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Hematology

Hematology Quiz Challenge

Test your knowledge on hematology and bleeding disorders with our comprehensive quiz. This quiz covers a wide range of topics, including symptoms, diagnostics, and treatments related to hematology. Whether you are a student, educator, or simply interested in hematology, this quiz is designed to enhance your understanding and retention of important concepts.

Multiple-choice questions
Covers a variety of topics in hematology
Suitable for all levels of knowledge

100 Questions25 MinutesCreated by LearningDoctor752

What are the symptoms of bleeding disorder?

Hematoma and suffusion

Petechia

Epistaxis and hemarthros

Intracerebral bleeding

All answers are correct

Characteristic of Epistaxis I’m bleeding disorder:

Bleeding from both sides

Nosebleeds <2 years of age

Nosebleed >10mn

Not associated with viral infection during whole year

All answers are correct

The history of specific hints for bleeding disorder in infant, toddler:

The hematoma / the petechia at birth

Macroscopic

Menorrhagia

Hyperglycemia

Epistaxis

The history of specific hints for bleeding disorder in children:

Epistaxis (age <2years, >10mn)

Amenorrhea

Epistaxis <10 mn

Menorrhagia

Petechia

The history of specific hints for bleeding disorder in adult:

Menorrhagia and postoperative bleeding

Amenorrhea

Epistaxis <10 mn

Intracerebral bleeding

Petechia

How many step in primary haemostasis

Global tests of the plasmoic coagulation paediatric normal values ( 0-7 days ):

INR 1.4

INR 1.9

INR 1.6

INR 1.7

INR 1.8

Normal value of aPTT in children 1-3 month:

Step of hemostasis:

Primary hemostasis and secondary hemostasis

Platelets activation

Platelets adhesion

Platelets aggregation

Intrinsic coagulation

Which one is true in Vit.K mangel:

Elevated INR, normal PTT, normal fibrinogen

Increased INR, normal PTT, normal fibrinogen

Increased PTT, normal INR

Increased fibrinogen, normal PTT

Decreased PTT, decreased INR

Definition beta order alpha thalassemia :

The reduced production of beta or alpha globin-chains

Increased production of beta or alpha globin-chain

Reduced production of beta or increased alpha globin-chains

Increased production of beta or reduced alpha globin chain

All answers are not correct

Types of thalassemia:

Thalassemia minor; intermedia; majors

Thalassemia minor; intermedia

Thalassemia minor; major

Thalassemia major; minor

All answers are not correct

Abnormal hemoglobin (beta globin gene):

Structural variants

513 know variants

Most know: Hbs; Hbc; HbE

Reduced beta-globin synthesis

Structural variants, Structural variants, Most know: Hbs; Hbc; HbE

Thalassemia beta:

Reduced beta globin synthesis

240 know variant

Mild to severe presentation

513 know variant

513 know variants, 513 know variants, Mild to severe presentations

Characteristics of routine laboratory results in thalassemia minor:

Microcytic anemia: Hb: 9,5 -12,5, MCV < 75fl

Hyperregenerative: retics increased or normal

Red cell count (RBC) normal

Metzner index (MCV) RBC<13; RDW (SC or %) normal (35-45 fl; 11-16%)

All answers are correct

Abnormal hemoglobin in Alpha globin gene:

Structural variant

323 know variant

Reduced synthesis

Ca-70 knew variant

Structural variants, 323 know variants

Thalassemia (alpha globin gene):

Structural variant

323 know variant

Reduced synthesis

Ca-70 know variant

Reduced synthesis, Ca-70 knew variants

Characteristics of routine laboratory results in Alpha Thalassemia minor:

Microcytosis MCV < 75fl

Hb:9-14.5; mild anemia maybe present or not

Retics increased or normal

Red cell count (RBC) normal; RDW(sd or %) normal (35-45fl ;11-16%)

All answers are correct

Future treatment options for HbE / Thalassemia:

