Hematology
Hematology Quiz Challenge
Test your knowledge on hematology and bleeding disorders with our comprehensive quiz. This quiz covers a wide range of topics, including symptoms, diagnostics, and treatments related to hematology. Whether you are a student, educator, or simply interested in hematology, this quiz is designed to enhance your understanding and retention of important concepts.
- Multiple-choice questions
- Covers a variety of topics in hematology
- Suitable for all levels of knowledge
What are the symptoms of bleeding disorder?
Hematoma and suffusion
Petechia
Epistaxis and hemarthros
Intracerebral bleeding
All answers are correct
Characteristic of Epistaxis I’m bleeding disorder:
Bleeding from both sides
Nosebleeds <2 years of age
Nosebleed >10mn
Not associated with viral infection during whole year
All answers are correct
The history of specific hints for bleeding disorder in infant, toddler:
The hematoma / the petechia at birth
Macroscopic
Menorrhagia
Hyperglycemia
Epistaxis
The history of specific hints for bleeding disorder in children:
Epistaxis (age <2years, >10mn)
Amenorrhea
Epistaxis <10 mn
Menorrhagia
Petechia
The history of specific hints for bleeding disorder in adult:
Menorrhagia and postoperative bleeding
Amenorrhea
Epistaxis <10 mn
Intracerebral bleeding
Petechia
How many step in primary haemostasis
2
3
5
7
9
Global tests of the plasmoic coagulation paediatric normal values ( 0-7 days ):
INR 1.4
INR 1.9
INR 1.6
INR 1.7
INR 1.8
Normal value of aPTT in children 1-3 month:
50
10
20
70
80
Step of hemostasis:
Primary hemostasis and secondary hemostasis
Platelets activation
Platelets adhesion
Platelets aggregation
Intrinsic coagulation
Which one is true in Vit.K mangel:
Elevated INR, normal PTT, normal fibrinogen
Increased INR, normal PTT, normal fibrinogen
Increased PTT, normal INR
Increased fibrinogen, normal PTT
Decreased PTT, decreased INR
Definition beta order alpha thalassemia :
The reduced production of beta or alpha globin-chains
Increased production of beta or alpha globin-chain
Reduced production of beta or increased alpha globin-chains
Increased production of beta or reduced alpha globin chain
All answers are not correct
Types of thalassemia:
Thalassemia minor; intermedia; majors
Thalassemia minor; intermedia
Thalassemia minor; major
Thalassemia major; minor
All answers are not correct
Abnormal hemoglobin (beta globin gene):
Structural variants
513 know variants
Most know: Hbs; Hbc; HbE
Reduced beta-globin synthesis
Structural variants, Structural variants, Most know: Hbs; Hbc; HbE
Thalassemia beta:
Reduced beta globin synthesis
240 know variant
Mild to severe presentation
513 know variant
513 know variants, 513 know variants, Mild to severe presentations
Characteristics of routine laboratory results in thalassemia minor:
Microcytic anemia: Hb: 9,5 -12,5, MCV < 75fl
Hyperregenerative: retics increased or normal
Red cell count (RBC) normal
Metzner index (MCV) RBC<13; RDW (SC or %) normal (35-45 fl; 11-16%)
All answers are correct
Abnormal hemoglobin in Alpha globin gene:
Structural variant
323 know variant
Reduced synthesis
Ca-70 knew variant
Structural variants, 323 know variants
Thalassemia (alpha globin gene):
Structural variant
323 know variant
Reduced synthesis
Ca-70 know variant
Reduced synthesis, Ca-70 knew variants
Characteristics of routine laboratory results in Alpha Thalassemia minor:
Microcytosis MCV < 75fl
Hb:9-14.5; mild anemia maybe present or not
Retics increased or normal
Red cell count (RBC) normal; RDW(sd or %) normal (35-45fl ;11-16%)
All answers are correct
Future treatment options for HbE / Thalassemia:
Transfusion protocol
Splenectomy
The transfusion protocol and splenectomy
Medication only
All answers are not correct
Treatment for splenectomy:
Should only be performed on children > 6 years
Cave: infections, 1year of penicillin post splenectomy required
Anti-pneumococcal vaccine required
Quality control
All answers are not true
Characteristic of malignant lymphadenopathy:
Hard consistency
Normal contour
Not painful
Fixed to surrounding tissue
All answers are correct
Classical finding of post infectious lymphadenopathy in young preschool kids:
Soft and elastic
No pain to palpation
No signs of inflammation
Less than 1cm measurement
All answers are correct
Common causes of viral lymphadenopathy:
Adenovirus
Cytomegalovirus
Epstein barre virus
Herpes simplex virus
All answers are correct
How many subtypes of NHL?
