Medi in Emergency 1

Une agricultrice de 54 ans est hospitalisée dans votre service pour une hématémèse. L’examen clinique retrouve des signes cliniques d’hypertension portale. L’hémodynamique est conservée, la numération de formule sanguine met en évidence une hyperéosinophilie. L’échographie abdominale retrouvedes nodules hépatique et splénique avec hypertension portable sévère. La sérologie revient positive en IgM pour Schistosoma mekongi. Quel est le traitement le plus approprié ?

Aux urgences, vous examinez un patient de 55 ans, éthylique chronique, présentant des troubles de la vigilance dans un contexte évident d’intoxication éthylique aiguë. Devant ces troubles de la vigilance sans agitation, vous effectuez de principe une mesure de la glycémie capillaire. Celle-ci est à 0,39 g/L. Quel est le meilleur traitement à mettre administrer en urgence chez ce patient?

Un enfant de 4 ans est amené aux urgences par ses parents pour une intoxication au paracétamol. L'enfant a échappé à la surveillance et a bu la fin d'un flacon de paracétamol qui était resté sur une table. Quelle est la prescription la plus appropriée comme antidote ?

Interne de garde à l'Hôpital National Pédiatrique, vous accueillez le petit Chanty, 18 mois, amené par sa mère pour une fièvre importante associée à des frissons et une altération de l'état général. A l’examen clinique, la température est à 39.2 ˚C, la tension artérielle à 90/60 mmHg, la fréquence cardiaque à 95/min. L’auscultation cardiopulmonaire est normale, l’examen cutané retrouve des éléments purpuriques. Quel traitement administrez-vous en urgence avant tout prélèvement ?

A 66-year-old man with known metastatic squamous cell carcinoma of the esophagus is brought to the emergency room for increasing lethargy and confusion. He is clinically dehydrated, his serum calcium level is 14 mg/dL, and his creatinine level is 2.5 mg/dL but 1 month ago was 0.9 mg/dL. Which therapy for his hypercalcemia should be instituted first?

Chez un malade adulte en état de choc hypovolémique par déshydratation suite à des pertes digestives, quel est le principe de votre expansion volémique initiale ?

Le 16/11/2014, 20h40, Vous êtes interne au service urgence porte d’un hôpital à Phnom Penh. Monsieur C.V, âgé de 53 ans amené par son fils pour une émission de selle noirâtre une fois à 17 heures. 20h45, l'hémorragie digestive est confirmée après votre examen. La tension artérielle est à 80/40mmHg, FC 110/mn, FR 22/mn, SpO2 96% en air ambiant, la température à 370C, Glasgow 15. Vous reprenez votre interrogatoire minutieux, vous avez noté que c’est le premier épisode de méléna. Il n’en a pas de l’antécédent médical, chirurgical ou familial connu. Il n'a jamais pris de médicament. Il n’a pas d’allergie connue. Il fume 1 paquet par jour et il boit du vin du riz 1 litre par jour depuis l’âge de 30 ans. A l'examen clinique, vous avez trouvé des angiomes stellaires, circulation veineuse collatérale avec ictère conjonctival. Quel type de médicament le plus utile prescrivez-vous pour ce patient?

Lors d'un IDM de topographie inférieure, on observe une chute de la pression artérielle à 80/50 mmHg, une bradycardie sinusale à 40/min, des sueurs et des nausées. L'auscultation pulmonaire est normale. Parmi les mesures thérapeutiques suivantes, laquelle retiendrez-vous en priorité?

Mademoiselle D, 18 ans, sans ATCD connu, est amenée aux urgences pour état confus. L’examen clinique retrouve : PA = 115/85 mmHg, T= 38,9°C, fréquence cardiaque à 110/min et fréquence respiratoire à 25/min. Pas de signe de localisation en examen neurologique. L’auscultation cardio-respiratoire est sans particularité. Le gaz du sang montre : Na = 132 mmol/L, K = 5,5 mmol/L, chlore = 102 mmol/L, Bicarbonates = 8 mmol/L, pH artériel = 7, pCO2 = 18 mmHg, pO2 = 110 mmol/L et Hb = 125 g/L. La bandelette urinaire montre : sang (-), protéines traces, leucocytes +++, nitrites +, cétones +++, glucose +++. La glycémie capillaire : Hi. Quel est l’ensemble des actes thérapeutiques en urgence pour sauver cette malade ?

Monsieur M, 60 ans, est adressé aux urgences pour altération de l’état général. Il est hypertendu, suivi régulièrement par son médecin traitant. Il présente depuis trois jours des diarrhées liquides. A l’examen clinique, la pression artérielle est à 90/60 mmHg, la fréquence cardiaque à 130/min. Le patient a perdu 3 kg depuis le début des diarrhées. L’auscultation cardiaque et pulmonaire est sans particularité. L’examen abdominal révèle une sensibilité diffuse, sans défense ni contracture. Il présente de légères marbrures, un pli cutané persistant et réclame toutes les 15 minutes un verre d’eau. Il est apyrétique. Le bilan biologique montre : urée = 1.65mg/L, créatinine = 210μmol/L, Bicarbonate = 17 mmol/L, Na❺ = 152mmol/L, K❺ = 7.2 mmol/L, calcémie = 86 g/L, phosphore = 35 mg/L, albuminémie = 50g/L. La numération globulaire est sans particularité. Le bilan biologique réalisé il y a trois mois était sans particularité. Sa diurèse des 12 dernières heures est évaluée à 200ml. Quel sera votre traitement en urgence ?

Un patient d’une cinquantaines d’années est vu 1h00 après le début d’une douleur thoracique infarctoïde. A l’ECG, il existe un sus décalage de ST en inférieur. La tension est à 9/6, la fréquence cardiaque à 50/mn, les jugulaires sont turgescentes, il n’y a pas de crépitant à l’auscultation pulmonaire. Les médicaments suivants, sauf un, sont prescrits, selon la voie d’administration appropriée, pendant la phase pré hospitalière:

Un patient de 60 ans, souffrant de silicose, a par ailleurs des épisodes de palpitations fréquents, prolongés et invalidants, par fibrillation auriculaire paroxystique. L’un des antiarythmiques ci-dessous est contre-indiqué. Lequel?

A 12-year-old boy presents to his pediatrician with frequent episodes of headache, nausea, blurry vision, and sweating. On physical examination, his temperature is 37.4 C (99.3 F), blood pressure is 148/94 mm Hg, pulse is 92/min, and respirations are 18/min. The rest of his examination is unremarkable. His 24-hour urinary vanillylmandelic acid (VMA) and metanephrines are increased. An abdominal CT reveals an extrarenal mass above the left kidney. Which of the following is the most appropriate pharmacotherapy?