Transfusion protocol

Splenectomy

The transfusion protocol and splenectomy

Medication only

All answers are not correct

Treatment for splenectomy:

Should only be performed on children > 6 years

Cave: infections, 1year of penicillin post splenectomy required

Anti-pneumococcal vaccine required

Quality control

All answers are not true

Characteristic of malignant lymphadenopathy:

Hard consistency

Normal contour

Not painful

Fixed to surrounding tissue

All answers are correct

Classical finding of post infectious lymphadenopathy in young preschool kids:

Soft and elastic

No pain to palpation

No signs of inflammation

Less than 1cm measurement

All answers are correct

Common causes of viral lymphadenopathy:

Adenovirus

Cytomegalovirus

Epstein barre virus

Herpes simplex virus

All answers are correct

How many subtypes of NHL?

Classification of NHL:

Small non-cleaved lymphoma

Lymphoblastic lymphoma

Diffuse large cells lymphoma

Anaplastic cells lymphoma

All answers are correct

Prognosis of Hodgkin lymphoma:

Relapse in 50%

Relapse in 20%

Relapse in 60%

Relapse in 70%

Relapse in 80%

Different type of NHL:

B cell lymphoma

Diffuse large cells lymphoma

Follicular lymphoma

Burkitt lymphoma

All answers are correct

What is the most common type of NHL in Africa?

The Burkitt lymphoma

Follicular lymphoma

Marginal zone lymphoma

Lymphoblastic lymphoma

B cells lymphoma

Red flags for untypical etiology of lymphadenopathy:

Supra clavicular lymph node

Posterior cervical lymph node

No improvement after 4 week

Persistence after 3 month

All answers are correct

The most Classical and frequecause of infectious lymphadenopathy:

The Staphylococcus Aureus

Atypical mycobacterium

Toxoplasmosis

Adenovirus

Enterovirus

Hb E is primarily in person of:

The original Southeast Asia

American original

Mediterranean original

African original

European original

What is alpha or beta thalassemia?

Reduced production of heme

Reduced production of alpha or beta-globin-chains

Reduced production of Red blood cell

Reduced production of white blood cell

Reduced production of platelet

What is the characteristic of thalassemia minor?

Severe anemia, intermittently transfusion required

Severe anemia, lifelong transfusion dependent

Healthy carrier, heterozygote states

Severe jaundice

Severe bleeding

What is the characteristics of thalassemia intermedia?

The severe anemia, intermittently transfusions required

Severe anemia, lifelong transfusion dependent

Healthy carrier, heterozygote state

Severe jaundice

Severe bleeding

What is the characteristics of thalassemia major?

Severe anemia, intermittently transfusions required

Severe anemia, lifelong transfusion dependent

Healthy carrier, heterozygote state

Severe jaundice

Severe bleeding

What is the cause of Hydrops fetalis?

The Alpha thalassemia

Betha thalassemia

Sickle cell disease

Iron overload

Hyperkaliemia

What is Hydrops fetalis?

Accumulation of excessive fluid in the allantoic

Accumulation of excessive fluid in amniotic space

Accumulation of excessive fluid in at least two fetal compartments

Accumulation of excessive fluid in peritoneal compartment

Accumulation of excessive fluid in pleural compartment

What is principle complication of repeated blood transfusion in thalassemia patient?

Calcium overload

The iron overload

Potassium overload

Sodium overload

Chlor overload

What is important risk factor of beta thalassemia?

The Family history of beta thalassemia

Family history of diabetes

Family history of hypertension

Family history of hypercholesterolemia

Family history of asthma

What is the main cause of abdominal pain in beta thalassemia patient?

Gastritis

Occlusion

Hypersplenism and splenic infarctions

Peritonitis

Cystitis

Which one of following diseases can prevent from malaria?

Vit B12 deficiency anemia

Betha thalassemia

The Sickle cell disease

Alpha thalassemia

Iron deficiency anemia

How many types of beta thalassemia are there?

What is Mentzer index?

