Lab cycle 2 - 2022
Understanding Clinical Laboratory Tests Quiz
Welcome to the Understanding Clinical Laboratory Tests Quiz! This quiz is designed to test your knowledge of various laboratory medicine topics, including diagnostic criteria, biochemical markers, and relevant pathophysiology.
Are you ready to challenge yourself? Here’s what to expect:
- 39 insightful questions
- Multiple choice format
- Learn while you assess your knowledge
One of the criteria of SIRS (Systemic Inflammatory Response Syndrome) is leukocytosis of:
17,000 per mm3
19,000 per mm3
12,000 per mm3
20,000 per mm2
15,000 per mm3
Which of the following enzmymes can by induced by phenytoin:
AST
Creatine kinase
Gamma GT
ALT
Alkaline phosphate
The biochemical markers of cholestasis is:
CT, gamma GT
ALT, ALP
ALP, gamma GT
Lipoprotein lipase
AST, ALP
Indicate the wrong statement regarding the CRP and ESR
ESR can be affected by anemia
The rate of change of ESR is less than that of CRP
In the evaluation of paraproteinemia´s CRP is more useful than ESR
CRP reflects an intensity of the acute phase response
ESR reflects an intensity of the acute phase response
Red blood cell casts in urine are seen in all of the following and are indicative of Select one:
IgA nephropathy, lupus nephritis, pyuria, and Wegener´s granulomatosis
B. IgA nephropathy, lupus nephritis, Goodpasture syndrome, and Wegener´s granulomatosis
IgA nephropathy, lupus nephritis, hepatic jaundice, and Wegener´s granulomatosis
IgA nephropathy, nephrotic syndrome, Goodpasture syndrome, and Wegener´s granulomatosis
IgA nephropathy, pyelonephritis, Goodpasture syndrome, and Wegener´s granulomatosis
What is false about cardiac troponins? Select one:
Troponins remain elevated up to 14 days
Tropoins enable late diagnosis
Troponins are cardiospecific
Troponins are present in skeletal muscle
Troponins rise within a few hours on onset of symptoms of myocardial infarction
Indicate the true statement from among the following
Alkaline phosphatase is an indicator of muscle damage
Amylase is an indicator of cholestatic liver disease
Lipase and amylase are indicators of cell damage in acute pancreatitis
AST is an indicator of osteoblast activity in bone
Gamma-glutamyl transpeptidase is a specific (sensitive) marker of liver disease
Indicate the wrong statement regarding the plasma proteins Select one:
Increase in total protein in a serum sample is usually due to an increase in the globulin fraction
Hypoalbuminemia occurs in advanced liver disease
Hypoalbuminemia can be induced by hypervolemia (or overhydration)
Decrease in total protein in a serum sample is usually due to hypoalbuminemia
Hypoalbuminemia in the inflammatory response is due to decreased albumin synthesis
Which protein binds iron in tissues. Select one:
Transferrin
Ferritin
Transthyretin
Haptoglobin
Iron binding globulin
Allergic conditions and parasitic invasion are typically associated with. Select one:
Lymphocytosis
Neutrophilia
Basophilia
Eosinophilia
Monocytosis
Relative anemia result from:
Decreased red blood cell production
Blood redistribution
Increased plasma volume
Increased red blood cell destruction
Blood loss
Hypoalbuminaemia due to increased loss occurs in: (two correct)
Burns
Malabsorption
Liver disease
Acute inflammation
Malnutrition
Nephrotic syndrome
Normocytosis (MCV normal) is observed in:
Acute blood loss, hemolysis, hypothyroidism
Iron deficiency, chronic diseases, beta-thalassemias
Myelodysplastic disorders/syndromes (MDS), vitamin B12 deficiency, hemolysis
Iron deficiency, bone marrow suppression, folate deficiency
Renal insufficiency (increased erythropoietin), acute blood loss, bone marrow suppression
The diagnosis of myeloma requires that two of the following are present:
A. Paraprotein in serum, paraprotein in urine, organ damage
B. Organ damage, high level of uric acid, paraprotein in urine
C. Hypercalcemia, paraprotein in serum, pancytopenia
D. Paraprotein in serum/urine, bone marrow infiltration with plasma cells, organ damage
E. Paraprotein in urine, aneamia, low platelet count
The moderate eosinophilia is defined as the eosinophil count
> 100/ microliter
> 500/ microliter
500-1000/ microliter
1500-5000/ microliter
1000-5000/ microliter
White blood cell (WBC) count range in early newborns (1st day of life) is: *****