1
2
4
6
7
Classification of NHL:
Small non-cleaved lymphoma
Lymphoblastic lymphoma
Diffuse large cells lymphoma
Anaplastic cells lymphoma
All answers are correct
Prognosis of Hodgkin lymphoma:
Relapse in 50%
Relapse in 20%
Relapse in 60%
Relapse in 70%
Relapse in 80%
Different type of NHL:
B cell lymphoma
Diffuse large cells lymphoma
Follicular lymphoma
Burkitt lymphoma
All answers are correct
What is the most common type of NHL in Africa?
The Burkitt lymphoma
Follicular lymphoma
Marginal zone lymphoma
Lymphoblastic lymphoma
B cells lymphoma
Red flags for untypical etiology of lymphadenopathy:
Supra clavicular lymph node
Posterior cervical lymph node
No improvement after 4 week
Persistence after 3 month
All answers are correct
The most Classical and frequecause of infectious lymphadenopathy:
The Staphylococcus Aureus
Atypical mycobacterium
Toxoplasmosis
Adenovirus
Enterovirus
Hb E is primarily in person of:
The original Southeast Asia
American original
Mediterranean original
African original
European original
What is alpha or beta thalassemia?
Reduced production of heme
Reduced production of alpha or beta-globin-chains
Reduced production of Red blood cell
Reduced production of white blood cell
Reduced production of platelet
What is the characteristic of thalassemia minor?
Severe anemia, intermittently transfusion required
Severe anemia, lifelong transfusion dependent
Healthy carrier, heterozygote states
Severe jaundice
Severe bleeding
What is the characteristics of thalassemia intermedia?
The severe anemia, intermittently transfusions required
Severe anemia, lifelong transfusion dependent
Healthy carrier, heterozygote state
Severe jaundice
Severe bleeding
What is the characteristics of thalassemia major?
Severe anemia, intermittently transfusions required
Severe anemia, lifelong transfusion dependent
Healthy carrier, heterozygote state
Severe jaundice
Severe bleeding
What is the cause of Hydrops fetalis?
The Alpha thalassemia
Betha thalassemia
Sickle cell disease
Iron overload
Hyperkaliemia
What is Hydrops fetalis?
Accumulation of excessive fluid in the allantoic
Accumulation of excessive fluid in amniotic space
Accumulation of excessive fluid in at least two fetal compartments
Accumulation of excessive fluid in peritoneal compartment
Accumulation of excessive fluid in pleural compartment
What is principle complication of repeated blood transfusion in thalassemia patient?
Calcium overload
The iron overload
Potassium overload
Sodium overload
Chlor overload
What is important risk factor of beta thalassemia?
The Family history of beta thalassemia
Family history of diabetes
Family history of hypertension
Family history of hypercholesterolemia
Family history of asthma
What is the main cause of abdominal pain in beta thalassemia patient?
Gastritis
Occlusion
Hypersplenism and splenic infarctions
Peritonitis
Cystitis
Which one of following diseases can prevent from malaria?
Vit B12 deficiency anemia
Betha thalassemia
The Sickle cell disease
Alpha thalassemia
Iron deficiency anemia
How many types of beta thalassemia are there?
5
6
3
8
9
What is Mentzer index?