Helpful tool to differentiating iron deficiency anemia from beta thalassemia

Helpful tool to diagnose anemia

Helpful tool to detect malaria

Helpful tool to detect cholera

Helpful tool to detect TB

What Mentzer value is diagnosis of iron deficiency more likely?

>13

What Mentzer value is diagnosis of thalassemia more likely?

<13

Which are differential diagnosis I of fetal bleeding?

Fetal maternal bleeding

Twin- twin transfusion

Bleeding from the placenta

Fetal maternal bleeding, Fetal maternal bleeding

All answers are correct

What is normal hematology values for newborn during first 6 month of life?

In 6 month Hb : 126g/l, MCV: 77fl, reticulocyte: 1-2%

In 6 month Hb: 137g/l, MCV: 78fl, reticulocyte:5-6%

In 6 month Hb: 137g/l, MCV:77fl, reticulocyte :5-7%

In 6 month Hb: 137g/l, MCV: 78fl, reticulocyte:5-8%

In 6 month Hb: 137g/l, MCV: 78fl, reticulocyte:5-9%

What is reasons of fetal and neonate hematopoiesis I?

Increased EPO-production after birth and HbF lower O2

Increased EPO-production after birth and higher HbF O2 affinity

Decreased EPO - production after birth and HbF higher O2 affinities

Decreased EPO-production after birth and HbF lower affinity

All answers are not correct

Which are differential diagnosis II bloodloss peri/ postpartal?

Intracranial bleeding (forceps, vacuum - extraction of head)

Vascular malformation

Iatrogen (blood test)

Intracranial bleeding, vascular malformation and iatrogens

Absence of hemolysis

What is normal ranges of hemoglobin of Newborn?

160g/l

161g/l

163g/l

164g/l

168g/l

Which is not differential diagnosis IV anemia with sign of hemolysis?

Immun-haemolysis

Membrane-instability (spherocyte)

Enzyme-deficiency (GGPD, pyruvutkinas-deficiency)

Haemoglobin opathie: alpha thalassemia

The Kleihauer - bethke tests

What management of marbus haemolyticus neonatal after delivery?

Phototherapy

Perfusion (PIV)

Exchange-transfusion (via ambilical - katheter)

Phototherapy and exchange - transfusion and if sever: albumin, IVIG

Morbus haemolytic neonatorum, expect one?

Immune-haemolysis of Newborn

Rhesus-incompatibility

AB0 incompatibility mostly mild

The intracerebral hemorrhages

Hydrop fetalis

How many blood volume per body weight of term infant?

85 ml/kg

90 ml/k

95 ml/kg

105 ml/kg

115 ml/kg

How many blood volume per body weight of preterm baby?

70-80 ml/kg

80-90 ml/kg

90-100 ml/kg

100-115 ml/kg

110-120 ml/kg

Neonatal RBCs can survive

20-30 days

30-40 days

35-50 days

50-60 days

60-70 days

All of these analysis for neonate with anemia and hemolysis, except one

Anemia

Increase reticulocyte

Hemolysis (LDH, Hb-Co, free Hb)

Hyperbilirubinemia

The hyperleucocytoses

All of these following are etiology in anemia of the preterm infant, except one

Insufficient EPO stimulation in the preterm neonate

Insufficient iron storage

Rapid growth (RBC mass doubles in 1-4 weeks of life

Cave: repeated blood sampling, iatrogenic blood loss

The birth asphyxias

Transfusion of Rh+ blood/platelets to Rh- female (emergency transfusion) we should give RhIgG prophylaxis

Maximum 72h after birth

4 days

5 days

6 days

1 week

When we give Rhesusprophylaxis to a Rh- mother and a Rh+ fetus

Give RhIgG in each gestation in 28Gw and postpartum (maximally 72h postpartum)

4 days after birth C. 5 days after birth

1 week after birth

2 weeks after birth

All answers are not correct

Bleeding signs due to thrombocytopenia:

