<div style='text-align: center;'><strong><span style='font-size: 36pt;'>Test 1 PDMS 4433 Hematology July 2018</span></strong></div>

A highly detailed illustration showing various blood cells and hematology concepts, incorporating visual elements of erythrocytes, leukocytes, and platelets in a vibrant, educational style.

Test Your Hematology Knowledge

Welcome to the Hematology Quiz, designed to test your understanding of blood science! This quiz contains 30 multiple-choice questions covering various aspects of hematology, including blood cell types, disorders, and diagnostic techniques.

Whether you're a student, a teacher, or just a curious learner, this quiz is a great way to reinforce your knowledge and discover new insights.

30 multiple choice questions
One hour time limit
Instant feedback on your answers

33 Questions8 MinutesCreated by AnalyzingBlood123

This test consist of 30 multiple choice questions (MCQ) only. You are given ONE HOUR to complete all questions.

Please enter your name and matrix no CORRECTLY on the following page.

This test consist of 30 multiple choice questions (MCQ) only. You are given ONE HOUR to complete all questions.

Please enter your name and matrix no CORRECTLY on the following page.

Pick the right flow of cell maturation from the bone marrow pluripotent stem cells.

Proliferation -> differentiation -> suppression of apoptosis -> maturation

Proliferation -> suppression of apoptosis -> differentiation -> maturation

Differentiation -> proliferation -> suppression of apoptosis -> maturation

Proliferation -> suppression of apoptosis -> differentiation -> maturation

Figure shows that the early stage of megakaryocyte under 100x magnification. Pick the CORRECT statement.

Platelet is formed from the fragmentation of cytoplasm of megakaryocyte.

Maturation process of thrombocyte starts from megakaryocyte followed by megakaryoblast.

Megakaryocyte is a large lobated nucleus cell originated from bone marrow responsible for the production of red blood cell.

Megakaroyocyte arise from the common lymphoid progenitor cell just like other blood component.

In megaloblastic anemia, the typical erythrocyte indices are:

MCV increased, MCH variable

MCV normal, MCH increased

MCV increased, MCH increased

MCV increased, MCH decreased

Please indicate your diagnosis for the above slide,

Peripheral blood film of megaloblastic anemia patient

Peripheral blood film of alpha thalassemia patient

Peripheral blood film of chronic myeloid leukemia patient

Peripheral blood film of normal patient

In iron deficiency anemia (IDA), the two red cell indices MCV and MCH are reduced with lood film shows small (microcytic) and pale (hypochromic) red cells. What is the etiology of this appearance?

Defect in hemoglobin synthesis

Accumulation of iron storage in blood

Wrong stain used

Iron storage is failed to be stored as ferritin inside the body

These are causes of IDA EXCEPT

Chronic blood loss (intestinal parasites, gastrointestinal bleeding)

Diversion of maternal iron to fetus/infant during pregnancy/lactation

Sufficient absorption of iron

Intravascular hemolysis with hemoglobinuria

Pick the CORRECT statement regarding the above picture.

Hepcidin secreted by the liver, controls the plasma iron concentration by inhibiting iron export by ferroportin from duodenal enterocytes and reticuloendothelial macrophages

Only 10–20 mg of iron is absorbed and lost every day. Importantly, the total amount of iron in the body can be regulated only by absorption, whereas iron loss occurs only passively from sloughing of skin and mucosal cells as well as from blood loss.

A decrease in hepcidin production leads to a decrease in plasma iron concentrations

Hepcidin expression is regulated by iron concentrations in kidney, by inflammatory stimuli, by erythroid iron demand, and by hypoxia via pathways involving expression of the HFE, TRF2, and HJV genes

How one can be exposed to folate deficiency?

Low dietary intake
Malabsorption gastrectomy @ Crohn’s disease
Excess utilization pregnancy, lactation, hemolytic anemia, malignant disease, inflammatory disease
Excess urinary folate loss

I only

I and ii

I, iii and iv

I, ii, iii and iv

In megaloblastic anemia, presentation of macrocytosis is common cause that vitamin B12 status is investigated. Pick the CORRECT statement for this reasoning.

Impaired DNA synthesis is characterized by the presence of megaloblastic red cell precursors in the bone marrow.
A delay in nuclear maturation is caused by impaired DNA synthesis results from a lack of vitamin B12 or folate seen in all lineages.
Vitamin B12 is required as coenzyme for methionine synthase during the remethylation of methionine from homocystine (methylcobalamin-dependent reaction).
Body stores typically 1-5mg of vitamin B12 so that deficiency states may not develope until several years after the metabolic requirement consistently exceeded dietary vitamin B12 intake and absorption.

I and iii

Ii and iii

I, iii and iv

I, ii, iii and iv

What is the definition of hemolytic anemia?

Anemias that result from an increase the rate of red cell destruction

Anemia with abnormally large cells

Anemia with presence of many pathological ring sideroblasts in the bone marrow

Anaemia occurs in patients with a variety of chronic inflammatory and malignant disease

Characterized by reduced synthesis of the hemoglobin subunit beta (hemoglobin beta chain) that results in microcytic hypochromic anemia, an abnormal peripheral blood smear with nucleated red blood cells, and reduced amounts of hemoglobin A (HbA) on hemoglobin analysis.

The statement above is BEST described the diagnosis of _________________.

Alpha thalassemia

Beta thalassemia

Hb S-thalasemia

Sicke cell anemia

Sickle-shaped
Hard (like a piece of wood)
Often get stuck in small blood vessels
Lives for 20 days or less

The following are the characteristics of __________

Platelet

White blood cell

Normal hemoglobin

Sickle hemoglobin

A ____________ is a map of the types of hemoglobin in the family tree. This helps to identify those with the trait and those with disease. In this pedigree, both parents have sickle trait, 1 in 4 children will have Sickle cell disease, one half will have trait and 1 in 4 will have normal hemoglobin.

World map

Mind map

Crossmatch

Pedigree

The hemoglobinopathies can be classified into three major categories:

Abnormal molecular structure of one or more of the polypeptide chains of globulin in the hemoglobin molecule.
A defect in the rate of synthesis of one or more of the polypeptide chains of globulin in the hemoglobin molecule.

What is the third category?

Disorders that are a combination of abnormal and normal molecular structure

Disorders that are a combination of abnormal molecular structure with a synthesis defect.

Disorders without any combination of abnormal molecular structure with a synthesis defect

Disorders with defect in the rate of synthesis of one or more of the polypeptide chains of globulin in the hemoglobin molecule

Aplastic anemia is defined as pancytopenia results from aplasia of the bone marrow. What does it mean by the term pancytopenia?

Reduction in the blood count of all major cell lines simultaneously

Reduction in the blood count of all major cell lines separately

Increase production in the blood count of all major cell lines simultaneously

Increase production in the blood count of all major cell lines separately

What is the diagnosis of the above figure.

Malarial parasite infection

Antigen antibody reaction causing the formation of auto aglutination

Abnormal membrane cell (hereditary elliptocytosis)

Abnormal hemoglobin (sickle cell anemia)

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Test 1 PDMS 4433 Hematology July 2018

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