Lab C3 ENTRY 2023
Medical Knowledge Challenge: Lab C3 ENTRY 2023
Test your understanding of key medical concepts with our comprehensive quiz designed for healthcare professionals and students alike. With 33 multiple choice questions, this quiz covers important topics in biochemistry, hematology, and endocrinology.
Prepare to explore:
- Hypercalcemia and Hypocalcemia
- Coagulation Disorders
- Kidney Disease Implications
- Leukemia Markers{li>Adrenocorticotropic Hormone Effects
Hypercalcemic crisis occurs above which minimum level of ionized calcium in mmol/L:
1.5
2.0
2.5
3.0
3.5
A patient has 1.8 mmol/L calcium and 25g/L albumin, what is his/her adjusted calcium level:
2.2
2.5
2.8
3.1
3.4
If calcium is low with no renal disease, and PTH is high - what are the most likely possibilities:
Vitamin D deficiency, post-thyroidal surgery
Idiopathic hyperparathyroidism, pseudohypoparathyroidism
Magnesium deficiency, post-thyroidal surgery
Vitamin D deficiency, pseudohypoparathyroidism
Vitamin D deficiency, magnesium deficiency
Which of the following actions of parathyroid hormone occur via vitamin D3?
Bone resorption of Ca
Bone mineralisation of Ca
Increased intestinal absorption of Ca
Increased renal reabsorption of Ca
Decreased renal reabsorption of Ca
The most common cause(s) of hypercalcemia is/are:
Hyperparathyroidism and malignancy
Hyperparathyroidism and renal disease
Inappropriate dosage of vitamin D
Calcium therapy
Granulomatous disease
All of the following are biochemical findings in pre-renal uremia except:
High plasma urea/creatinine (BUN/creatinine) ratio
Metabolic acidosis
High plasma potassium concentration
High urinary sodium concentration
High urine osmolality
ATN (acute tubular necrosis) may develop as a consequence of:
Post-renal blockage
Nephrotoxins
Acute blood loss
Septic shock
All above
Factors that precipitate pre-renal uremia include:
Burns
Prolonged vomiting
Diarrhoea
Reduced cardiac output
All above
All of the following are consequences of chronic kidney disease except:
Normochronic normocytic anemia
Primary hyperthyroidism
Metabolic acidosis
Fluid depletion
Hyperkalemia
All of the following are common causes of hypocalcaemia in the course of chronic renal failure except:
Decreased formation of 1,25(OH)2D3
Decreased intestinal calcium absorption
Decreased urinary calcium reabsorption
Increased serum phosphate level
Increased phosphate retention
Lupus inhibitor has the following characteristic
Binds to phospholipids on mitochondrial membrane, in vivo has prothrombotic characteristic, in vitro it can lengthen APTT times
Binds to phospholipids on cell membrane, in vivo has prothrombotic characteristic, in vitro it can shorten APTT times
Binds to phospholipids on mitochondrial membrane, in vivo has anti - coagulant characteristic, in vitro it can lengthen APTT times
Binds to phospholipids on cell membrane, in vivo has prothrombotic characteristic, in vitro it can lengthen APTT times
Binds to phospholipids on mitochondrial membrane, in vivo has anti - coagulant characteristic, in vitro it can lengthen APTT times
Von Willebrand disease has the following characteristics
Increased activity of VWF and gives decreased ability to form fibrin clots
Missing or defective VWF and gives increased likelihood of fibrin clots
Missing or defective VWF and gives disseminated intravascular coagulation
Missing or defective VWF and gives decreased ability to form fibrin clots
Increased activity of VWF and gives increased likelihood of fibrin clots
Thrombocytosis can arise from
Post - splenectomy, malignancy, acute blood loss, infection, myeloproliferative disorder
Post - splenectomy, malignancy, acute blood loss, infection, thin basement membrane disease
Splenomegaly, malignancy, alcohol, infection, myeloproliferative disorder
Splenomegaly, malignancy, acute blood loss, infection, myeloproliferative disorder
Post - splenectomy, malignancy, acute blood loss, factor deficiency, myeloproliferative disorder
The coagulation profile for hemophilia is
Fibrinogen raised, d - dimers normal, PTT raised, platelets raised, PT normal
Fibrinogen normal, d - dimers high, PTT raised, platelets raised, PT normal
Fibrinogen normal, d - dimers normal, PTT raised, platelets normal , PT raised
Fibrinogen raised, d - dimers high, PTT raised, platelets low, PT normal
Fibrinogen normal, d - dimers normal, PTT raised, platelets normal , PT normal
High d - dimer are found with
Warfarin treatment, chronic liver disease, normal pregnancy, DIC, arterial clot
Pulmonary embolism, chronic liver disease, normal pregnancy, DIC, arterial clot
Pulmonary embolism, chronic liver disease, normal pregnancy, DIC, heparin treatment
Pulmonary embolism, chronic liver disease, normal pregnancy, DIC, anti - thrombin treatment
Anti - coagulant therapy, chronic liver disease, normal pregnancy, DIC, arterial clot
Which test is used to monitor anticoagulation with hirudin treatment
Anti - Xa concentration
Ecarin clotting time
Heparin induced thrombocytopenia test
Activated whole blood clotting time
Thrombin time
Pseudothrombocytopenia arises from
EDTA - dependent incomplete mixing of blood sample which causes clots to form
EDTA - dependent reduction in total number of platelets
Anticoagulant effects
Thrombolytic agent effects
EDTA - dependent increases in total number of platelets
APT can be carried out by