Petechia

Mucosal bleeding

Haematoma

Suffusion

All answers are correct

Vascular Purpura (Petechia/Purpura) due to an abnormal vessel wall :

Vascular occlusion

Increased transmural pressure

Connective tissue abnormality

Abnormal endothelial junction

All answers are correct

Vascular occlusion in Vascular purpura due to:

Embolism, thrombotic

Infection

Cholesterol, fat

Dysproteinemias

All answers are correct

Increased transmural pressure in Vascular purpura due to:

High altitude

Cough

Valsalva

All answers are not correct

High altitude, Cough, Valsava

Cause of Connective tissue abnormalities

Congenital (Connective tissue disease)

Trauma

Steroids

Dysproteinemias

All answers are correct

Abnormal endothelial junction due to:

The Inflammation

Steroids

Cough

Cholesterol

Scurvy

Cause of Abnormal endothelium:

Congenital (angiomas, ect...)

Trauma

Kaposi's sarcoma

All answers are not correct

Congenital, Trauma, Kaposi's sarcoma

Differential diagnosis in thrombocytopenia:

Von Willebrands Disease

Schoenlein Hennoch

Bernhard Soulier

Ehlers Danlos

All answers are correct

Definition for ITP: except one

Is an immune disorder in which accelerated destruction of platelet

Sensitized by autoantibodies

Immune complexes lead to thrombocytopenia

Sudden onset of bruising

No sensitized by autoantibodies

Hemolytic Uremic syndrome classical symptom: except one

Fever

Thrombocytopenia

Laborsigns of kidney failure

The Vomiting

Fragmentocyts

Purpura Schönlen Hennoch: except one

Immune vasculitis

Children all ages

1 week after viral infection

Palpable purpura

The abdominal pain 70%

Characteristics of childhood-acute ITP: which one is correct

The sudden onset of bruising, petechiae in a previously well young child

No history of an infection illness

Abnormal physical examination

WBC or Hb abnormal

Any normality in blood cell count easily explain

Therapy for ITP which one is correct:

If no bleeding (except for petechia) do not treat

No sport, see the doctor if fever > 38.5 C

Increasing bleeding sign

Inform patients, regular consultation, avoid trauma

All answers are correct

Systemic treatment options for ITP: except one

Steroids 2-4mg/kg po for 5 days then reduce over 2 weeks to minimal dose

Immunoglobuline 0.4-0.8/kg iv

Thrombopoietin analgo

Anti-CD-20 antibody

The Splenectomy in chronic ITP in children <6 years

Intracranial bleeding (ICH) in ITP, all statements are true , except one

ICH are rare

In the 1990 with 1-2% over estimate

The increasing bleeding symptoms in >70% before ICH

New febrile infection

Cave trauma

Hemophilia A is a genetic deficiency in clotting

Factor-VIII

Factor VII

Factor V

Factor II

Factor X

Hemophilia B is a hereditary bleeding disorder caused by a lack of blood clotting

Factor X

Factor VII

Factor V

Factor-IX

Factor II

Clinical presentation of Morbus von Willebrand (VWD)

Mild Mucosal bleeding, Epistaxis, Menorrhagia

Bleeding during teething

Per-operation bleeding

Joint-bleeding are very rare, only occurs with Type III

All answers are correct

Laboratory in VWD

INR normal

PTT can be prolonged

Bleeding-time or PFA abnormal

Abnormal von Willebrand-Factor (VWF)

All answers are correct

Von Willwbrand Factor, which one is the wrong answer?

Prevalence in Europe 1:100- 1:1000 (incl. Subclinical form)

The Only male

Release in case of endothelial damage and platelet activation

Plasma von Willebrand factor carries factor VIII

Von Willebrand disease: often abnormal PTT

Which of the following is seen in idiopathic thrombocytopenic purpura?

Thrombocytosis

Increased prothrombin time

The Increased bleeding time

Increased clotting time

All answers are not correct

Which of the following disease is known as the " kissing disease"?

