostic markers to recognize normal versus abnormal WBC presentations, enhancing your diagnostic confidence.

  6. Improve Identification Speed and Accuracy -

    Boost your proficiency and turnaround time in identifying leukocytes, preparing you for both exams and real-world hematology scenarios.

Cheat Sheet

  1. Leukocyte Differential Frequency Mnemonic -

    Use the classic mnemonic "Never Let Monkeys Eat Bananas" to remember the relative abundance of neutrophils, lymphocytes, monocytes, eosinophils, and basophils. This quick memory trick is invaluable for the white blood cell identification quiz and streamlines your review during exams. According to ASH guidelines, neutrophils typically compose 50 - 70% of WBCs, lymphocytes 20 - 40%, monocytes 2 - 8%, eosinophils 1 - 4%, and basophils 0.5 - 1%.

  2. Neutrophil Morphology and Function -

    Recognize neutrophils by their multi-lobed nucleus (usually 3 - 5 lobes) and fine pale granules in the cytoplasm. These first responders play a central role in bacterial defense via phagocytosis and neutrophil extracellular traps (NETs). University pathology labs often use 1000× oil immersion on Wright-Giemsa - stained smears to identify their characteristic appearance.

  3. Lymphocyte Subtypes and Cytology -

    Differentiate small, medium, and large lymphocytes by nuclear-to-cytoplasm ratio; small lymphs have scant cytoplasm, while large lymphs may show visible nucleoli. Recall that T cells, B cells, and NK cells each have specialized markers (e.g., CD3 for T cells) used in flow cytometry. Reviewing these features boosts accuracy in any leukocyte quiz.

  4. Monocyte Identification and Differentiation -

    Spot monocytes by their large size, kidney-shaped or horseshoe nucleus, and abundant gray-blue cytoplasm often containing fine vacuoles. After migrating into tissues, monocytes mature into macrophages and dendritic cells, key players in antigen presentation. Training sets from university hematology departments emphasize their size (15 - 30 µm) as a distinguishing feature.

  5. Eosinophils and Basophils in Slides -

    Memorize that eosinophils exhibit bright red-orange granules around a bi-lobed nucleus, while basophils have dark purple-black granules obscuring their S-shaped nucleus. Eosinophils target parasitic infections and modulate allergic responses, whereas basophils release histamine and heparin to mediate inflammation. Practicing with slide banks from research repositories can help you nail these in your wbc identification quiz.

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