5,800 to 13,200 per mm3
5.8 to 13.2 × 109 per μL
4,500 to 11,000 per mm3
5,000 to 20,000 per mm3
13,000 to 38,000 per mm3
White blood cell (WBC) count range in pregnant women (third trimester) is Select one:
5,800 to 13. 200 per mm3
13,000 to 38,000 per mm3
4,500 to 11,000 per mm3
5.8 to 13.2 × 109 per μL
5,000 to 20,000 per mm3
Increase in MCH is associated with:
Thalassemia’s
Sideroblastic anemia
Anemia of chronic disease
Macrocytic anemia
Iron deficiency anemia
Indicate the wrong statement regarding the immunoglobulins
Paraproteins may be found on electrophoresis
Paraproteins are found in heavy chain disease
In 50% of cases of multiple myeloma only light chains are found
Paraproteins are found in multiple myeloma
Light chains in urine are referred to as Bence-Jones proteinuria
Indicate the wrong statement:
Leukocytosis alone is a good predictor of bacteremia
Viral infections can cause leukocytosis due to lymphocytosis
The release of immature cells into the peripheral blood cell is called the “left-shift”
In the acute stage of many bacterial infections mature and immature neutrophils are present
Leukocytosis alone is a poor indication for obtaining blood culture
Macrocytic anemias (increased MCV) are observed in:
Iron deficiency, bone marrow suppression, alpha-thalassemia
Acute blood loss, hemolysis, hypothyroidism, chronic diseases
Renal insufficiency (↓ erythropoietin), acute blood loss, sideroblastic anemia
Iron deficiency, chronic diseases, beta-thalassemia’s
Myelodysplastic disorders/syndromes (MDS), vitamin B12 deficiency, folate deficiency
Which of the following are known to decrease in response to injury:
T3, selenium, albumin, iron, HDL
Properdin, haptoglobin, C3 complement, alpha1- antitrypsin, selenium
Haptoglobin, C5 complement, HDL, LDL, caeruloplasmin, TSH
Haptoglobin, C4 and C5 complement, alpha1- antitrypsin, caeruloplasmin, fibrinogen
Haptoglobin, C3 complement, HDL, alpha2-macriglobulin, serum amyloid-A
Increased hemoglobin concentration can be observed in:
Pernicious anemia, extreme physical exercise
Hemoglobinopathies, congestive hear failure
Polycythemia vera, chronic obstructive pulmonary disease
Hodgkin´s disease, living in high altitudes
Hemolysis, treatment with methyldopa
Indicate the wrong statement regarding the immunoglobulins/paraproteins Select one:
Urine electrophoresis can show the presence of Bence-Jones protein
Benign paraproteinaemia refers to the presence of plasma fibrinogen in the gamma region on electrophoresis
Paraprotein (monoclonal hypergammaglobulinaemia) and polyclonal hypergammaglobulinaemia can be distinguished by gel electrophoresis
Paraprotein is an intact immunoglobulin (or its fragment)
Paraproteins are found in Waldenström's macroglobulinaemia
Increased red blood cell destruction occurs in:
Iron deficiency anemia
Megaloblastic anemia
Macroangiopathic anemia
Pure red cell aplasia
Thalassemia´s
The appearance of smudge cells on a peripheral-blood smear is a characteristic feature of:
CLL (chronic lymphocytic leukemia)
Solid tumors (cancers)
Polycythemia vera
Essential thrombocytosis
Myelofibrosis
Conditions associated with normocytic anemia with appropriate bone marrow response (increased reticulocytes) include
Acute posthemorrhagic anemia, red blood cell aplasia
Hemolytic anemia, aplastic anemia
Aplastic anemia, red blood cell aplasia
Aplastic anemia, red blood cell aplasia, hemolytic anemia
Acute posthemorrhagic anemia, hemolytic anemia
Conditions associated with normocytic anemia with impaired bone marrow response (decreased reticulocytes) include:
Aplastic anemia, red blood cell aplasia
Aplastic anemia, red blood cell aplasia, hemolytic anemia
Acute posthemorrhagic anemia, hemolytic anemia
Acute posthemorrhagic anemia, red blood cell aplasia
Hemolytic anemia, aplastic anemia
Indicate the true statement from among the following:
Lipase is an indicator of muscle damage
Creatine kinase is an indicator of muscle damage
Amylase is an indicator of cholestasis
AST is an indicator of osteoblast activity in bone
Alkaline phosphatase is an indicator of acute MI
Leukemoid reaction describes an increased whiote blood cell count (cells(mm3) in the range of approximately:
20,000-40,000
100,000-120,000
100,000-150,000
50,000-100,000
11,000-30,000
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