Helpful tool to differentiating iron deficiency anemia from beta thalassemia
Helpful tool to diagnose anemia
Helpful tool to detect malaria
Helpful tool to detect cholera
Helpful tool to detect TB
What Mentzer value is diagnosis of iron deficiency more likely?
>13
7
8
4
5
What Mentzer value is diagnosis of thalassemia more likely?
7
8
4
<13
5
Which are differential diagnosis I of fetal bleeding?
Fetal maternal bleeding
Twin- twin transfusion
Bleeding from the placenta
Fetal maternal bleeding, Fetal maternal bleeding
All answers are correct
What is normal hematology values for newborn during first 6 month of life?
In 6 month Hb : 126g/l, MCV: 77fl, reticulocyte: 1-2%
In 6 month Hb: 137g/l, MCV: 78fl, reticulocyte:5-6%
In 6 month Hb: 137g/l, MCV:77fl, reticulocyte :5-7%
In 6 month Hb: 137g/l, MCV: 78fl, reticulocyte:5-8%
In 6 month Hb: 137g/l, MCV: 78fl, reticulocyte:5-9%
What is reasons of fetal and neonate hematopoiesis I?
Increased EPO-production after birth and HbF lower O2
Increased EPO-production after birth and higher HbF O2 affinity
Decreased EPO - production after birth and HbF higher O2 affinities
Decreased EPO-production after birth and HbF lower affinity
All answers are not correct
Which are differential diagnosis II bloodloss peri/ postpartal?
Intracranial bleeding (forceps, vacuum - extraction of head)
Vascular malformation
Iatrogen (blood test)
Intracranial bleeding, vascular malformation and iatrogens
Absence of hemolysis
What is normal ranges of hemoglobin of Newborn?
160g/l
161g/l
163g/l
164g/l
168g/l
Which is not differential diagnosis IV anemia with sign of hemolysis?
Immun-haemolysis
Membrane-instability (spherocyte)
Enzyme-deficiency (GGPD, pyruvutkinas-deficiency)
Haemoglobin opathie: alpha thalassemia
The Kleihauer - bethke tests
What management of marbus haemolyticus neonatal after delivery?
Phototherapy
Perfusion (PIV)
Exchange-transfusion (via ambilical - katheter)
O2
Phototherapy and exchange - transfusion and if sever: albumin, IVIG
Morbus haemolytic neonatorum, expect one?
Immune-haemolysis of Newborn
Rhesus-incompatibility
AB0 incompatibility mostly mild
The intracerebral hemorrhages
Hydrop fetalis
How many blood volume per body weight of term infant?
85 ml/kg
90 ml/k
95 ml/kg
105 ml/kg
115 ml/kg
How many blood volume per body weight of preterm baby?
70-80 ml/kg
80-90 ml/kg
90-100 ml/kg
100-115 ml/kg
110-120 ml/kg
Neonatal RBCs can survive
20-30 days
30-40 days
35-50 days
50-60 days
60-70 days
All of these analysis for neonate with anemia and hemolysis, except one
Anemia
Increase reticulocyte
Hemolysis (LDH, Hb-Co, free Hb)
Hyperbilirubinemia
The hyperleucocytoses
All of these following are etiology in anemia of the preterm infant, except one
Insufficient EPO stimulation in the preterm neonate
Insufficient iron storage
Rapid growth (RBC mass doubles in 1-4 weeks of life
Cave: repeated blood sampling, iatrogenic blood loss
The birth asphyxias
Transfusion of Rh+ blood/platelets to Rh- female (emergency transfusion) we should give RhIgG prophylaxis
Maximum 72h after birth
4 days
5 days
6 days
1 week
When we give Rhesusprophylaxis to a Rh- mother and a Rh+ fetus
Give RhIgG in each gestation in 28Gw and postpartum (maximally 72h postpartum)
4 days after birth C. 5 days after birth
1 week after birth
2 weeks after birth
All answers are not correct
Bleeding signs due to thrombocytopenia:
Petechia
Mucosal bleeding
Haematoma
Suffusion
All answers are correct
Vascular Purpura (Petechia/Purpura) due to an abnormal vessel wall :
Vascular occlusion
Increased transmural pressure
Connective tissue abnormality
Abnormal endothelial junction
All answers are correct
Vascular occlusion in Vascular purpura due to:
Embolism, thrombotic
Infection
Cholesterol, fat
Dysproteinemias
All answers are correct
Increased transmural pressure in Vascular purpura due to:
High altitude
Cough
Valsalva
All answers are not correct
High altitude, Cough, Valsava
Cause of Connective tissue abnormalities
Congenital (Connective tissue disease)
Trauma
Steroids
Dysproteinemias
All answers are correct
Abnormal endothelial junction due to:
The Inflammation
Steroids
Cough
Cholesterol
Scurvy
Cause of Abnormal endothelium:
Congenital (angiomas, ect...)