A 12-year-old girl presents to the ED for left eye pain and swelling for 2 days. The patient has had cough, congestion, and rhinorrhea for the last week that is improving. On examination, her temperature is 100.8°F, HR 115 beats per minute, RR 12 breaths per minute, and BP 110/70 mm Hg. On eye examination, there is purple-red swelling of both upper and lower eyelids with injection of the conjunctiva. Pupils are equal and reactive to light. There is restricted lateral gaze. Visual acuity is 20/70 in the left eye and 20/25 in the right eye. The rest of the physical examination is normal. What is the most appropriate next step in management?

A 12-year-old girl with mild asthma comes to the office for a health maintenance visit. Her mother states that she is using her albuterol inhaler 2-3 times a week and that she has a cough that wakes her up at night about 3 times a month. On physical examination, she has diffuse inspiratory and expiratory wheezes. She has no accessory muscle use. Pulse oximetry shows 95% oxygen saturation on room air. Which of the following is the most appropriate treatment for her at this time?

A 13-year-old boy is brought to the pediatrician by his mother because of increasing body hair. Several months earlier he had been diagnosed with 17α-hydroxylase deficiency and treated with hydrocortisone. Physical examination reveals an overweight boy with a moderate amount of both chest and genital hair, and some facial hair growth. His physical examination is otherwise unremarkable. Which of the following is the best treatment for this patient?

A 14-year-old boy dives into the shallow end of a swimming pool and hits his head against the bottom. When he is rescued, he shows a complete lack of neurologic function below the neck. He is still breathing on his own, but he cannot move or feel his arms and legs. The paramedics carefully immobilize his neck for transportation to the hospital, and they alert the emergency department to his impending arrival. Once there, which of the following would most likely have an immediate benefit for this patient?

A 14-year-old girl, angry at her mother for taking away her MP3 player, takes an unknown quantity of a friend’s pills. Within the first hour she is sleepy, but in the emergency center she develops a widened QRS complex on her electrocardiogram (ECG), hypotension, and right bundle branch block. The therapy you would initiate for this ingestion is which of the following?

A 15-year-old boy with Duchenne muscular dystrophy is brought to the emergency department with increasing respiratory distress and cyanosis. On examination, he is diaphoretic, with gasping respirations, poor air entry, and diminished responsiveness. He is tachycardic at 160 beats/min. His chest x-ray film shows a lingular pneumonia, and he is intubated. He improves over the next 10 days with antibiotics but is not extubated secondary to hypoventilation on weaning because of muscle weakness. Which of the following modalities will most likely help wean him off the ventilator?

A 15-year-old is participating in high school football practice in August in Texas. He had complained of headache and nausea earlier in practice, but kept playing after a cup of water. He is now confused and combative. He is dizzy and sweating profusely. His temperature is 41°C (105.8°F). Therapy should consist of which of the following?

A 16-year-old adolescent boy with a history of severe hemophilia A is undergoing an elective inguinal hernia repair. Which of the following is the best option for preventing or treating a bleeding complication in the setting of this disease?

A 16-year-old girl with a history of ulcerative colitis managed with steroid therapy presents to the emergency department with a 36-hour history of nausea, crampy abdominal pain, and severe bloody diarrhea. On examination, the patient is febrile and pale, with a blood pressure of 90/60 mmHg and heart rate of 130 beats/min. Her abdomen is distended and diffusely tender. A complete blood count (CBC) demonstrates a leukocytosis with a left shift. The patient receives IV fluid resuscitation and nasogastric (NG) tube decompression. Further therapeutic interventions should include which one of the following?

A 19-year-old man is brought to the ED by EMS after he was found lying on the floor at a dance club. EMS states that the patient seemed unconscious at the dance club, but as soon as they transferred him onto the gurney, he became combative. Upon arrival in the ED, his BP is 120/65 mmHg, HR is 75 beats per minute, temperature is 98.9°F, RR is 12 breaths per minute, and oxygen saturation is 98% on room air. On physical examination, his pupils are midsized, equal, and reactive to light. His skin is warm and dry. Lung, cardiac, and abdominal examinations are unremarkable. As you walk away from the bedside, you hear the monitor alarm signaling zero respirations and the oxygen saturation starts to drop. You perform a sternal rub and the patient sits up in bed and starts yelling at you. As you leave him for the second time, you hear the monitor alarm again signal zero respirations. You administer naloxone, but there is no change in his condition. Which of the following is most likely the substance ingested by this patient?

A 19-year-old man receives un-cross-matched blood during resuscitation after a gunshot wound to the abdomen. He develops fever, tachycardia, and oliguria during the transfusion and is diagnosed as having a hemolytic reaction. Which of the following is the most appropriate next step in the management of this patient?

A 19-year-old woman presents to the ED with abdominal pain, nausea, vomiting, diarrhea, and hematemesis after ingesting an unknown substance in a suicide attempt. Which of the following antidotes are correctly paired?

A 20-year-old female is brought to the emergency room after getting struck by a motor vehicle. She appears confused. According to her parents, she has no other medical problems and does not take any prescription medications. However, they have noticed her increase in appetite recently. She occasionally drinks alcohol and smokes half a pack of cigarettes daily. Her temperature is 37.2°C (99°F), blood pressure is 150/90mmHg, pulse is 110/min, and respirations are 22/min. Examination reveals dry mouth and conjunctival injection. Pupils are equal, reactive to light and accommodation. She has impaired time orientation and shortterm memory. Which of the following is the most likely explanation for this patient's symptoms?

A 20-year-old G1 at 32 weeks presents for her routine obstetric (OB) visit. She has no medical problems. She is noted to have a blood pressure of 150/96 mm Hg, and her urine dip shows 1+ protein. She complains of a constant headache and vision changes that are not relieved with rest or a pain reliever. The patient is sent to the hospital for further management. At the hospital, her blood pressure is 158/98 mm Hg and she is noted to have tonicclonic seizure. Which of the following is indicated in the management of this patient?

A 20-year-old G1 at 36 weeks is being monitored for preeclampsia; she rings the bell for the nurse because she is developing a headache and feels funny. As you and the nurse enter the room, you witness the patient undergoing tonic-clonic seizure. You secure the patient’s airway, and within a few minutes the seizure is over. The patient’s blood pressure monitor indicates a pressure of 160/110 mm Hg. Which of the following medications is recommended for the prevention of a recurrent eclamptic seizure?

