Practice Exam 4
T-Cell Development Quiz
Test your knowledge of T-cell development and the thymus with this comprehensive quiz! Dive into essential concepts related to lymphocyte maturation, selection processes, and the key players involved in the immune response. Whether you are a student or a professional, this quiz is a valuable resource for mastering immunology.
Key Features:
- 24 challenging multiple-choice questions
- In-depth coverage of T-cell biology
- Instant feedback on your performance
T-cells originate in the
Bone Marrow
Thymus
Lymph node
Secondary Lymphoid tissue
T-cells develop in the thymus
True
False
T-cells migrate through the ____ to the thymus
Afferent lymphatics
Efferent lymphatics
Blood
Lymph
The thymus is involved in lymphocyte re-circulation
True
False
Which is false regarding positive selection
Occurs in the cortex
Checking if a TCR will bind to 1 of 12 MHC
Checks to see if TCR binds too strongly to MHC
All of the above is true
Negative selection occurs in the cortex
True
False
Which of the following is a professional antigen presenting cells
Macrophages
B-cells
Dendritic cells
All of them are
____ uses AIRE to test TCRs
MTEC
Dendritic cells
PAPCs
None of them
Double Positive has CD4 and CD8 on the cell surface
True
False
____ keep T-cells on the correct path of development
IL-7
NOTCH-1
CCL19
A and B
All of the above
Hassall's Corpuscles is the site of proliferation
True
False
All of the following is true regarding DiGeorge's Syndrome except
No thymus formation
Deletion of chromosome 21
T-cells are absent
All are true
The thymus is most active during ____, but largest during ____
Adulthood, puberty
Puberty, young age
Young age, puberty
Adulthood, young age
The surrogate alpha chain for a TCR is known as preT-alpha
True
False
Once the beta chain successfully binds to the surrogate alpha chain, the TCR becomes double positive
True
False
The 2 checkpoints for TCR development are:
Pre-TCR, Single Positive
Single Positive, TCR
Double Negative, Pre-TCR
Pre-TCR, TCR
Single positive takes place during negative selection
True
False
Which is in the correct order?
Pre-TCR, Double Positive, Double Negative, Single Positive
Pre-TCR, Double Negative, Double Positive, Single Poitive
Double Positive, Single Positive, Double Negative, Pre-TCR
Double Negative, Double Positive, Single Positive, Pre-TCR
Thymocytes have a ____ day window to create a functional TCR
3-4
1-2
5-6
7-10
Gamma Delta TCR goes through positive selction
True
False
Why does Negative Selection take place in the medulla?
It does not take place in the medulla
It contains MTEC that use AIRE to create self-peptides that are normally found in the periphery
It contains PAPC that use AIRE to create self peptides that are normally found in the periphery
To go through peripheral tolerance
Regulatory T-cells job is to down regulate an immune response
True
False
CD4 is activated by MHC1, CD8 is activated by MHC2
True
False
NOTCH-1 is only present during Double Negative development
True
False
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