Trauma
Kaposi's sarcoma
All answers are not correct
Congenital, Trauma, Kaposi's sarcoma
Differential diagnosis in thrombocytopenia:
Von Willebrands Disease
Schoenlein Hennoch
Bernhard Soulier
Ehlers Danlos
All answers are correct
Definition for ITP: except one
Is an immune disorder in which accelerated destruction of platelet
Sensitized by autoantibodies
Immune complexes lead to thrombocytopenia
Sudden onset of bruising
No sensitized by autoantibodies
Hemolytic Uremic syndrome classical symptom: except one
Fever
Thrombocytopenia
Laborsigns of kidney failure
The Vomiting
Fragmentocyts
Purpura Schönlen Hennoch: except one
Immune vasculitis
Children all ages
1 week after viral infection
Palpable purpura
The abdominal pain 70%
Characteristics of childhood-acute ITP: which one is correct
The sudden onset of bruising, petechiae in a previously well young child
No history of an infection illness
Abnormal physical examination
WBC or Hb abnormal
Any normality in blood cell count easily explain
Therapy for ITP which one is correct:
If no bleeding (except for petechia) do not treat
No sport, see the doctor if fever > 38.5 C
Increasing bleeding sign
Inform patients, regular consultation, avoid trauma
All answers are correct
Systemic treatment options for ITP: except one
Steroids 2-4mg/kg po for 5 days then reduce over 2 weeks to minimal dose
Immunoglobuline 0.4-0.8/kg iv
Thrombopoietin analgo
Anti-CD-20 antibody
The Splenectomy in chronic ITP in children <6 years
Intracranial bleeding (ICH) in ITP, all statements are true , except one
ICH are rare
In the 1990 with 1-2% over estimate
The increasing bleeding symptoms in >70% before ICH
New febrile infection
Cave trauma
Hemophilia A is a genetic deficiency in clotting
Factor-VIII
Factor VII
Factor V
Factor II
Factor X
Hemophilia B is a hereditary bleeding disorder caused by a lack of blood clotting
Factor X
Factor VII
Factor V
Factor-IX
Factor II
Clinical presentation of Morbus von Willebrand (VWD)
Mild Mucosal bleeding, Epistaxis, Menorrhagia
Bleeding during teething
Per-operation bleeding
Joint-bleeding are very rare, only occurs with Type III
All answers are correct
Laboratory in VWD
INR normal
PTT can be prolonged
Bleeding-time or PFA abnormal
Abnormal von Willebrand-Factor (VWF)
All answers are correct
Von Willwbrand Factor, which one is the wrong answer?
Prevalence in Europe 1:100- 1:1000 (incl. Subclinical form)
The Only male
Release in case of endothelial damage and platelet activation
Plasma von Willebrand factor carries factor VIII
Von Willebrand disease: often abnormal PTT
Which of the following is seen in idiopathic thrombocytopenic purpura?
Thrombocytosis
Increased prothrombin time
The Increased bleeding time
Increased clotting time
All answers are not correct
Which of the following disease is known as the " kissing disease"?