A 20-year-old woman arrives at the emergency department actively seizing with QRS prolongation on ECG per paramedics. The patient’s roommate called emergency medical services after the patient collapsed, was not responsive to questioning, and began having clonic jerks bilaterally in her upper extremities. The patient’s roommate denies any knowledge of the patient consuming alcohol or illicit drugs. She does not believe the patient had any plan of harming herself, but does acknowledge that the patient has seemed “down” lately and was recently prescribed medication for generalized anhedonia. Which of the following is the most appropriate first-line treatment?

A 21-year-old man comes to the ER with palpitations and dizziness that began suddenly one hour ago. He notes having similar past episodes provoked by fatigue or strong emotions. He says he can usually stop the episodes by putting his head into cold water or squatting and taking a deep breath. However, these techniques are not working this time. Presently, his blood pressure is 60/30 mmHg and his heart rate is 240/min. He is diaphoretic with cold extremities. An EKG rhythm strip shows a regular, narrow complex tachycardia. Which of the following is the best next step in managing his condition?

A 21-year-old man presents to the ED. He has a known history of type 1 diabetes. He is hypotensive with BP of 95/65 mmHg, tachycardic at 120 beats per minute, and tachypneic at 30 breaths per minute. Laboratory results reveal a WBC 20,000/μL, hematocrit 45%, platelets 225/μL, sodium 131 mEq/L, potassium 5.3 mEq/L, chloride 95 mEq/L, bicarbonate 5 mEq/L, BUN 20 mg/dL, creatinine 0.9 mg/dL, and glucose 425 mg/dL. Arterial blood gas reveals a pH of 7.2. Urinalysis reveals glucosuria and ketosis. There is a fruity odor to his breath. Which of the following provides the strongest evidence for the diagnosis?

A 21-year-old woman at 36 weeks gestation is admitted for delivery. She has severe preeclampsia. Her blood pressure is 190/110 mmHg, pulse is 80/min and respirations are 16/min. Physical examination shows 3+ pitting edema of the legs and brisk deep tendon reflexes. Fundoscopic examination shows no abnormalities. Laboratory studies show elevated BUN, serum creatinine and serum transaminases. Urinalysis shows 4+ proteinuria. Intravenous hydralazine and magnesium sulfate was initiated on admission. After stabilization, intravenous oxytocin and artificial rupture of membranes (AROM) was administered for induction of labor. Two hours later, her blood pressure is 150/90 mmHg, pulse is 78/min and respirations are 9/min. Repeat examination shows hyporeflexia and a completely effaced cervix that is 5cm dilated. Which of the following is the most appropriate next step in management?

A 22-year-old man presents to the emergency department complaining of fever, nausea, vomiting, and right lower quadrant pain. He has no significant medical history and does not take any medications. He is a senior in college and denies cigarette smoking or drug use. He drinks alcohol occasionally. Physical examination reveals a temperature of 38.6°C, with all other vital signs within normal limits. ACT scan of his abdomen confirms acute appendicitis. Laboratory analyses reveal a leukocytosis but no electrolyte abnormalities. He is taken to the operating room and undergoes a successful laparoscopic appendectomy. Following the procedure, he is given intravenous fluids containing 5% dextrose in a 0.45% (½normal) saline solution at a rate of 150 ml/hr. The next morning the patient feels well but he then becomes progressively confused throughout the afternoon. You are called to his bedside after he has two grand mal seizures lasting 30 seconds apiece. Serum chemistries drawn at that time reveal a sodium concentration of 115mEq/L. What is the most appropriate therapy for this patient?

A 22-year-old woman is brought to the ED by ambulance complaining of sudden onset of severe abdominal pain for 1 hour. The pain is in the RLQ and is not associated with nausea, vomiting, fever, or diarrhea. On the pelvic examination you palpate a tender right adnexal mass. The patient’s last menstrual period was 6 weeks ago. Her BP is 95/65 mm Hg, HR is 124 beats per minute, temperature is 99.8°F, and RR is 20 breaths per minute. Which of the following are the most appropriate next steps in management?

A 22-year-old woman is brought to the ED by paramedics who state that they found the patient hunched over on a park bench barely breathing. The patient is rousable only to painful stimuli. Her initial vitals include an HR of 78 beats per minute, a BP of 125/58 mmHg, and a respiratory rate of 6 breaths per minute with an oxygen saturation of 94% on 2-L nasal cannula. Upon physical examination, the patient has clear breath sounds bilaterally and no signs of trauma. Her pupils are 2 mm bilaterally and reactive to light. Which of the following agents may be used to restore this patient’s respirations?

A 22-year-old woman is brought to the emergency department after a motorcycle accident in which she sustained severe crush injuries of her lower extremities. In the field, her Glasgow Coma Score was 14. She is awake and alert on arrival after having been given morphine for pain control. Any details of her past medical history are unknown. Initial examination shows a blood pressure of 140/80 mm Hg and pulse of 100/min. Her oxygen saturation on room air is 95% by pulse oximeter. An ECG is obtained and shows very large, peaked T-waves in leads V1-V6. Which of the following is the most appropriate initial step in patient care?

A 22-year-old woman presents to the ED by ambulance from a dance club. The paramedics report that the patient was agitated in the club and had a generalized seizure. Her BP is 165/100 mmHg, HR is 119 beats per minute, temperature is 101.9°F, RR is 17 breaths per minute, oxygen saturation is 98% on room air, and fingerstick glucose is 92 mg/dL. On examination, the patient is hyperactive and appears to be hallucinating. Her pupils are dilated to 6 mm bilaterally and reactive. Her neck is supple. Examination of the heart is unremarkable except for tachycardia. Her lungs are clear and abdomen is soft and nontender. The patient moves all four extremities. Laboratory results are as follows: Sodium 109 mEq/L, WBC 12,000/mm3, Potassium 3.5 mEq/L, Hct 49%, Chloride 83 mEq/L, Platelets 350/μL, Bicarbonate 20 mEq/L, BUN 10 mg/dL, Creatinine 1 mg/dL, Glucose 103 mg/dL. Which of the following substances did this patient most likely consume?

A 23-year-old man is brought to the emergency room because of confusion and hallucinations. While in ER, he has an episode of generalized tonic-clonic seizures. His past medical history is significant for illicit drug use. His temperature is 40.0°C (104.0°F), pulse is 95/min, and blood pressure is 120/80 mm Hg. He is confused and disoriented. Fundoscopy is with in normal limits. There is no neck stiffness. The neurological examination shows upgoing plantar reflexes bilaterally. Lumbar puncture is performed and CSF analysis shows the following: Glucose 35mg/dl, Protein 80mg/dl, WBC count 150/cm3, Neutrophils 10%, Lymphocytes 90%, Gram stain Negative. CT scan of the brain without contrast is normal. Which of the following is the most appropriate next step in the management of this patient?