Acquired immunodeficiency syndrome

The Infectious mononucleosis

Primary syphilis

Recurrent aphthous stomatitis

Down’s syndrome

To prevent excessive bleeding during surgery a patient with hemophilia A may be given:

Whole blood

Fresh frozen plasma

Factor-VIII concentrate

Factor IX concentrate

Factor V

Leucocytopenia is seen in:

Influenza

Agranulocytosis

Liver cirrhosis

Anemia

All answers are correct

Which of the following is not associated with hemorrhage?

Ecchymosis

Petechiae

The melanosis

Purpura

Rash

The etiology of aplastic anemia:

Congenital

Cytotoxic drugs, organic solvents and Idiosyncratic drug reaction

Viral infection

Immune disorder

All answers are correct

Supportive Care for Childhood Leukaemia are:

Antiemetics, Analgetic

Antinfectious Therapy and Transfusion

Ambulatory Care-Facility

Psycho-Social-Support

All answers are correct

The diagnosis of Acute Lymphoblastic Leukaemia are:

Bone marrow aspiration/biopsy

Flowcytometry (FACS)

Cytogenetic

Immunophenotype

All answers are correct

Prophylaxis for bacterial infections in aplastic anaemia:

Neutrophiles/Lymphocytes < 0.5: Give Cotrimoxazole

Antifungal prophylaxis (Itroconazol)

Acute Infection (T >38.5C) Treat as fever and neutropenia (oncology: Amoxicillin and Aminoglycoside)

Use antifungal drugs (Amphotericin B) after 4-5d of fever

All answers are correct

In the syndrome of marrow failure there is:

Splenomegaly

Hepatomegaly

Jaundice

Hematuria

Anemia, fever, purpura

The difference type of blood components/products are:

Packed red cells (red cell suspension, RBC-concentrate)

Fresh frozen plasma

Platelet

Cryoprecipitate

All Answers are correct

What are the risks of blood transfusion:

Transmission of infections from donor (HIV, Hepatitis B, C, Syphilis)

Bacterial contamination

Wrong dose or product causing volume overload and blood grouping

Allergic and other immunological transfusion reaction

All answers are correct

The most likely transfusion transmitted infection is:

Yersinia enterocolitica

Hepatitis A

Hepatitis B

Hepatitis C

The Staph Epidermidis

What are the topical problems of blood transfusion in children :

Reactions to the product, contamination

Volume overload

Line problem

Electrolyte disturbance

All answers are correct

What are the tests for each blood donation:

Bloodgroups

HbsAg, Anti-HCV, HCV (PCR), Liver-Enzyms (< 50/70 U)

HIV (PCR), anti-HIV-1/2

Anti-Treponema pallidum

All answers are correct

The trigger for blood transfusion for clinically relevant anaemia in neonates and children:

Respiratory irregularities/ apnea

Lethargy, poor suck

Tachycardia, hypotension, increased lactate levels

0xygene Extraction >40%

All answers are correct

The trigger for blood transfusion in neonates and infants under 4 months of age:

Anemia term/preterm first day of life (100g/l)

Term/preterm neonates requiring intensive care (100g/l)

Chronic 0xygene dependency / severe lung disease (100g/l)

>2-4 weeks of age, stable infant (60g/l)

All answers are correct

The trigger for blood transfusion in children and older infants above 4months of age:

Acute blood loss, haemolysis and Postoperatively <60g/l

Chronic anaemia (Fe-deficiency, chron. Blood loss) <50g/l

Cardiology, chronic lung disease 70-80g/l

Oncology /post BMT/aplastic anaemia (stable child) 50-60g/l

All answers are correct

The Fresh frozen plasma is indicated for:

Liver disease

Warfarin anticoagulant overdose

Massive transfusion (for 4 RBC-concentrates give 1 FFP)

Dilution or consumption (DIC)

All answers are correct

How many types of aplastic anemia:

8 types

7 types

6 types

5 types

2 types

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