Practice Exam 4

A detailed infographic illustrating T-cell development, including the thymus, double positive and negative selection processes in a professional and educational style.

T-Cell Development Quiz

Test your knowledge of T-cell development and the thymus with this comprehensive quiz! Dive into essential concepts related to lymphocyte maturation, selection processes, and the key players involved in the immune response. Whether you are a student or a professional, this quiz is a valuable resource for mastering immunology.

Key Features:

24 challenging multiple-choice questions
In-depth coverage of T-cell biology
Instant feedback on your performance

24 Questions6 MinutesCreated by LearningCell512

T-cells originate in the

Bone Marrow

Thymus

Lymph node

Secondary Lymphoid tissue

T-cells develop in the thymus

True

False

T-cells migrate through the ____ to the thymus

Afferent lymphatics

Efferent lymphatics

Blood

Lymph

The thymus is involved in lymphocyte re-circulation

True

False

Which is false regarding positive selection

Occurs in the cortex

Checking if a TCR will bind to 1 of 12 MHC

Checks to see if TCR binds too strongly to MHC

All of the above is true

Negative selection occurs in the cortex

True

False

Which of the following is a professional antigen presenting cells

Macrophages

B-cells

Dendritic cells

All of them are

____ uses AIRE to test TCRs

MTEC

Dendritic cells

PAPCs

None of them

Double Positive has CD4 and CD8 on the cell surface

True

False

Hassall's Corpuscles is the site of proliferation

True

False

All of the following is true regarding DiGeorge's Syndrome except

No thymus formation

Deletion of chromosome 21

T-cells are absent

All are true

The thymus is most active during ____, but largest during ____

Adulthood, puberty

Puberty, young age

Young age, puberty

Adulthood, young age

The surrogate alpha chain for a TCR is known as preT-alpha

True

False

Once the beta chain successfully binds to the surrogate alpha chain, the TCR becomes double positive

True

False

The 2 checkpoints for TCR development are:

Pre-TCR, Single Positive

Single Positive, TCR

Double Negative, Pre-TCR

Pre-TCR, TCR

Single positive takes place during negative selection

True

False

Which is in the correct order?

Pre-TCR, Double Positive, Double Negative, Single Positive

Pre-TCR, Double Negative, Double Positive, Single Poitive

Double Positive, Single Positive, Double Negative, Pre-TCR

Double Negative, Double Positive, Single Positive, Pre-TCR

Thymocytes have a ____ day window to create a functional TCR

3-4

1-2

5-6

7-10

Gamma Delta TCR goes through positive selction

True

False

Why does Negative Selection take place in the medulla?

It does not take place in the medulla

It contains MTEC that use AIRE to create self-peptides that are normally found in the periphery

It contains PAPC that use AIRE to create self peptides that are normally found in the periphery

To go through peripheral tolerance

Regulatory T-cells job is to down regulate an immune response

True

False

CD4 is activated by MHC1, CD8 is activated by MHC2

True

False

NOTCH-1 is only present during Double Negative development

True

False

Practice Exam 4

T-Cell Development Quiz

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