A 23-year-old man presents to the ED with left lower abdominal pain and left testicular pain that started 1 to 2 weeks ago and has gradually worsened. He has some nausea and vomiting. His HR is 98 beats per minute, BP is 125/65 mmHg, temperature is 100.9°F, and RR is 18 breaths per minute. Physical examination reveals a tender left testicle with a firm nodularity on the posterolateral aspect of the testicle. Pain is relieved slightly with elevation of the testicle and the cremasteric reflex in normal. You make the presumptive diagnosis of epididymitis. Which of the following is the next best step?

A 23-year-old woman presents to the ED complaining of abdominal pain, nausea, and vomiting. She has a history of depression but is not currently taking any antidepressant medications. Upon further questioning, the patient states that she ingested a bottle of pills in her medicine cabinet approximately 3 hours ago. Her BP is 115/65 mmHg, HR is 101 beats per minute, temperature is 100.1°F, RR is 29 breaths per minute, and oxygen saturation is 100% on room air. Physical examination is unremarkable except for mild diffuse abdominal tenderness. Laboratory results reveal a white blood cell (WBC) count of 10,300/μL, hematocrit 46%, platelets 275/μL, aspartate transaminase (AST) 70 U/L, alanine transaminase (ALT) 85 U/L, alkaline phosphatase 75 U/L, sodium 143 mEq/L, potassium 3.7 mEq/L, chloride 98 mEq/L, bicarbonate 8 mEq/L, blood urea nitrogen (BUN) 22 mg/dL, creatinine 0.9 mg/dL, and glucose 85 mg/dL. Arterial blood gas values on room air are pH 7.51, PCO2 11 mm Hg, and PO2 134 mm Hg. Which of the following substances did this patient most likely ingest?

A 23-year-old woman undergoes total thyroidectomy for carcinoma of the thyroid gland. On the second postoperative day, she begins to complain of a tingling sensation in her hands. She appears quite anxious and later complains of muscle cramps. Which of the following is the most appropriate initial management strategy?

A 24-year-old firefighter sustains 30% total body surface area (TBSA) burns to his torso, face, and extremities. His wounds are treated topically with silver nitrate. Which of the following complications is associated with use of this agent?

A 24-year-old man presents in septic shock from an empyema. He is febrile to 103°F, tachycardic in the 120s, and hypotensive to the 90s. His oxygen saturation is 98% on 2-L oxygen. His white blood cell count is 25,000/mL and creatinine is 0.8 mg/dL. His blood pressure does not respond to fluid administration despite a CVP of 15. Which of the following therapies is indicated in managing this patient?

A 24-year-old man with a history of depression is brought to the emergency room because of a drug overdose. He is experiencing some nausea and vomiting, but no other symptoms. Physical examination and vital signs are normal. Six hours prior to presentation, he intentionally took 40 tablets of acetaminophen (500mg/tablet). Which of the following is the most appropriate next step in management?

A 24-year-old woman comes into the emergency department with recurrent episodes of palpitations, headache, and tremor. Her blood pressure is 155/95 mmHg, heart rate is 135/min, temperature is 37.9°C (100.2°F), and respiratory rate is 12/min. A CT of the abdomen shows a suprarenal mass. After confirming the diagnosis with a laboratory test, the physician informs the patient that she will require immediate therapy and surgical resection of the mass within the next few weeks. In order to achieve short-term control of her blood pressure, which of the following agents is most appropriate?

A 24-year-old woman is brought to the ED after being found on a nearby street hunched over and in mild respiratory distress. Upon arrival, she is tachypneic at 24 breaths per minute with an oxygen saturation of 97% on face mask oxygen administration. Upon physical examination, the patient appears to be in mild distress with supraclavicular retractions. Scattered wheezing is heard throughout bilateral lung fields. Which of the following medications should be administered first?

A 24-year-old woman is brought to the emergency room after ingesting 14 acetaminophen tablets, 500 mg each, two hours ago. She does not smoke but drinks alcohol on the weekends. She is alert and oriented. Her temperature is 37.2°C (99°F), blood pressure is 110/60mmHg, pulse is 90/min and respirations are 18/min. Examination shows no abnormalities. Laboratory studies show: Hct 40%, WBC 6,000/mm3, Platelet 390,000/mm3. Which of the following is the most appropriate next step in management?

A 24-year-old woman presents to the ED at 4 AM with severe left eye pain that woke her up from sleep. She wears soft contact lenses and does not routinely take them out to sleep. She is in severe pain and wearing sunglasses in the examination room. You give her a drop of proparacaine to treat her pain prior to your examination. On examination, her vision is at baseline and she has no afferent pupillary defect. There is some perilimbic conjunctival erythema. On fluorescein examination, a linear area on the left side of the cornea is highlighted when cobalt blue light is applied. No underlying white infiltrate is visualized. No white cells or flare are visualized in the anterior chamber. What is the most appropriate treatment for this condition?

A 24-year-old woman presents to the emergency department (ED) complaining of right eye pain and blurry vision since waking up this morning. She states that the pain began after taking out contact lenses that were in her eyes for over 1 week. Her blood pressure (BP) is 120/75 mm Hg, heart rate (HR) is 75 beats per minute, temperature is 99.1°F, and respiratory rate (RR) is 16 breaths per minute. Her right and left eye visual acuity is 20/60 and 20/20, respectively. Her conjunctivae are injected. The slitlamp examination reveals a large area of fluorescein uptake over the visual axis. Which of the following is the most appropriate therapy?

A 25-year-old man is brought into the ED by two police officers because of suspected drug use. The patient is extremely agitated and is fighting the police officers. It takes three hospital staff members and the two police officers to keep him on the stretcher. His vital signs are BP 150/80 mmHg, HR 107 beats per minute, temperature 99.7°F, RR 18 breaths per minute, and oxygen saturation 99% on room air. Physical examination is unremarkable except for cool, diaphoretic skin, persistent vertical and horizontal nystagmus, and occasional myoclonic jerks. Which of the following is the most likely diagnosis?

A 25-year-old man is carried into the ED by two of his friends who state that he is not breathing. The patient has a history of heroin abuse. His vital signs are BP 115/70 mmHg, HR 99 beats per minute, temperature 98.9°F, RR 3 breaths per minute, and oxygen saturation 87% on room air. You notice fresh needle marks and miotic pupils. You begin bag-valvemask ventilation and his oxygen saturation increases to 99%. Which of the following is the most appropriate next step in management?