Oxalate block, followed by adding excess calcium, phospholipids, tissue factor, kaolin
Citrate block, followed by adding excess calcium, phospholipids, kaolin
Citrate block, followed by adding excess calcium, phospholipids, tissue factor, kaolin
Calcium block, followed by adding excess citrate, phospholipids, kaolin
Citrate block, followed by adding excess calcium, thromboplastin, kaolin
Anticardiolipin antibodies have the following characteristics
Binds to phospholipids on mitochondrial membrane, are found in syphilis, antiphospholipid syndrome, livedoid vasculitis
Binds to phospholipids on cell membrane, in vivo has prothrombotic characteristic, in vitro it can shorten APTT times
Binds to phospholipids on mitochondrial membrane, in vivo has anti - coagulant characteristic, in vitro it can lengthen APTT times
Binds to phospholipids on cell membrane, are found in syphilis, antiphospholipid syndrome, livedoid vasculitis
Binds to phospholipids on mitochondrial membrane, in vivo has prothrombotic characteristic, in vitro it can shorten APTT times
The coagulation profile for Von Willebrand disease is
INR normal or high, platelets normal or low, d - dimers high, fibrinogen normal, APTT normal or high
INR high, platelets normal , d - dimers normal, fibrinogen normal, APTT normal
INR normal, platelets normal or low, d - dimers high, fibrinogen low, APTT normal or high
INR high, platelets normal or low, d - dimers normal, fibrinogen high, APTT normal
INR normal, platelets normal or low, d - dimers normal, fibrinogen normal, APTT normal or high
Disseminated intravascular coagulation most often gives rise to
Thrombocytosis, vitamin b12 deficiency, bleeding, microvascular thrombosis, organ failure
Thrombocytopenia, coagulation factor deficiency, bleeding, reduced fibrin clots, organ failure
Thrombocytosis, coagulation factor deficiency, bleeding,microvascular thrombosis, organ failure
Thrombocytopenia, coagulation factor deficiency, bleeding,microvascular thrombosis, organ failure
Thrombocytopenia, vitamin B12 deficiency, bleeding,microvascular thrombosis, organ failure
The coagulation profile for advanced liver disease is
APTT normal or raised, fibrinogen low, d - dimers normal or raised, PT high, platelets low
APTT normal, fibrinogen low, d - dimers normal or raised, PT high, platelets low
APTT normal or raised, fibrinogen high, d - dimers normal or raised, PT high, platelets low
APTT normal, fibrinogen low ,d - dimers normal or raised, PT high, platelets low
APTT normal or raised, fibrinogen high, d - dimers normal or raised, PT high, platelets high
High APTT is found with
Von willebrand disease, sepsis, splenectomy, heparin treatment, DIC
Myeloproliferative disorders, normal pregnancy, anti - phospholipid syndrome, heparin treatment, DIC
Myeloproliferative disorders, sepsis, anti - phospholipid syndrome, heparin treatment, DIC
Essential thrombocythemia, normal pregnancy, anti - phospholipid syndrome, heparin treatment, DIC
Von Willebrand disease, sepsis, anti - phospholipid syndrome, heparin treatment, DIC
Thrombocytopenia can arise from
Autoimmune diseases, thin basement membrane disease, splenectomy, factor deficiencies, alcohol
Infections, Myeloproliferative disorders, splenectomy, factor deficiencies, alcohol
Autoimmune diseases, thin basement membrane disease, splenomegaly, factor deficiencies, alcohol
Autoimmune diseases, Myeloproliferative disorders, splenectomy, factor deficiencies, alcohol
Infections, Myeloproliferative disorders, splenomegaly, factor deficiencies, acute blood loss
High prothrombin time is found in
Warfarin treatment, chronic liver disease, vitamin k malabsorption, sepsis, DIC
Warfarin treatment, antiphospholipid syndrome, vitamin k malabsorption, sepsis, DIC
Warfarin treatment, Von Willebrand disease, normal pregnancy, sepsis, DIC
Warfarin treatment, hemophilia , vitamin k malabsorption, sepsis, DIC
Warfarin treatment, hemophilia, normal pregnancy, sepsis, DIC
A diagnosis (clinical) of MEN1 can be made if the patient has at least two of the following, except:
Parathyroid adenoma
Pheochromocytoma
Pituitary adenoma
Adrenal cortex tumor
Pancreatic endocrine tumor
Use of the cytotoxic drug cisplatin might result in:
Hypercalcemia and hypermagnesemia
Hyperkalemia and hypermagnesemia
Hypocalcemia and hypomagnesemia
Hyperkalemia and hypomagnesemia
Hypokalemia and hypomagnesemia
Rapid cell turnover in leukemia often results in:
High alkaline phosphatase
High calcitonin and CEA
High serum urate and lactate dehydrogenase
High CA125 and HCG
High AST and ALT
Which two markers are most often used in screening
Acid phosphatase and CA-125
HCG and calcitonin
Calcitonin and CA-125
Prostate-specific antigen and CEA
Paraprotein and CA-125
Ectopic adrenocorticotropic hormone is most commonly associated with:
Metastatic spread to the liver
Carcinoma of the head of the pancreas
Small cell carcinoma of the lung
Choriocarcinoma
Medullary carcinoma of the thyroid
Carcinoid tumors can convert dietary tryptophan into:
Gastrin
Serotonin
Calcitonin
Glucagon
Somatostatin
Pituitary tumors in MEN1 produce:
Prolactin, VIP
Gastrin, ACTH
Somatostatin, growth hormone
Prolactin, ACTH
Growth hormone, VIP
Which two markers are most often used in prognosis:
Acid phosphatase and CA-125
HCG and AFP
Calcitonin and CA-125
Prostate-specific antigen and CEA
Paraprotein and CA-125
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