Acquired immunodeficiency syndrome
The Infectious mononucleosis
Primary syphilis
Recurrent aphthous stomatitis
Down’s syndrome
To prevent excessive bleeding during surgery a patient with hemophilia A may be given:
Whole blood
Fresh frozen plasma
Factor-VIII concentrate
Factor IX concentrate
Factor V
Leucocytopenia is seen in:
Influenza
Agranulocytosis
Liver cirrhosis
Anemia
All answers are correct
Which of the following is not associated with hemorrhage?
Ecchymosis
Petechiae
The melanosis
Purpura
Rash
The etiology of aplastic anemia:
Congenital
Cytotoxic drugs, organic solvents and Idiosyncratic drug reaction
Viral infection
Immune disorder
All answers are correct
Supportive Care for Childhood Leukaemia are:
Antiemetics, Analgetic
Antinfectious Therapy and Transfusion
Ambulatory Care-Facility
Psycho-Social-Support
All answers are correct
The diagnosis of Acute Lymphoblastic Leukaemia are:
Bone marrow aspiration/biopsy
Flowcytometry (FACS)
Cytogenetic
Immunophenotype
All answers are correct
Prophylaxis for bacterial infections in aplastic anaemia:
Neutrophiles/Lymphocytes < 0.5: Give Cotrimoxazole
Antifungal prophylaxis (Itroconazol)
Acute Infection (T >38.5C) Treat as fever and neutropenia (oncology: Amoxicillin and Aminoglycoside)
Use antifungal drugs (Amphotericin B) after 4-5d of fever
All answers are correct
In the syndrome of marrow failure there is:
Splenomegaly
Hepatomegaly
Jaundice
Hematuria
Anemia, fever, purpura
The difference type of blood components/products are:
Packed red cells (red cell suspension, RBC-concentrate)
Fresh frozen plasma
Platelet
Cryoprecipitate
All Answers are correct
What are the risks of blood transfusion:
Transmission of infections from donor (HIV, Hepatitis B, C, Syphilis)
Bacterial contamination
Wrong dose or product causing volume overload and blood grouping
Allergic and other immunological transfusion reaction
All answers are correct
The most likely transfusion transmitted infection is:
Yersinia enterocolitica
Hepatitis A
Hepatitis B
Hepatitis C
The Staph Epidermidis
What are the topical problems of blood transfusion in children :
Reactions to the product, contamination
Volume overload
Line problem
Electrolyte disturbance
All answers are correct
What are the tests for each blood donation:
Bloodgroups
HbsAg, Anti-HCV, HCV (PCR), Liver-Enzyms (< 50/70 U)
HIV (PCR), anti-HIV-1/2
Anti-Treponema pallidum
All answers are correct
The trigger for blood transfusion for clinically relevant anaemia in neonates and children:
Respiratory irregularities/ apnea
Lethargy, poor suck
Tachycardia, hypotension, increased lactate levels
0xygene Extraction >40%
All answers are correct
The trigger for blood transfusion in neonates and infants under 4 months of age:
Anemia term/preterm first day of life (100g/l)
Term/preterm neonates requiring intensive care (100g/l)
Chronic 0xygene dependency / severe lung disease (100g/l)
>2-4 weeks of age, stable infant (60g/l)
All answers are correct
The trigger for blood transfusion in children and older infants above 4months of age:
Acute blood loss, haemolysis and Postoperatively <60g/l
Chronic anaemia (Fe-deficiency, chron. Blood loss) <50g/l
Cardiology, chronic lung disease 70-80g/l
Oncology /post BMT/aplastic anaemia (stable child) 50-60g/l
All answers are correct
The Fresh frozen plasma is indicated for:
Liver disease
Warfarin anticoagulant overdose
Massive transfusion (for 4 RBC-concentrates give 1 FFP)
Dilution or consumption (DIC)
All answers are correct
How many types of aplastic anemia:
8 types
7 types
6 types
5 types
2 types
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