A 26-year-old bar employee is brought to the emergency room because of agitated, combative behavior in which three people had to restrain her. She has also been hallucinating during this entire period. Her temperature is 37.7°C (100°F), blood pressure is 160/90 mmHg, pulse is 126/min, and respirations are 18/min. She is confused and agitated during the examination. Pupils are 6 mm in diameter and respond to light; prominent nystagmus is present. The remainder of her examination is unremarkable. Which of the following is the most likely diagnosis?

A 26-year-old woman presents to the ED with fever, malaise, and an evolving rash in the right axilla that she initially thought was from an insect bite that she received while hiking 1 week earlier. She complains of generalized fatigue, nausea, headache, and joint pain over the past several days. Her vitals are BP of 120/75 mmHg, HR of 75 beats per minute, RR of 16 breaths per minute, and temperature of 101°F. On physical examination, she is awake and alert, with a nonfocal neurologic examination. Her neck is supple, but she is diffusely tender over the shoulder, knee, and hip joints bilaterally without any distinct effusions. Her abdomen is soft and nontender. She has a 9-cm erythematous annular plaque with partial central clearing and a bright red outer border and a target center under her right axilla. Which of the following is the next best step?

A 27 -year-old white female comes to the office and complains of a headache for the last two weeks. She characterizes the headache as intermittent, "feels like a dull ache", 5/10 in severity, and associated with nausea and vomiting. She is afebrile and never had such a headache before. She has no visual complaints. She is a non-smoker and drinks alcohol only on weekends. Her only drugs are oral contraceptive pills (OCPs). Her menses are regular, and she has never conceived. She has no family history of similar problem. Her pulse is 80/min, temperature is 37.1°C, blood pressure is 120/75mmHg and respirations are 15/min. She is 5 feet 10 inches tall, and her weight is 210 lbs. The neurological examination is non-focal, and there are no signs of meningeal irritation. Funduscopy reveals papilledema. MRI of the brain is normal. Which of the following complications is likely to develop if this patient is left untreated?

A 27-year-old man presents to the ED extremely agitated complaining of mild chest pain and dyspnea. He states that he was snorting cocaine all afternoon. You place him on a monitor and get his vital signs. His BP is 215/130 mmHg, HR is 112 beats per minute, temperature is 100.1°F, RR is 17 breaths per minute, and oxygen saturation is 98% on room air. An ECG reveals sinus tachycardia at a rate of 116. Which of the following is the most appropriate medication to administer?

A 27-year-old woman presents to the ED complaining of an intensely pruritic rash all-over her body, abdominal cramping, and chest tightness. She states that 1 hour ago she was at dinner and accidentally ate some shrimp. She has a known anaphylactic allergy to shrimp. Her BP is 115/75 mmHg, HR is 95 beats per minute, temperature is 98.9°F, RR is 20 breaths per minute, and oxygen saturation is 97% on room air. She appears anxious, and her skin is flushed with urticarial lesions. Auscultation of her lungs reveals scattered wheezes with decreased air entry. Which of the following is the most appropriate next step in management?

A 28-year-old man presents to ER with fever, chills, and generalized weakness for the past one week. He has no history of pre-existing heart disease, but he was admitted to the hospital six months ago for cellulitis of the right arm. His temperature is 40.0°C (104°F), pulse is 110/min, respirations are 22/min, and blood pressure is 110/65 mmHg. Oropharynx is clear. Lungs are clear to auscultation. A holosystolic murmur is heard at the lower sternum which increases in intensity with inspiration. His blood is drawn and sent for culture. What is the most appropriate initial antibiotic therapy for this patient?

A 29-year-old male is brought to the emergency room because of sudden onset confusion and fever. He was recently admitted to the hospital for hallucinations and was discharged instable condition. His temperature is 38.6°C (101.6°F), blood pressure is 150/100 mmHg, pulse is 112/min, and respirations are 24/min. Mucus membranes are dry. Profuse diaphoresis is present. Lungs are clear to auscultation. Abdominal muscles are rigid. Muscle tone is increased; "lead pipe rigidity" is noted in all four extremities. Deep tendon reflexes are 2+. Tremor is noted. Which of the following is the most likely diagnosis?

A 30-year-old man is brought to the ED by police officers. The patient is agitated, vomiting, and complaining of body aches. He states that he is withdrawing from his medication. His vital signs are BP 160/85 mmHg, RR 20 breaths per minute, HR 107 beats per minute, and temperature 99.7°F. On examination he is diaphoretic, has rhinorrhea, piloerection, and hyperactive bowel sounds. Which of the following substances is this patient most likely withdrawing from?

A 31-year-old man is brought to the ED by EMS who state that the man was found lying on the floor of his garage. He is rousable in the ED, speaks with slurred speech, and vomits. His BP is 140/85 mmHg, HR is 94 beats per minute, temperature is 98.8°F, RR is 17 breaths per minute, and oxygen saturation is 99% on room air. You place an IV line, draw blood, and start a liter of normal saline running through the line. Laboratory results reveal serum sodium 139 mEq/L, potassium 3.5 mEq/L, chloride 101 mEq/L, bicarbonate 14 mEq/L, BUN 15 mg/dL, creatinine 1 mg/dL, glucose 105 mg/dL, arterial blood pH 7.27, COHb 4%, and lactate 2.8 mEq/L. Urinalysis shows 1+ protein, trace ketones, WBC 4/hpf (high-power field), red blood cell (RBC) 2 to 3/hpf, and multiple envelope-shaped and needle shaped crystals. Which of the following conditions would best explain his metabolic acidosis?

A 31-year-old woman with a known psychiatric history presents to the ED after ingesting an unknown quantity of pills from her medication vial. In the ED, she complains of nausea, abdominal cramping, and feels unsteady on her feet. On physical examination, you observe that she is tachycardic and ataxic. Which of the following substances will best be treated by activated charcoal that could present like this?

A 32-year-old male comes to the hospital complaining of pain, swelling and redness of his right arm. His past medical history is significant for substance abuse. His temperature is 38.9°C (102.0°F), blood pressure is 110/60 mmHg, pulse is 110/min and respirations are 14/min. He is started on intravenous clindamycin. The next day the swelling and pain improve, but he develops nausea, vomiting, abdominal cramps and diarrhea. He is restless and asks for pain medication to treat his aching muscles and joints. His temperature now is 37.3°C (99.1°F), blood pressure is 120/70 mmHg, pulse is 80/min and respirations are 16/min. His laboratory studies at the time of admission and the following day show: Hemoglobin 13.0 g/L (12.8 g/L), Leukocyte count 17,500/mm3 (8,500/mm3), NeutrophiIs 86% (64%), Lymphocytes 14% (26%). Which of the following is the most appropriate next step in management?

