VI pdf quiz part 1

Viruses usually initiate infection by first interacting with receptors on the surface of cells. Which of the following statements is most accurate about cellular receptors for viruses?

Which of the following can be used to quantitate the titer of infectious viruses?

Which one of the following states a principle regarding viral nucleic acid?

Two mutants of poliovirus have been isolated, one (MutX) with a mutation in gene X and the second (MutY) with a mutation in gene Y. If cells are infected with each mutant alone, no virus is produced. If a cell is coinfected with both MutX and MutY, which one of the following is most likely to occur?

Which one of the following viruses possesses an RNA genome that is infectious when purified?

Viruses belonging to which of the following groups are likely to establish latent infections?

Some viruses are characterized by helical symmetry of the viral nucleocapsid. Which of the following statements about viruses with helical symmetry is most accurate?

Virus-infected cells often develop morphologic changes referred to as cytopathic effects. Which of the following statements about virus-induced cytopathic changes is most accurate?

Some viruses encode for a viral RNA-dependent RNA polymerase. Which of the following states a principle about viral RNA polymerases?

Arboviruses are classified into several different virus families but are grouped together based on which of the following common characteristics?

Many viruses can be grown in the laboratory. Which of the following statements about virus propagation is not true?

Laboratory infections can be acquired when working with viruses unless good laboratory safety practices are followed. Which of the following is not a good biosafety practice?

Small viruses are in the same size range as which of the following?

Which one of the following is a fundamental principle of viral disease causation?

The skin is a formidable barrier to virus entry, but a few viruses are able to breach this barrier and initiate infection of the host. Which of the following is an example of a virus that enters through skin abrasions?

A 40-year-old man has HIV/AIDS characterized by a low CD4 count and a high viral load. Highly active antiretroviral therapy (HAART) will be initiated. One of the drugs under consideration is a nucleoside analog that inhibits viral reverse transcriptase and is active against both HIV and hepatitis B virus. That drug is

. Interferons are an important part of the host defense against viral infections. What is interferon’s principal mode of action?

A 9-month-old girl is taken to the emergency room because of fever and persistent cough. Rales are heard in her left chest on physical examination. An infiltrate in her left lung is seen on the chest radiograph. Pneumonia is diagnosed. Which of the following is the most likely cause?

A 63-year-old woman is hospitalized for treatment of leukemia. One day after admission she develops chills, fever, cough, headache, and myalgia. She states that her husband had a similar illness a few days earlier. There is major concern about a respiratory virus outbreak in the staff of the chemotherapy ward and in the patients on that ward. A synthetic amine that inhibits influenza A virus by blocking viral uncoating is chosen for prophylactic treatment of the staff and patients. That drug is

Which one of the following statements describes an advantage of killed-virus vaccines over attenuated live-virus vaccines?

What type of hepatitis B vaccine is currently in use in the United States?

Which one of the following phrases accurately describes viral neutralizing antibodies?

Many viruses use the respiratory tract as the route of entry to initiate infections. Which of the following virus groups does not?

. Which of the following licensed virus vaccines is a subunit vaccine prepared using recombinant DNA technology?

Which of the following viruses is the most common cause of neonatal infections in the United States?

Which one of the following statements concerning interferons is least accurate?

Each of the following statements concerning viral vaccines is correct except

Which one of the following best describes a physicochemical property of parvoviruses?

An 8-year-old child recently had erythema infectiosum. Her 33-year-old mother subsequently developed arthralgia followed by painful arthritis with swelling in the small joints of both hands. In addition to the apparent tropism for joints, human parvovirus B19 is highly tropic for which cell type?

Which of the following is available as a treatment or preventive for parvovirus B19 infections?

Human erythroviruses and bocaviruses share the following properties except for which one?

A 42-year-old man with HIV/AIDS presented with aplastic anemia. Using the PCR, parvovirus B19 was detected in his serum. The patient presumably acquired his parvovirus B19 infection from another person. The most likely route of transmission is

Which one of the following is a disease in which the role of parvovirus B19 has not been established?

Which one of the following best describes the replication of human parvovirus B19?

Which one of the following statements is most accurate concerning human infections by parvovirus B19?

Human bocavirus is a newly discovered parvovirus. It has been detected most frequently in which type of sample?

What adenovirus protein or proteins regulate early transcription of the viral genes and modulate the cell cycle?

What adenovirus protein serves as primer for initiation of viral DNA synthesis?

What adenovirus protein comprises the majority of capsomeres making up the virus capsid?

A 3-month-old infant had watery diarrhea and fever for 10 days. Rotavirus or adenovirus types 40 and 41 are the suspected agents. What type of specimen would be most appropriate for detection of adenovirus types 40 and 41 infection in this patient?

Which of the following human diseases has not been associated with adenoviruses?

A 2½-year-old child attending nursery school acquires a mild respiratory infection. Other children in the nursery school have similar illnesses. Which adenovirus types are the most likely causes of the illnesses?

Which adenovirus types are frequent causes of acute respiratory disease among military recruits?

Which of the following events led to reappearance of acute respiratory disease outbreaks among U.S. Military recruits in the late 1990s?

Which of the following groups of individuals is at the lowest risk of adenovirus disease?

Adenoviruses can cause eye infections that are highly contagious. Which of the following is least likely to be a means of transmission during an outbreak of epidemic keratoconjunctivitis?

There are 57 known sero types of human adenoviruses. Which of the following statements is most accurate?

Each of the following statements concerning adenoviruses is correct except

Which of the following conditions is least likely to be caused by adenoviruses?

A previously healthy 3-year-old boy develops a classic viral childhood illness. Which of the following primary viral infections of childhood is usually symptomatic?

Which one of the following is a recommended therapy for herpes simplex virus genital infection?

Most herpesvirus infections are endemic worldwide. Which one of the following viruses shows marked geographic differences in seroprevalence?

A 19-year-old female college student has a fever, sore throat, and lymphadenopathy accompanied by lymphocytosis with atypical cells and an increase in sheep cell agglutinins. The diagnosis is most likely

A Tzanck smear of a scraping obtained from a vesicle on the skin demonstrates multinucleated giant cells. Multinucleated giant cells are associated with which of the following viruses?

Which of the following statements about betaherpesviruses is not true?

A 28-year-old woman has recurrent genital herpes. Which of the following statements about genital herpes infections is true?

Which of the following viruses causes a mononucleosis-like syndrome and is excreted in the urine?

A 53-year-old woman develops fever and focal neurologic signs. Magnetic resonance imaging shows a left temporal lobe lesion. Which of the following tests would be most appropriate to confirm a diagnosis of herpes simplex encephalitis in this patient?

Which of the following tumors is caused by a virus other than Epstein-Barr virus?

An outbreak of a rash called “mat herpes” occurred among high school students who had competed in a wrestling tournament. Which of the following statements is most accurate?

The shingles vaccine is recommended for which of the following groups?

The most common congenital infection is caused by

Which of the following groups are at increased risk for herpes zoster?

Which one of the following is the best explanation for the selective action of acyclovir (acycloguanosine) in herpes simplex virus (HSV)-infected cells?

Each of the following statements concerning herpesvirus latency is correct except

Vaccines have been demonstrated to be efficacious in preventing herpesvirus disease in which one of the following situations?

Herpes simplex virus type 1 (HSV-1) is distinct from herpes simplex virus type 2 (HSV-2) in several different ways. Which one of the following is the least accurate statement?

Each of the following statements concerning Epstein-Barr virus is correct except