A 32-year-old male is admitted to the hospital because of confusion. He was recently diagnosed with schizophrenia His temperature is 38.6°C (101.6°F), blood pressure is 160/100 mmHg, pulse is 116/min, and respirations are 22/min. He is not oriented to time, place or person. Mucus membranes are dry. Profuse diaphoresis is present. Lungs are clear to auscultation. Abdominal, neck and extremity muscles are rigid. Muscle tone is increased. Deep tendon reflexes are 2+. Laboratory studies show a serum CK of 50,000 IU/L. CSF fluid analysis shows a total white blood cell count of 5/microL. Which of the following is the most appropriate next step in management?

A 32-year-old man is brought to the ED by EMS for confusion. EMS reports that the patient was at a local pharmacy filing his prescriptions when the pharmacist noticed the patient sweating and having difficulty answering questions. In the ED, the patient’s BP is 130/68 mmHg, HR is 120 beats per minute, temperature is 98.9°F, and RR is 12 breaths per minute. The patient is unable to explain what happened. His fingerstick glucose is 410 mg/dL and his urine is positive for ketones. An electrolyte panel reveals Na + 131 mEq/L, K + 4 mEq/L, Cl − 91 mEq/L, and Ca 2+ 11 mEq/L. Which of the following electrolytes are most important to supplement during the management of his medical condition?

A 32-year-old woman is brought to the emergency department by her husband because of slurred speech and difficulty walking. She has also been very drowsy for the past several hours, a non-typical behavior for a very active woman. She has a history of bipolar disorder, insomnia, migraine headaches, seizures and hypothyroidism. Her temperature is 37°C (98.6°F), blood pressure is 110/70 mmHg, pulse is 76/min, and respirations are 16/min. She is lethargic and falls asleep during the interview and physical examination. Pupils are 5 mm in size and reactive to light. Neck is supple. Oropharynx is clear. Chest auscultation is unremarkable. Abdomen is soft and non-tender; bowel sounds are normal. Limited neurologic examination shows 1+ deep tendon reflexes in all four extremities; there is no Babinski sign; strength is 5/5 throughout. There is no nystagmus or hand tremor. Blood sugar is 130 mg/dL. Which of the following is the most likely cause of her symptoms?

A 32-year-old woman presents to the ED with 7 days of vaginal discharge and pelvic pain. She is sexually active and admits to several recent “one night stands.” She denies trauma/injury and does not have any urinary or other abdominal complaints. Her HR is 85 beats per minute, BP is 135/90 mmHg, RR is 18 breaths per minute, and temperature is 101.4°F. On bimanual examination, you note a copious, thin, white discharge with mild diffuse adnexal tenderness with significant cervical motion tenderness. There are no rashes, skin lesions, or adenopathy. Laboratory results are notable for a WBC of 18,000/μL. A urinalysis shows WBCs but is otherwise within normal limits. Which of the following is the most appropriate next step in management?

A 33-year-old woman presents to the ED with a painful sprained ankle. She has a past medical history of depression for which she is taking phenelzine, a monoamine oxidase inhibitor. After you place an elastic wrap on her ankle, she asks you to prescribe her some pain medication. Which of the following medications is contraindicated in patients taking a monoamine oxidase inhibitor?

A 34-year-old Caucasian female comes to the emergency department and complains that her heart is "racing out of control." She began to feel this way only this morning. She denies any chest pain or shortness of breath. Over the past few months, she has unintentionally lost 10 pounds. Her past medical history is significant for panic attacks, but she claims she has not had an attack for over 10 years. She is very concerned because her father died of a heart attack at the age of 40. The EKG reveals sinus tachycardia at a rate of 120/min. The initial labs show: CBC: Hb 12.9g/dL, Ht 39%, MCV 88 fl, Platelet count 200,000/cmm, Leukocyte count 8,500/cmm, Neutrophils 67%, Eosinophils 1%, Lymphocytes 24%, Monocytes 8%. Serum: Serum Na 139 mEq/L, Serum K 4.2 mEq/L, Chloride 100 mEq/L, Bicarbonate 25 mEq/L, BUN 10 mg/dL, Serum Creatinine 1.0 mg/dL, Calcium 9.1 mg/dL, Blood Glucose 102 mg/dL, TSH < 0.1 microU/mL, Free T4 4.6 ng/dL (N0.9-24). Which of the following is the best immediate step to control this patient's symptoms?

A 34-year-old homeless male is brought to the ER in a confused state. He complains of flank pain. His past medical history is unknown. His temperature is 36.8°C (98.2F), blood pressure is 110/60 mmHg, pulse is 110/min and respirations are 22/min. His appearance is disheveled. Pupils are equal, 4 mm in size and reactive to light. Funduscopic examination is within normal limits. Lungs have crackles at both bases. Mild costovertebral angle tenderness is present. Foley catheter is placed and urine appears red. Laboratory studies show: Serum sodium 136 mEq/L, Serum potassium 3.5 mEq/L, Chloride 93 mEq/L, Bicarbonate 6 mEq/L, Blood urea nitrogen (BUN) 34 mg/dl, Serum creatinine 2.8 mg/dl, Blood glucose 80 mg/dl, Calcium 6.5 mg/dl, Serum ketones negative, Plasma lactate 2.4 mEq/L. Which of the following is the most appropriate next step in management?

A 34-year-old homeless man is brought to the emergency room in a confused state. He complains of epigastric pain, vomiting and blurred vision. His temperature is 36.8°C (98.2°F), blood pressure is 110/60 mmHg, pulse is 110/min and respirations are 22/min. Physical examination shows poor oral hygiene and dry mucous membranes. Lungs are clear to auscultation. Abdominal exam shows mild epigastric discomfort. Funduscopic examination reveals optic disc hyperemia. Laboratory studies show: Serum sodium 136 mEq/L, Serum potassium 3.0 mEq/L, Chloride 93 mEq/L, Bicarbonate 6 mEq/L, Blood urea nitrogen (BUN) 30 mg/dL, Serum creatinine 0.8 mg/dL, Blood glucose 80 mg/dL, Serum ketones negative, Plasma lactate 2.2 mEq/L. Which of the following is the most likely cause of his symptoms?

A 34-year-old male is brought to the emergency room after being involved in a motor vehicle accident. He suffers blunt abdominal trauma and bilateral femur fractures. He has no significant past medical history. On physical examination, his blood pressure is 80/40 mmHg and his heart rate is 110/min. He receives several units of packed red blood cells. Once stabilized, the patient begins complaining of a tingling sensation in his toes and fingers. His serum calcium level is noted to be 7.2 mg/dL. Which of the following is the most likely cause of this patient's current symptoms?

A 35-year-old agitated man presents to the ED in police custody. He denies any past medical history and takes no medication. He admits to using some drugs today. His BP is 195/90 mmHg, HR is 121 beats per minute, temperature is 100.1°F, RR is 18 breaths per minute, and oxygen saturation is 99% on room air. On examination, he is diaphoretic, and has pupils that are 8 mm in diameter, along with 3+ patella reflexes bilaterally. Electrocardiogram (ECG) reveals sinus tachycardia with a rate of 123. Which of the following toxic syndromes is this patient exhibiting?

A 35-year-old woman is brought to the emergency room after an apparent suicide attempt. Her current prescription of imipramine was found at her bedside along with a suicide note. En route to the hospital, she suffered a seizure. She has been treated with many different anti-depressants over the past several years without improvement. Her temperature is 38.3°C (101°F), blood pressure is 90/50 mmHg, pulse is 120/min and respirations are 24/min. EKG shows QRS widening (0.18sec). She is given sodium bicarbonate along with supportive treatment. Which of the following is the most likely mechanism that explains the beneficial effects of sodium bicarbonate?

A 36-year-old female presents to the emergency room complaining of chest pain that started suddenly while she was shopping at the mall. She also reports shortness of breath, palpitations and diaphoresis. The pain is retrosternal and radiates to the left arm. There are no aggravating or relieving factors. On review of systems, the patient reports having had a runny nose, sore throat and dry cough for the past 3 days. Her past medical history is significant for panic attacks, for which she takes paroxetine, and dysfunctional uterine bleeding, for which she takes estrogen. Her family history is significant for the sudden death of her father at age 44 from a heart attack. Social history reveals that she has smoked one pack of cigarettes per day for the past 15 years. Which of the following is the most appropriate initial therapy for this patient?

A 36-year-old immigrant woman is brought to the ED from her workplace. She was found to be agitated and behaving bizarrely. The patient’s past medical history and medications are unknown. Her BP is 162/92 mmHg, HR is 140 beats per minute, temperature is 101.8°F, and RR is 18 breaths per minute. On examination, the patient is delirious, tremulous, and has a large goiter. Which of the following is the most appropriate management of this patient?

A 36-year-old male presents with the sensation of a racing heart. His blood pressure is 110/70 mmHg, respiratory rate 14/minute, and O2 saturation 98%. His ECG shows a narrow QRS complex tachycardia with rate 180, which you correctly diagnose as paroxysmal atrial tachycardia. Carotid massage and Valsalva maneuver do not improve the heart rate. Which of the following is the initial therapy of choice?

A 36-year-old white female is brought to the emergency department due to paraplegia and bladder incontinence. She immediately tells you that she has, "multiple sclerosis in remission." She has a history of optic neuritis and internuclear ophthalmoplegia, and both resolved with treatment. At that time, MRI showed plaques in the periventricular region. She is currently not taking any medications. Which of the following is the most appropriate next step in the management of this patient?

A 36-year-old woman, gravida 2, para 1, at 16 weeks' gestation undergoes amniocentesis for evaluation of Down syndrome. She has no past medical history. Immediately after the procedure she becomes breathless, cyanotic and loses consciousness. Minutes later, she experiences a generalized tonic-clonic seizure. A generalized purpuric rash is noted. Her blood pressure is 90/50 mm Hg, pulse is 110/min, and respirations are 26/min. Oxygen saturation is 75% on 100% facemask. Which of the following is the most appropriate next step in management?

A 37-year-old man who just finished a full course of penicillin for pharyngitis presents to the ED requesting to be checked out again. He states he took the antibiotics exactly as prescribed and initially felt somewhat improved, but over the last 2 to 3 days has had increased pain and progressive difficulty swallowing. His BP is 130/65 mmHg, HR is 95 beats per minute, temperature is 100.1°F, RR is 16 breaths per minute, and oxygen saturation is 99%. On examination, the patient is in no acute distress but has a fluctuant mass on the right side of his neck. You visualize a normal soft palate with swelling of the right tonsillar arch and deviation of the uvula to the left, but additional examination is limited because he is unable to open his mouth fully. Review of his records reveals a throat culture that was positive for Streptococcus. Which of the following is the most appropriate next step in management?

37-year-old woman is brought into the ED by her friend who states that the patient swallowed approximately 50 capsules of 325-mg acetaminophen (APAP) 6 hours ago in an attempted suicide. The patient states she feels nauseated and vomits while you take her history. Her BP is 100/75 mmHg, HR is 97 beats per minute, temperature is 98.9°F, RR is 18 breaths per minute, and oxygen saturation is 99% on room air. Examination is unremarkable except for mild epigastric tenderness. Which of the following is the correct antidote for APAP overdose?

A 37-year-old woman is brought to the surgical floor after undergoing a routine vaginal hysterectomy that morning. She had been fasting since midnight the night prior to her surgery. She has no past medical history except for uterine fibroids and takes only oral contraceptive pills regularly. During the procedure, she was reported to lose approximately 300 mL of blood. On the floor, she appears well but complains of some fatigue. Her blood pressure is 110/60 mm Hg, and her pulse is 100/min. She is not taking food or water yet because of persistent nausea and vomiting postoperatively. Which of the following is the most appropriate next step in management?

A 38-year-old homeless man is brought to the emergency room. He is obtunded and unable to speak. No previous medical history is known. His temperature is 34.0°C (93.2°F), blood pressure is 90/60 mmHg, pulse is 60/min and respirations are 6/min. Oxygen saturation is 86% on room air. Pupils are 5 mm in size, bilaterally. Oropharynx is dry. Lungs are clear to auscultation. Abdomen is soft; bowel sounds are decreased; there is no organomegaly. Extremities reveal several needle marks. Babinski sign is negative. Deep tendon reflexes are 2+ throughout. Which of the following is the most appropriate next step in management?

A 38-year-old man is brought to the emergency room by EMS after an apparent suicide attempt. En route to the hospital, he appeared confused and suffered a seizure. He has a history of hypertension and major depression. His temperature is 37.7°C (100°F), blood pressure is 70/40 mmHg, pulse is 40/min, and respirations are 12/min. Examination shows normal heart sounds and diffuse wheezing. Extremities are cold and clammy. EKG shows AV block. The patient is given intravenous fluids and atropine; however, his bradycardia and hypotension do not improve. Which of the following is the most appropriate next step in management?

A 38-year-old woman presents to the emergency department and complains of persistent vomiting that has increased in severity over the last week. Her other complaints are muscular weakness, twitching and cramps. Her urine output has decreased over the last 20 hours. Her past medical history is significant for a previously diagnosed prepyloric peptic ulcer. Her pulse is 100/min, blood pressure is 100/60 mmHg, respirations are 12/min, and temperature is 37.2°C (99°F). Physical examination reveals dry oral mucosa and decreased skin turgor. Abdominal examination reveals hypoactive bowel sounds and mild tenderness on palpation of the epigastrium. Nasogastric suction is started, and intravenous normal saline is given. Laboratory studies show: Serum sodium 135 mEq/L, Serum potassium 2.8 mEq/L, Chloride 81 mEq/L, Bicarbonate 40 mEq/L, Blood urea nitrogen (BUN) 42 mg/dl, Serum creatinine 1.3 mg/dl, Calcium 8.6 mg/dl, Ionized calcium 0.7 mmol/L (1.1-1.3 mmoi/L), Serum pH 7.54. Which of the listed agents should be added to the patient's current therapy?

A 39-year-old woman, brought into the ED by her family, states that she has had 4 days of diarrhea and has now started acting “crazy” with mood swings and confusion. The family states that she usually takes a medication for a problem with her neck. Her BP is 130/45 mmHg, HR is 140 beats per minute, temperature is 101.5°F, and her respiratory rate (RR) is 22 breaths per minute. An electrocardiogram (ECG) reveals atrial fibrillation with a normal QRS complex. After you address the airway, breathing, and circulation (ABCs), which of the following is the most appropriate next step in management?

A 39-year-old woman, brought into the ED by her family, states that she has had 4 days of diarrhea and has now started acting “crazy” with mood swings and confusion. The family states that she usually takes a medication for a problem with her neck. Her BP is 130/45 mmHg, HR is 140 beats per minute, temperature is 101.5°F, and her respiratory rate (RR) is 22 breaths per minute. An electrocardiogram (ECG) reveals atrial fibrillation with a normal QRS complex. After you address the airway, breathing, and circulation (ABCs), which of the following is the most appropriate next step in management?

A 42-year-old man presents to the ED via ambulance after activating EMS for dyspnea. He is currently on an oxygen face mask and was administered one nebulized treatment of a β2-agonist by the paramedics. His initial vitals include an RR of 16 breaths per minute with an oxygen saturation of 96% on room air. The patient appears to be in mild distress with some intercostal retractions. Upon chest auscultation, there are minimal wheezes localized over bilateral lower lung fields. The patient’s symptoms completely resolve after two more nebulizer treatments. Which of the following medications, in addition to a rescue β2-agonist inhaler, should be prescribed for outpatient use?

A 42-year-old man who is actively seizing is brought to the ED by EMS after a massive ingestion of an unknown substance. The man is known to have a history of acquired immunodeficiency syndrome (AIDS). An intravenous (IV) line is established and anticonvulsant therapy is administered. After high doses of diazepam, phenobarbital, and phenytoin, it is determined that the seizures are refractory to standard anticonvulsant therapy. Which of the following substances did this patient most likely ingest?

A 45-year-old female presents to emergency room complaining of urinary frequency, burning during urination, and weakness. Her last menstrual period was one year ago, and she is not sexually active. She is not taking any medications. Her temperature is 37.8°C (100°F), blood pressure is 120/76 mmHg, pulse is 80/min, and respirations are 14/min. Very mild costovertebral angle tenderness is present. IV ceftriaxone is started. Two days later, the patient feels much better. Antibiotic susceptibility testing returned with an uropathogen (E.coli) highly sensitive to ceftriaxone, gentamicin, ciprofloxacin and trimethoprim/sulfamethoxazole (TMP/SMX). Which of the following is the most reasonable next step in the management of this patient?

A 45-year-old male, found unconscious, is brought to the emergency room. His airway is maintained, and oxygen is administered. His temperature is 39.0°C (102.5°F), pulse is 102/min, blood pressure is 90/65 mmHg and respirations are 23/min. Intravenous access is secured and blood and urine samples are drawn. Lab results are as follows: Sodium 134 mEq/L, Potassium 5.9 mEq/L, Chloride 101 mEq/L, Bicarbonate 22 mEq/L, Blood urea nitrogen 110 mg/dl, Glucose 1000 mg/dl, Serum calcium 10.2 mg/dl, Amylase 100 U/L, Aspartate aminotransferase 15 U/L, Alanine aminotransferase 17 U/L, Ammonia 15 micro-moi/L (Normal is 9-33 micro-moi/L), PT 13 sec, APTT 30 sec. Arterial blood gases: PH 7.40, PaCO2 38 mm Hg, PaO2 90 mm Hg. Which of the following is the most appropriate initial infusion you should order for this patient?

A 45-year-old man comes to the emergency department (ED) with severe right flank pain. He is tossing in bed due to the pain. KUB done in the ED shows no abnormalities; however, abdominal ultrasound shows a 5 mm stone in the right ureter. Urinalysis shows: Urine pH 4.5 (normal is 5-6), WBC Absent, RBC 2-3/HPF, Bacteria Absent, Nitrites Negative, Esterase Negative. Which of the following is the most beneficial next step in management?

A 45-year-old woman is brought to the ER by ambulance after a neighbor found her to be in a somewhat obtunded state with an empty bottle of medication next to her. While en route to the ER she suffered a tonic clonic seizure. Her past medical history is significant for major depression. Her temperature is 38.3°C (100.9°F), blood pressure is 90/70 mmHg, pulse is 120/min, and respirations are 16/min. She is able to respond to painful stimuli. Pupils are 8 mm in size bilaterally. Skin is warm and flushed. Lungs are clear to auscultation. Abdomen is soft and non-tender. Bowel sounds are decreased. There is no neck stiffness. EKG shows QRS duration of 130 msec, a change from her previous EKG a month ago. Which of the following is the most appropriate next step in management?

A 45-year-old woman presents to the emergency department (ED) with vomiting and severe right flank pain that radiates to her groin. She has been to the ED twice in the past due to similar episodes of renal colic, and was subsequently discharged on both occasions. She admits to not seeking further medical care because she has no insurance. KUB shows a renal stone. 24-hour urine collection shows a urinary calcium excretion of 350 mg (normal is less than 250 mg in women). Laboratory studies show a serum calcium concentration of 8.9 mg/dL; serum PTH is normal. An x-ray film of the chest shows no abnormalities. Further investigations fail to reveal the cause of her hypercalciuria. Apart from advising her to increase her fluid intake, which of the following interventions will benefit this patient?

A 45-year-old woman undergoes an uneventful laparoscopic cholecystectomy for which she receives 1 dose of cephalosporin. One week later, she returns to the emergency room with fever, nausea, and copious diarrhea and is suspected of having pseudomembranous colitis. She is afebrile and has no peritoneal signs on abdominal examination. She has a mild leukocytosis with a left shift. Which of the following is the appropriate initial management strategy?